An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

    Tell a stranger that you talk to yourself, and you're likely to get written off as eccentric. But the truth is that we all have a voice in our head. When we talk to ourselves, we often hope to tap into our inner coach but find our inner critic instead. When we're facing a tough task, our inner coach can buoy us up: Focus--you can do this. But, just as often, our inner critic sinks us entirely: I'm going to fail. They'll all laugh at me. What's the use?In Chatter, acclaimed psychologist Ethan Kross explores the silent conversations we have with ourselves. Interweaving groundbreaking behavioral and brain research from his own lab with real-world case studies--from a pitcher who forgets how to pitch, to a Harvard undergrad negotiating her double life as a spy--Kross explains how these conversations shape our lives, work, and relationships. He warns that giving in to negative and disorienting self-talk--what he calls "chatter"--can tank our health, sink our moods, strain our social connections, and cause us to fold under pressure.But the good news is that we're already equipped with the tools we need to make our inner voice work in our favor. These tools are often hidden in plain sight--in the words we use to think about ourselves, the technologies we embrace, the diaries we keep in our drawers, the conversations we have with our loved ones, and the cultures we create in our schools and workplaces.Brilliantly argued, expertly researched, and filled with compelling stories, Chatter gives us the power to change the most important conversation we have each day: the one we have with ourselves.

    After he had a panic attack on live television, he went on a strange and circuitous journey that ultimately led him to become one of meditation’s most vocal public proponents.Here’s what he’s fixated on now: Science suggests that meditation can lower blood pressure, mitigate depression and anxiety, and literally rewire key parts of the brain, among numerous other benefits. And yet there are millions of people who want to meditate but aren’t actually practicing. What’s holding them back?In this guide to mindfulness and meditation for beginners and experienced meditators alike, Harris and his friend Jeff Warren, a masterful teacher and “Meditation MacGyver,” embark on a cross-country quest to tackle the myths, misconceptions, and self-deceptions that stop people from meditating. They rent a rock-star tour bus (whose previous occupants were Parliament Funkadelic) and travel across eighteen states, talking to scores of would-be meditators—including parents, military cadets, police officers, and even a few celebrities. They create a taxonomy of the most common issues (“I suck at this,” “I don’t have the time,” etc.) and offer up science-based life hacks to help people overcome them.The book is filled with game-changing and deeply practical meditation instructions. Amid it all unspools the strange and hilarious story of what happens when a congenitally sarcastic, type-A journalist and a groovy Canadian mystic embark on an epic road trip into America’s neurotic underbelly, as well as their own.

    Based on the breakthrough Nobel Prize-winning science of autophagy—the process by which cells remove toxins, recycle parts, and repair their own damage—Glow15 is a lifestyle plan that will make you look and feel younger. In just 15 days, you’ll begin to harness the power of autophagy to drop pounds, get glowing skin, and restore your energy through • DIET Discover IFPC: a combination of intermittent fasting and protein cycling to lose weight—and wrinkles. • ENERGY Drink an autophagy-activating ketogenic tea to boost your metabolism. • EXERCISE Do less to get more out of your workouts. • SLEEP Identify your sleep type and create a customized routine for your best rest yet. • BEAUTY Find the newest ingredients and cutting-edge treatments to get glowing. Naomi Whittel travels from spice markets in Bangalore, India, to farms in Okinawa, Japan, to vineyards in Bordeaux, France, with one mission: to discover the purest health-promoting ingredients that can help women transform their lives. Her travels give her unprecedented access to renowned scientists around the world, and in Glow15 she shares the research and advice she’s learned from these experts, who include MDs, dermatologists, sleep doctors, nutritionists, and fitness physiologists. Get step-by-step guidelines from America’s best-loved “wellness explorer” for each part of this easy-to-follow program, including more than 50 delicious autophagy-boosting recipes, as well as illustrated exercises you can do at home. Plus, find out what this 44-year-old CEO and mother of four does to defy aging—from her personal autophagy hacks, to youth-boosting “Powerphenols,” to how to get glowing.

    Many people think of microbes as germs to be eradicated, but those that live with us—the microbiome—build our bodies, protect our health, shape our identities, and grant us incredible abilities. In this astonishing book, Ed Yong takes us on a grand tour through our microbial partners, and introduces us to the scientists on the front lines of discovery. Yong, whose humor is as evident as his erudition, prompts us to look at ourselves and our animal companions in a new light—less as individuals and more as the interconnected, interdependent multitudes we assuredly are. The microbes in our bodies are part of our immune systems and protect us from disease. Those in cows and termites digest the plants they eat. In the deep oceans, mysterious creatures without mouths or guts depend on microbes for all their energy. Bacteria provide squids with invisibility cloaks, help beetles to bring down forests, and allow worms to cause diseases that afflict millions of people. I Contain Multitudes is the story of these extraordinary partnerships, between the creatures we are familiar with and those we are not. It reveals how we humans are disrupting these partnerships and how we might manipulate them for our own good. It will change both our view of nature and our sense of where we belong in it.

    But if we are supposedly evolution’s greatest creation, why do we have such bad knees? Why do we catch head colds so often—two hundred times more often than a dog does? How come our wrists have so many useless bones? Why is the vast majority of our genetic code pointless? And are we really supposed to swallow and breathe through the same narrow tube? Surely there’s been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last. The human body is one big pile of compromises. But that is also a testament to our greatness: as Lents shows, humans have so many design flaws precisely because we are very, very good at getting around them.   A rollicking, deeply informative tour of humans’ four billion year long evolutionary saga, Human Errors both celebrates our imperfections and offers an unconventional accounting of the cost of our success.

    Apply mindfulness to your relationship with food and you may be surprised to find that eating becomes a source of joy--instead an angst-ridden activity haunted by nutritionally based guilt, calorie-counting, and even more serious problems like eating disorders. For nearly a decade, Jan Bays's guide to eating mindfully has been transforming people's relationship with food--and based on her continued work with those people as well as new data emerging on the topic, she has created this significantly revised and refined version of the original, which contains even more essential information on mindful eating, as well as inspiring new examples from her workshop participants. She shows how to: - Tune into your body's own wisdom about what, when, and how much to eat- Eat less while feeling fully satisfied- Identify your habits and patterns with food- Develop a more compassionate attitude toward your struggles with eating- Discover what you're really hungry for The 75-minute audio program of exercises from the original book has also been revised and will now be available as an audio download.

    The author uses two of his Midwestern hometown grocery chains, Heinen's and Fazio's, and his memories of his father's love of food and grocery shopping as the foundation for this engaging narrative. While he notes that many other writers have covered the history of the grocery store, the broken industrial food production system, and the nutritional benefits of various foods, Ruhlman delivers -a reported reflection on the grocery store in America,

    These three Great Untruths are part of a larger philosophy that sees young people as fragile creatures who must be protected and supervised by adults. But despite the good intentions of the adults who impart them, the Great Untruths are harming kids by teaching them the opposite of ancient wisdom and the opposite of modern psychological findings on grit, growth, and antifragility. The result is rising rates of depression and anxiety, along with endless stories of college campuses torn apart by moralistic divisions and mutual recriminations. This is a book about how we got here. First Amendment expert Greg Lukianoff and social psychologist Jonathan Haidt take us on a tour of the social trends stretching back to the 1980s that have produced the confusion and conflict on campus today, including the loss of unsupervised play time and the birth of social media, all during a time of rising political polarization. This is a book about how to fix the mess. The culture of “safety” and its intolerance of opposing viewpoints has left many young people anxious and unprepared for adult life, with devastating consequences for them, for their parents, for the companies that will soon hire them, and for a democracy that is already pushed to the brink of violence over its growing political divisions. Lukianoff and Haidt offer a comprehensive set of reforms that will strengthen young people and institutions, allowing us all to reap the benefits of diversity, including viewpoint diversity. This is a book for anyone who is confused by what’s happening on college campuses today, or has children, or is concerned about the growing inability of Americans to live and work and cooperate across party lines.

    Charting the most cutting-edge scientific breakthroughs, and marshalling his decades of research and clinical practice, Walker explains how we can harness sleep to improve learning, mood and energy levels, regulate hormones, prevent cancer, Alzheimer's and diabetes, slow the effects of aging, and increase longevity. He also provides actionable steps towards getting a better night's sleep every night.

    The answers will surprise and delight you as Alexandra Horowitz, a cognitive scientist, explains how dogs perceive their daily worlds, each other, and that other quirky animal, the human.Temple Grandin meets Stephen Pinker in this engaging and informative look at what goes on inside the minds of dogs—from a cognitive scientist with a background at The New Yorker.With more than 52 million pet dogs in America today, it’s clear we are a nation of unabashed dog-lovers. Yet the relationship between dogs and humans remains a fascinating mystery, as no one really knows what goes on in the canine mind. Now, in Inside of a Dog, Alexandra Horowitz fuses her perspectives as both scientist and dog-owner to deliver a fresh look at the world of dogs—as seen from the animal’s point of view. Inspired by her years of living with her own dog, Pumpernickel, who was a constant source of delight and mystery, Horowitz’s mind became filled with questions and ideas. In crisp, clear prose, she draws on her research in the field of dog cognition to give readers a sense of a dog’s perceptual and cognitive abilities—and paints a picture of what the canine experience is like. Horowitz’s own scientific journey, and the insights she uncovered, allowed her to understand her dog better and appreciate her more.Containing up-to-the minute research and providing many moments of dog-behavior recognition, this lively and absorbing book helps dog owners to see their best friend’s behavior in a different, and revealing light, allowing them to understand their pets and enjoy their company even more.

     For too long we’ve blamed dietary fat for weight gain and health problems. The truth is, a diet that’s high in natural, healthy fats can actually help your body burn fat! That’s the secret behind the ketogenic diet. As you get more of your calories from healthy fats and cut back on carbs, you’ll start burning fat, losing weight, and feeling strong and energetic—without feeling hungry or deprived. The Keto Diet does away with the “one size fits all” philosophy offering a customizable approach that is tailored to the unique needs of the individual. Leanne provides the tools to empower everyone to develop a personalized nutrition plan, offering limitless options while taking away the many restrictions of a traditional ketogenic diet. A one-stop guide to the ketogenic way of eating, The Keto Diet shows you how to transition to and maintain a whole foods–based, paleo-friendly, ketogenic diet with a key focus on practical strategies—and tons of mouthwatering recipes. It includes: • Over 125 healthy and delicious whole-food recipes that will help your body burn fat, including: Chicken Crisps Bacon-Wrapped Mini Meatloaf’s Keto Sandwich Bread Waldorf-Stuffed Tomatoes No Nuts! Granola with Clusters Chicken Pot Pie Chocolate-Covered Coffee Bites • Five 28-day meal plans that walk you through a month of eating keto • Tools to make your high-fat life a breeze including guides for your favorite grocery stores, yes/no food lists, food sensitivity replacements, how to go dairy-free to reduce inflammation, and more. The Keto Diet will help you gain energy, lose weight, improve your health, and turn you into the ultimate fat-burning machine—all without restricting or even counting calories. You’ll have all the tools you need to fall in love with your body and banish your fear of fat forever!

    Vincent Pedre understands gut problems firsthand. He suffered from IBS for years before becoming an expert in functional medicine and learning how to heal his body from the inside. Dr. Pedre used his own experience to develop The Gut C.A.R.E. Program—an approach that draws from both Western and Eastern methodologies, combining integrative and functional medicine—that has a proven success record in his private practice in New York. Now, for the first time, Dr. Pedre makes his revolutionary plan for health and wellness available to everyone.Happy Gut takes readers step-by-step through Gut C.A.R.E.—Cleanse, Activate, Restore, and Enhance—which eliminates food triggers, clears the gut of unfriendly pathogens, and replaces them with healthy probiotics and nutrients that repair and heal the gut. Rather than masking symptoms with medication, he shows us how to address the problem at its core to restore the gastrointestinal system to its proper functioning state. By fixing problems in the gut, followers of Dr. Pedre’s program have found that their other health woes are also cured and have lost weight, gained energy, and improved seemingly unrelated issues, such as seasonal allergies, in addition to eliminating their chronic muscle and abdominal pain.Complete with recipes and meal plans including gluten-free, low-fat, and vegetarian options, a 28-day gut cleanse, yoga postures to help digestion, and testimonials from many of his patients, Happy Gut will help you feel better and eliminate gut issues for life.

    News & World Report, Dr. Ornish's Program is now covered by Medicare when offered virtually at home.Dean Ornish, M.D., has directed revolutionary research proving, for the first time, that lifestyle changes can often reverse--undo!--the progression of many of the most common and costly chronic diseases and even begin reversing aging at a cellular level.Medicare and many insurance companies now cover Dr. Ornish's lifestyle medicine program for reversing chronic disease because it consistently achieves bigger changes in lifestyle, better clinical outcomes, larger cost savings, and greater adherence than have ever been reported--based on forty years of research published in the leading peer-reviewed medical and scientific journals.Now, in this landmark book, he and Anne Ornish present a simple yet powerful new unifying theory explaining why these same lifestyle changes can reverse so many different chronic diseases and how quickly these benefits occur. They describe what it is, why it works, and how you can do it:- Eat well a whole foods, plant-based diet naturally low in fat and sugar and high in flavor. The "Ornish diet" has been rated "#1 for Heart Health" by U.S. News & World Report for eleven years since 2011. - Move more moderate exercise such as walking - Stress less including meditation and gentle yoga practices - Love more how love and intimacy transform loneliness into healingWith seventy recipes, easy-to-follow meal plans, tips for stocking your kitchen and eating out, recommended exercises, stress-reduction advice, and inspiring patient stories of life-transforming benefits--for example, several people improved so much after only nine weeks they were able to avoid a heart transplant--Undo It! empowers readers with new hope and new choices.Praise for Undo It! "The Ornishes' work is elegant and simple and deserving of a Nobel Prize, since it can change the world!"--Richard Carmona, M.D., MPH, FACS, seventeenth Surgeon General of the United States"If you want to see what medicine will be like ten years from now, read this book today."--Rita F. Redberg, M.D., editor in chief, JAMA Internal Medicine"This is one of the most important books on health ever written."--John Mackey, CEO, Whole Foods Market

    And, like most consumers, he often reads the ingredients label -- without a clue as to what most of it means. So when his young daughter asked, "Daddy, what's polysorbate 60?" he was at a loss -- and determined to find out. From the phosphate mines in Idaho to the corn fields in Iowa, from gypsum mines in Oklahoma to the vanilla harvest in Madagascar, Twinkie, Deconstructed is a fascinating, thoroughly researched romp of a narrative that demystifies some of the most common processed food ingredients -- where they come from, how they are made, how they are used -- and why. Beginning at the source (hint: they're often more closely linked to rock and petroleum than any of the four food groups), we follow each Twinkie ingredient through the process of being crushed, baked, fermented, refined, and/or reacted into a totally unrecognizable goo or powder with a strange name -- all for the sake of creating a simple snack cake. An insightful exploration into the food industry, if you've ever wondered what you're eating when you consume foods containing mono- and diglycerides or calcium sulfate (the latter, a food-grade equivalent) this book is for you.