As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    Through Chasten’s joyful, witty social media posts, the public gained a behind-the-scenes look at his life with Pete on the trail—moments that might have ranged from the mundane to the surprising, but that were always heartfelt.Chasten has overcome a multitude of obstacles to get here. In this moving, uplifting memoir, he recounts his journey to finding acceptance as a gay man. He recalls his upbringing in rural Michigan, where he knew he was different, where indeed he felt different from his father and brothers. He recounts his coming out and how he’s healed from revealing his secret to his family, friends, community, and the world. And he tells the story of meeting his boyfriend, whom he would marry and who would eventually become a major Democratic leader.With unflinching honesty, unflappable courage, and great warmth, Chasten Buttigieg relays his experience of growing up in America and embracing his true self, while inspiring others to do the same.

    She reveals the story of her own growth in tandem with the growth of an ongoing movement for equality. This is the story at the heart of My Life on the Road.

    The critically acclaimed series became America’s most watched—and most talked about—network show, even building on its fan base in the drama’s second season. As Kate Pearson, Chrissy Metz presents a character that has never been seen on television, yet viewers see themselves in her, no matter what they look like or where they come from. Considered a role model just for being her authentic self, Chrissy found herself on magazine covers and talk shows, walking red carpets, and as the subject of endless conversations on social media “I don’t know what you’ve been through to play her,” she is often told by fans, “but it was something.”In This is Me, Chrissy Metz shares her story with a raw honesty that will leave readers both surprised but also inspired. Infused with the same authenticity she brings to her starring role, Chrissy’s This is Me is so much more than your standard Hollywood memoir or collection of personal essays. She embraces the spirit of Shonda Rhimes’ Year of Yes, and shares how she has applied the lessons she learned from both setbacks and successes. A born entertainer, Chrissy finds light in even her darkest moments, and leaves the reader feeling they are spending time with a friend who gets it.Chrissy Metz grew up in a large family, one that always seemed to be moving, and growing. Her father disappeared one day, leaving her mother to work a series of menial jobs and his children to learn to live with the threat of hunger and the electricity being cut off. When her mother remarried, Chrissy hoped for “normal” but instead experienced a form of mental pain that seemed crafted just for her. The boys who showed her attention did so with strings attached as well, and Chrissy accepted it, because for her, love always came with conditions.When she set out for Los Angeles, it was the first time she had been away from her family and from Florida. And for years, she got barely an audition. So how does a woman with the deck stacked against her radiate such love, beauty and joy? This too is at the heart of This is Me. With chapters that alternate from autobiographical to instructional, Chrissy offers practical applications of her hard-won insights in a series of “Bee Mindful” interstitials. There she invites you to embrace gratitude in “Say Thank You” or to be honest with your partner and yourself in “The Shrouded Supreme.” Blending love and experience, Chrissy encourages us all to claim our rightful place in a world that may be trying to knock us down, find our own unique gifts, and pursue our dreams.

    Wong told the world her remarkably unfiltered thoughts on marriage, sex, Asian culture, working women, and why you never see new mom comics on stage but you sure see plenty of new dads.The sharp insights and humor are even more personal in this completely original collection. She shares the wisdom she's learned from a life in comedy and reveals stories from her life off stage, including the brutal singles life in New York (i.e. the inevitable confrontation with erectile dysfunction), reconnecting with her roots (and drinking snake blood) in Vietnam, tales of being a wild child growing up in San Francisco, and parenting war stories. Though addressed to her daughters, Ali Wong's letters are absurdly funny, surprisingly moving, and enlightening (and disgusting) for all.

    In this remarkable symphony of essays adapted and expanded from his ground-breaking, critically acclaimed podcast, John Green reviews different facets of the human-centered planet - from the QWERTY keyboard and Halley's Comet to Penguins of Madagascar - on a five-star scale.Complex and rich with detail, the Anthropocene's reviews have been praised as 'observations that double as exercises in memoiristic empathy', with over 10 million lifetime downloads. John Green's gift for storytelling shines throughout this artfully curated collection about the shared human experience; it includes beloved essays along with six all-new pieces exclusive to the book.

    No one in the system can help him. No one can tell him if he has a family. No one can tell him why, with obvious African-American features, he has the last name of Klakowicz.Along the way, a single faint light comes only from a neighbor’s small acts of kindness and caring—and a box of books. From one of those books he learns that he has to fight in any way he can—for victory is in the battle. His victory is to excel in school.Against all odds, the author succeeded. He attended college, graduated, became a successful corporate executive, and married a wonderful woman with whom he established a loving family of his own. Through it, he dug voraciously through records and files and found his history, his birth family—and the ultimate disappointment as some family members embrace him, but others reject him.Readers won’t be the same after reading this powerful story. They will share in the hurts and despair but also in the triumph against daunting obstacles. They will share this story with their family, with their friends, with their neighbors.

    Leah Remini has never been the type to hold her tongue. That willingness to speak her mind, stand her ground, and rattle the occasional cage has enabled this tough-talking girl from Brooklyn to forge an enduring and successful career in Hollywood. But being a troublemaker has come at a cost. That was never more evident than in 2013, when Remini loudly and publicly broke with the Church of Scientology. Now, in this frank, funny, poignant memoir, the former King of Queens star opens up about that experience for the first time, revealing the in-depth details of her painful split with the church and its controversial practices. Indoctrinated into the church as a child while living with her mother and sister in New York, Remini eventually moved to Los Angeles, where her dreams of becoming an actress and advancing Scientology's causes grew increasingly intertwined. As an adult, she found the success she'd worked so hard for, and with it a prominent place in the hierarchy of celebrity Scientologists alongside people such as Tom Cruise, Scientology's most high-profile adherent. Remini spent time directly with Cruise and was included among the guests at his 2006 wedding to Katie Holmes. But when she began to raise questions about some of the church's actions, she found herself a target. In the end, she was declared by the church to be a threat to their organization and therefore a "Suppressive Person," and as a result, all of her fellow parishioners—including members of her own family—were told to disconnect from her. Forever. Bold, brash, and bravely confessional, Troublemaker chronicles Leah Remini's remarkable journey toward emotional and spiritual freedom, both for herself and for her family. This is a memoir designed to reveal the hard-won truths of a life lived honestly—from an author unafraid of the consequences.

    For a single mother living paycheck to paycheck who had always been the caregiver rather than the one needing care, the catastrophic illness was both a crisis and an initiation into new ideas about mortality and the gendered politics of illness.A twenty-first-century Illness as Metaphor, as well as a harrowing memoir of survival, The Undying explores the experience of illness as mediated by digital screens, weaving in ancient Roman dream diarists, cancer hoaxers and fetishists, cancer vloggers, corporate lies, John Donne, pro-pain ”dolorists,” the ecological costs of chemotherapy, and the many little murders of capitalism. It excoriates the pharmaceutical industry and the bland hypocrisies of ”pink ribbon culture” while also diving into the long literary line of women writing about their own illnesses and ongoing deaths: Audre Lorde, Kathy Acker, Susan Sontag, and others.A genre-bending memoir in the tradition of The Argonauts, The Undying will break your heart, make you angry enough to spit, and show you contemporary America as a thing both desperately ill and occasionally, perversely glorious.

    Beth spends her days riding the buses in her Pennsylvania city. The drivers, a lively group, are her mentors; her fellow passengers are her community. One day, Beth asked Rachel to accompany her on the buses for an entire year; the book is the chronicle of that remarkable time. Rachel, a writer and college teacher whose hyperbusy life camouflaged her emotional isolation, had much to learn in her sister's extraordinary world. Here are life lessons from which every reader can profit: how to live in the moment, how to pay attention to what really matters, how to change, how to love, —and how to slow down and enjoy the ride. Simon elegantly braids together riveting memories of terrifying maternal abandonment, fierce sisterly loyalty, and astonishing forgiveness. She brings to light the almost invisible world of mental retardation, finds unlikely heroes in everyday life, and portrays her very special sister Beth as the endearing and indomitable person she is. This heartwarming book takes the reader on an inspirational journey, at once unique and universal.

    Will George lure her into assisted living? When hell freezes over. He can’t bring himself to force her from the home both treasure—the place where his father’s voice lingers, the scene of shared jokes, skirmishes, and, behind the dusty antiques, a rarely acknowledged conflict: Betty, who speaks her mind but cannot quite reveal her heart, has never really accepted the fact that her son is gay.As these two unforgettable characters try to bring their different worlds together, Hodgman reveals the challenges of Betty’s life and his own struggle for self-respect, moving readers from their small town—crumbling but still colorful—to the star-studded corridors of Vanity Fair. Evocative of The End of Your Life Book Club and The Tender Bar, Hodgman’s New York Times bestselling debut is both an indelible portrait of a family and an exquisitely told tale of a prodigal son’s return.

    A beach body by summer. A trip to Disneyland around the corner. A promotion on the horizon. Everyone wants to believe that they are headed toward good, better, best. But what happens when the life you hoped for is put on hold indefinitely?Kate Bowler believed that life was a series of unlimited choices, until she discovered, at age 35, that her body was wracked with cancer. In No Cure for Being Human, she searches for a way forward as she mines the wisdom (and absurdity) of today's "best life now" advice industry, which insists on exhausting positivity and on trying to convince us that we can out-eat, out-learn, and out-perform our humanness. We are, she finds, as fragile as the day we were born.With dry wit and unflinching honesty, Kate Bowler grapples with her diagnosis, her ambition, and her faith as she tries to come to terms with her limitations in a culture that says anything is possible. She finds that we need one another if we're going to tell the truth: Life is beautiful and terrible, full of hope and despair and everything in between--and there's no cure for being human.

    What does she look like?" As the only African American soloist dancing with the prestigious American Ballet Theatre, Misty Copeland has made history. But when she first placed her hands on the barre at an after-school community center, no one expected the undersized, anxious thirteen-year-old to become a ground-breaking ballerina. When she discovered ballet, Misty was living in a shabby motel room, struggling with her five siblings for a place to sleep on the floor. A true prodigy, she was dancing en pointe within three months of taking her first dance class and performing professionally in just over a year: a feat unheard of for any classical dancer. But when Misty became caught between the control and comfort she found in the world of ballet and the harsh realities of her own life (culminating in a highly publicized custody battle), she had to choose to embrace both her identity and her dreams, and find the courage to be one of a kind. With an insider's unique point of view, Misty opens a window into the life of a professional ballerina who lives life center stage: from behind the scenes at her first auditions to her triumphant roles in some of the most iconic ballets. But in this beautifully written memoir, she also delves deeper to reveal the desire and drive that made her dreams reality. Life in Motion is a story of passion and grace for anyone who has dared to dream of a different life.