Whether eating, taking drugs, engaging in sex, or doing good deeds, the pursuit of pleasure is a central drive of the human animal. In The Compass of Pleasure Johns Hopkins neuroscientist David J. Linden explains how pleasure affects us at the most fundamental level: in our brain. As he did in his award-winning book, The Accidental Mind, Linden combines cutting-edge science with entertaining anecdotes to illuminate the source of the behaviors that can lead us to ecstasy but that can easily become compulsive. Why are drugs like nicotine and heroin addictive while LSD is not? Why has the search for safe appetite suppressants been such a disappointment? The Compass of Pleasure concludes with a provocative consideration of pleasure in the future, when it may be possible to activate our pleasure circuits at will and in entirely novel patterns.

    She is also a superbly gifted writer–witty, insightful, at once deeply humane and refreshingly wry. In Another Day in the Frontal Lobe, Dr. Firlik draws on this rare combination to create a neurosurgeon’s Kitchen Confidential–a unique insider’s memoir of a fascinating profession.Neurosurgeons are renowned for their big egos and aggressive self-confidence, and Dr. Firlik confirms that timidity is indeed rare in the field. “They’re the kids who never lost at musical chairs,” she writes. A brain surgeon is not only a highly trained scientist and clinician but also a mechanic who of necessity develops an intimate, hands-on familiarity with the gray matter inside our skulls. It’s the balance between cutting-edge medical technology and manual dexterity, between instinct and expertise, that Firlik finds so appealing–and so difficult to master. Firlik recounts how her background as a surgeon’s daughter with a strong stomach and a keen interest in the brain led her to this rarefied specialty, and she describes her challenging, atypical trek from medical student to fully qualified surgeon. Among Firlik’s more memorable cases: a young roofer who walked into the hospital with a three-inch-long barbed nail driven into his forehead, the result of an accident with his partner’s nail gun, and a sweet little seven-year-old boy whose untreated earache had become a raging, potentially fatal infection of the brain lining. From OR theatrics to thorny ethical questions, from the surprisingly primitive tools in a neurosurgeon’s kit to glimpses of future techniques like the “brain lift,” Firlik cracks open medicine’s most prestigious and secretive specialty. Candid, smart, clear-eyed, and unfailingly engaging, Another Day in the Frontal Lobe is a mesmerizing behind-the-scenes glimpse into a world of incredible competition and incalculable rewards.From the Hardcover edition.

    The 4th Edition of this bestseller has been completely revised and reorganized to present a more up-to-date approach to the field, with less emphasis on traditional hospital-based practice. It uses the APGO/CREOG curriculum objectives as a framework, with a special emphasis on women's health issues. A new, full-color design with many illustrations and photographs complements the text. Plus, a free downloadable PDA software program provides a complete guide to the most common disorders. The smart way to study Elsevier titles STUDENT CONSULT will help you master difficult concepts and study more efficiently in print and online Perform rapid searches. Integrate bonus content from other disciplines. Download text to your handheld device. And a lot more. Each STUDENT CONSULT title comes with full text online, a unique image library, case studies, USMLE style questions, and online note-taking to enhance your learning experience.

    When his company assigns him to a new project situated in a small town in Oregon, he initially refuses the offer, until he realizes that this change may be exactly what he needs to come to terms with his problems.While the town of Woodberry is perfect at first glance and his neighbors friendly, this quickly changes when Chris starts asking about the radio tower perched on top of the highest hill in the town. He is warned not to talk about the tower and soon becomes increasingly aware that he is closely watched. To make things worse, each time the tower lights start blinking, the townsfolk go into a hypnotic trance and their behavior turns hostile.Chris’ new life quickly turns into a desperate fight for survival, as he realizes that he’s not the first victim to become trapped in the town.

     What is it like to be the senior surgeon when a young woman is brought to casualty with a life-threatening bleed? What does the fear of cancer do to a person? Is it ever best not to tell the patient everything? Tender is the Scalpel’s Edge draws on Gautam Das’s real-life experiences working in Britain’s busy NHS hospitals, from the plunging depths of a patient dying on the operating table to the euphoria of a life saved by teamwork and skill. Described in exquisite detail and with extreme sensitivity, Gautam shares his journey from a medical student fighting his own inner demons to a senior NHS consultant surgeon. Shards of his earlier life in India add to the richness of the narrative in tales that observe life with all its contradictions, like the little village boy with bone cancer. While other anecdotes take in the lighter side of life, Tender is the Scalpel’s Edge is written to inform and engross the general reader, as well as those with a curiosity of life behind the surgeon’s mask. Written in a manner similar to other medical biographies including Henry Marsh’s Do No Harm, Atul Gawande’s Being Mortal and When Breath Becomes Air by Paul Kalanithi, Tender is the Scalpel’s Edge is a moving collection of true stories from a professional at the frontline of medical care.

    Indeed, most are only barely aware of the diseases caused by them, except, perhaps, for mad cow disease. Yet prions are the stuff of a revolutionary science?a science that might lead to cures for some of humankind?s most devastating diseases.Fatal Flaws is a scientific detective story about this elusive protein, starting with the discovery of kuru, a disease unique to New Guinea in the 1950s that baffled scientists and carried with it whispers of cannibalism. Kuru began a scientific stampede to seek out the agent of this mysterious disease?the prion?a misfolded protein whose existence some of the world?s top scientists still find difficult to accept. Today, the subject of prions remains controversial, yet the proteins might promise new treatments for some of the most intractable brain diseases, ones that affect millions around the planet, including Parkinson?s, ALS and Alzheimer?s.In Fatal Flaws, Jay Ingram unties a complicated interweaving of biology, medicine, human tragedy, surprise and disbelief in the world of prions, and he unravels some of history?s most stunning revelations about disease, the brain and infection.

    He decided right then, at the age of nine, what he wanted to be when he grew up...an undertaker. The day he turned twenty-one, Casey joined the ranks of Morton-Albright, a family owned and operated mortuary, in the small Florida town of Angel Shoals. Immediately, he felt right at home. He seems to have a gift for embalming. The Morton and Albright families welcome him like the family he never had. The quirky and mischievous Natalie Albright is the girl he's always dreamed of. And within the walls of Morton-Albright, Casey feels a reassuring presence that calms him, like nothing ever has before. But his happiness will be short-lived if the mortuary falls victim to a rapacious funeral-home giant. With family secrets being uncovered, contested wills, and rumors of illegal funeral practices circling, the lives entwined in this funeral home become filled with intrigue, deception, and, of course, death. Bringing abundant experience and a fresh wit to the page, Miles Keaton Andrew offers a clever, spirited, darkly humorous first novel, rich with dialogue and full of nuanced characters.

    A man who sees cartoon characters running across the room; a girl whose world turns all Alice in Wonderland; another who transforms into a ragdoll whenever she even thinks about moving.The brain is the most complex structure in the universe. Neurologists must puzzle out life-changing diagnoses from the tiniest of clues. It’s the ultimate medical detective work. In this riveting book, one of the UK’s leading neurologists will take you with her as she follows the clues of her patients’ symptoms. It’s a journey that will open your eyes to the unfathomable intricacies of our brains, and the infinite variety of human capacity and experience.

    Like most people, you probably wake up, get hungry for meals and doze off in bed around the same time every day. If you’ve ever experienced jet lag or pulled an all-nighter, you know that this schedule can easily be thrown off kilter. But for some people, that imbalance—difficulty sleeping at night, hunger at odd times, or sudden fatigue at noon—is a constant. If you're one of those people, Dr. Satchin Panda, one of the leading researchers on circadian rhythms, has a plan to reset your body clock.Beginning with an in-depth explanation of the circadian clock—why it’s important, how it works, and how to know it isn’t working—The Circadian Code outlines lifestyle changes to make to get back on track. It's a concrete plan to enhance weight loss, improve sleep, optimize exercise, and manage technology so that it doesn’t interfere with your body’s natural rhythm. Dr. Panda’s life-changing methods show you how to prevent and reverse ailments like diabetes, cancer, and dementia, as well as microbiome conditions like acid reflux, heartburn, and irritable bowel disease.

    . . on addiction.”—Ezra Klein, New York Times.“Accessible and enjoyable. The Craving Mind brilliantly combines the latest science with universal real-life experiences—from falling in love to spending too much time with our phones.”—Arianna Huffington We are all vulnerable to addiction. Whether it’s a compulsion to constantly check social media, binge eating, smoking, excessive drinking, or any other behaviors, we may find ourselves uncontrollably repeating. Why are bad habits so hard to overcome? Is there a key to conquering the cravings we know are unhealthy for us?   This book provides groundbreaking answers to the most important questions about addiction. Dr. Judson Brewer, a psychiatrist and neuroscientist who has studied the science of addictions for twenty years, reveals how we can tap into the very processes that encourage addictive behaviors in order to step out of them. He describes the mechanisms of habit and addiction formation, then explains how the practice of mindfulness can interrupt these habits. Weaving together patient stories, his own experience with mindfulness practice, and current scientific findings from his own lab and others, Dr. Brewer offers a path for moving beyond our cravings, reducing stress, and ultimately living a fuller life.

    Albert Errington, aged seventy-nine, lived alone in his Bristol home and appears to have taken a nasty tumble down the stairs late one night. His death seems a terrible shock for his son and daughter, and his long-term carer. But ever-observant, DI Harland is sure this isn't an accidental death. And he will find out who is trying to get away with murder . . .

    Eddie Flynn in the book that won the 2012 Northern Crime competition. "Eddie Flynn is part Philip Marlowe, part Eddie Gumshoe, a likeable wisecracking guy ... humour ... violent confrontations ... well recommended." - EUROCRIME "... great concise writing style ... fast paced action ... Donovan makes you feel as though you are uncovering the truth ... well worth reading." - NEWBOOKSMAG Family feuds, booze and bad company. Teenager Rebecca Slater's walk on the wild side has taken a downward spiral. And now she's disappeared. But her family don't seem to have noticed. Wealthy, private, dysfunctional, the Slaters deny that their daughter is missing – even as they block all attempts by Rebecca's friends to contact her. So the friends contact a private investigator. Eddie Flynn is good at finding people. And he's good at spotting lies. It doesn't take him long to see through the Slaters' denials. So he digs around, and isn't too surprised when some unpleasant people come scuttling out of the cracks in their perfect world. But for these people the teenager's disappearance is part of a plan. One that's too important to be threatened by an investigator with more persistence than sense. So it's time for the investigator to disappear...

    No explanations. No apologies.Packing up his guitar and his dreams he returned to his family’s destination dude ranch in Wyoming.Plan B.The only other thing he knew, the cowboy life.When all was said and done that’s where he belonged anyway…wasn’t it?The tabloids and gossip pipelines fixated on it for about a minute, until it was buried under the next big story…Pastry chef Sophia Russo had it all. A Le Cordon Bleu pedigree, a successful career with a five-star restaurant group, a prince charming fiancé and a luxurious condo in the River North district of Chicago.Until it became the metaphoric equivalent of a train wreck—in the blink of an eye, she found herself in a freefall. No job, no condo, no fiancé.After months of laying low, working at her parent’s bakery in downtown Chicago, Sophia and her bestie Amelia embark on their dream vacation. Destination: a real-life working dude ranch in Wyoming.Neither Gunner nor Sophia expect to be pierced by Cupid’s arrow, but some things you just can’t call.Sophia has no intention of giving in to her attraction to gorgeous cowboy Gunner Cane.Gunner has his own reasons for keeping things on the professional side with beautiful guest Sophia Russo.But there’s no denying the sizzling chemistry between them…which just might be more than they can handle.The past collides with the present as old love interests appear and unsolved mysteries surface.

    The Other Brain is the story of glia, which make up approximately 85 percent of the cells in the brain. Long neglected as little more than cerebral packing material ("glia" means glue), glia are sparking a revolution in brain science.Glia are completely different from neurons, the brain cells that we are familiar with. Scientists are discovering that glia have their own communication network, which operates in parallel to the more familiar communication among neurons. Glia provide the insulation for the neurons, and glia even regulate the flow of information between neurons.But it is the potential breakthroughs for medical science that are the most exciting frontier in glia research today. Diseases such as brain cancer and multiple sclerosis are caused by diseased glia. Glia are now believed to play an important role in such psychiatric illnesses as schizophrenia and depression, and in neurodegenerative diseases such as Parkinson's and Alzheimer's. They are linked to infectious diseases such as HIV and prion disease (mad cow disease, for example) and to chronic pain. Scientists have discovered that glia repair the brain and spinal cord after injury and stroke. The more we learn about these cells that make up the "other" brain, the more important they seem to be.Written by a neuroscientist who is a leader in the research to reveal the secrets of these brain cells, The Other Brain offers a firsthand account of science in action. It takes us into the laboratories where important discoveries are being made, and it explains how scientists are learning that glial cells come in different types, with different capabilities. It tells the story of glia research from its origins to the most recent discoveries and gives readers a much more complete understanding of how the brain works and where the next breakthroughs in brain science and medicine are likely to come.

    While studying brain scans of several family members, he discovered that one perfectly matched a pattern he d found in the brains of serial killers. This meant one of two things: Either his family s scans had been mixed up with those of felons or someone in his family was a psychopath.Even more disturbing: The scan in question was his own.This is Fallon s account of coming to grips with this discovery and its implications. How could he, a happy family man who had never been prone to violence, be a psychopath? How much did his biology influence his behavior?Fallon shares his journey to answer these questions and the discoveries that ultimately led to his conclusion: Despite everything science can teach, humans are even more complex than we can imagine."