. . and How to Break Them encourages improvisation and play, while explaining Justin Warner's unique ideas about "flavor theory"-like color theory, but for your tongue. By introducing eleven laws based on familiar foods (e.g., "The Law of Peanut Butter and Jelly"; "The Law of Coffee, Cream, and Sugar"), the book will teach you why certain flavors combine brilliantly, and then show how these combinations work in 110 more complex and inventive recipes (Tomato Soup with "Grilled Cheese" Ravioli; Scallops with Black Sesame and Cherry). At the end of every recipe, Justin "breaks the law" by adding a seemingly discordant flavor that takes the combination to a new level.

    Jerry Avorn has some sobering news. Drawing on more than twenty-five years of patient care, teaching, and research at Harvard Medical School, he shares his firsthand experience of the wide gap in our knowledge of the effectiveness of one medication as compared to another. In Powerful Medicines, he reminds us that every pill we take represents a delicate compromise between the promise of healing, the risk of side effects, and an increasingly daunting price. The stakes on each front grow higher every year as new drugs with impressive power, worrisome side effects, and troubling costs are introduced.This is a comprehensive behind-the-scenes look at issues that affect everyone: our shortage of data comparing the worth of similar drugs for the same condition; alarming lapses in the detection of lethal side effects; the underuse of life-saving medications; lavish marketing campaigns that influence what doctors prescribe; and the resulting upward spiral of costs that places vital drugs beyond the reach of many Americans.In this engagingly written book, Dr. Avorn asks questions that will interest every consumer: How can a product judged safe by the Food and Drug Administration turn out to have unexpectedly lethal side effects? Why has the nation’s drug bill been growing at nearly 20 percent per year? How can physicians and patients pick the best medication in its class? How do doctors actually make their prescribing decisions, and why do those decisions sometimes go wrong? Why do so many Americans suffer preventable illnesses and deaths that proper drug use could have averted? How can the nation gain control over its escalating drug budget without resorting to rationing or draconian governmental controls?Using clinical case histories taken from his own work as a practitioner, researcher, and advocate, Dr. Avorn demonstrates the impressive power of the well-conceived prescription as well as the debacles that can result when medications are misused. He describes an innovative program that employs the pharmaceutical industry’s own marketing techniques to reduce use of some of the most overprescribed and overpriced products. Powerful Medicines offers timely and practical advice on how the nation can improve its drug-approval process, and how patients can work with doctors to make sure their prescriptions are safe, effective, and as affordable as possible. This is a passionate and provocative call for action as well as a compelling work of clear-headed science.From the Hardcover edition.

    Kinesiology of the Musculoskeletal System is the most comprehensive, research-based, reader-friendly text on kinesiology ever published. Beautifully and abundantly illustrated in two-color, this dynamic, accessible resource presents complex scientific information in an approach designed to draw the reader in and explore the fundamental principles of kinesiology of the trunk and extremities as well as in relation to joints, muscles, and biomechanics.Comprehensive coverage - not only of kinesiology of the trunk and extremitites, but also of the underlaying principles of kinesiology with respect to joints, muscles and biomechanics - explains the 'why?' as well as the 'how?'A definitive chapter on the kinesiology of human gait!Clear and reader-friendly, which is great for study and revision for students of all levelsSpecial Focus boxes throughout the text provide abundant clinical examples and gives the students a chance to probe deeper into the topicTopics at a Glanceat the beginning of each chapter, allow students with less time to quickly locate the essential informationOver 550 superb line-drawings - making difficult kinesiologic concepts easier to graspAppendices include glossary of key terms - a handy reference toolThe author has many years of experience in physical therapy - specifically kinesiology - and is a teacher, clinician and researcher.

    Each chapter takes you through a new body system and includes surprising facts like "there are no muscles in the fingers and toes" and "by the time you finish reading this sentence, 50 million of your cells will have died and been replaced."With How the Body Works, you'll understand the how and why as well as be wowed by the astonishing ways our bodies work.

    The Eighth Edition has been thoroughly revised and updated and is available in both print and e-book formats.Janeway s Immunobiology continues to set the standard for currency and authority with its clear writing style and organization, uniform art program, and scientific accuracy. It presents a consistent point of view throughout that of the host s interaction with an environment containing many species of potentially harmful microorganisms. The full-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text. The 16 chapters in this readable, accessible textbook are organized and presented in such a way as to help deliver a complete one-semester immunology course, beginning with innate immunity, then moving to adaptive immunity, and ending with applied clinical immunology.Discussion questions are provided at the end of Chapters 2 to 16. These questions can be used for review, or as the basis for discussion in class or in informal study groups. Summaries conclude each section and each chapter. As in previous editions, a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo.New in the Eighth EditionInnate immunity has been updated and expanded and is now presented in two separate chapters (Chapters 2 and 3), as well as being further emphasized in the rest of the textbook. Chapter 2 covers antimicrobial peptides and the complement system, and Chapter 3 deals with cellular innate receptors and cell-mediated innate immunity (e.g. TLRs, phagocytosis, NK cells, interferon production, innate-like lymphocytes). The section on complement has been reworked and reconceived explaining the lectin pathway first making it easier to teach by placing it into the context of innate recognition. Evolution is now incorporated throughout the text, helping students see similar strategies used by different organisms. The text and figures of Chapter 7 Signaling Through Immune System Receptors have been revised to present a cohesive synthesis of signaling for immunology, focusing on improved illustration of antigen recognition signaling and lymphocyte activation. Signaling through other receptors is dealt with wherever appropriate throughout the book. Updated chapter on B-cell immune responses (Chapter 10), especially on trafficking of B cells in peripheral lymphoid organs (e.g. lymph nodes) and the locations at which they encounter antigen. Coverage of mucosal immunity (Chapter 12) has been brought up to date, including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria. Chapter 13, Failures of Host Defense Mechanisms, has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways. Chapter 16, Manipulation of the Immune Response, has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines. Many new and revised figures illustrate the processes and mechanisms underlying the concepts presented in the text. The icons used have been updated and expanded to incorporate a new emphasis on signaling pathways. New references have been added throughout the text.

    This clear, concise look at the basic principles and concepts of genetics uses a human genetics perspective to discuss the methods and experiments upon which genetic principles are based, such as DNA replication.

    While these are essential, many young ecologists need to figure out how to actually do research themselves. How to Do Ecology provides nuts-and-bolts advice on how to develop a successful thesis and research program. This book presents different approaches to posing testable ecological questions. In particular, it covers the uses, strengths, and limitations of manipulative experiments in ecology. It will help young ecologists consider meaningful treatments, controls, replication, independence, and randomization in experiments, as well as where to do experiments and how to organize a season of work. This book also presents strategies for analyzing natural patterns, the value of alternative hypotheses, and what to do with negative results.Science is only part of being a successful ecologist. This engagingly written book offers students advice on working with other people and navigating their way through the land mines of research. Findings that don't get communicated are of little value. How to Do Ecology suggests effective ways to communicate information in the form of journal articles, oral presentations, and posters. Finally, it outlines strategies for developing successful grant and research proposals. Numerous checklists, figures, and boxes throughout the book summarize and reinforce the main points. In short, this book makes explicit many of the unspoken assumptions behind doing good research in ecology, and provides an invaluable resource for meaningful conversations among ecologists.

    “A must read for all individuals with migraine!”—Ronald J. Tusa, M.D., PH.D., Professor of Neurology and Otolaryngology, Dizziness and Balance Center, Emory University Based on the breakthrough understanding that virtually all headaches are forms of migraine—because migraine is not a specific type of headache, but the built-in mechanism that causes headaches of all kinds, along with neck stiffness, sinus congestion, dizziness, and other problems—Dr. Buchholz’s Heal Your Headache offers a simple, transforming program.Step 1: Avoid the “Quick Fix.” Too often painkillers only make matters worse because of the crippling complication known as rebound.Step 2: Reduce your triggers. The crux of the program: a migraine diet that eliminate the foods that push headache sufferers over the top.Step 3: Raise your threshold. When diet and other lifestyle changes aren’t enough, preventive medication can help stay the course. That’s it. In three steps, you can turn your headache problems around.Includes answers to questions like:What is a migraine anyway?Why do I get more headaches than most people?Of all the potential dietary triggers, what are the major culprits?Will my headaches get better when I get older?Why does the weather give me headaches?How long will it take me to get over rebound when I stop taking my Excedrin?Are my children doomed to suffer from headaches?Why do I wake up every morning with a headache?

    

    Turn to any page, and you'll find essential point-of-care guidance on all the major conditions seen in clinical medicine. Completely updated to reflect all the major advances and new clinical developments, the new edition of the Manual is the most indispensable yet. It continues to focus on diagnosis and therapy with an emphasis on patient care and offers authoritative, high-yield coverage of: Etiology and epidemiology Clinically relevant pathophysiology Signs & Symptoms o Differential Diagnosis Physical and Laboratory Findings Therapeutics o Practice GuidelinesNEW FEATURESFull-color presentation for the first time!Full-color images of clinical conditions encountered in dermatology, cardiology, and eye diseases New chapters on end-of-life care, congenital heart disease in the adult patient, non-invasive cardiac examination, and metabolic syndromeLook for these other great Harrison's titles:Harrison's Principles of Internal Medicine, 17eHarrison's Online available through Accessmedicine.com

    Presented in an eye-popping package and filled with hyperdetailed photography of individual buds, this essential guide to marijuana is smart, practical, and exceedingly beautiful. The "Primer" section explores the culture of this complex flower and explains the botany that makes each strain unique. The "Buds" section describes the variations of lineage, flavor, and mental or physical high that define 170 exceptional strains. Poised to become the go-to marijuana guide for recreational and medicinal users alike, Green is easy to pick up and impossible to put down.

    From miraculous pregnancies to dirty protests, and from violent attacks on prisoners to heartbreaking acts of self-harm, she has witnessed it all. In this memoir, Amanda reveals the stories, the patients and the cases that have shaped a career helping those most of us would rather forget.

    Terms are introduced in the context of human anatomy and physiology to help you understand exactly what they mean, and case studies and vignettes throughout the book demonstrate how they're used in practice. With all this plus NEW animations and games on the companion CD, you'll be amazed at how easily medical terminology becomes part of your vocabulary.

    The proctored TEAS test, developed by Assessment Technologies, Inc. (ATI), measures basic essential skills in reading, mathematics, science, and English and language usage. With revised and updated questions throughout, this study guide contains instructional content in each of the four key areas, along with practice tests and answer keys, and a comprehensive test and answer key.

    National Geographic answers all the questions about technology, biology, chemistry, physics, math, engineering, computers, and mechanics--in an indispensable book that reveals the science behind virtually everything. How does the voice of a distant radio announcer make it through your alarm clock in the morning? How does your gas stove work? How does the remote control open your garage door? What happens when you turn the key in the ignition? What do antibiotics really do? Divided into four big realms--Mechanics, Natural Forces, Materials & Chemistry, Biology & Medicine--The Science of Everything takes readers on a fascinating tour, using plain talk, colorful photography, instructive diagrams, and everyday examples to explain the science behind all the things we take for granted in our modern world.