As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    In this, the first biography of the writer, D. T. Max sets out to chart Wallace’s tormented, anguished and often triumphant battle to succeed as a novelist as he fights off depression and addiction to emerge with his masterpiece, Infinite Jest. Since his untimely death by suicide at the age of forty-six in 2008, Wallace has become more than the quintessential writer for his time—he has become a symbol of sincerity and honesty in an inauthentic age.  In the end, as Max shows us, what is most interesting about Wallace is not just what he wrote but how he taught us all to live. Written with the cooperation of Wallace’s family and friends and with access to hundreds of his unpublished letters, manuscripts, and audio tapes, this portrait of an extraordinarily gifted writer is as fresh as news, as intimate as a love note, as painful as a goodbye.

    She also had a dream that one day she would be a comedian on TV.She has seen both these dreams come true.At last, Tina Fey's story can be told. From her youthful days as a vicious nerd to her tour of duty on Saturday Night Live; from her passionately halfhearted pursuit of physical beauty to her life as a mother eating things off the floor; from her one-sided college romance to her nearly fatal honeymoon—from the beginning of this paragraph to this final sentence.Tina Fey reveals all, and proves what we've all suspected: you're no one until someone calls you bossy.

    Growing up, she learned the proper way to eat a guava, the sound of tree frogs in the mango groves at night, the taste of the delectable sausage called morcilla, and the formula for ushering a dead baby's soul to heaven. As she enters school we see the clash, both hilarious and fierce, of Puerto Rican and Yankee culture. When her mother, Mami, a force of nature, takes off to New York with her seven, soon to be eleven children, Esmeralda, the oldest, must learn new rules, a new language, and eventually take on a new identity. In this first volume of her much-praised, bestselling trilogy, Santiago brilliantly recreates the idyllic landscape and tumultuous family life of her earliest years and her tremendous journey from the barrio to Brooklyn, from translating for her mother at the welfare office to high honors at Harvard.

    It was stolen moments spent with the empowered literary characters of Jane Austen and Louisa May Alcott that helped her to imagine an alternative way of life. Trapped as a teenager in a sexually and emotionally dysfunctional marriage to a man she barely knew, the tension between Deborah’s desires and her responsibilities as a good Satmar girl grew more explosive until she gave birth at nineteen and realized that, for the sake of herself and her son, she had to escape.

    The real life and faith journey of Loretta Young -- her strong devotion to her Catholic faith and her passion for helping others in need.

    The name alone conjures images of chestnut-lined boulevards, sidewalk cafés, breathtaking façades around every corner--in short, an exquisite romanticism that has captured the American imagination for as long as there have been Americans.In 1995, Adam Gopnik, his wife, and their infant son left the familiar comforts and hassles of New York City for the urbane glamour of the City of Light. Gopnik is a longtime New Yorker writer, and the magazine has sent its writers to Paris for decades--but his was above all a personal pilgrimage to the place that had for so long been the undisputed capital of everything cultural and beautiful. It was also the opportunity to raise a child who would know what it was to romp in the Luxembourg Gardens, to enjoy a croque monsieur in a Left Bank café--a child (and perhaps a father, too) who would have a grasp of that Parisian sense of style we Americans find so elusive.So, in the grand tradition of the American abroad, Gopnik walked the paths of the Tuileries, enjoyed philosophical discussions at his local bistro, wrote as violet twilight fell on the arrondissements. Of course, as readers of Gopnik's beloved and award-winning "Paris Journals" in The New Yorker know, there was also the matter of raising a child and carrying on with day-to-day, not-so-fabled life. Evenings with French intellectuals preceded middle-of-the-night baby feedings; afternoons were filled with trips to the Musée d'Orsay and pinball games; weekday leftovers were eaten while three-star chefs debated a "culinary crisis."As Gopnik describes in this funny and tender book, the dual processes of navigating a foreign city and becoming a parent are not completely dissimilar journeys--both hold new routines, new languages, a new set of rules by which everyday life is lived. With singular wit and insight, Gopnik weaves the magical with the mundane in a wholly delightful, often hilarious look at what it was to be an American family man in Paris at the end of the twentieth century. "We went to Paris for a sentimental reeducation - I did anyway - even though the sentiments we were instructed in were not the ones we were expecting to learn, which I believe is why they call it an education."

    There was the location: an impoverished, nuclear waste-riddled area of the American Midwest. There was her mother, a woman who speaks almost entirely in strange koans and warnings of impending danger. Above all, there was her gun-toting, guitar-riffing, frequently semi-naked father, who underwent a religious conversion on a submarine and discovered a loophole which saw him approved for the Catholic priesthood by the future Pope Benedict XVI - despite already having a wife and children.When the expense of a medical procedure forces the 30-year-old Patricia to move back in with her parents, husband in tow, she must learn to live again with her family's simmering madness, and to reckon with the dark side of a childhood spent in the bosom of the Catholic Church. Told with the comic sensibility of a brasher, bluer Waugh or Wodehouse, this is at the same time a lyrical and affecting story of how, having ventured into the underworld, we can emerge with our levity and our sense of justice intact.

    Her yearlong quest to face her terrors, great and small, is moving, enriching, and hilarious—we readers are lucky to be along for the ride.”—Julie Powell, bestselling author of Julie & JuliaIn the tradition of My Year of Living Biblically and Eat Pray Love comes My Year with Eleanor, Noelle Hancock’s hilarious tale of her decision to heed the advice of First Lady Eleanor Roosevelt and do one thing a day that scares her in the year before her 30th birthday. Fans of Sloane Crosley and Chelsea Handler will absolutely adore Hancock’s charming and outrageous chronicle of her courageous endeavor and delight in her poignant and inspiring personal growth.

    The story of Sylvia Beach's love for Shakespeare and Company supplies the lifeblood of this book.

    For most of that time, she didn't know why. All of her trips to the ER and her daily anguish, pain, and lethargy only ever resulted in one question: How could any one person be this sick? Several drug addictions, three major hospitalizations, and over $100,000 later, she finally had a diagnosis: late-stage Lyme disease. Sick is Khakpour's arduous, emotional journey—as a woman, a writer, and a lifelong sufferer of undiagnosed health problems—through the chronic illness that perpetually left her a victim of anxiety, living a life stymied by an unknown condition.Divided by settings, Khakpour guides the reader through her illness by way of the locations that changed her course—New York, LA, New Mexico, and Germany—as she meditates on both the physical and psychological impacts of uncertainty, and the eventual challenge of accepting the diagnosis she had searched for over the course of her adult life. With candor and grace, she examines her subsequent struggles with mental illness, her addiction to the benzodiazepines prescribed by her psychiatrists, and her ever-deteriorating physical health. A story about survival, pain, and transformation, Sick is a candid, illuminating narrative of hope and uncertainty, boldly examining the deep impact of illness on one woman's life.

    It begins as the day-today record of the life of a typical eleven-year-old girl, preoccupied by piano lessons and birthday parties. But as war engulfs Sarajevo, Zlata Filipovic becomes a witness to food shortages, the deaths of friends, and learns to wait out bombardments in a neighbor’s cellar. Yet throughout she remains courageous and observant. The result is a book that has the power to move and instruct readers a world away.

    Author Willie Morris, then editor of Harper's Magazine in New York, wrote GOOD OLD BOY when his son David, age ten, asked, "What was it like to grow up in Mississippi?" Morris's response turned into a timeless story of growing up in Yazoo City, Mississippi, in the early 1950s, roaming the town with his friends and playing practical jokes and having adventures. GOOD OLD BOY is recommended for sixth through ninth grade.

    The disintegration of this group, a process that has been slowly occurring now for more than forty years, has been reported with growing frequency and alarm, but has never before been written about as searingly from the inside. J. D. Vance tells the true story of what a social, regional, and class decline feels like when you were born with it hung around your neck.The Vance family story begins hopefully in postwar America. J. D.’s grandparents were “dirt poor and in love,” and moved north from Kentucky’s Appalachia region to Ohio in the hopes of escaping the dreadful poverty around them. They raised a middle-class family, and eventually one of their grandchildren would graduate from Yale Law School, a conventional marker of success in achieving generational upward mobility. But as the family saga of Hillbilly Elegy plays out, we learn that J.D.'s grandparents, aunt, uncle, sister, and, most of all, his mother struggled profoundly with the demands of their new middle-class life, never fully escaping the legacy of abuse, alcoholism, poverty, and trauma so characteristic of their part of America. With piercing honesty, Vance shows how he himself still carries around the demons of his chaotic family history.A deeply moving memoir, with its share of humor and vividly colorful figures, Hillbilly Elegy is the story of how upward mobility really feels. And it is an urgent and troubling meditation on the loss of the American dream for a large segment of this country.

    As this question fills the airwaves with anticipation, their legions of fans continue to multiply and ask a different series of questions, like—Who are these people?What’s the secret to their success? And is Chip actually that funny in real life? By renovating homes in Waco, Texas, and changing lives in such a winsome and engaging way, Chip and Joanna have become more than just the stars of Fixer Upper, they have become America’s new best friends.The Magnolia Story is the first book from Chip and Joanna, offering their fans a detailed look at their life together. From the very first renovation project they ever tackled together, to the project that nearly cost them everything; from the childhood memories that shaped them, to the twists and turns that led them to the life they share on the farm today.They both attended Baylor University in Waco. However, their paths did not cross until Chip checked his car into the local Firestone tire shop where Joanna worked behind the counter. Even back then Chip was a serial entrepreneur who, among other things, ran a lawn care company, sold fireworks, and flipped houses. Soon they were married and living in their first fixer upper. Four children and countless renovations later, Joanna garners the attention of a television producer who notices her work on a blog one day.In The Magnolia Story fans will finally get to join the Gaines behind the scenes and discover:-The time Chip ran to the grocery store and forgot to take their new, sleeping baby-Joanna’s agonizing decision to close her dream business to focus on raising their children-When Chip buys a houseboat, sight-unseen, and it turns out to be a leaky wreck-Joanna’s breakthrough moment of discovering the secret to creating a beautiful home-Harrowing stories of the financial ups and downs as an entrepreneurial couple-Memories and photos from Chip and Jo’s wedding-The significance of the word magnolia and why it permeates everything they do-The way the couple pays the popularity of Fixer Upper forward, sharing the success with others, and bolstering the city of Waco along the wayAnd yet there is still one lingering question for fans of the show: Is Chip really that funny? “Oh yeah,” says Joanna. “He was, and still is, my first fixer upper.”