The Human Genome Project finished sequencing human DNA. It seemed it was only a matter of time until we had all the answers to the secrets of life on this planet. The cutting-edge of biology, however, is telling us that we still don't even know all of the questions. How is it that, despite each cell in your body carrying exactly the same DNA, you don't have teeth growing out of your eyeballs or toenails on your liver? How is it that identical twins share exactly the same DNA and yet can exhibit dramatic differences in the way that they live and grow? It turns out that cells read the genetic code in DNA more like a script to be interpreted than a mould that replicates the same result each time. This is epigenetics and it's the fastest-moving field in biology today. The Epigenetics Revolution traces the thrilling path this discipline has taken over the last twenty years. Biologist Nessa Carey deftly explains such diverse phenomena as how queen bees and ants control their colonies, why tortoiseshell cats are always female, why some plants need a period of cold before they can flower, why we age, develop disease and become addicted to drugs, and much more. Most excitingly, Carey reveals the amazing possibilities for humankind that epigenetics offers for us all - and in the surprisingly near future.

    This riveting narrative offers an account of COVID-19, reminding us of women's leadership and resilience, reflecting back hope and humanity as we all figure out a new normal, together. Throughout history, men have fought, lost, and led us through the world's defining crises. That all changed with COVID-19. In Canada, women's presence in the response to the pandemic has been notable. Women are our nurses, doctors, PSWs. Our cashiers, long-haulers, cooks. In Canada, women are leading the fast-paced search for a vaccine. They are leading our provinces and territories. At home, they are leading families through self-isolation, often bearing the responsibility for their physical and emotional health. They are figuring out what working from home looks like, and many of them are doing it while homeschooling their kids. Women crafted the blueprint for kindness during the pandemic, from sewing masks to kicking off international mutual-aid networks. And, perhaps not surprisingly, women have also suffered some of the biggest losses, bearing the brunt of our economic skydive. Through intimate portraits of Canadian women in diverse situations and fields, Women of the Pandemic is a gripping narrative record of the early months of COVID-19, a clear-eyed look at women's struggles, which highlights their creativity, perseverance, and resilience as they charted a new path forward during impossible times.

    As body armor and advanced trauma care helped save the lives—if not the limbs—of American soldiers fighting in Afghanistan and Iraq, Walter Reed quickly became the world leader in amputee rehabilitation. But no matter the injury, physical therapy began the moment the soldiers emerged from surgery. Days at Walter Reed were intense, chaotic, consuming, and heartbreaking, but they were also filled with camaraderie and humor. Working in a glassed-in fishbowl gymnasium, Levine, her colleagues, and their combat-injured patients were on display at every moment to tour groups, politicians, and celebrities. Some would shudder openly at the sight—but inside the glass and out of earshot, the PTs and the patients cracked jokes, played pranks, and compared stumps. With dazzling storytelling, Run, Don’t Walk introduces a motley array of oddball characters including:  Jim, a retired lieutenant-colonel who stays up late at night baking cake after cake, and the militant dietitian who is always after him; a surgeon who only speaks in farm analogies; a therapy dog gone rogue; —and Levine’s toughest patient, the wild, defiant Cosmo, who comes in with one leg amputated and his other leg shattered. Entertaining, engrossing, and ultimately inspiring, Run, Don’t Walk is a fascinating look into a hidden world.

    Millions have been infected and killed. The economic crash caused by the pandemic is the worst since the Great Depression, with the International Monetary Fund estimating that it will cost over $9 trillion of global wealth in the next few years. Many will be left impoverished and hungry. Fragile states will be further hollowed out, creating conditions ripe for conflict and mass displacement. Meanwhile, international institutions and alliances already under strain before the pandemic are teetering, while the United States and China, already at loggerheads before the crisis, are careening toward a new Cold War. China's secrecy and assertiveness have shattered hopes that it will become a responsible stakeholder in the international order.Colin Kahl and Thomas Wright's Aftershocks is both a riveting journalistic account of one of the strangest years on record and a comprehensive analysis of the pandemic's ongoing impact on the foundational institutions and ideas that have shaped the modern world. This is the first crisis in decades without a glimmer of American leadership and it shows--there has been no international cooperation on a quintessential global challenge. Every country has followed its own path--nationalizing supplies, shutting their borders, and largely ignoring the rest of the world. The international order the United States constructed seven decades ago is in tatters, and the world is adrift. None of this came out of the blue. Public health experts and intelligence analysts had warned for a decade that a pandemic of this sort was inevitable. The crisis broke against a global backdrop of rising nationalism, backsliding democracy, declining public trust in governments, mounting rebellion against the inequalities produced by globalization, resurgent great power competition, and plummeting international cooperation.And yet, there are some signs of hope. The COVID-19 crisis reminds us of our common humanity and shared fate. The public has, for the most part, responded stoically and with kindness. Some democracies--South Korea, Taiwan, Germany, New Zealand, among others--have responded well. America may emerge from the crisis with a new resolve to deal with non-traditional threats, like pandemic disease, and a new demand for effective collective action with other democratic nations. America may also finally be forced to come to grips with our nation's inadequacies, and to make big changes at home and abroad that will set the stage for opportunities the rest of this century holds.But one thing is certain: America and the world will never be the same again.

    What is going on? Anatomy of an Epidemic challenges readers to think through that question themselves. First, Whitaker investigates what is known today about the biological causes of mental disorders. Do psychiatric medications fix “chemical imbalances” in the brain, or do they, in fact, create them? Researchers spent decades studying that question, and by the late 1980s, they had their answer. Readers will be startled—and dismayed—to discover what was reported in the scientific journals. Then comes the scientific query at the heart of this book: During the past fifty years, when investigators looked at how psychiatric drugs affected long-term outcomes, what did they find? Did they discover that the drugs help people stay well? Function better? Enjoy good physical health? Or did they find that these medications, for some paradoxical reason, increase the likelihood that people will become chronically ill, less able to function well, more prone to physical illness?  This is the first book to look at the merits of psychiatric medications through the prism of long-term results. Are long-term recovery rates higher for medicated or unmedicated schizophrenia patients? Does taking an antidepressant decrease or increase the risk that a depressed person will become disabled by the disorder? Do bipolar patients fare better today than they did forty years ago, or much worse? When the National Institute of Mental Health (NIMH) studied the long-term outcomes of children with ADHD, did they determine that stimulants provide any benefit?  By the end of this review of the outcomes literature, readers are certain to have a haunting question of their own: Why have the results from these long-term studies—all of which point to the same startling conclusion—been kept from the public?  In this compelling history, Whitaker also tells the personal stories of children and adults swept up in this epidemic. Finally, he reports on innovative programs of psychiatric care in Europe and the United States that are producing good long-term outcomes. Our nation has been hit by an epidemic of disabling mental illness, and yet, as Anatomy of an Epidemic reveals, the medical blueprints for curbing that epidemic have already been drawn up.

    Gut, an international bestseller, gives the alimentary canal its long-overdue moment in the spotlight. With quirky charm, rising science star Giulia Enders explains the gut’s magic, answering questions like: Why does acid reflux happen? What’s really up with gluten and lactose intolerance? How does the gut affect obesity and mood? Communication between the gut and the brain is one of the fastest-growing areas of medical research—on par with stem-cell research. Our gut reactions, we learn, are intimately connected with our physical and mental well-being. Enders’s beguiling manifesto will make you finally listen to those butterflies in your stomach: they’re trying to tell you something important.

    When Dr. Judy Mikovits finished her presentation the room was silent for a moment, then one of the scientists said, �Oh my God!” The resulting investigation would be like no other in science.For Dr. Mikovits, a twenty-year veteran of the National Cancer Institute, this was the midpoint of a five-year journey that would start with the founding of the Whittemore-Peterson Institute for Neuro-Immune Disease at the University of Nevada, Reno, and end with her as a witness for the federal government against her former employer, Harvey Whittemore, for illegal campaign contributions to Senate Majority Leader Harry Reid.On this journey Dr. Mikovits would face the scientific prejudices against CFS, wander into the minefield that is autism, and through it all struggle to maintain her faith in God and the profession to which she had dedicated her life. This is a story for anybody interested in the peril and promise of science at the very highest levels in our country.

    The Repository for Germinal Choice–nicknamed the Nobel Prize sperm bank–opened to notorious fanfare in 1980, and for two decades, women flocked to it from all over the country to choose a sperm donor from its roster of Nobel-laureate scientists, mathematical prodigies, successful businessmen, and star athletes. But the bank quietly closed its doors in 1999–its founder dead, its confidential records sealed, and the fate of its children and donors unknown. In early 2001, award-winning columnist David Plotz set out to solve the mystery of the Nobel Prize sperm bank.Plotz wrote an article for Slate inviting readers to contact him–confidentially–if they knew anything about the bank. The next morning, he received an email response, then another, and another–each person desperate to talk about something they had kept hidden for years. Now, in The Genius Factory, Plotz unfolds the full and astonishing story of the Nobel Prize sperm bank and its founder’s radical scheme to change our world.Believing America was facing genetic catastrophe, Robert Graham, an eccentric millionaire, decided he could reverse the decline by artificially inseminating women with the sperm of geniuses. In February 1980, Graham opened the Repository for Germinal Choice and stocked it with the seed of gifted scientists, inventors, and thinkers. Over the next nineteen years, Graham’s “genius factory” produced more than two hundred children.What happened to them? Were they the brilliant offspring that Graham expected? Did any of the “superman” fathers care about the unknown sons and daughters who bore their genes? What were the mothers like? Crisscrossing the country and logging countless hours online, Plotz succeeded in tracking down previously unknown family members–teenage half-brothers who ended up following vastly different paths, mothers who had wondered for years about the identities of the donors they had selected on the basis of code names and brief character profiles, fathers who were proud or ashamed or simply curious about the children who had been created from their sperm samples. The children of the “genius factory” are messengers from the future–a future that is bearing down on us fast. What will families be like when parents routinely “shop” for their kids’ genes? What will children be like when they’re programmed for greatness? In this stunning, eye-opening book, one of our finest young journalists previews America’s coming age of genetic expectations.From the Hardcover edition.

    It documents the scale of devastation, the likely causes and consequences, and the resilience with which people faced those pandemics.The book also provides the first comprehensive coverage of the world's greatest demographic disaster ever to descend upon a country in a short period of time - the influenza pandemic in India in 1918, which claimed more lives than all the battle casualties of World War I. And it shows the continuing relevance of learning from those times to tackle contemporary challenges, such as COVID-19.

    Dr. Jeremy Brown, currently Director of Emergency Care Research at the National Institutes of Health, expounds on the flu's deadly past to solve the mysteries that could protect us from the next outbreak. In Influenza, he talks with leading epidemiologists, policy makers, and the researcher who first sequenced the genetic building blocks of the original 1918 virus to offer both a comprehensive history and a roadmap for understanding what’s to come.Dr. Brown digs into the discovery and resurrection of the flu virus in the frozen victims of the 1918 epidemic, as well as the bizarre remedies that once treated the disease, such as whiskey and blood-letting. Influenza also breaks down the current dialogue surrounding the disease, explaining the controversy over vaccinations, antiviral drugs like Tamiflu, and the federal government’s role in preparing for pandemic outbreaks. Though 100 years of advancement in medical research and technology have passed since the 1918 disaster, Dr. Brown warns that many of the most vital questions about the flu virus continue to confound even the leading experts.Influenza is an enlightening and unnerving look at a shapeshifting deadly virus that has been around long before people—and warns us that it may be many more years before we are able to conquer it for good.

    But most of us know very little about how the disease works, why we treat it the way we do, and the personalities whose dedication got us where we are today. For fifty years, Dr. Vincent T. DeVita Jr. has been one of those key players: he has held just about every major position in the field, and he developed the first successful chemotherapy treatment for Hodgkin’s lymphoma, a breakthrough the American Society of Clinical Oncologists has called the top research advance in half a century of chemotherapy. As one of oncology’s leading figures, DeVita knows what cancer looks like from the lab bench and the bedside. The Death of Cancer is his illuminating and deeply personal look at the science and the history of one of the world’s most formidable diseases. In DeVita’s hands, even the most complex medical concepts are comprehensible.Cowritten with DeVita’s daughter, the science writer Elizabeth DeVita-Raeburn, The Death of Cancer is also a personal tale about the false starts and major breakthroughs, the strong-willed oncologists who clashed with conservative administrators (and one another), and the courageous patients whose willingness to test cutting-edge research helped those oncologists find potential treatments. An emotionally compelling and informative read, The Death of Cancer is also a call to arms. DeVita believes that we’re well on our way to curing cancer but that there are things we need to change in order to get there. Mortality rates are declining, but America’s cancer patients are still being shortchanged—by timid doctors, by misguided national agendas, by compromised bureaucracies, and by a lack of access to information about the strengths and weaknesses of the nation’s cancer centers.With historical depth and authenticity, DeVita reveals the true story of the fight against cancer. The Death of Cancer is an ambitious, vital book about a life-and-death subject that touches us all.

    The Fifth Edition features updated information throughout, including new theories and models such as the Healthy Action Process Approach (HAPA) and the Community Readiness Model (CRM), sections on grant writing and preparing a budget, real-life examples of marketing principles and processes, and a new classification system for evaluation approaches and designs. Health Education, Health Promotion, Health Educators, and Program Planning, Models for Program Planning in Health Promotion, Starting the Planning Process, Assessing Needs, Measurement, Measures, Measurement Instruments and Sampling, Mission Statement, Goals, and Objectives, Theories and Models Commonly Used for Health Promotion Interventions, Interventions, Community Organizing and Community Building, Identification and Allocation of Resources, Marketing: Making Sure Programs Respond to Wants and Needs of Consumers, Implementation: Strategies and Associated Concerns, Evaluation: An Overview, Evaluation Approaches and Designs, Data Analysis and Reporting. Intended for those interested in learning the basics of planning, implementing, and evaluating health promotion programs

    Dickson Despommier's visionary book provides a blueprint for securing the world's food supply and at the same time solving one of the gravest environmental crises facing us today."--StingImagine a world where every town has their own local food source, grown in the safest way possible, where no drop of water or particle of light is wasted, and where a simple elevator ride can transport you to nature's grocery store - imagine the world of the vertical farm.When Columbia professor Dickson Despommier set out to solve America's food, water, and energy crises, he didn't just think big - he thought up. Despommier's stroke of genius, the vertical farm, has excited scientists, architects, and politicians around the globe. Now, in this groundbreaking book, Despommier explains how the vertical farm will have an incredible impact on changing the face of this planet for future generations.Despommier takes readers on an incredible journey inside the vertical farm, buildings filled with fruits and vegetables that will provide local food sources for entire cities.Vertical farms will allow us to:- Grow food 24 hours a day, 365 days a year- Protect crops from unpredictable and harmful weather- Re-use water collected from the indoor environment- Provide jobs for residents- Eliminate use of pesticides, fertilizers, or herbicides- Drastically reduce dependence on fossil fuels- Prevent crop loss due to shipping or storage- Stop agricultural runoffVertical farms can be built in abandoned buildings and on deserted lots, transforming our cities into urban landscapes which will provide fresh food grown and harvested just around the corner. Possibly the most important aspect of vertical farms is that they can built by nations with little or no arable land, transforming nations which are currently unable to farm into top food producers. In the tradition of the bestselling The World Without Us, The Vertical Farm is a completely original landmark work destined to become an instant classic

    In Missing Microbes, Dr. Martin Blaser invites us into the wilds of the human microbiome where for hundreds of thousands of years bacterial and human cells have existed in a peaceful symbiosis that is responsible for the health and equilibrium of our body. Now, this invisible eden is being irrevocably damaged by some of our most revered medical advances—antibiotics—threatening the extinction of our irreplaceable microbes with terrible health consequences. Taking us into both the lab and deep into the fields where these troubling effects can be witnessed firsthand, Blaser not only provides cutting edge evidence for the adverse effects of antibiotics, he tells us what we can do to avoid even more catastrophic health problems in the future. http://us.macmillan.com/missingmicrob...

    Don’t, and die. Today, hyperboles dominate the media, which makes parsing science from fiction an arduous task when deciding what to eat, what chemicals to avoid, and what’s best for the environment. In Is That a Fact?, bestselling author Dr. Joe Schwarcz carefully navigates through the storm of misinformation to help us separate fact from folly and shrewdness from foolishness.Are GMOs really harmful? Or could they help developing countries? Which “miracle weight-loss foods” gained popularity through exuberant data dredging? Is BPA dangerous or just a victim of unforgiving media hype? Is organic better? Dr. Joe questions the reliability and motives of “experts” in this lighthearted but critical look at what’s fact and what’s plain nonsense.