Can a person think herself to orgasm? Why doesn't Viagra help women-or, for that matter, pandas? Can a dead man get an erection? Is vaginal orgasm a myth? Mary Roach shows us how and why sexual arousal and orgasm-two of the most complex, delightful, and amazing scientific phenomena on earth-can be so hard to achieve and what science is doing to make the bedroom a more satisfying place.

    Some of these drugs are truly transformative, offering major improvements in how long patients live or how they feel--but what is often missing from the popular narrative is that, far too often, these new drugs have marginal or minimal benefits. Some are even harmful. In Malignant, hematologist-oncologist Dr. Vinayak K. Prasad writes about the many sobering examples of how patients are too often failed by cancer policy and by how oncology is practiced. Throughout this work, Prasad illuminates deceptive practices which- promote novel cancer therapies long before credible data are available to support such treatment; and- exaggerate the potential benefits of new therapies, many of which cost thousands and in some cases hundreds of thousands of dollars.Prasad then critiques the financial conflicts of interest that pervade the oncology field, the pharmaceutical industry, and the US Food and Drug administration.This is a book about how the actions of human beings--our policies, our standards of evidence, and our drug regulation--incentivize the pursuit of marginal or unproven therapies at lofty and unsustainable prices. Prasad takes us through how cancer trials are conducted, how drugs come to market, and how pricing decisions are made, asking how we can ensure that more cancer drugs deliver both greater benefit and a lower price. Ultimately, Prasad says,- more cancer clinical trials should measure outcomes that actually matter to people with cancer;- patients on those trials should look more like actual global citizens;- we need drug regulators to raise, not perpetually lower, the bar for approval; and- we need unbiased patient advocates and experts.This well-written, opinionated, and engaging book explains what we can do differently to make serious and sustained progress against cancer--and how we can avoid repeating the policy and practice mistakes of the past.

    In this book you will see how commonly performed operations can be found to be useless or even harmful when properly evaluated. That these claims come from an experienced, practicing orthopedic surgeon who performs many of these operations himself, makes the unsettling argument particularly compelling. Of course no surgeon is recommending invasive surgery in bad faith, but Ian Harris argues that the evidence for the success for many common operations, including knee arthroscopies, back fusion or cardiac stenting, become current accepted practice without full examination of the evidence.

    With over one million downloads per episode, these discussions have clearly hit a nerve, frequently walking a tightrope where either host or guest - and sometimes both - lose their footing, but always in search off a greater understanding of the world in which we live. for Harris, honest conversation, no matter how difficult or controversial, represents the only path to moral and intellectual progress.This book includes a dozen of the best conversations from 'MAKING SENSE', including talks with Daniel Kahneman, Timothy Snyder, Nick Bostrom, and Glen Loury, on topics that range from the nature of consciousness and free will, to politics and extremism, to living ethically. Together they shine a light on what it means to "make sense" in the modern world.RUNNING TIME ⇒ 22hrs.©2020 Sam Harris (P)2020 HarperAudio

    The Power of Rest provides a low-cost, low-risk answer to some pressing health concerns, and is an important adjunct for those already investing time, energy, and money in their health. Readers interested in a new plan to help with sleep disruptions, fatigue, lack of zest, weight loss, or diabetes will find many helpful suggestions in The Power of Rest.

    In this delightful and compelling exploration of our most neglected sense, veteran science reporter Bob Holmes shows us just how much we’re missing.Considering every angle of flavor from our neurobiology to the science and practice of modern food production, Holmes takes readers on a journey to uncover the broad range of factors that can affect our appreciation of a fine meal or an exceptional glass of wine. He peers over the shoulders of some of the most fascinating food professionals working today, from cutting-edge chefs to food engineers to mathematicians investigating the perfect combination of pizza toppings. He talks with flavor and olfactory scientists, who describe why two people can experience remarkably different sensations from the same morsel of food, and how something as seemingly unrelated as cultural heritage can actually impact our sense of smell.Along the way, even more surprising facts are revealed: that cake tastes sweetest on white plates; that wine experts’ eyes can fool their noses; and even that language can affect our sense of taste. Flavor expands our curiosity and understanding of one of our most intimate sensations, while ultimately revealing how we can all sharpen our senses and our enjoyment of the things we taste.Certain to fascinate everyone from gourmands and scientists to home cooks and their guests, Flavor will open your mind—and palette—to a vast, exciting sensory world.

    Drawing on momentous (yet dimly remembered) historical epidemics, contemporary analyses, and cutting-edge research from a range of scientific disciplines, bestselling author, physician, sociologist, and public health expert Nicholas A. Christakis explores what it means to live in a time of plague—an experience that is paradoxically uncommon to the vast majority of humans who are alive, yet deeply fundamental to our species.Unleashing new divisions in our society as well as opportunities for cooperation, this 21st-century pandemic has upended our lives in ways that will test, but not vanquish, our already frayed collective culture. Featuring new, provocative arguments and vivid examples ranging across medicine, history, sociology, epidemiology, data science, and genetics, Apollo's Arrow envisions what happens when the great force of a deadly germ meets the enduring reality of our evolved social nature.

    Lab 257 blows the lid off the stunning true nature and checkered history of Plum Island. It shows that the seemingly bucolic island in the shadow of New York City is a ticking biological time bomb that none of us can safely ignore.Based on declassified government documents, in-depth interviews, and access to Plum Island itself, this is an eye-opening, suspenseful account of a federal government germ laboratory gone terribly wrong. For the first time, Lab 257 takes you deep inside this secret world and presents startling revelations on virus outbreaks, biological meltdowns, infected workers, the periodic flushing of contaminated raw sewage into area waters, and the insidious connections between Plum Island, Lyme disease, and the deadly West Nile virus. The book also probes what's in store for Plum Island's new owner, the Department of Homeland Security, in this age of bioterrorism.Lab 257 is a call to action for those concerned with protecting present and future generations from preventable biological catastrophes.

    From childhood onward, we learn how big a "portion" is and how sweet is too sweet. We learn to enjoy green vegetables -- or not. But how does this education happen? What are the origins of taste? In First Bite, award-winning food writer Bee Wilson draws on the latest research from food psychologists, neuroscientists, and nutritionists to reveal that our food habits are shaped by a whole host of factors: family and culture, memory and gender, hunger and love. Taking the reader on a journey across the globe, Wilson introduces us to people who can only eat foods of a certain color; prisoners of war whose deepest yearning is for Mom's apple pie; a nine year old anosmia sufferer who has no memory of the flavor of her mother's cooking; toddlers who will eat nothing but hotdogs and grilled cheese sandwiches; and researchers and doctors who have pioneered new and effective ways to persuade children to try new vegetables. Wilson examines why the Japanese eat so healthily, whereas the vast majority of teenage boys in Kuwait have a weight problem -- and what these facts can tell Americans about how to eat better. The way we learn to eat holds the key to why food has gone so disastrously wrong for so many people. But Wilson also shows that both adults and children have immense potential for learning new, healthy eating habits. An exploration of the extraordinary and surprising origins of our tastes and eating habits, First Bite also shows us how we can change our palates to lead healthier, happier lives.

    Judy Melinek began her training as a New York City forensic pathologist. With her husband T.J. and their toddler Daniel holding down the home front, Judy threw herself into the fascinating world of death investigation, performing autopsies, investigating death scenes, counseling grieving relatives. Working Stiff chronicles Judy's two years of training, taking readers behind the police tape of some of the most harrowing deaths in the Big Apple, including a firsthand account of the events of September 11, the subsequent anthrax bio-terrorism attack, and the disastrous crash of American Airlines flight 587.Lively, action-packed, and loaded with mordant wit, Working Stiff offers a firsthand account of daily life in one of America's most arduous professions, and the unexpected challenges of shuttling between the domains of the living and the dead. The body never lies, and through the murders, accidents, and suicides that land on her table, Dr. Melinek lays bare the truth behind the glamorized depictions of autopsy work on shows like CSI and Law and Order to reveal the secret story of the real morgue.

    While it’seasy to see that stress affects health and well-being, or that your blood pressure rises when you’re angry, cutting-edge research shows that the mind-body connection goes much further.Numerous studies on the brain’s interaction with the body demonstrate that health is directly affected by our social environments, socioeconomic status, culture, behaviors, relationships, psychological states, and habits of mind, among many factors. Current mind-body science reveals facts such as these: As few as eight weeks of mindfulness meditation can meaningfully boost your immune system. Extreme stress and low social support increase the risk of breast cancer by a factor of 9. Contact with nature is correlated with numerous positive health outcomes, including improved attention for children, reduced stress, and enhanced work performance. Chronic hostility portends calcification of the coronary arteries, even in young people. Expressive writing by patients is correlated with improved outcomes for both asthma and rheumatoid arthritis.Mind-body medicine—working in tandem with traditional medical practice—makes use of a large spectrum of psychological, physical, and behavioral treatments, drawn from many disciplines, in an approach to health care that aims to treat the whole person. It provides highly effective resources for preventing and treating a wide range of medical conditions, such as cardiovascular disease, stress, cancer, and depression—as well as for fostering the ultimate goals of health care: truly optimal and lasting physical health, and emotional and psychological well-being.A knowledge of this exciting field offers you critical understanding of the state of the art of health care and a significant new direction in medicine. But beyond valuable knowledge, a grounding in mind-body medicine gives you numerous practical, empowering tools for your own health care, as well as that of your family—tools that can make a profound difference for healthful, vibrant living.In Mind-Body Medicine: The New Science of Optimal Health, you’ll study this subject in compelling depth, with the expert guidance of Professor Jason M. Satterfield of the University of California, San Francisco. These 36 eye-opening lectures offer you a comprehensive overview of the field, providing rigorous answers to the questions of what makes us sick, what makes us well, and what we can do about it.You’ll look closely at the anatomical and biological systems through which what is “outside” in the environment gets “inside” to affect our minds and bodies. You’ll also examine recent research on subjects ranging from the impact our emotions and psychology have on health to the crucial roles that social, cultural, and behavioral factors play. And you’ll learn about effective mind-body treatments for numerous common medical conditions and diseases.Finally, you’ll finish the course with a toolbox of ideas and interventions for your personal wellness goals, empowering you to partner more effectively with your medical providers and maximize your own health.A Remarkable New Context for Health Care Professor Satterfield, a highly respected professor of clinical medicine and a specialist on the intersection of psychological factors and physical health, brings to the table his deep knowledge of mind-body science and extensive clinical experience in its application.In the course’s opening, he introduces you to the model of “biopsychosocial medicine,” which looks at the relationship between biological, psychological, and social factors in health.In studying how the biopsychosocial model is applied in modern medicine, you delve into these core subject areas:Biological pathways:You first investigate the anatomy and physiology of four biological systems through which the “outside” gets “in.” By reviewing a detailed study of the autonomic nervous system and the neuroendocrine system, discover how the brain activates the body’s two stress-response systems, and how these systems crucially affect health and well-being. Learn also about the physiology of immune function and the effects of stress on immune response and healing. Study the mechanisms of genetics as well as fascinating research indicating that your behavior can alter your genetic material, for better or worse—changes that can be passed on to future generations.Psychological factors in health: In the course of nine lectures, you look in depth at the critical ways in which psychology affects the body. Learn how negative emotional states such as anger and hostility can influence both the onset and progression of disease, and how positive emotions aid substantially in healing and wellness. Study how cognition—the ways in which we think and process our experiences—affects emotional states and behavior. Drawing from cognitive and other behavioral therapies, learn effective techniques for reshaping thinking, emotions, and behavior. Review evidence that certain personality types may be predisposed to conditions such as cardiovascular disease and depression, and learn how we can compensate for risk-carrying personality traits by working with cognitions and emotions. Investigate the neuroscience of behavior and the important effects of our behaviors on both disease and disease prevention. Look at stress as an integration of biological, cognitive, and social factors, and see how we can approach stress response and coping as a developmental skill. Social and ecological factors: You also study the important effects on health of factors such as culture, identity, socioeconomic status, social support, communities, and public health policy. Examine the studied correlations of income to health, education level to longevity, and ethnicity to susceptibility to disease, and consider how we can use this knowledge to benefit both individual and public health. Review research linking social support to health in many medical conditions, such as heart disease, cancer, and pregnancy; and do a detailed assessment to evaluate and strengthen your own social support network. Investigate how spiritual affiliations and practices have distinct physical benefits, such as reducing blood pressure, cortisol, and inflammation; improving lipid profiles and cardiovascular health; and extending life expectancy. Assess how physical environments affect health, how national and local culture impacts health-related behaviors, and how public initiatives can create healthier behaviors, environments, and communities.Tools and Strategies for Optimal WellnessBuilding on the biopsychosocial model, you study mind-body treatments for common conditions such as cardiovascular disease, stress, cancer, obesity, chronic pain, depression, anxiety, and post-traumatic stress disorder.Here, you learn about specific practices and interventions that you can use in your own health care program, such as these. Stress management: For both personal and occupational stress, learn about a spectrum of stress management approaches, from cognitive restructuring and perspective shifting to meditation, breathing techniques, relaxation training, and the learnable skill of resilience. Strategies for successful behavior change: With reference to concerns such as lifestyle change, weight management, and disease prevention, study the leading models of effective behavior change, as well as specific approaches such as the strategies of motivational interviewing, the four key elements of change, and the internal skills of self-regulation. Heart disease—prevention and treatment: Survey psychosocial interventions for heart disease, including a range of behavior change approaches, stress and emotion management, somatic quieting, social connection, and dramatic evidence that cardiac disease can be reversed through lifestyle change. Treatment of pain: Study mind-body factors in pain experience, and learn about treatments including cognitive and behavior change, acupuncture, mindfulness-based stress reduction, and biofeedback. Fatigue, headaches, insomnia: Investigate the variety of medical conditions that show no clear organic cause, such as chronic fatigue, tension headaches, and sleep disorders; and review effective psychological, physical, and behavioral approaches to treatment.Professor Satterfield’s teaching combines an extraordinary breadth of knowledge, clear and accessible explanations of the science involved, and a highly compassionate approach to patient care. He enriches the lectures with stories and case studies of patients in treatment for stress, heart conditions, insomnia, trauma, and other health challenges, showing you what mind-body medicine looks like in clinical practice and how you can integrate its lessons into your health program and daily life.With the knowledge and tools you’ll learn in Mind-Body Medicine: The New Science of Optimal Health, you can begin your own biopsychosocial assessment, identify your strengths and challenges in partnership with your medical providers, and take authentic steps toward your fullest physical and mental wellness.

    Your brain can't function. You are asked to make decisions about treatment almost immediately, when you are not in your right mind. And yet you pull yourself together and start asking questions. Beside you is your doctor, whose job it is to solve the awful puzzle of bone marrow gone wrong. The two of you are in it together. In When Blood Breaks Down, Mikkael Sekeres, a leading cancer specialist, takes readers on the journey that patient and doctor travel together.Sekeres, who writes regularly for the Well section of the New York Times, tells the compelling stories of three people who receive diagnoses of adult leukemia within hours of each other: Joan, a 48-year-old surgical nurse, a caregiver who becomes a patient; David, a 68-year-old former factory worker who bows to his family's wishes and pursues the most aggressive treatment; and Sarah, a 36-year-old pregnant woman who must decide whether to undergo chemotherapy and put her fetus at risk. We join the intimacy of the conversations Sekeres has with his patients, and watch as he teaches trainees. Along the way, Sekeres also explores leukemia in its different forms and the development of drugs to treat it--describing, among many other fascinating details, the invention of the bone marrow transplant (first performed experimentally on beagles) and a treatment that targets the genetics of leukemia.The lessons to be learned from leukemia, Sekeres shows, are not merely medical; they teach us about courage and grace and defying the odds.

    . . trust your vibes. If you’re ready to step into a Divine, more energetically uplifting experience and live an easier, more satisfying way of life, you’ll learn how to do so within these pages. In this work, Sonia presents real-life stories of those who learned to tap into their intuition to drastically change and improve their lives; see what they do, how they think, the choices they make, and the attitudes and perspectives they own.  In modeling yourself after sixth-sensory people, you too can activate your own intuitive channel. Your intuition supports your creativity, helps heal your emotional wounds, and calms your anxious and uncertain heart. It brings you peace of mind and shows you how to live in a higher, more harmonious way.

    But is it possible America's most troubling impact on the globalizing world has yet to be accounted for? In "Crazy Like Us," Ethan Watters reveals that the most devastating consequence of the spread of American culture has not been our golden arches or our bomb craters but our bulldozing of the human psyche itself: We are in the process of homogenizing the way the world goes mad. America has been the world leader in generating new mental health treatments and modern theories of the human psyche. We export our psychopharmaceuticals packaged with the certainty that our biomedical knowledge will relieve the suffering and stigma of mental illness. We categorize disorders, thereby defining mental illness and health, and then parade these seemingly scientific certainties in front of the world. The blowback from these efforts is just now coming to light: It turns out that we have not only been changing the way the world talks about and treats mental illness -- we have been changing the mental illnesses themselves.For millennia, local beliefs in different cultures have shaped the experience of mental illness into endless varieties." Crazy Like Us" documents how American interventions have discounted and worked to change those indigenous beliefs, often at a dizzying rate. Over the last decades, mental illnesses popularized in America have been spreading across the globe with the speed of contagious diseases. Watters travels from China to Tanzania to bring home the unsettling conclusion that the virus is us: As we introduce Americanized ways of treating mental illnesses, we are in fact spreading the diseases.In post-tsunami Sri Lanka, Watters reports on the Western trauma counselors who, in their rush to help, inadvertently trampled local expressions of grief, suffering, and healing. In Hong Kong, he retraces the last steps of the teenager whose death sparked an epidemic of the American version of anorexia nervosa. Watters reveals the truth about a multi-million-dollar campaign by one of the world's biggest drug companies to change the Japanese experience of depression -- literally marketing the disease along with the drug.But this book is not just about the damage we've caused in faraway places. Looking at our impact on the psyches of people in other cultures is a gut check, a way of forcing ourselves to take a fresh look at our own beliefs about mental health and healing. When we examine our assumptions from a farther shore, we begin to understand how our own culture constantly shapes and sometimes creates the mental illnesses of our time. By setting aside our role as the world's therapist, we may come to accept that we have as much to learn from other cultures' beliefs about the mind as we have to teach.

    From distressed small communities in Central Appalachia to wealthy suburbs; from disparate cities to once-idyllic farm towns; it's a heartbreaking trajectory that illustrates how this national crisis has persisted for so long and become so firmly entrenched. Beginning with a single dealer who lands in a small Virginia town and sets about turning high school football stars into heroin overdose statistics, Macy endeavors to answer a grieving mother's question-why her only son died-and comes away with a harrowing story of greed and need. From the introduction of OxyContin in 1996, Macy parses how America embraced a medical culture where overtreatment with painkillers became the norm. In some of the same distressed communities featured in her bestselling book Factory Man, the unemployed use painkillers both to numb the pain of joblessness and pay their bills, while privileged teens trade pills in cul-de-sacs, and even high school standouts fall prey to prostitution, jail, and death.Through unsparing, yet deeply human portraits of the families and first responders struggling to ameliorate this epidemic, each facet of the crisis comes into focus. In these politically fragmented times, Beth Macy shows, astonishingly, that the only thing that unites Americans across geographic and class lines is opioid drug abuse. But in a country unable to provide basic healthcare for all, Macy still finds reason to hope-and signs of the spirit and tenacity necessary in those facing addiction to build a better future for themselves and their families.