In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. In England, cows attack their owners in the milking parlors, while in the American West, thousands of deer starve to death in fields full of grass.What these strange conditions–including fatal familial insomnia, kuru, scrapie, and mad cow disease–share is their cause: prions. Prions are ordinary proteins that sometimes go wrong, resulting in neurological illnesses that are always fatal. Even more mysterious and frightening, prions are almost impossible to destroy because they are not alive and have no DNA–and the diseases they bring are now spreading around the world.In The Family That Couldn’t Sleep, essayist and journalist D. T. Max tells the spellbinding story of the prion’s hidden past and deadly future

    Jerry Avorn has some sobering news. Drawing on more than twenty-five years of patient care, teaching, and research at Harvard Medical School, he shares his firsthand experience of the wide gap in our knowledge of the effectiveness of one medication as compared to another. In Powerful Medicines, he reminds us that every pill we take represents a delicate compromise between the promise of healing, the risk of side effects, and an increasingly daunting price. The stakes on each front grow higher every year as new drugs with impressive power, worrisome side effects, and troubling costs are introduced.This is a comprehensive behind-the-scenes look at issues that affect everyone: our shortage of data comparing the worth of similar drugs for the same condition; alarming lapses in the detection of lethal side effects; the underuse of life-saving medications; lavish marketing campaigns that influence what doctors prescribe; and the resulting upward spiral of costs that places vital drugs beyond the reach of many Americans.In this engagingly written book, Dr. Avorn asks questions that will interest every consumer: How can a product judged safe by the Food and Drug Administration turn out to have unexpectedly lethal side effects? Why has the nation’s drug bill been growing at nearly 20 percent per year? How can physicians and patients pick the best medication in its class? How do doctors actually make their prescribing decisions, and why do those decisions sometimes go wrong? Why do so many Americans suffer preventable illnesses and deaths that proper drug use could have averted? How can the nation gain control over its escalating drug budget without resorting to rationing or draconian governmental controls?Using clinical case histories taken from his own work as a practitioner, researcher, and advocate, Dr. Avorn demonstrates the impressive power of the well-conceived prescription as well as the debacles that can result when medications are misused. He describes an innovative program that employs the pharmaceutical industry’s own marketing techniques to reduce use of some of the most overprescribed and overpriced products. Powerful Medicines offers timely and practical advice on how the nation can improve its drug-approval process, and how patients can work with doctors to make sure their prescriptions are safe, effective, and as affordable as possible. This is a passionate and provocative call for action as well as a compelling work of clear-headed science.From the Hardcover edition.

    We all have one, but most of us will never see one. The heart surgeon now has that privilege but, for centuries, the heart was out of reach even for surgeons. So when a surgeon nowadays opens up a ribcage and mends a heart, it remains something of a miracle, even if, to some, it is merely plumbing. As with plumbers, the quality of surgeons’ work varies. As with plumbers, surgeons’ opinion of their own prowess and their own attitude to risk are not always reliable. Measurement is key. We’ve had a century of effective evidence-based medicine. We’ve had barely a decade of thorough monitoring of clinical outcomes. Thanks to the ground-breaking risk modelling of pioneering surgeons like Samer Nashef, we at last know how to judge whether an operation is in a patient’s best interest, which hospital and surgeon would be best for that operation, when it might best be performed and what the exact level of risk is. We have at last made what is important in surgery measurable. But how should surgeons, and their patients, use these newfound insights? Ever since his days as a medical student, Samer Nashef has challenged the medical profession to be more open and more accurate about the success of surgical procedures, for the sake of the patients. In The Naked Surgeon, he unclothes his own profession to demonstrate to his reader (and prospective patient) many revelations, such as the paradox at the heart of the cardiac surgeon’s craft: the more an operation is likely to kill you, the better it is for you. And he does so with absolute clarity, fluency and not a little wit.

    As she maps the necessary skills and an actionable framework for meaningful connection, she gives us the language and tools to access a universe of new choices and second chances—a universe where we can share and steward the stories of our bravest and most heartbreaking moments with one another in a way that builds connection. Over the past two decades, Brown’s extensive research into the experiences that make us who we are has shaped the cultural conversation and helped define what it means to be courageous with our lives. Atlas of the Heart draws on this research, as well as on Brown’s singular skills as a storyteller, to show us how accurately naming an experience doesn’t give the experience more power, it gives us the power of understanding, meaning, and choice. Brown shares, “I want this book to be an atlas for all of us, because I believe that, with an adventurous heart and the right maps, we can travel anywhere and never fear losing ourselves.”

    He has kept a blog of his daily working life since 2003 and his award-winning writing is, by turn, moving, cynical, funny, heart-rending, and compassionate. From the tragic to the hilarious, the stories Tom tells give a fascinatingand at times alarming picture of life in inner-city Britain, and the people who are paid to mop up after it.

    These writers recount intensely personal and profoundly moving end-of-life accounts that cover a wide spectrum of human experience. All six authors are donating their royalties to a Maine hospice; Down East will also donate 10 percent of proceeds to the same cause.

    The bestselling author of Shadow Divers returns with a riveting story of exploration, mystery, and the discovery of an unknown world--this time about one man's incredible odyssey from blindness into sight.

    Mara Altman's volatile and apprehensive relationship with her body has led her to wonder about a lot of stuff over the years. Like, who decided that women shouldn't have body hair? And how sweaty is too sweaty? Also, why is breast cleavage sexy but camel toe revolting? Isn't it all just cleavage? These questions and others like them have led to the comforting and sometimes smelly revelations that constitute Gross Anatomy, an essay collection about what it's like to operate the bags of meat we call our bodies.Divided into two sections, "The Top Half" and "The Bottom Half," with cartoons scattered throughout, Altman's book takes the reader on a wild and relatable journey from head to toe—as she attempts to strike up a peace accord with our grody bits.With a combination of personal anecdotes and fascinating research, Gross Anatomy holds up a magnifying glass to our beliefs, practices, biases, and body parts and shows us the naked truth: that there is greatness in our grossness.

    In the midst of all this death, a bizarre disease appeared in Europe. Eventually known as encephalitis lethargica, or sleeping sickness, it would spread across the world, leaving millions dead or locked in institutions. Then, in 1927, it would disappear as suddenly as it had arrived-or so the doctors at first thought. Asleep, set in 1920s and '30s New York, follows a group of neurologists through hospitals and insane asylums as they try to solve this worldwide epidemic. The symptoms could include not only unending sleep but dangerous insomnia, facial tics, catatonia, Parkinson's, and even violent insanity. Molly Caldwell Crosby, acclaimed author of The American Plague, explores the frightening history of this forgotten disease- and details the frantic effort to conquer it before it strikes again.

    When Sarah Perry was twelve, she saw a partial eclipse of the sun, an event she took as a sign of good fortune for her and her mother, Crystal. But that brief moment of darkness ultimately foreshadowed a much larger one: two days later, Crystal was murdered in their home in rural Maine, just a few feet from Sarah’s bedroom.   The killer escaped unseen; it would take the police twelve years to find him, time in which Sarah grew into adulthood, struggling with abandonment, police interrogations, and the effort of rebuilding her life when so much had been lost. Through it all she would dream of the eventual trial, a conviction—all her questions finally answered. But after the trial, Sarah’s questions only grew. She wanted to understand her mother’s life, not just her final hours, and so she began a personal investigation, one that drew her back to Maine, taking her deep into the abiding darkness of a small American town.   Told in searing prose, After the Eclipse is a luminous memoir of uncomfortable truth and terrible beauty, an exquisite memorial for a mother stolen from her daughter, and a blazingly successful attempt to cast light on her life once more.

    As he would later write in the first of a series of award-winning columns for "Vanity Fair," he suddenly found himself being deported "from the country of the well across the stark frontier that marks off the land of malady." Over the next eighteen months, until his death in Houston on December 15, 2011, he wrote constantly and brilliantly on politics and culture, astonishing readers with his capacity for superior work even in extremis.Throughout the course of his ordeal battling esophageal cancer, Hitchens adamantly and bravely refused the solace of religion, preferring to confront death with both eyes open. In this account of his affliction, he describes the torments of illness, discusses its taboos, and explores how disease transforms experience and changes our relationship to the world around us. By turns personal and philosophical, Hitchens embraces the full panoply of human emotions as cancer invades his body and compels him to grapple with the enigma of mortality.

     Feed a cold, starve a lawyer Don't call a rose a rose; call her Mrs. Schwartz If you drink, don't drive; if you smoke, don't bother wearing your seatbelt

    What is going on? Anatomy of an Epidemic challenges readers to think through that question themselves. First, Whitaker investigates what is known today about the biological causes of mental disorders. Do psychiatric medications fix “chemical imbalances” in the brain, or do they, in fact, create them? Researchers spent decades studying that question, and by the late 1980s, they had their answer. Readers will be startled—and dismayed—to discover what was reported in the scientific journals. Then comes the scientific query at the heart of this book: During the past fifty years, when investigators looked at how psychiatric drugs affected long-term outcomes, what did they find? Did they discover that the drugs help people stay well? Function better? Enjoy good physical health? Or did they find that these medications, for some paradoxical reason, increase the likelihood that people will become chronically ill, less able to function well, more prone to physical illness?  This is the first book to look at the merits of psychiatric medications through the prism of long-term results. Are long-term recovery rates higher for medicated or unmedicated schizophrenia patients? Does taking an antidepressant decrease or increase the risk that a depressed person will become disabled by the disorder? Do bipolar patients fare better today than they did forty years ago, or much worse? When the National Institute of Mental Health (NIMH) studied the long-term outcomes of children with ADHD, did they determine that stimulants provide any benefit?  By the end of this review of the outcomes literature, readers are certain to have a haunting question of their own: Why have the results from these long-term studies—all of which point to the same startling conclusion—been kept from the public?  In this compelling history, Whitaker also tells the personal stories of children and adults swept up in this epidemic. Finally, he reports on innovative programs of psychiatric care in Europe and the United States that are producing good long-term outcomes. Our nation has been hit by an epidemic of disabling mental illness, and yet, as Anatomy of an Epidemic reveals, the medical blueprints for curbing that epidemic have already been drawn up.

    But in The Night the Lights Went Out, he finds himself far out of his depths. On the night of the 2018 Deadspin Awards, he suffered a mysterious fall that caused him to smash his head so hard on a cement floor that he cracked his skull in three places and suffered a catastrophic brain hemorrhage. For two weeks, he remained in a coma. The world was gone to him, and him to it.In his long recovery from his injury, including understanding what his family and friends went through as he lay there dying, coming to terms with his now permanent disabilities, and trying to find some lesson in this cosmic accident, he leaned on the one sure thing that he knows and that didn't leave him--his writing.Drew takes a deep dive into what it meant to be a bystander to his own death and figuring out who this new Drew is: a Drew that doesn't walk as well, doesn't taste or smell or see or hear as well, and a Drew that is often failing as a husband and a father as he bounces between grumpiness, irritability, and existential fury. But what's a good comeback story without heartbreak? Eager to get back what he lost, Drew experiences an awakening of a whole other kind in this incredibly funny, medically illuminating, and heartfelt memoir.

    Sometimes, they're wrong. At Chelsea General, surgeons answer for bad outcomes at the Morbidity and Mortality conference, known as M & M. This extraordinary peek behind the curtain into what is considered the most secretive meeting in all of medicine is the back drop for the entire book.Monday Mornings, by Dr. Sanjay Gupta, follows the lives of five surgeons at Chelsea General as they push the limits of their abilities and confront their personal and professional failings, often in front of their peers at M & M. It is on Monday mornings that reflection and introspection occurs, usually in private. It is Monday Mornings that provides a unique look at the real method in which surgeons learn - through their mistakes. It is Monday Mornings when, if you're lucky, you have a chance at redemption.