Indeed, these tiny structures inside our cells are important beyond imagining. Without mitochondria, we would have no cell suicide, no sculpting of embryonic shape, no sexes, no menopause, no aging.In this fascinating and thought-provoking book, Nick Lane brings together the latest research in this exciting field to show how our growing insight into mitochondria has shed light on how complex life evolved, why sex arose (why don't we just bud?), and why we age and die. These findings are of fundamental importance, both in understanding life on Earth, but also in controlling our own illnesses, and delaying our degeneration and death. Readers learn that two billion years ago, mitochondria were probably bacteria living independent lives and that their capture within larger cells was a turning point in the evolution of life, enabling the development of complex organisms. Lane describes how mitochondria have their own DNA and that its genes mutate much faster than those in the nucleus. This high mutation rate lies behind our aging and certain congenital diseases. The latest research suggests that mitochondria play a key role in degenerative diseases such as cancer. We also discover that mitochondrial DNA is passed down almost exclusively via the female line. That's why it has been used by some researchers to trace human ancestry daughter-to-mother, to "Mitochondrial Eve," giving us vital information about our evolutionary history.Written by Nick Lane, a rising star in popular science, Power, Sex, Suicide is the first book for general readers on the nature and function of these tiny, yet fascinating structures.

    When death is sudden or unexplained, it falls to Shepherd to establish the cause. Each post-mortem is a detective story in its own right - and Shepherd has performed over 23,000 of them. Through his skill, dedication and insight, Dr Shepherd solves the puzzle to answer our most pressing question: how did this person die?From serial killer to natural disaster, 'perfect murder' to freak accident, Shepherd takes nothing for granted in pursuit of truth. And while he's been involved in some of the most high-profile cases of recent times, it's often the less well known encounters that prove the most perplexing, intriguing and even bizarre. In or out of the public eye, his evidence has put killers behind bars, freed the innocent and turned open-and-shut cases on their heads.But a life in death, bearing witness to some of humanity's darkest corners, exacts a price and Shepherd doesn't flinch from counting the cost to him and his family.

    Witty and accessible, Paul Lockhart’s controversial approach will provoke spirited debate among educators and parents alike and it will alter the way we think about math forever.Paul Lockhart, has taught mathematics at Brown University and UC Santa Cruz. Since 2000, he has dedicated himself to K-12 level students at St. Ann’s School in Brooklyn, New York.

    In The Alchemy of Us, scientist and science writer Ainissa Ramirez examines eight inventions--clocks, steel rails, copper communication cables, photographic film, light bulbs, hard disks, scientific labware, and silicon chips--and reveals how they shaped the human experience. Ramirez tells the stories of the woman who sold time, the inventor who inspired Edison, and the hotheaded undertaker whose invention pointed the way to the computer. She describes, among other things, how our pursuit of precision in timepieces changed how we sleep; how the railroad helped commercialize Christmas; how the necessary brevity of the telegram influenced Hemingway's writing style; and how a young chemist exposed the use of Polaroid's cameras to create passbooks to track black citizens in apartheid South Africa. These fascinating and inspiring stories offer new perspectives on our relationships with technologies.Ramirez shows how materials were shaped by inventors, but also how those materials shaped culture, chronicling each invention and its consequences--intended and unintended. Filling in the gaps left by other books about technology, Ramirez showcases little-known inventors--particularly people of color and women--who had a significant impact but whose accomplishments have been hidden by mythmaking, bias, and convention. Doing so, she shows us the power of telling inclusive stories about technology. She also shows that innovation is universal--whether it's splicing beats with two turntables and a microphone or splicing genes with two test tubes and CRISPR.

    Thomas Young devised it in the early 1800s to show that light behaves like a wave, and in doing so opposed Isaac Newton. Nearly a century later, Albert Einstein showed that light comes in quanta, or particles, and the experiment became key to a fierce debate between Einstein and Niels Bohr over the nature of reality. Richard Feynman held that the double slit embodies the central mystery of the quantum world. Decade after decade, hypothesis after hypothesis, scientists have returned to this ingenious experiment to help them answer deeper and deeper questions about the fabric of the universe.How can a single particle behave both like a particle and a wave? Does a particle exist before we look at it, or does the very act of looking create reality? Are there hidden aspects to reality missing from the orthodox view of quantum physics? Is there a place where the quantum world ends and the familiar classical world of our daily lives begins, and if so, can we find it? And if there's no such place, then does the universe split into two each time a particle goes through the double slit?With his extraordinarily gifted eloquence, Anil Ananthaswamy travels around the world and through history, down to the smallest scales of physical reality we have yet fathomed. Through Two Doors at Once is the most fantastic voyage you can take.

    Now, physicist Leonard Susskind has teamed up with data engineer Art Friedman to present the theory and associated mathematics of the strange world of quantum mechanics.In this follow-up to The Theoretical Minimum, Susskind and Friedman provide a lively introduction to this famously difficult field, which attempts to understand the behavior of sub-atomic objects through mathematical abstractions. Unlike other popularizations that shy away from quantum mechanics’ weirdness, Quantum Mechanics embraces the utter strangeness of quantum logic. The authors offer crystal-clear explanations of the principles of quantum states, uncertainty and time dependence, entanglement, and particle and wave states, among other topics, and each chapter includes exercises to ensure mastery of each area. Like The Theoretical Minimum, this volume runs parallel to Susskind’s eponymous Stanford University-hosted continuing education course.An approachable yet rigorous introduction to a famously difficult topic, Quantum Mechanics provides a tool kit for amateur scientists to learn physics at their own pace.

    Through that observation, astronomers could calculate the size of the solar system—but only if they could compile data from many different points of the globe, all recorded during the short period of the transit. Overcoming incredible odds and political strife, astronomers from Britain, France, Russia, Germany, Sweden, and the American colonies set up observatories in remote corners of the world, only to have their efforts thwarted by unpredictable weather and warring armies. Fortunately, transits of Venus occur in pairs: eight years later, the scientists would have another opportunity to succeed.   Chasing Venus brings to life the personalities of the eighteenth-century astronomers who embarked upon this complex and essential scientific venture, painting a vivid portrait of the collaborations, the rivalries, and the volatile international politics that hindered them at every turn. In the end, what they accomplished would change our conception of the universe and would forever alter the nature of scientific research.

    Richard Gott leads time travel out of the world of H. G. Wells and into the realm of scientific possibility. Building on theories posited by Einstein and advanced by scientists such as Stephen Hawking and Kip Thorne, Gott explains how time travel can actually occur. He describes, with boundless enthusiasm and humor, how travel to the future is not only possible but has already happened, and he contemplates whether travel to the past is also conceivable. Notable not only for its extraordinary subject matter and scientific brilliance, Time Travel in Einstein’s Universe is a delightful and captivating exploration of the surprising facts behind the science fiction of time travel.

    This fascinating collection of historical curiosities explores some of the strangest cases that have perplexed doctors across the world.From seventeenth-century Holland to Tsarist Russia, from rural Canada to a whaler in the Pacific, many are monuments to human stupidity – such as the sailor who swallowed dozens of penknives to amuse his shipmates, or the chemistry student who in 1850 arrived at a hospital in New York with his penis trapped inside a bottle, having unwisely decided to relieve himself into a vessel containing highly reactive potassium. Others demonstrate exceptional surgical ingenuity long before the advent of anaesthesia – such as a daring nineteenth-century operation to remove a metal fragment from beneath a conscious patient’s heart. We also hear of the weird, often hilarious remedies employed by physicians of yore – from crow’s vomit to port-wine enemas – the hazards of such everyday objects as cucumbers and false teeth, and miraculous recovery from apparently terminal injuries.

    During World War I, the young women who were hired to work in America's radium watch dial factories were considered the lucky ones. They were paid well, they got to work with the luminous element dubbed "liquid sunshine" that was all the rage, and they were helping the war effort by providing instruments that shone in the dark. And their bodies literally glowed because of the amount of radium they were ingesting. In her new book, The Radium Girls: The Dark Story of America's Shining Women, author Kate Moore gives voice to two groups of workers who became horribly ill and fought back against the companies that poisoned them. Using diaries and letters from the women, their statements in court documents, medical records and archived x-rays, as well as using ancestry documents to track down their relatives for interviews, Moore showcases the forgotten young women whose legal fight led to life-changing workplace safety regulations amid one of the biggest scandals of America's twentieth century. Preorder and find out how their story ends on May 2.

    For more than two centuries, our understanding of the laws of nature expanded rapidly. But today, despite our best efforts, we know nothing more about these laws than we knew in the 1970s. Why is physics suddenly in trouble? And what can we do about it?One of the major problems, according to Smolin, is string theory: an ambitious attempt to formulate a “theory of everything” that explains all the particles and forces of nature and how the universe came to be. With its exotic new particles and parallel universes, string theory has captured the public’s imagination and seduced many physicists.But as Smolin reveals, there’s a deep flaw in the theory: no part of it has been tested, and no one knows how to test it. In fact, the theory appears to come in an infinite number of versions, meaning that no experiment will ever be able to prove it false. As a scientific theory, it fails. And because it has soaked up the lion’s share of funding, attracted some of the best minds, and effectively penalized young physicists for pursuing other avenues, it is dragging the rest of physics down with it.With clarity, passion, and authority, Smolin charts the rise and fall of string theory and takes a fascinating look at what will replace it. A group of young theorists has begun to develop exciting ideas that, unlike string theory, are testable. Smolin not only tells us who and what to watch for in the coming years, he offers novel solutions for seeking out and nurturing the best new talent—giving us a chance, at long last, of finding the next Einstein.

    Space is the venue of physics; it's where things exist, where they move and take shape. Yet over the past few decades, physicists have discovered a phenomenon that operates outside the confines of space and time: nonlocality-the ability of two particles to act in harmony no matter how far apart they may be. It appears to be almost magical. Einstein grappled with this oddity and couldn't come to terms with it, describing it as "spooky action at a distance." More recently, the mystery has deepened as other forms of nonlocality have been uncovered. This strange occurrence, which has direct connections to black holes, particle collisions, and even the workings of gravity, holds the potential to undermine our most basic understandings of physical reality. If space isn't what we thought it was, then what is it? In Spooky Action at a Distance, George Musser sets out to answer that question, offering a provocative exploration of nonlocality and a celebration of the scientists who are trying to explain it. Musser guides us on an epic journey into the lives of experimental physicists observing particles acting in tandem, astronomers finding galaxies that look statistically identical, and cosmologists hoping to unravel the paradoxes surrounding the big bang. He traces the often contentious debates over nonlocality through major discoveries and disruptions of the twentieth century and shows how scientists faced with the same undisputed experimental evidence develop wildly different explanations for that evidence. Their conclusions challenge our understanding of not only space and time but also the origins of the universe-and they suggest a new grand unified theory of physics. Delightfully readable, Spooky Action at a Distance is a mind-bending voyage to the frontiers of modern physics that will change the way we think about reality.Long-listed for the 2016 PEN/E. O. Wilson Literary Science Writing Award“An important book that provides insight into key new developments in our understanding of the nature of space, time and the universe. It will repay careful study.” —John Gribbin, The Wall Street Journal “An endlessly surprising foray into the current mother of physics' many knotty mysteries, the solving of which may unveil the weirdness of quantum particles, black holes, and the essential unity of nature.” —Kirkus Reviews (starred review)

    The Psychopath Test is a fascinating journey through the minds of madness. Jon Ronson's exploration of a potential hoax being played on the world's top neurologists takes him, unexpectedly, into the heart of the madness industry. An influential psychologist who is convinced that many important CEOs and politicians are, in fact, psychopaths teaches Ronson how to spot these high-flying individuals by looking out for little telltale verbal and nonverbal clues. And so Ronson, armed with his new psychopath-spotting abilities, enters the corridors of power. He spends time with a death-squad leader institutionalized for mortgage fraud in Coxsackie, New York; a legendary CEO whose psychopathy has been speculated about in the press; and a patient in an asylum for the criminally insane who insists he's sane and certainly not a psychopath. Ronson not only solves the mystery of the hoax but also discovers, disturbingly, that sometimes the personalities at the helm of the madness industry are, with their drives and obsessions, as mad in their own way as those they study. And that relatively ordinary people are, more and more, defined by their maddest edges.

    In this gloriously entertaining romp through human history, peppered with amusing pop culture references, Greg Jenner explores the gradual and often unexpected evolution of our daily routines.This is not a story of politics, wars or great events, instead Greg Jenner has scoured Roman rubbish bins, Egyptian tombs and Victorian sewers to bring us the most intriguing, surprising and sometimes downright silly nuggets from our past. Drawn from across the world, spanning a million years of humanity, this book is a smorgasbord of historical delights. It is a history of all those things you always wondered - and many you have never considered. It is the story of your life, one million years in the making.The UK paperback edition (2016) is revised and updated with extra facts.OTHER REVIEWS:"If you find yourself secretly relishing your children's Horrible Histories books, you will love Greg Jenner's jolly account of how we have more in common with our ancestors than we might think ... all human life is here, amusingly conveyed in intriguing nuggets of gossipy historical anecdote" (DAILY MAIL)"A wonderful idea, gloriously put into practice, Greg Jenner is as witty as he is knowledgeable" (TOM HOLLAND)"Delightful, surprising and hilarious, this is a fascinating history of the everyday objects and inventions we take for granted" (LAUREN LAVERNE)"Greg Jenner's magpie mind takes you through the history of who we are and what we do, answering tons of questions you never thought to ask" (AL MURRAY)"Like visiting the most wonderful and cluttered museum, each chapter like another room teetering with illuminating ideas and information" (ROBIN INCE)"Hugely entertaining...full of astonishing insights" (HISTORY REVEALED MAGAZINE)"Jenner has a vivid, colloquial turn of phrase...lively, funny and completely absorbing" (CURRENT ARCHAEOLOGY MAGAZINE)

    Charting the most cutting-edge scientific breakthroughs, and marshalling his decades of research and clinical practice, Walker explains how we can harness sleep to improve learning, mood and energy levels, regulate hormones, prevent cancer, Alzheimer's and diabetes, slow the effects of aging, and increase longevity. He also provides actionable steps towards getting a better night's sleep every night.