And certainly no one wants to overeat for years, become overweight, and end up with a high risk of diabetes or heart disease--yet two thirds of Americans do precisely that. Even though we know better, we often eat too much. Why does our behavior betray our own intentions to be lean and healthy? The problem, argues obesity and neuroscience researcher Stephan J. Guyenet, is not necessarily a lack of willpower or an incorrect understanding of what to eat. Rather, our appetites and food choices are led astray by ancient, instinctive brain circuits that play by the rules of a survival game that no longer exists. And these circuits don’t care about how you look in a bathing suit next summer.To make the case, The Hungry Brain takes readers on an eye-opening journey through cutting-edge neuroscience that has never before been available to a general audience. The Hungry Brain delivers profound insights into why the brain undermines our weight goals and transforms these insights into practical guidelines for eating well and staying slim. Along the way, it explores how the human brain works, revealing how this mysterious organ makes us who we are.

    13 b&w illustrations.

    Yet there’s a black hole at the heart of biology. We do not know why complex life is the way it is, or, for that matter, how life first began. In The Vital Question, award-winning author and biochemist Nick Lane radically reframes evolutionary history, putting forward a solution to conundrums that have puzzled generations of scientists.For two and a half billion years, from the very origins of life, single-celled organisms such as bacteria evolved without changing their basic form. Then, on just one occasion in four billion years, they made the jump to complexity. All complex life, from mushrooms to man, shares puzzling features, such as sex, which are unknown in bacteria. How and why did this radical transformation happen?The answer, Lane argues, lies in energy: all life on Earth lives off a voltage with the strength of a lightning bolt. Building on the pillars of evolutionary theory, Lane’s hypothesis draws on cutting-edge research into the link between energy and cell biology, in order to deliver a compelling account of evolution from the very origins of life to the emergence of multicellular organisms, while offering deep insights into our own lives and deaths.Both rigorous and enchanting, The Vital Question provides a solution to life’s vital question: why are we as we are, and indeed, why are we here at all?

    In Living With Darwin, Philip Kitcher stokes the flames swirling around Darwin's theory, sifting through the scientific evidence for evolution, Creation Science, and Intelligent Design, and revealing why evolution has been the object of such vehement attack. Kitcher first provides valuable perspective on the present controversy, describing the many puzzles that blocked evolution's acceptance in the early years, and explaining how scientific research eventually found the answers to these conundrums. Interestingly, Kitcher shows that many of these early questions have been resurrected in recent years by proponents of Intelligent Design. In fact, Darwin himself considered the issue of intelligent design, and amassed a mountain of evidence that effectively refuted the idea. Kitcher argues that the problem with Intelligent Design isn't that it's not science, as many critics say, but that it's dead science, raising questions long resolved by scientists. But Kitcher points out that it is also important to recognize the cost of Darwin's success--the price of life with Darwin. Darwinism has a profound effect on our understanding of our place in the universe, on our religious beliefs and aspirations. It is in truth the focal point of a larger clash between religious faith and modern science. Unless we can resolve this larger issue, the war over evolution will go on.

    Far less well-known is a much greater catastrophe that took place at the end of the Permian period 251 million years ago: 90 percent of life was destroyed, including saber-toothed reptiles and their rhinoceros-sized prey on land, as well as vast numbers of fish and other species in the sea.This book documents not only what happened during this gigantic mass extinction but also the recent rekindling of the idea of catastrophism. Was the end-Permian event caused by the impact of a huge meteorite or comet, or by prolonged volcanic eruption in Siberia? The evidence has been accumulating through the 1990s and into the new millennium, and Michael Benton gives his verdict at the very end. From field camps in Greenland and Russia to the laboratory bench, When Life Nearly Died involves geologists, paleontologists, environmental modelers, geochemists, astronomers, and experts on biodiversity and conservation. Their working methods are vividly described and explained, and the current disputes are revealed. The implications of our understanding of crises in the past for the current biodiversity crisis are also presented in detail. 46 b/w illustrations.

    What drives species to evolve? How can intricate structures such as the human eye, the spider's web or the wings of birds develop, seemingly by chance? Regarding evolution's most complex achievements as peaks on a metaphorical mountain, Climbing Mount Improbable reveals the ways in which the theory of natural selection can precisely explain the beautiful, bizarre and seemingly 'designed' complexity of living things.And through it all runs the thread of DNA, the molecule of life, responsible for its own destiny on an unending pilgrimage through time. Accompanied by evocative illustrations, Dawkins's eloquent descriptions of the living world's astonishing adaptations throw back the curtain on the mysteries of 'Mount Improbable'.An alternative cover edition for this ISBN can be found here.

    Fascinating... may presage a paradigm shift in medicine." --Kirkus Reviews (starred review)Teeming with information and big ideas... Outstanding."--Booklist (starred review) The origin of asthma, autism, Alzheimer's, allergies, cancer, heart disease, obesity, and even some kinds of depression is now clear. Award-winning researcher on the microbiome, professor Rodney Dietert presents a new paradigm in human biology that has emerged in the midst of the ongoing global epidemic of noncommunicable diseases.The Human Superorganism makes a sweeping, paradigm-shifting argument. It demolishes two fundamental beliefs that have blinkered all medical thinking until very recently: 1) Humans are better off as pure organisms free of foreign microbes; and 2) the human genome is the key to future medical advances. The microorganisms that we have sought to eliminate have been there for centuries supporting our ancestors. They comprise as much as 90 percent of the cells in and on our bodies--a staggering percentage! More than a thousand species of them live inside us, on our skin, and on our very eyelashes. Yet we have now significantly reduced their power and in doing so have sparked an epidemic of noncommunicable diseases--which now account for 63 percent of all human deaths.Ultimately, this book is not just about microbes; it is about a different way to view humans. The story that Dietert tells of where the new biology comes from, how it works, and the ways in which it affects your life is fascinating, authoritative, and revolutionary. Dietert identifies foods that best serve you, the superorganism; not new fad foods but ancient foods that have made sense for millennia. He explains protective measures against unsafe chemicals and drugs. He offers an empowering self-care guide and the blueprint for a revolution in public health. We are not what we have been taught. Each of us is a superorganism. The best path to a healthy life is through recognizing that profound truth.

    But by itself, DNA is just an inert blueprint for life. It is the ribosome--an enormous molecular machine made up of a million atoms--that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases. But this is also a human story of Ramakrishnan's unlikely journey, from his first fumbling experiments in a biology lab to being the dark horse in a fierce competition with some of the world's best scientists. In the end, Gene Machine is a frank insider's account of the pursuit of high-stakes science.

    Mastering the fat hormone leptin is the single most important factor in preventing obesity, diabetes, and heart disease. The Leptin Diet contains five simple lifestyle guidelines to get the hormone leptin into balance for permanent weight loss, increased energy, and optimum health. What is Leptin? Fat cells produce the powerful hormone leptin, a primary force instructing metabolism, weight loss, and hormone balance. Leptin communicates directly to your brain, telling the brain how much fat is in storage. It controls appetite, energy, and metabolic rate. Leptin problems are the primary reason for food cravings, overeating, faulty metabolism, the obsession with food, and heart disease. Read The Leptin Diet and notice the difference!

    Yet it is so ravaged by human activity that half its species could be gone by the end of the present century. These two contrasting truths—unexpected magnificence and underestimated peril—have become compellingly clear during the past two decades of research on biological diversity.In this dazzlingly intelligent and ultimately hopeful book, Wilson describes what treasures of the natural world we are about to lose forever—in many cases animals, insects, and plants we have only just discovered, and whose potential to nourish us, protect us, and cure our illnesses is immeasurable—and what we can do to save them. In the process, he explores the ethical and religious bases of the conservation movement and deflates the myth that environmental policy is antithetical to economic growth by illustrating how new methods of conservation can ensure long-term economic well-being.The Future of Life is a magisterial accomplishment: both a moving description of our biosphere and a guidebook for the protection of all its species, including humankind.

    After 3.8 billion years humankind is about to start evolving by new rules...From leading geopolitical expert and technology futurist Jamie Metzl comes a groundbreaking exploration of the many ways genetic-engineering is shaking the core foundations of our lives -- sex, war, love, and death.At the dawn of the genetics revolution, our DNA is becoming as readable, writable, and hackable as our information technology. But as humanity starts retooling our own genetic code, the choices we make today will be the difference between realizing breathtaking advances in human well-being and descending into a dangerous and potentially deadly genetic arms race.Enter the laboratories where scientists are turning science fiction into reality. Look towards a future where our deepest beliefs, morals, religions, and politics are challenged like never before and the very essence of what it means to be human is at play. When we can engineer our future children, massively extend our lifespans, build life from scratch, and recreate the plant and animal world, should we?

    In the process, Roberts looks at how the taming of the oceans has shaped human civilization and affected marine life.We have always been fish eaters, from the dawn of civilization, but in the last twenty years we have transformed the oceans beyond recognition. Putting our exploitation of the seas into historical context, Roberts offers a devastating account of the impact of modern fishing techniques, pollution, and climate change, and reveals what it would take to steer the right course while there is still time. Like Four Fish and The Omnivore’s Dilemma, The Ocean of Life takes a long view to tell a story in which each one of us has a role to play.

    Dennett, whom Chet Raymo of The Boston Globe calls "one of the most provocative thinkers on the planet," focuses his unerringly logical mind on the theory of natural selection, showing how Darwin's great idea transforms and illuminates our traditional view of humanity's place in the universe. Dennett vividly describes the theory itself and then extends Darwin's vision with impeccable arguments to their often surprising conclusions, challenging the views of some of the most famous scientists of our day.

    Now, he presents his conclusions in this brave and pioneering book. Axe argues that the key to understanding our origin is the “design intuition”—the innate belief held by all humans that tasks we would need knowledge to accomplish can only be accomplished by someone who has that knowledge. For the ingenious task of inventing life, this knower can only be God.Starting with the hallowed halls of academic science, Axe dismantles the widespread belief that Darwin’s theory of evolution is indisputably true, showing instead that a gaping hole has been at its center from the beginning. He then explains in plain English the science that proves our design intuition scientifically valid. Lastly, he uses everyday experience to empower ordinary people to defend their design intuition, giving them the confidence and courage to explain why it has to be true and the vision to imagine what biology will become when people stand up for this truth.Armed with that confidence, readers will affirm what once seemed obvious to all of us—that living creatures, from single-celled cyanobacteria to orca whales and human beings, are brilliantly conceived, utterly beyond the reach of accident.Our intuition was right all along.

    Yet something about our species distinguished it from the pack, and ultimately led to its survival while the rest became extinct. Just what was it that allowed Homo sapiens to become masters of the planet? Ian Tattersall, curator emeritus at the American Museum of Natural History, takes us deep into the fossil record to uncover what made humans so special. Surveying a vast field from initial bipedality to language and intelligence, Tattersall argues that Homo sapiens acquired a winning combination of traits that was not the result of long-term evolutionary refinement. Instead, the final result emerged quickly, shocking our world and changing it forever.