Increased emphasis on gene activity, signal transduction and the emphasis on the roles of paracrine factors in development.

    It provides a simple mathematical framework which can be used to understand and even design biological circuits. The textavoids specialist terms, focusing instead on several well-studied biological systems that concisely demonstrate key principles. An Introduction to Systems Biology: Design Principles of Biological Circuits builds a solid foundation for the intuitive understanding of general principles. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models.

    Our brains exist as historical products, developing in interaction with themselves and with their surroundings. Hence there is a thin line between the organization of the nervous system and the political and social organization that both conditions and is conditioned by human experience. Looking carefully at contemporary neuroscience, it is hard not to notice that the new way of talking about the brain mirrors the management discourse of the neo-liberal capitalist world in which we now live, with its talk of decentralization, networks, and flexibility. Consciously or unconsciously, science cannot but echo the world in which it takes place. In the neo-liberal world, 'plasticity' can be equated with 'flexibility'—a term that has become a buzzword in economics and management theory. The plastic brain would thus represent just another style of power, which, although less centralized, is still a means of control. In this book, Catherine Malabou develops a second, more radical meaning for plasticity. Not only does plasticity allow our brains to adapt to existing circumstances, it opens a margin of freedom to intervene, to change those very circumstances. Such an understanding opens up a newly transformative aspect of the neurosciences. In insisting on this proximity between the neurosciences and the social sciences, Malabou applies to the brain Marx's well-known phrase about history: people make their own brains, but they do not know it. This book is a summons to such knowledge.Collection: Perspectives in Continental Philosophy

    She describes the "neurobiological platform of bonding" that, modified by evolutionary pressures and cultural values, has led to human styles of moral behavior. The result is a provocative genealogy of morals that asks us to reevaluate the priority given to religion, absolute rules, and pure reason in accounting for the basis of morality. Moral values, Churchland argues, are rooted in family values displayed by all mammals--the caring for offspring. The evolved structure, processes, and chemistry of the brain incline humans to strive not only for self-preservation but for the well-being of allied selves--first offspring, then mates, kin, and so on, in wider and wider "caring" circles. Separation and exclusion cause pain, and the company of loved ones causes pleasure; responding to feelings of social pain and pleasure, brains adjust their circuitry to local customs. In this way, caring is apportioned, conscience molded, and moral intuitions instilled. A key part of the story is oxytocin, an ancient body-and-brain molecule that, by decreasing the stress response, allows humans to develop the trust in one another necessary for the development of close-knit ties, social institutions, and morality. A major new account of what really makes us moral, Braintrust challenges us to reconsider the origins of some of our most cherished values.

    Arguments still rage about the implications of his evolutionary theory, and scepticism about the value of Darwin's contribution to knowledge is widespread. In this analysis of Darwin's major insights and arguments, Jonathan Howard reasserts the importance of Darwin's work for the development of modern science and culture."--BOOK JACKET.

    When choosing whether to start a family, or deciding on a career, we often think we can assess the options by imagining what different experiences would be like forus. L. A. Paul argues that, for choices involving dramatically new experiences, we are confronted by the brute fact that we can know very little about our subjective futures. This has serious implications for our decisions. If we make life choices in the way we naturally and intuitively want to--byconsidering what we care about, and what our future selves will be like if we choose to have the experience--we only learn what we really need to know after we have already committed ourselves. If we try to escape the dilemma by avoiding an experience, we have still made a choice.Choosing rationally, then, may require us to regard big life decisions as choices to make discoveries, small and large, about the intrinsic nature of experience, and to recognize that part of the value of living authentically is to experience one's life and preferences in whatever way they mayevolve in the wake of the choices one makes.Using classic philosophical examples about the nature of consciousness, and drawing on recent work in normative decision theory, cognitive science, epistemology, and the philosophy of mind, Paul develops a rigorous account of transformative experience that sheds light on how we should understandreal-world experience and our capacity to rationally map our subjective futures.

    The topic is examined in terms of its implications for a wide range of disciplines including philosophy, religion, feminism, postmodernism, sociology and psychology. In its defense, both classical and contemporary theistic arguments are criticized, and, the argument from evil, and impossibility arguments, along with a non religious basis for morality are defended. These essays give a broad understanding of atheism and a lucid introduction to this controversial topic.

    Richard Dawkins, for example, jolted us into realizing that we are just survival mechanisms for our own genes, sophisticated robots in service of huge colonies of replicators to whom concepts of rationality, intelligence, agency, and even the human soul are irrelevant.Accepting and now forcefully responding to this decentering and disturbing idea, Keith Stanovich here provides the tools for the "robot's rebellion," a program of cognitive reform necessary to advance human interests over the limited interest of the replicators and define our own autonomous goals as individual human beings. He shows how concepts of rational thinking from cognitive science interact with the logic of evolution to create opportunities for humans to structure their behavior to serve their own ends. These evaluative activities of the brain, he argues, fulfill the need that we have to ascribe significance to human life. We may well be robots, but we are the only robots who have discovered that fact. Only by recognizing ourselves as such, argues Stanovich, can we begin to construct a concept of self based on what is truly singular about humans: that they gain control of their lives in a way unique among life forms on Earth—through rational self-determination.

    As a moral philosopher, Joyce is interested in whether any implications follow from this hypothesis. Might the fact that the human brain has been biologically prepared by natural selection to engage in moral judgment serve in some sense to vindicate this way of thinking -- staving off the threat of moral skepticism, or even undergirding some version of moral realism? Or if morality has an adaptive explanation in genetic terms -- if it is, as Joyce writes, "just something that helped our ancestors make more babies" -- might such an explanation actually undermine morality's central role in our lives? He carefully examines both the evolutionary "vindication of morality" and the evolutionary "debunking of morality," considering the skeptical view more seriously than have others who have treated the subject.Interdisciplinary and combining the latest results from the empirical sciences with philosophical discussion, The Evolution of Morality is one of the few books in this area written from the perspective of moral philosophy. Concise and without technical jargon, the arguments are rigorous but accessible to readers from different academic backgrounds. Joyce discusses complex issues in plain language while advocating subtle and sometimes radical views. The Evolution of Morality lays the philosophical foundations for further research into the biological understanding of human morality.

    

    More than anything else, he argues, it is the neglect of consciousness that results in so much barrenness and sterility in psychology, the philosophy of mind, and cognitive science: there can be no study of mind that leaves out consciousness. What is going on in the brain is neurophysiological processes and consciousness and nothing more -- no rule following, no mental information processing or mental models, no language of thought, and no universal grammar. Mental events are themselves features of the brain, "like liquidity is a feature of water."Beginning with a spirited discussion of what's wrong with the philosophy of mind, Searle characterizes and refutes the philosophical tradition of materialism. But he does not embrace dualism. All these "isms" are mistaken, he insists. Once you start counting types of substance you are on the wrong track, whether you stop at one or two. In four chapters that constitute the heart of his argument, Searle elaborates a theory of consciousness and its relation to our overall scientific world view and to unconscious mental phenomena. He concludes with a criticism of cognitive science and a proposal for an approach to studying the mind that emphasizes the centrality of consciousness to any account of mental functioning.In his characteristically direct style, punctuated with persuasive examples, Searle identifies the very terminology of the field as the main source of truth. He observes that it is a mistake to suppose that the ontology of the mental is objective and to suppose that the methodology of a science of the mind must concern itself only with objectively observable behavior; that it is also a mistake to suppose that we know of the existence of mental phenomena in others only by observing their behavior; that behavior or causal relations to behavior are not essential to the existence of mental phenomena; and that it is inconsistent with what we know about the universe and our place in it to suppose that everything is knowable by us.

    Starting with a statement of the "hard problem" of consciousness, Chalmers builds a positive framework for the science of consciousness and a nonreductive vision of the metaphysics of consciousness. He replies to many critics of The Conscious Mind, and then develops a positive theory in new directions. The book includes original accounts of how we think and know about consciousness, of the unity of consciousness, and of how consciousness relates to the external world. Along the way, Chalmers develops many provocative ideas: the "consciousness meter," the Garden of Eden as a model of perceptual experience, and The Matrix as a guide to the deepest philosophical problems about consciousness and the external world. This book will be required reading for anyone interested in the problems of mind, brain, consciousness, and reality.

    Hundreds of specialized organs, bones, muscles, nerve fibers, blood vessels, and other anatomical features comprise an interdependent network of bodily systems that enables the human organism to survive. Now the component parts of this intricate flesh-and-bone machine can be absorbed and understood by means of an ingenious format: a coloring book that can help mature children and adult colorists learn anatomy.An affordable anatomy class, this easy learning study aid contains careful, scientifically accurate line renderings of the body's organs and major systems: skeletal, muscular, nervous, digestive, reproductive, and more. A total of 43 coloring pages (often with several illustrations on each) offers numerous views, cross-sections, diagrams and detailed closeups, labelled and numbered to correspond with suggestions for coloring. These suggestions are specially designed to emphasize the structural relationship in the body. By working through each system, the reader will gain not only an intimate knowledge of the location, appearance and role of the body parts, this learning tool will also be laying the groundwork for more sophisticated studies of anatomy.

    With the assistance of a co-author, this popular student textbook has now been updated to include techniques such as membrane chromatography, aqueous phase partitioning, engineering recombinant proteins for purification and due to the rapid advances in bioinformatics/proteomics a discussion of the analysis of complex protein mixtures by 2D-electrophoresis and RPHPLC prior to sequencing by mass spectroscopy. Written with the student firmly in mind, no previous knowledge of biochemistry, and little of chemistry, is assumed. It is intended to provide an introduction to enzymology, and a balanced account of all the various theoretical and applied aspects of the subject which are likely to be included in a course.

    Loosely based in its principles around the Biblical proverb "As a man thinketh in his heart, so is he," As a Man Thinketh asserts the powerful idea that belief is central to bringing about positive events in one's life. From Poverty to Power, Allen's first book, relies on a similar philosophy but addresses themes of adversity and suffering more directly and offers his simple wisdom as a means of overcoming difficulty. Allen's writings are powerful and relevant today as they were over a century ago, and this collection brings their solace and inspiration to modern listeners.