As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    Odder still, she reveals that she’s suffering from a persistent memory problem. Routinely, she “loses” parts of her day, finding herself in places she doesn’t remember going to or being told about conversations she doesn’t remember having. Her problems are so pervasive that she often feels like an impersonator in her own life; she doesn’t recognize the people who call themselves her friends, and she can’t even remember being intimate with her own husband. Baer recognizes that Karen is on the verge of suicide and, while trying various medications to keep her alive, attempts to discover the root cause of her strange complaints. It’s the work of months, and then years, to gain Karen’s trust and learn the true extent of the trauma buried in her past. What she eventually reveals is nearly beyond belief, a narrative of a childhood spent grappling with unimaginable horror. How has Karen survived with even a tenuous grasp on sanity?Then Baer receives an envelope in the mail. It’s marked with Karen’s return address but contains a letter from a little girl who writes that she’s seven years old and lives inside of Karen. Soon Baer receives letters from others claiming to be parts of Karen. Under hypnosis, these alternate Karen personalities reveal themselves in shocking variety and with undeniable traits—both physical and psychological. One “alter” is a young boy filled with frightening aggression; another an adult male who considers himself Karen’s protector; and a third a sassy flirt who seeks dominance over the others. It’s only by compartmentalizing her pain, guilt, and fear in this fashion—by “switching time” with alternate selves as the situation warrants—that Karen has been able to function since childhood.Realizing that his patient represents an extreme case of multiple personality disorder, Baer faces the daunting task of creating a therapy that will make Karen whole again. Somehow, in fact, he must gain the trust of each of Karen’s seventeen “alters” and convince them of the necessity of their own annihilation.As powerful as Sybil or The Three Faces of Eve, Switching Time is the first complete account of such therapy to be told from the perspective of the treating physician, a stunningly devoted healer who worked selflessly for decades so that Karen could one day live as a single human being.From the Hardcover edition.

    She is also a superbly gifted writer–witty, insightful, at once deeply humane and refreshingly wry. In Another Day in the Frontal Lobe, Dr. Firlik draws on this rare combination to create a neurosurgeon’s Kitchen Confidential–a unique insider’s memoir of a fascinating profession.Neurosurgeons are renowned for their big egos and aggressive self-confidence, and Dr. Firlik confirms that timidity is indeed rare in the field. “They’re the kids who never lost at musical chairs,” she writes. A brain surgeon is not only a highly trained scientist and clinician but also a mechanic who of necessity develops an intimate, hands-on familiarity with the gray matter inside our skulls. It’s the balance between cutting-edge medical technology and manual dexterity, between instinct and expertise, that Firlik finds so appealing–and so difficult to master. Firlik recounts how her background as a surgeon’s daughter with a strong stomach and a keen interest in the brain led her to this rarefied specialty, and she describes her challenging, atypical trek from medical student to fully qualified surgeon. Among Firlik’s more memorable cases: a young roofer who walked into the hospital with a three-inch-long barbed nail driven into his forehead, the result of an accident with his partner’s nail gun, and a sweet little seven-year-old boy whose untreated earache had become a raging, potentially fatal infection of the brain lining. From OR theatrics to thorny ethical questions, from the surprisingly primitive tools in a neurosurgeon’s kit to glimpses of future techniques like the “brain lift,” Firlik cracks open medicine’s most prestigious and secretive specialty. Candid, smart, clear-eyed, and unfailingly engaging, Another Day in the Frontal Lobe is a mesmerizing behind-the-scenes glimpse into a world of incredible competition and incalculable rewards.From the Hardcover edition.

    She witnesses nurses drawing straws to see who would tend to the patient inside, all of them reluctant to enter the room. Out of impulse, Ruth herself enters the quarantined space and immediately begins to care for the young man who cries for his mother in the last moments of his life. Before she can even process what she's done, word spreads in the community that Ruth is the only person willing to help these young men afflicted by AIDS, and is called upon to nurse them. As she forges deep friendships with the men she helps, she works tirelessly to find them housing and jobs, even searching for funeral homes willing to take their bodies - often in the middle of the night. She cooks meals for tens of people out of discarded food found in the dumpsters behind supermarkets, stores rare medications for her most urgent patients, teaches sex-ed to drag queens after hours at secret bars, and becomes a beacon of hope to an otherwise spurned group of ailing gay men on the fringes of a deeply conservative state.Throughout the years, Ruth defies local pastors and nurses to help the men she cares for: Paul and Billy, Angel, Chip, Todd and Luke. Emboldened by the weight of their collective pain, she fervently advocates for their safety and visibility, ultimately advising Governor Bill Clinton on the national HIV-AIDS crisis.This deeply moving and elegiac memoir honors the extraordinary life of Ruth Coker Burks and the beloved men who fought valiantly for their lives with AIDS during a most hostile and misinformed time in America.

    He didn't talk. He hid under tables and surrounded himself with a cage of chairs. He hadn't been out of the building in the four years since he'd come in. He was afraid of water and wouldn't take a shower. He was afraid to be naked, to change his clothes. He was nearly 16.Desperate to see change in the boy, the staff of Kevin's adolescent treatment center hired Hayden. As Hayden read to him and encouraged him to read, crawling down into his cage of chairs with him, Kevin talked. Then he started to draw and paint and showed himself to have a quick wit and a rolling, seething, murderous hatred for his stepfather.

    In the span of twelve hours, lives can be lost, life-altering medical treatment decisions made, and dreams fulfilled or irrevocably stolen. In Brown’s skilled hands--as both a dedicated nurse and an insightful chronicler of events--we are given an unprecedented view into the individual struggles as well as the larger truths about medicine in this country, and by shift’s end, we have witnessed something profound about hope and healing and humanity. Every day, Theresa Brown holds patients' lives in her hands. On this day there are four. There is Mr. Hampton, a patient with lymphoma to whom Brown is charged with administering a powerful drug that could cure him--or kill him; Sheila, who may have been dangerously misdiagnosed; Candace, a returning patient who arrives (perhaps advisedly) with her own disinfectant wipes, cleansing rituals, and demands; and Dorothy, who after six weeks in the hospital may finally go home. Prioritizing and ministering to their needs takes the kind of skill, sensitivity, and, yes, humor that enable a nurse to be a patient’s most ardent advocate in a medical system marked by heartbreaking dysfunction as well as miraculous success.

    Instead, he finds that he has joined a new world where race is front and center. The recipient of a scholarship designed to increase black student enrollment, Tweedy soon meets a professor who bluntly questions whether he belongs in medical school, a moment that crystallizes the challenges he will face throughout his career. Making matters worse, in lecture after lecture the common refrain for numerous diseases resounds, "More common in blacks than in whites."Black Man in a White Coat examines the complex ways in which both black doctors and patients must navigate the difficult and often contradictory terrain of race and medicine. As Tweedy transforms from student to practicing physician, he discovers how often race influences his encounters with patients. Through their stories, he illustrates the complex social, cultural, and economic factors at the root of many health problems in the black community. These issues take on greater meaning when Tweedy is himself diagnosed with a chronic disease far more common among black people. In this powerful, moving, and deeply empathic book, Tweedy explores the challenges confronting black doctors, and the disproportionate health burdens faced by black patients, ultimately seeking a way forward to better treatment and more compassionate care.

    Brenda Maddox tells a powerful story of a remarkably single-minded, forthright, and tempestuous young woman who, at the age of fifteen, decided she was going to be a scientist, but who was airbrushed out of the greatest scientific discovery of the twentieth century.

    Thrown into a profession of gallows humor and vivid characters (both living and very dead), Caitlin learned to navigate the secretive culture of those who care for the deceased.Smoke Gets in Your Eyes tells an unusual coming-of-age story full of bizarre encounters and unforgettable scenes. Caring for dead bodies of every color, shape, and affliction, Caitlin soon becomes an intrepid explorer in the world of the dead. She describes how she swept ashes from the machines (and sometimes onto her clothes) and reveals the strange history of cremation and undertaking, marveling at bizarre and wonderful funeral practices from different cultures.Her eye-opening, candid, and often hilarious story is like going on a journey with your bravest friend to the cemetery at midnight. She demystifies death, leading us behind the black curtain of her unique profession. And she answers questions you didn’t know you had: Can you catch a disease from a corpse? How many dead bodies can you fit in a Dodge van? What exactly does a flaming skull look like?Honest and heartfelt, self-deprecating and ironic, Caitlin's engaging style makes this otherwise taboo topic both approachable and engrossing. Now a licensed mortician with an alternative funeral practice, Caitlin argues that our fear of dying warps our culture and society, and she calls for better ways of dealing with death (and our dead).

    It was also a land withered by drought and hunger, and a place where hope and opportunity were hard to find. But William had read about windmills in a book called Using Energy, and he dreamed of building one that would bring electricity and water to his village and change his life and the lives of those around him. His neighbors may have mocked him and called him misala—crazy—but William was determined to show them what a little grit and ingenuity could do.Enchanted by the workings of electricity as a boy, William had a goal to study science in Malawi's top boarding schools. But in 2002, his country was stricken with a famine that left his family's farm devastated and his parents destitute. Unable to pay the eighty-dollar-a-year tuition for his education, William was forced to drop out and help his family forage for food as thousands across the country starved and died.Yet William refused to let go of his dreams. With nothing more than a fistful of cornmeal in his stomach, a small pile of once-forgotten science textbooks, and an armory of curiosity and determination, he embarked on a daring plan to bring his family a set of luxuries that only two percent of Malawians could afford and what the West considers a necessity—electricity and running water. Using scrap metal, tractor parts, and bicycle halves, William forged a crude yet operable windmill, an unlikely contraption and small miracle that eventually powered four lights, complete with homemade switches and a circuit breaker made from nails and wire. A second machine turned a water pump that could battle the drought and famine that loomed with every season.Soon, news of William's magetsi a mphepo—his "electric wind"—spread beyond the borders of his home, and the boy who was once called crazy became an inspiration to those around the world.Here is the remarkable story about human inventiveness and its power to overcome crippling adversity. The Boy Who Harnessed the Wind will inspire anyone who doubts the power of one individual's ability to change his community and better the lives of those around him.

    Or the "Phantom of Fine Hall," a figure many students had seen shuffling around the corridors of the math and physics building wearing purple sneakers and writing numerology treatises on the blackboards. The Phantom was John Nash, one of the most brilliant mathematicians of his generation, who had spiraled into schizophrenia in the 1950s. His most important work had been in game theory, which by the 1980s was underpinning a large part of economics. When the Nobel Prize committee began debating a prize for game theory, Nash's name inevitably came up—only to be dismissed, since the prize clearly could not go to a madman. But in 1994 Nash, in remission from schizophrenia, shared the Nobel Prize in economics for work done some 45 years previously.Economist and journalist Sylvia Nasar has written a biography of Nash that looks at all sides of his life. She gives an intelligent, understandable exposition of his mathematical ideas and a picture of schizophrenia that is evocative but decidedly unromantic. Her story of the machinations behind Nash's Nobel is fascinating and one of very few such accounts available in print (the CIA could learn a thing or two from the Nobel committees).

    Her home on the border with China gave her some exposure to the world beyond the confines of the Hermit Kingdom and, as the famine of the 1990s struck, she began to wonder, question and to realise that she had been brainwashed her entire life. Given the repression, poverty and starvation she witnessed surely her country could not be, as she had been told “the best on the planet”?Aged seventeen, she decided to escape North Korea. She could not have imagined that it would be twelve years before she was reunited with her family.She could not return, since rumours of her escape were spreading, and she and her family could incur the punishments of the government authorities – involving imprisonment, torture, and possible public execution. Hyeonseo instead remained in China and rapidly learned Chinese in an effort to adapt and survive. Twelve years and two lifetimes later, she would return to the North Korean border in a daring mission to spirit her mother and brother to South Korea, on one of the most arduous, costly and dangerous journeys imaginable.This is the unique story not only of Hyeonseo’s escape from the darkness into the light, but also of her coming of age, education and the resolve she found to rebuild her life – not once, but twice – first in China, then in South Korea. Strong, brave and eloquent, this memoir is a triumph of her remarkable spirit.

    In short, powerful chapters, Higashida explores school memories, family relationships, the exhilaration of travel, and the difficulties of speech. He also allows readers to experience profound moments we take for granted, like the thought-steps necessary for him to register that it's raining outside. Acutely aware of how strange his behavior can appear to others, he aims throughout to foster a better understanding of autism and to encourage society to see people with disabilities as people, not as problems.With an introduction by bestselling novelist David Mitchell, Fall Down 7 Times Get Up 8 also includes a dreamlike short story Higashida wrote especially for this edition. Both moving and of practical use, this book opens a window into the mind of an inspiring young man who meets every challenge with tenacity and good humor. However often he falls down, he always gets back up.

    By night he spent it as fast as he could, on drugs, sex, and international globe-trotting. From the binge that sank a 170-foot motor yacht and ran up a $700,000 hotel tab, to the wife and kids waiting at home, and the fast-talking, hard-partying young stockbrokers who called him king and did his bidding, here, in his own inimitable words, is the story of the ill-fated genius they called . . .THE WOLF OF WALL STREETIn the 1990s Jordan Belfort, former kingpin of the notorious investment firm Stratton Oakmont, became one of the most infamous names in American finance: a brilliant, conniving stock-chopper who led his merry mob on a wild ride out of the canyons of Wall Street and into a massive office on Long Island. Now, in this astounding and hilarious tell-all autobiography, Belfort narrates a story of greed, power, and excess that no one could invent.Reputedly the prototype for the film Boiler Room, Stratton Oakmont turned microcap investing into a wickedly lucrative game as Belfort’s hyped-up, coked-out brokers browbeat clients into stock buys that were guaranteed to earn obscene profits—for the house. But an insatiable appetite for debauchery, questionable tactics, and a fateful partnership with a breakout shoe designer named Steve Madden would land Belfort on both sides of the law and into a harrowing darkness all his own.From the stormy relationship Belfort shared with his model-wife as they ran a madcap household that included two young children, a full-time staff of twenty-two, a pair of bodyguards, and hidden cameras everywhere—even as the SEC and FBI zeroed in on them—to the unbridled hedonism of his office life, here is the extraordinary story of an ordinary guy who went from hustling Italian ices at sixteen to making hundreds of millions. Until it all came crashing down . . .

    She takes us by her side down hospital corridors to visit the wards and meet her unforgettable patients.In the neonatal unit, premature babies fight for their lives, hovering at the very edge of survival, like tiny Emmanuel, wrapped up in a sandwich bag. On the cancer wards, the nurses administer chemotherapy and, long after the medicine stops working, something more important--which Watson learns to recognize when her own father is dying of cancer. In the pediatric intensive care unit, the nurses wash the hair of a little girl to remove the smell of smoke from the house fire. The emergency room is overcrowded as ever, with waves of alcohol and drug addicted patients as well as patients like Betty, a widow suffering chest pain, frail and alone. And the stories of the geriatric ward--Gladys and older patients like her--show the plight of the most vulnerable members of our society.