Through serendipity— by chewing, brewing, and snorting—some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the five-thousand-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze-age medicine, a worm-killing birch fungus, knotted to his leggings. Nowadays, Big Pharma conglomerates spend billions of dollars on state-of the art laboratories staffed by PhDs to discover blockbuster drugs. Yet, despite our best efforts to engineer cures, luck, trial-and-error, risk, and ingenuity are still fundamental to medical discovery.The Drug Hunters is a colorful, fact-filled narrative history of the search for new medicines from our Neolithic forebears to the professionals of today, and from quinine and aspirin to Viagra, Prozac, and Lipitor. The chapters offer a lively tour of how new drugs are actually found, the discovery strategies, the mistakes, and the rare successes. Dr. Donald R. Kirsch infuses the book with his own expertise and experiences from thirty-five years of drug hunting, whether searching for life-saving molecules in mudflats by Chesapeake Bay or as a chief science officer and research group leader at major pharmaceutical companies.

    Supersized life spans are going to radically alter society, and present an unprecedented opportunity to change our approach not only to old age but to all of life’s stages. The ramifications are just beginning to dawn on us.... yet in the meantime, we keep thinking about, and planning for, life as it used to be lived. In A Long Bright Future, longevity and aging expert Laura Carstensen guides us into the new possibilities offered by a longer life. She debunks the myths and misconceptions about aging that stop us from adequately preparing for the future both as individuals and as a society: that growing older is associated with loneliness and unhappiness, and that only the genetically blessed live well and long. She then focuses on other important components of a long life, including finances, health, social relationships, Medicare and Social Security, challenging our preconceived notions of “old age” every step of the way.

    Personal, poignant, and meticulously precise, these stories evoke Chekhov, Maugham, and William Carlos Williams, admitting readers to the beating heart of medicine. Internal Medicine is an account of what it means to be a doctor, to be mortal, and to be human.

    With case studies and advice for a fitter life, this is an intriguing and thought-provoking book, one which should be read by anyone who cares about their wellbeing.

    Now he shares what he's seen and heard on the Other Side.In this book, John shares with us fifteen fascinating stories of what happens when clients ask him to contact their dead friends and relatives. Included here are the story of a 30-something New Yorker who was unable to stop fantasizing about suicide until he conveys healing words from her dead fiancé; an account of an encounter with a grieving young woman in a drugstore--and the message he conveys from her dead six-year-old son; and a disturbing story of an unsolved murder case solved by information he received from the other side.Above all, this is a book filled with comfort, love, forgiveness, and hope. For Thomas John, death is not the end, it is just the beginning. Our friends and relatives are still with us. They care for us. They watch over us. And, in times of particular need, they offer us their help.

    We have all benefited from the medical discoveries of primate research--vaccines for polio, rubella, and hepatitis B are just a few. But we have also learned more in recent years about how intelligent apes and monkeys really are: they can speak to us with sign language, they can even play video games (and are as obsessed with the games as any human teenager). And activists have also uncovered widespread and unnecessarily callous treatment of animals by researchers (in 1982, a Silver Spring lab was charged with 17 counts of animal cruelty). It is a complex issue, made more difficult by the combative stance of both researchers and animal activists. In The Monkey Wars, Deborah Blum gives a human face to this often caustic debate--and an all-but-human face to the subjects of the struggle, the chimpanzees and monkeys themselves. Blum criss-crosses America to show us first hand the issues and personalities involved. She offers a wide-ranging, informative look at animal rights activists, now numbering some twelve million, from the moderate Animal Welfare Institute to the highly radical Animal Liberation Front (a group destructive enough to be placed on the FBI's terrorist list). And she interviews a wide variety of researchers, many forced to conduct their work protected by barbed wire and alarm systems, men and women for whom death threats and hate mail are common. She takes us to Roger Fouts's research center in Ellensburg, Washington, where we meet five chimpanzees trained in human sign language, and we visit LEMSIP, a research facility in New York State that has no barbed wire, no alarms--and no protesters chanting outside--because its director, Jan Moor-Jankowski, listens to activists with respect and treats his animals humanely. And along the way, Blum offers us insights into the many side-issues involved: the intense battle to win over school kids fought by both sides, and the danger of transplanting animal organs into humans. As it stands now, Blum concludes, the research community and its activist critics are like two different nations, nations locked in a long, bitter, seemingly intractable political standoff....But if you listen hard, there really are people on both sides willing to accept and work within the complex middle. When they can be freely heard, then we will have progressed to another place, beyond this time of hostilities. In The Monkey Wars, Deborah Blum gives these people their voice.

    

    

    —Brother David Stendl-Rast"Libraries offering titles on mysticism, inner transformation, or dealing with grief will find this a unique and welcome addition."—Library JournalThis powerful book, written by an Episcopal priest, tells of her intense relationship with Brother Raphael Robin, a seventy-year-old Trappist monk and hermit. Both believed that a relationship can continue beyond this life, and here Cynthia Bourgeault describes her search for that connection before and after Robin's death. Bourgeault's previous books include The Wisdom Jesus and Centering Prayer and Inner Awakening.

    The view 16-year-old Thomas Osborne first had of Muskoka was at night, trudging alone with his even younger brother along unmarked primitive roads to find their luckless father who, in 1875, had decided to make a new start for his beleaguered family on some "free land" in the bush east of the pioneer village of Huntsville, Ontario. The miracle is that Thomas lived to tell the tale.For the next five years Thomas endured starvation, falling through the ice and freezing, accidents with axes and boats, and narrow escapes from wolves and bears. Many years later, after returning to the United States, Osborne wrote down all his adventures in a graphic memoir that has become, in the words of author and journalist Roy MacGregor, "an undiscovered Canadian classic."Reluctant Pioneer provides a brooding sense of adventure and un- sentimental realism to deliver a powerful account of pioneer life where tragedies arrive as naturally as rain and where humour resides in irony.

    Well, I was diagnosed 24 years ago, and I still learned something new on every page.”—Michael Kinsley, Vanity Fair columnist and author of Old Age: A Beginner’s Guide Here is the book that John Vine and his wife, Joanne, wish they could have consulted when John was first diagnosed with Parkinson’s disease—a nontechnical, personal guide written from the patient’s perspective. Relying on his experiences over the past 12 years, John writes knowledgeably about all aspects of the disease. John also interviewed other Parkinson’s patients and their partners, whose stories and advice he includes throughout the book. “I wish we’d had John Vine’s book when my brother-in-law was diagnosed. The book is highly informative, unflinchingly honest, and reassuringly optimistic. It’s just what the doctor should have ordered.”—Cokie Roberts, best-selling author and political commentator on ABC News and NPR “John Vine details, in a compelling and accessible way, his experience with Parkinson’s disease. His book is an extraordinary guide to living successfully with Parkinson’s, and a must read for all who want to better understand the condition. Although diagnosed with Parkinson’s, my father lived an active and productive life until his death at age 94. As the book makes clear, while each patient’s journey is unique, common approaches are indispensable in treating the symptoms of the disease.”—Eric H. Holder, Jr. served as the 82nd Attorney General of the United States from 2009 to 2015 “John Vine has written the best primer I’ve ever read for newly diagnosed Parkinson’s patients and their families. It helps them cope with the shock of diagnosis, gives them (jargon-free) the scientific basics they need to know, describes the symptoms they may experience (making clear that every case is different) and catalogs the resources available to navigate living with Parkinson’s. John humanizes the book by describing his own experience and that of 22 other patients and their partners. I’d urge every neurologist to have copies of Vine’s primer on hand to help new PD on their journey forward.”—Morton Kondracke, author of Saving Milly: Love, Politics and Parkinson’s Disease and a member of the Founders' Council of the Michael J. Fox Foundation “My husband has PD, and I devoured this book. It’s wise, wonderfully readable, and, above all, helpful. Since John Vine has PD, he speaks with great authority about the challenges, both physical and psychological. If you have Parkinson’s, live with someone who has it, or just know someone battling the disease, A Parkinson’s Primer is for you.”—Lesley Stahl, award-winning television journalist on the CBS News program 60 Minutes “This is a remarkable book describing the personal experiences of many individuals, including the author, living with Parkinson’s disease. It captures the fact that although there are many possible symptoms in this disease, each person experiences different symptoms and copes with them in various ways. The thoughtful and insightful comments and coping strategies should be helpful for persons with PD, and their partners, regardless of the stage of the disease.”—Stephen Grill, MD, PhD, Director of the Parkinson’s & Movement Disorders Center of Maryland John M. Vine is a lawyer at Covington & Burling LLP in Washington, DC, where he is the senior member and former head of the firm’s employee benefits group. He was diagnosed with Parkinson’s in 2004.

    Dr Kendrick, a well-known statin sceptic and author of the bestselling The Great Cholesterol Con, has returned to the diet-heart-cholesterol battlefield to warn that people are being conned.In relaxed and humorous style, he lifts the rock to allow the reader to peer underneath. He points out that statins, even in high-risk individuals, increase life expectancy by a mere four days after five years of treatment. Yet adverse effects have been swept under the carpet by researchers who are closely tied to the industry.The way to avoid heart disease, and strokes, is simple - but, as this riveting book shows, it has nothing to do with lowering cholesterol levels.

    This volume is comprised of the years 1900 through 1959, and includes all of the best known cases of the period, as well as many more lesser-known murders, all presented in a compelling chronological narrative that takes the reader on a grisly journey through the blood-soaked avenues of early twentieth century crime. Featuring: The Peasenhall Murder. The Seal Chart Murder. The Atlanta Ripper. The Villisca Axe Murders. The Axeman of New Orleans. The Green Bicycle Case. Little Lord Fauntleroy. Hinterkaifeck Farm. The St. Aubin Street Massacre. The Wallace Case. The Atlas Vampire. The Brighton Trunk Crime. The Cleveland Torso Murderer. The Horror in Room 1046. Who Put Bella in the Wych Elm? The Pitchfork Murder. The Sodder Children. The Phantom Killer. The Black Dahlia. Somerton Man. The Grimes Sisters. The Boy in the Box. And Much More!

    Now he looks at the complex and surprising ways the weak can defeat the strong, the small can match up against the giant, and how our goals (often culturally determined) can make a huge difference in our ultimate sense of success. Drawing upon examples from the world of business, sports, culture, cutting-edge psychology, and an array of unforgettable characters around the world, David and Goliath is in many ways the most practical and provocative book Malcolm Gladwell has ever written.

    The author traces the early histories of the cars, how they were discovered, and where they are.