Richard Davenport-Hines, an eminent, prize-winning historian, uncovers the centrality of drug abuse in our modern industrial society, from the drug habits of Charles Dickens and John F. Kennedy to today's $400 billion annual worldwide trade in illicit drugs (the same volume as the oil industry). A vivid portrayal of the people and events that have shaped the history of narcotics, The Pursuit of Oblivion reveals that, contrary to the assumption underlying current drug policies, our need to escape reality and our body's need for physical pleasure are both ineradicable aspects of our humanity, unchangeable by government initiative.

    We get cancer because we can't avoid it—it's a bug in the system of life itself.Cancer exists in nearly every animal and has afflicted humans as long as our species has walked the earth. In Rebel Cell: Cancer, Evolution, and the New Science of Life's Oldest Betrayal, Kat Arney reveals the secrets of our most formidable medical enemy, most notably the fact that it isn't so much a foreign invader as a double agent: cancer is hardwired into the fundamental processes of life. New evidence shows that this disease is the result of the same evolutionary changes that allowed us to thrive. Evolution helped us outsmart our environment, and it helps cancer outsmart its environment as well—alas, that environment is us.Explaining why "everything we know about cancer is wrong," Arney, a geneticist and award-winning science writer, guides readers with her trademark wit and clarity through the latest research into the cellular mavericks that rebel against the rigid biological "society" of the body and make a leap towards anarchy.We need to be a lot smarter to defeat such a wily foe—smarter even than Darwin himself. In this new world, where we know that every cancer is unique and can evolve its way out of trouble, the old models of treatment have reached their limits. But we are starting to decipher cancer's secret evolutionary playbook, mapping the landscapes in which these rogue cells survive, thrive, or die, and using this knowledge to predict and confound cancer's next move.Rebel Cell is a story about life and death, hope and hubris, nature and nurture. It's about a new way of thinking about what this disease really is and the role it plays in human life. Above all, it's a story about where cancer came from, where it's going, and how we can stop it.

    A decade later, the price for any of us to order our own personal genome sequence—a comprehensive map of the 3 billion letters in our DNA—is rapidly and inevitably dropping to just $1,000. Dozens of men and women—scientists, entrepreneurs, celebrities, and patients—have already been sequenced, pioneers in a bold new era of personalized genomic medicine. The $1,000 genome has long been considered the tipping point that would open the floodgates to this revolution. Do you have gene variants associated with Alzheimer’s or diabetes, heart disease or cancer? Which drugs should you consider taking for various diseases, and at what dosage? In the years to come, doctors will likely be able to tackle all of these questions—and many more—by using a computer in their offices to call up your unique genome sequence, which will become as much a part of your medical record as your blood pressure. Indeed, many experts are advocating that all newborns have a complete genome analysis done so that preventive measures and preemptive medicine can begin early in life. How has this astonishing achievement been accomplished? And what will it mean for our lives? To research the story of this unfolding revolution, critically acclaimed science writer Kevin Davies has spent the past few years traveling to the leading centers and interviewing the entrepreneurs and pioneers in the race to achieve the $1,000 genome. He vividly brings to life the extraordinary drama of this grand scientific achievement, revealing the masterful ingenuity that has transformed the process of decoding DNA and delivering the information it possesses to the public at large. Davies also profiles the future of genomic medicine and thoughtfully explores the many pressing issues raised by the tidal wave of personal genetic information. Will your privacy be protected? Will you be pressured, by insurance companies or by your employer, to get your genome sequenced? What psychological toll might there be to discovering you are at risk for certain diseases like Alzheimer’s? And will the government or the medical establishment come between you and your genome?One thing that is not in question is that we are moving swiftly into the personalized medicine era, and The $1,000 Genome is an essential guide to this brave new future.

    Well-known for his experiences at the poles and climbing Everest, he has also endured some of the hottest conditions on the planet, where temperatures regularly exceed 40 degrees and, without water and shelter, death is inevitable.

    Set out logically and systematically, this best-selling textbook has comprehensive coverage of essential skills necessary for history taking and examining the patient. Highly regarded by students world-wide, this text continues to grow in strength. Clinical Examination, 5th edition has been revised and updated to include: more evidence-based medicine; new full-color artwork; and a fresh new look allowing greater accessibility for readers. The new edition covers clinical examination and concepts in a systems approach in a clear, consistent and user-friendly approach. Readers using this edition of Clinical Examination will have access to www.studentconsult.com. Here you will receive full online access to the text and numerous interactive extras such as video clips demonstrating some of the more difficult examinations & MCQ's. Written by two internationally renowned authors, Clinical Examination, 5th edition will continue to provide students with a superb reference for performing clinical methods.

    Written for both the casual reader and the science buff hungry for new information, The Vision Revolution is a resource that dispels commonly believed perceptions about sight and offers answers drawn from the field’s most recent research.Changizi focuses on four “why” questions:1. Why do we see in color?2. Why do our eyes face forward?3. Why do we see illusions?4. Why does reading come so naturally to us?Why Do We See in Color?It was commonly believed that color vision evolved to help our primitive ancestors identify ripe fruit. Changizi says we should look closer to home: ourselves. Human color vision evolved to give us greater insights into the mental states and health of other people. People who can see color changes in skin have an advantage over their color-blind counterparts; they can see when people are blushing with embarrassment, purple-faced with exertion or the reddening of rashes. Changizi’s research reveals that the cones in our eyes that allow us to see color are exquisitely designed exactly for seeing color changes in the skin. And it’s no coincidence that the primates with color vision are the ones with bare spots on their faces and other body parts; Changizi shows that the development of color vision in higher primates closely parallels the loss of facial hair, culminating in the near hairlessness and highly developed color vision of humans.Why Do Our Eyes Face Forward?Forward-facing eyes set us apart from most mammals, and there is much dispute as to why we have them. While some speculate that we evolved this feature to give us depth perception available through stereo vision, this type of vision only allows us to see short distances, and we already have other mechanisms that help us to estimate distance. Changizi’s research shows that with two forward-facing eyes, primates and humans have an x-ray ability. Specifically, we’re able to see through the cluttered leaves of the forest environment in which we evolved. This feature helps primates see their targets in a crowded, encroached environment. To see how this works, hold a finger in front of your eyes. You’ll find that you’re able to look “through” it, at what is beyond your finger. One of the most amazing feats of two forward-facing eyes? Our views aren’t blocked by our noses, beaks, etc.Why Do We See Illusions?We evolved to see moving objects, not where they are, but where they are going to be. Without this ability, we couldn’t catch a ball because the brain’s ability to process visual information isn’t fast enough to allow us to put our hands in the right place to intersect for a rapidly approaching baseball. “If our brains simply created a perception of the way the world was at the time light hit the eye, then by the time that perception was elicited—which takes about a tenth of a second for the brain to do—time would have marched on, and the perception would be of the recent past,” Changizi explains. Simply put, illusions occur when our brain is tricked into thinking that a stationary two-dimensional picture has an element that is moving. Our brains project the “moving” element into the future and, as a result, we don’t see what’s on the page, but what our brain thinks will be the case a fraction of a second into the future.Why Does Reading Come So Naturally to Us?We can read faster than we can hear, which is odd, considering that reading is relatively recent, and we’ve evolved to process speech for millions of years. Changizi’s research reveals that language has been carefully designed to tap in to elements of the visual processing center that have evolved for tens of millions of years. Visual signs of all languages are shaped like objects in nature, Changizi says, because we have evolved to see nature easily. “People have noticed letters in nature for some time, and there are artists who have a spent a lot of time photographing Latin letters in natural scenes or on butterfly wings,” Changizi says. “For example, if you look at an upper corner of the room you are in, you will see three contours meeting at a point, making a shape close to that of a ‘Y.’“ The Vision Revolution expands upon how our ancestors found the shapes of Latin letters and delves into how visual signs can have similar shapes even though their inspirations come from very different environments.In addition to these four areas, The Vision Revolution explores other phenomena such as cyclopses, peeking and many more you hadn’t even thought to wonder about. Changizi shows how deeply involved these evolutionary aspects of our vision are in why we see the way we do—and what the future holds for us.“…to understand how culture interacts with vision, one must understand not just the eye’s design, but the actual mechanisms we have evolved,” Changizi says, “for culture can tap in to both the designed responses of our brains and the unintended responses.”The Vision Revolution is a book that finally gives attention to what before has been largely neglected by other works on human vision—a book that looks at the “why.”

    They've heard everything from “My two-year-old gets constant ear infections. Should I give her antibiotics? Or probiotics?” to “I heard that my son’s asthma was caused by a lack of microbial exposure. Is this true, and if so what can I do about it now?”Google these questions, and you’ll be overwhelmed with answers. The internet is rife with speculation and misinformation about the risks and benefits of what most parents think of as simply germs, but which scientists now call the microbiome: the combined activity of all the tiny organisms inside our bodies and the surrounding environment that have an enormous impact on our health and well-being. Who better to turn to for answers than Drs. Gilbert and Knight, two of the top scientists leading the investigation into the microbiome—an investigation that is producing fascinating discoveries and bringing answers to parents who want to do the best for their young children. Dirt Is Good is a comprehensive, authoritative, accessible guide you've been searching for.

    The latest scientific research reveals that the balance of bacteria in an individual’s microbiome can have a profound impact on inflammation throughout the body. In those with psoriasis or autoimmune arthritis, there is often a characteristic lack of certain beneficial bacteria that normally regulate the immune system – known as “keystone” species. This is typically coupled with an overabundance of potentially harmful bacteria that further trigger the inflammatory response. The Keystone Approach calms inflammation at the source by restoring the balance of good and bad bacteria in the microbiome. Based on an in-depth analysis of the latest scientific evidence, The Keystone Approach also explains how to optimize the Mediterranean diet for the greatest reduction in inflammation, along with providing detailed guidance for choosing supplements supported by good-quality clinical trials. ---- Rebecca Fett is a science writer with a degree in molecular biotechnology and biochemistry from the University of Sydney. She previously spent ten years as a biotechnology patent litigation attorney in New York, where she specialized in analyzing the scientific and clinical evidence for immune-targeting biologic medicines

    Medical care is in crisis, we are repeatedly told, and so it is. Barely one in five Americans thinks the medical system works well. Enter David M. Cutler, a Harvard economist who served on President Clinton's health care task force and later advised presidential candidate Bill Bradley. One of the nation's leading experts on the subject, Cutler argues in Your Money or Your Life that health care has in fact improvedexponentially over the last fifty years, and that the successes of our system suggest ways in which we might improve care, make the system easier to deal with, and extend coverage to all Americans. Cutler applies an economic analysis to show that our spending on medicine is well worth it--and thatwe could do even better by spending more. Further, millions of people with easily manageable diseases, from hypertension to depression to diabetes, receive either too much or too little care because of inefficiencies in the way we reimburse care, resulting in poor health and in some cases prematuredeath. The key to improving the system, Cutler argues, is to change the way we organize health care. Everyone must be insured for the medical system to perform well, and payments should be based on the quality of services provided not just on the amount of cutting and poking performed. Lively and compelling, Your Money or Your Life offers a realistic yet rigorous economic approach to reforming health care--one that promises to break through the stalemate of failed reform.

    The latest headlines feature the human papillomavirus (HPV) alleged to cause cervical cancer and the avian flu virus, H5N1. The public is also continually terrorized by reports about SARS, BSE, hepatitis C, AIDS, Ebola, and polio. However, this virus mayhem ignores very basic scientific facts: the existence, the pathogenicity and the deadly effects of these agents have never been proven. The authors of Virus Mania, journalist Torsten Engelbrecht and doctor of internal medicine Claus K�hnlein, show that these alleged contagious agents are, in fact, particles produced by the cells themselves as a consequence of certain stress factors such as drugs, malnutrition, pesticides and heavy metals.The central aim of this book is to steer the discussion back to a real scientific debate and put medicine back on the path of an impartial analysis of the facts. It will put medical experiments, clinical trials, statistics and government policies under the microscope, revealing that the people charged with protecting our health and safety have deviated from this path. To substantiate these statements, the authors cite dozens of highly renowned scientists and present approximately 1,100 pertinent scientific references.The topic of this book is of pivotal significance. The pharmaceutical companies and top scientists rake in enormous sums of money by attacking germs and the media boosts its audience ratings and circulations with sensationalized reporting (the coverage of the New York Times and Der Spiegel are specifically analyzed). "The primary purpose of commercially-funded clinical research is to maximize financial return on investment, not health," says John Abramson of Harvard Medical School. Virus Mania will inform you on how such an environment took root-and how to empower yourself for a healthy life.

    The adventure begins during the author's formative years in medical school and takes the reader through two decades of thought-provoking rural and urban-based ER and family practice experiences. Humorously written in an engaging mash-up of formal prose and informal medical slang with a nod to pop culture and ancient mythology, Dude is a powerful book that is certain to please readers of all stripes.