But a medical revolution is underway that can solve this problem: Astonishing new research is revealing that the health of your brain is, to an extraordinary degree, dictated by the state of your microbiome - the vast population of organisms that live in your body and outnumber your own cells ten to one. What's taking place in your intestines today is determining your risk for any number of brain-related conditions.In BRAIN MAKER, Dr. Perlmutter explains the potent interplay between intestinal microbes and the brain, describing how the microbiome develops from birth and evolves based on lifestyle choices, how it can become "sick," and how nurturing gut health through a few easy strategies can alter your brain's destiny for the better. With simple dietary recommendations and a highly practical program of six steps to improving gut ecology, BRAIN MAKER opens the door to unprecedented brain health potential.

    There is no better way to study the big questions in philosophy than to compare how the world's greatest minds have analyzed these questions, defined the terms, and then reasoned out potential solutions. Once you've compared the arguments, the final step is always deciding for yourself whether you find an explanation convincing.This course gives you the tools to follow and create logical arguments while exploring famous philosophers' viewpoints on these important questions. Although progress has been made toward answers, brilliant thinkers have continued to wrestle with many big questions that inspire thoughtful people everywhere. These questions include: What is knowledge? Does God exist? Do humans have free will? What is right and wrong? How should society be organized?Given the complexity of these big questions, it should be no surprise that many controversies are far from settled. In fact, by the end of these 36 lectures, you may be even less sure of the right answers to some of the questions than you were at the beginning. But being a philosopher means constantly testing your views - giving a reasoned defense if you believe you are right and modifying your ideas when you realize you are wrong. You'll discover that great thinkers before you have offered convincing answers to hard questions, philosophers after them have made equally persuasive objections, and then still others have refined the debate even further - causing the issues to come into sharper and sharper focus.Join Plato, St. Anselm, Descartes, Locke, Hume, Kant, Mill, Smith, Marx, Rawls, and many others in an exploration of fundamental questions. Get ready to think big!

    From his intimate knowledge of S., the mnemonist, gained from conversations and testing over a period of almost thirty years, A. R. Luria is able to reveal in rich detail not only the obvious strengths of S.’s astonishing memory but also his surprising weaknesses: his crippling inability to forget, his pattern of reacting passively to life, and his uniquely handicapped personality.

    Loyal, obedient, and affectionate, they are truly “man’s best friend.” But do dogs love us the way we love them? Emory University neuroscientist Gregory Berns had spent decades using MRI imaging technology to study how the human brain works, but a different question still nagged at him: What is my dog thinking?   After his family adopted Callie, a shy, skinny terrier mix, Berns decided that there was only one way to answer that question—use an MRI machine to scan the dog’s brain. His colleagues dismissed the idea. Everyone knew that dogs needed to be restrained or sedated for MRI scans. But if the military could train dogs to operate calmly in some of the most challenging environments, surely there must be a way to train dogs to sit in an MRI scanner.   With this radical conviction, Berns and his dog would embark on a remarkable journey and be the first to glimpse the inner workings of the canine brain. Painstakingly, the two worked together to overcome the many technical, legal, and behavioral hurdles. Berns’s research offers surprising results on how dogs empathize with human emotions, how they love us, and why dogs and humans share one of the most remarkable friendships in the animal kingdom.   How Dogs Love Us answers the age-old question of dog lovers everywhere and offers profound new evidence that dogs should be treated as we would treat our best human friends: with love, respect, and appreciation for their social and emotional intelligence.

    What makes evolution such a profoundly provocative concept, so convincing to most scientists, yet so socially and politically divisive? The Theory of Evolution: A History of Controversy is an examination of the varied elements that so often make this science the object of strong sentiments and heated debate. Professor Edward J. Larson leads you through the "evolution" of evolution, with an eye toward enhancing your understanding of the development of the theory itself and the roots of the controversies that surround it. In these lectures you will: Explore pre-Darwinian theories of the origins of life, from Genesis and the ancient Greeks to such 18th- and 19th-century scientists as Georges Cuvier and Chevalier de Lamarck Follow the life and work of Charles Darwin, and the impact of his 1859 masterpiece, On the Origin of Species. Darwin's theory of evolution by natural selection was immediately recognized as a threat to traditional religion, but was quickly accepted (the first printing of Origin of Species sold out on the first day) Examine the history of evolutionary science after Darwin-a fascinating story that includes the "rediscovery," after 35 years, of Gregor Mendel's work on genetic variation; the unearthing of prehominid, or early human, fossils by Raymond Dart in 1925 and the Leakey family in the 1950s; and the confusion created by the sensational, but later discredited, discovery of Piltdown Man-a fake evolutionary "missing link"-in 1912 Trace the history of religious objections to evolution, from those of Darwin's own time to contemporary efforts to teach creation science in American schools. This includes a detailed discussion of the famous Scopes "monkey trial," which in fact was a staged media event, designed to create publicity for the town of Dayton, Tennessee. Are Our Genes more Important than We Are? This course makes it clear that the history of controversy surrounding evolution is not limited to a dispute between science and religion. Even within the scientific community, the fine details of the theory of evolution have long been a matter of passionate dispute. In fact, in the last third of the 19th century, the principal objections were scientific, not religious. Although the fossil record was a key piece of evidence for evolution, it had gaps that could be used to argue against the theory. And both proponents and critics wondered how altruistic human qualities such as love and generosity could possibly have evolved through the competitive, often harsh, processes that Darwin described. From Professor Larson's presentation, you will learn that new ideas in evolution science have often created new controversies. For example, is it truly possible, as some scientists now maintain, that humans exist merely to ensure the survival of their genes? Such research has created disagreement among scientists about the degree to which evolution drives human behavior, and has further alienated many segments of the public. Evolution's "Dark Side": Social Darwinism In these lectures, you will review perhaps the most sinister controversy associated with the theory of evolution: social Darwinism. From the beginning, the Darwinian theory of evolution has been linked to economic and political views. Thomas Malthus's theories of population growth and competition for limited resources even inspired Darwin's thinking on natural selection. Unfortunately, later supporters of evolution carried this line of thinking too far. Beginning with Herbert Spencer, who coined the term "survival of the fittest," Darwin's ideas were used as evidence for a wide range of social beliefs, from laissez-faire capitalism to racism, colonialism, and, in perhaps the worst application, Nazism. In the United States, social Darwinism has served as a basis for the creation of IQ tests and for eugenics programs that resulted in the forced sterilization of thousands of mentally ill or retarded Americans. Unsettling Implications: The Growing Gulf Between Science and Religion During the late 19th century, largely through the efforts of scientists who sought to integrate evolutionary science with spiritual belief, evolution was widely accepted by the religious community in the United States. Today, this is hardly the case. In his last four lectures, Professor Larson examines the trends that have, since 1920, widened the gulf between science and religion. These include an increase in fundamentalist Protestantism, the weakening of liberal Protestantism as a counteracting force, and the growing power of a firmly conservative South. In the 1960s, federally funded neo-Darwinian textbooks provoked a conservative backlash. Beginning with the publication of Henry M. Morris's The Genesis Flood, efforts to gain equal time for the teaching of creation science, based on biblical teachings, gathered strength. Rebuffed by the courts, creationism continues to thrive through the increasing numbers of private Christian schools and through home schooling. The growing gulf between science and religion has unsettling implications for our society. Large segments of the American population reject the naturalism of current evolutionary thinking. Nine of 10 Americans believe in spiritual causes for life, with only 10 percent accepting the purely naturalistic explanations espoused by evolution. Strikingly, these statistics are almost exactly the opposite among the scientific community. A Pulitzer Prize-Winning Teacher As both a historian of science and a professor of law, Professor Edward J. Larson brings exceptional qualifications to this subject. His book, Summer for the Gods: The Scopes Trial and America's Continuing Debate Over Science and Religion, won the 1998 Pulitzer Prize in History. His analysis provides an invaluable perspective on the volatile history of what is arguably the single most significant idea of modern times.

    Lieberman traces the field from its birth as a mystic pseudo-science through its adolescence as a cult of "shrinks" to its late blooming maturity — beginning after World War II — as a science-driven profession that saves lives. With fascinating case studies and portraits of the luminaries of the field — from Sigmund Freud to Eric Kandel — Shrinks is a gripping and illuminating read, and an urgent call-to-arms to dispel the stigma of mental illnesses by treating them as diseases rather than unfortunate states of mind.“A lucid popular history...At once skeptical and triumphalist. It shows just how far psychiatry has come.” —Julia M. Klein, Boston Globe

    In Projections, he combines his groundbreaking access to the brain's inner circuitry with a deep empathy for his patients to examine what mental illness reveals about the mind and the origin of human feelings--how the broken can illuminate the unbroken. An internationally acclaimed professor of bioengineering and psychiatry at Stanford, Deisseroth's true passion is clinical psychiatry, and it is the stories of his patients that form the backbone of Projections. Through these case studies, he tells the larger story of how we can understand the physical and biological origins of human emotion in the brain. As such, he describes vividly how humans experience feelings both in the simple and ancient circuits of our brains and in the poignant moments of suffering in our daily lives. The stories of Deisseroth's patients are rich with humanity and shine an unprecedented light on the self and the ways in which it breaks down. A young woman with an eating disorder reveals how the mind can rebel against the brain's most primitive drives of hunger and thirst; while an older gentleman, smothered into silence by depression and dementia, illuminates how humans evolved to feel joy and its absence; and a lonely Uyghur woman far from home teaches the importance of rich social bonds. An illuminating and essential work, Projections transforms the way we understand the brain as a biological and as an emotional object.A groundbreaking tour of the human mind that illuminates the biological nature of our inner worlds and emotions, through gripping, moving—and, at times, harrowing—clinical stories“[A] scintillating and moving analysis of the human brain and emotions.”—Nature“Beautifully connects the inner feelings within all human beings to deep insights from modern psychiatry and neuroscience.”—Robert Lefkowitz, Nobel Laureate

    Throughout our life, we look for ways to keep our mind sharp and effortlessly productive. Now, globetrotting neurosurgeon Dr. Sanjay Gupta offers insights from top scientists all over the world, whose cutting-edge research can help you heighten and protect brain function and maintain cognitive health at any age. Keep Sharp debunks common myths about aging and cognitive decline, explores whether there’s a “best” diet or exercise regimen for the brain, and explains whether it’s healthier to play video games that test memory and processing speed, or to engage in more social interaction. Discover what we can learn from “super-brained” people who are in their eighties and nineties with no signs of slowing down—and whether there are truly any benefits to drugs, supplements, and vitamins. Dr. Gupta also addresses brain disease, particularly Alzheimer’s, answers all your questions about the signs and symptoms, and shows how to ward against it and stay healthy while caring for a partner in cognitive decline. He likewise provides you with a personalized twelve-week program featuring practical strategies to strengthen your brain every day. Keep Sharp is the only owner’s manual you’ll need to keep your brain young and healthy regardless of your age!

    We can actually observe a person's brain registering a joke or experiencing a painful memory. Drawing on the latest imaging technology and the expertise of distinguished scientists, Rita Carter explores the geography of the human brain. Her writing is clear, accessible, witty, and the book's 150 illustrations—most in color—present an illustrated guide to that wondrous, coconut-sized, wrinkled gray mass we carry inside our heads.Mapping the Mind charts the way human behavior and culture have been molded by the landscape of the brain. Carter shows how our personalities reflect the biological mechanisms underlying thought and emotion and how behavioral eccentricities may be traced to abnormalities in an individual brain. Obsessions and compulsions seem to be caused by a stuck neural switch in a region that monitors the environment for danger. Addictions stem from dysfunction in the brain's reward system. Even the sense of religious experience has been linked to activity in a certain brain region. The differences between men and women's brains, the question of a "gay brain," and conditions such as dyslexia, autism, and mania are also explored.Looking inside the brain, writes Carter, we see that actions follow from our perceptions, which are due to brain activity dictated by a neuronal structure formed from the interplay between our genes and the environment. Without sidestepping the question of free will, Carter suggests that future generations will use our increasing knowledge of the brain to "enhance those mental qualities that give sweetness and meaning to our lives, and to eradicate those that are destructive."

    A Whole New Mind takes readers to a daring new place, and a provocative and necessary new way of thinking about a future that's already here.

    Their visionary answers flow from the frontiers of psychology, philosophy, economics, physics, sociology, and more. Surprising and enlightening, these insights will revolutionize the way you think about yourself and the world.Contributors include:Daniel Kahneman on the “focusing illusion”Jonah Lehrer on controlling attentionRichard Dawkins on experimentationAubrey De Grey on conquering our fear of the unknownMartin Seligman on the ingredients of well-beingNicholas Carr on managing “cognitive load”Steven Pinker on win-win negotiatingDaniel Goleman on understanding our connection to the natural worldMatt Ridley on tapping collective intelligenceLisa Randall on effective theorizingBrian Eno on “ecological vision”J. Craig Venter on the multiple possible origins of life  Helen Fisher on temperamentSam Harris on the flow of thoughtLawrence Krauss on living with uncertainty

    As the cancer progressed and was treated, the author experienced behavioral and cognitive symptoms connected to a range of mental disorders, including her professional specialty, schizophrenia. Lipska's family and associates were alarmed by the changes in her behavior, which she failed to acknowledge herself. Gradually, after a course of immunotherapy, Lipska returned to normal functioning, recalled her experience and, through her knowledge of neuroscience, identified the ways in which her brain changed during treatment. Lipska admits her condition was unusual; after recovery she was able to return to her research and resume her athletic training and compete in a triathalon. Most patients with similar brain cancers rarely survive to describe their ordeal. Lipska's memoir, coauthored with journalist McArdle, shows that strength and courage but also a encouraging support network are vital to recovery

    With more than one in every five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide. If we are not victims ourselves, we all know someone struggling with the merciless compulsion to alter their experience by changing how their brain functions.Drawing on years of research--as well as personal experience as a recovered addict--researcher and professor Judy Grisel has reached a fundamental conclusion: for the addict, there will never be enough drugs. The brain's capacity to learn and adapt is seemingly infinite, allowing it to counteract any regular disruption, including that caused by drugs. What begins as a normal state punctuated by periods of being high transforms over time into a state of desperate craving that is only temporarily subdued by a fix, explaining why addicts are unable to live either with or without their drug. One by one, Grisel shows how different drugs act on the brain, the kind of experiential effects they generate, and the specific reasons why each is so hard to kick.Grisel's insights lead to a better understanding of the brain's critical contributions to addictive behavior, and will help inform a more rational, coherent, and compassionate response to the epidemic in our homes and communities.

    Some philosophers argue that consciousness is something extra, beyond the physical workings of the brain. Others think that if we persist in our standard scientific methods, our questions about consciousness will eventually be answered. And some even suggest that the mystery is so deep, it will never be solved. Decades have been spent trying to explain consciousness from within our current scientific paradigm, but little progress has been made.Now, Philip Goff offers an exciting alternative that could pave the way forward. Rooted in an analysis of the philosophical underpinnings of modern science and based on the early twentieth-century work of Arthur Eddington and Bertrand Russell, Goff makes the case for panpsychism, a theory which posits that consciousness is not confined to biological entities but is a fundamental feature of all physical matter--from subatomic particles to the human brain. In Galileo's Error, he has provided the first step on a new path to the final theory of human consciousness.

    Whether it's something as minor as a brush with the common cold or as serious as Ebola, we all have grappled with infections and will continue to encounter them as we age.On a worldwide scale, infectious diseases account for 26 percent of all deaths, second only to cardiovascular diseases. And unlike chronic diseases, infectious diseases are unique in their potential for explosive global impacts.Now, in the 24 engaging lectures of Introduction to Infectious Diseases, you can get a comprehensive overview of diseases from the mundane to the fatal from renowned physician and award-winning professor Dr. Barry Fox.Begin with an overview of the microscopic particles responsible for disease: bacteria, fungi, hybrid germs, and viruses. You will see how they invade the body; look through the microscope at pathogens to identify their inner components; follow germs through to different body systems and see what effects they have; and learn why we may be losing the battle against some germs.