Growing understanding of the immune system, and especially the creation of immune memory (long lasting protection), which can be harnessed in the design of vaccines, have been major breakthroughs in medicine.In this Very Short Introduction, Paul Klenerman describes the immune system, and how it works in health and disease. In particular he focuses on the human immune system, considering how it evolved, the basic rules that govern its behavior, and the major health threats where it is important. Theimmune system comprises a series of organs, cells and chemical messengers which work together as a team to provide defence against infection. Klenerman discusses these components, the critical signals that trigger them and how they exert their protective effects, including so-called innate immuneresponses, which react very fast to infection, and adaptive immune responses, which have huge diversity and a capacity to recognize and defend against a massive array of micro-organisms. Klenerman also considers what happens when our immune systems fail to be activated effectively, leading toserious infections, problems with inherited diseases, and also HIV/AIDS. At the opposite extreme, as Klenerman shows, an over-exaggerated immune response leads to inflammatory diseases such as Multiple Sclerosis and Rheumatoid Arthritis, as well as allergy and asthma. Finally he looks at the Immunesystem v2.o - how immune therapies and vaccines can be advanced to protect us against the major diseases of the 21st century.ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, andenthusiasm to make interesting and challenging topics highly readable.

    Allen and Cowling start with the simple "prokaryotic" cell--cells with no nucleus--and show how the bodies of more complex plants and animals consist of billions of "eukaryotic" cells, of varying kinds, adapted to fill different roles--red blood cells, muscle cells, branched neurons. The authors also show that each cell is an astonishingly complex chemical factory, the activities of which we have only begun to unravel in the past fifty years.

    He suggests that the great events and confrontations of 1775—Congress’s belligerent economic ultimatums to Britain, New England’s rage militaire, the exodus of British troops and expulsion of royal governors up and down the seaboard, and the new provincial congresses and hundreds of local  committees that quickly reconstituted local authority in Patriot hands­—achieved a  sweeping Patriot control of territory and local government that Britain was never able to overcome.  These each added to the Revolution’s essential momentum so when the British finally attacked in great strength the following year, they could not regain the control they had lost in 1775.Analyzing the political climate, economic structures, and military preparations, as well as the roles of ethnicity, religion, and class, Phillips tackles the eighteenth century with the same skill and insights he has shown in analyzing contemporary politics and economics.  The result is a dramatic narrative brimming with original insights. 1775 revolutionizes our understanding of America’s origins.

    A wealthy Boston widow, Ann Hibbens was hanged in 1656 for casting spells on her neighbors. The case of Ann Cole, who was "taken with very strange Fits," fueled an outbreak of witchcraft accusations in Hartford a generation before the notorious events at Salem.More than three hundred years later, the question "Why?" still haunts us. Why were these and other women likely witches—vulnerable to accusations of witchcraft and possession? Carol F. Karlsen reveals the social construction of witchcraft in seventeenth-century New England and illuminates the larger contours of gender relations in that society.

    Daley, politician and self-promoter extraordinaire, from his inauspicious youth on Chicago's South Side through his rapid climb to the seat of power as mayor and boss of the Democratic Party machine. A bare-all account of Daley's cardinal sins as well as his milestone achievements, this scathing work by Chicago journalist Mike Royko brings to life the most powerful political figure of his time: his laissez-faire policy toward corruption, his unique brand of public relations, and the widespread influence that earned him the epithet of "king maker." The politician, the machine, the city--Royko reveals all with witty insight and unwavering honesty, in this incredible portrait of the last of the backroom Caesars.New edition includes an Introduction in which the author reflects on Daley's death and the future of Chicago.

    Kevin Passmore opens his book with a series of scenes from fascist life--a secret meeting of the Romanian Iron Guard; Mussolini meeting the king of Italy; a rally of Hungarian doctors calling for restrictions on the number of Jews entering the profession. He then looks at the paradoxes of fascism through its origins in the political and social crisis of the late nineteenth century, the history of fascist movements and regimes in Italy and Germany, and the fortunes of failed fascist movements in Romania, Hungary and Spain. He shows how fascism employs propaganda and popular culture to propagate itself and how it exported its ideas outside Europe, through Nazi and Spanish post-war escape routes to Latin America. The book concludes with a discussion of the recent revival of the extreme right in Austria, Italy, France, and Russia.

    This book describes what schizophrenia is really like, how the illness progresses, and the treatments that have been applied. It also summarizes the most up-to-date knowledge available about the biological bases of this disorder. Finally it attempts to give some idea of what it is like to have schizophrenia and what this disorder tells us about the relationship between mind and brain.

    Taking a thematic rather than strictly chronological approach, W.F. Bynum, explores the key turning points in the history of Western medicine-such as the first surgical procedures, the advent of hospitals, the introduction of anesthesia, X-Rays, vaccinations, and many other innovations, as well as the rise of experimental medicine. The book also explores Western medicine's encounters with Chinese and Indian medicine, as well as nontraditional treatments such as homeopathy, chiropractic, and other alternative medicines. Covering a vast amount of information, this Very Short Introduction sheds new light on medicine's past, while at the same time engaging with contemporary issues, discoveries, and controversies, such as the spiraling costs of health care, lack of health insurance for millions, breakthrough treatments, and much more. For readers who wish to understand the how we have arrived at our current state of medical practice and knowledge, this book is essential reading.About the Series: Combining authority with wit, accessibility, and style, Very Short Introductions offer an introduction to some of life's most interesting topics. Written by experts for the newcomer, they demonstrate the finest contemporary thinking about the central problems and issues in hundreds of key topics, from philosophy to Freud, quantum theory to Islam.

    Readers will find an enlightening history of the vacuum: how the efforts to make a better vacuum led to the discovery of the electron; the ideas of Newton, Mach, and Einstein on the nature of space and time; the mysterious aether and how Einstein did away with it; and the latest ideas that the vacuum is filled with the Higgs field. The story ranges from the absolute zero of temperature and the seething vacuum of virtual particles and anti-particles that fills space, to the extreme heat and energy of the early universe. About the Series: Combining authority with wit, accessibility, and style, Very Short Introductions offer an introduction to some of life's most interesting topics. Written by experts for the newcomer, they demonstrate the finest contemporary thinking about the central problems and issues in hundreds of key topics, from philosophy to Freud, quantum theory to Islam.

    In 300 fast-moving pages, Davidson guides his readers through 500 years, from the first contact between the two halves of the world to the rise of America as a superpower in an era of atomic perils and diminishing resources.   In short, vivid chapters the book brings to life hundreds of individuals whose stories are part of the larger American story. Pilgrim William Bradford stumbles into an Indian deer trap on his first day in America; Harriet Tubman lets loose a pair of chickens to divert attention from her escaping slaves; the toddler Andrew Carnegie, later an ambitious industrial magnate, gobbles his oatmeal with a spoon in each hand. Such stories are riveting in themselves, but they also spark larger questions to ponder about freedom, equality, and unity in the context of a nation that is, and always has been, remarkably divided and diverse.

    From Martin Luther, Frederick Schiller, and Johann Wolfgang von Goethe to Karl Marx, Sigmund Freud, Thomas Mann, Bertolt Brecht, and Gunter Grass, Germany has produced an impressive number of great writers and great works. In German Literature: A Very Short Introduction, Nicholas Boyle illuminates the particular character and power of German literature and explores its impact on the larger cultural world. Boyle presents an engrossing tour of German literature from the Middle Ages to the 20th century, focussing especially on the last 250 years. He examines key themes like idealism, modernism, materialism, trauma and memory, showing how they have imbued the great German writers with such distinctive voices. Indeed, this brief introduction offers broad coverage of German literature, revealing the links between German literature and the German nation, examining the literary and philosophical responses of German writers to social, political, and economic change, and seeking out the connections between Germany's intellectual traditions and its often violent and tragic history. About the Series: Combining authority with wit, accessibility, and style, Very Short Introductions offer an introduction to some of life's most interesting topics. Written by experts for the newcomer, they demonstrate the finest contemporary thinking about the central problems and issues in hundreds of key topics, from philosophy to Freud, quantum theory to Islam.

    What are the true roots of these influences, however, and how do our interpretations of these aspects of the classics differ from their original reality? This introduction to the classics begins with a visit to the British Museum to view the frieze which once decorated the Apollo Temple a Bassae. Through these sculptures John Henderson and Mary Beard prompt us to consider the significance of the study of Classics as a means of discovery and enquiry, its value in terms of literature, philosophy, and culture, its source of imagery, and the reasons for the continuation of these images into and beyond the twentieth century. Designed for the general reader and student alike, A Very Short Introduction to Classics challenges readers to adopt a fresh approach to the Classics as a major cultural influence, both in the ancient world and twentieth-century--emphasizing the continuing need to understand and investigate this enduring subject.About the Series: Combining authority with wit, accessibility, and style, Very Short Introductions offer an introduction to some of life's most interesting topics. Written by experts for the newcomer, they demonstrate the finest contemporary thinking about the central problems and issues in hundreds of key topics, from philosophy to Freud, quantum theory to Islam.

    This very short introduction to the condition offers a clear statement on what is currently known about autism and Asperger's syndrome.

    Ideal for anyone who wants to read a great work for the first time or revisit an old favorite, these new editions open the door to the stories and ideas that have shaped our world.

    Christian W. McMillen provides a concise yet comprehensive account of pandemics throughout human history, illustrating how pandemic disease has shaped history and, at the same time, social behavior has influenced pandemic disease. Extremely interesting from a medical standpoint, the study of pandemics also provides unexpected, broader insights into culture and politics.