. . superbly shows that ‘[i]f we can let go of our conceit,’ we will see the preciousness of life in all its forms.”—Publishers Weekly (starred review)“Highly instructive . . . a warm, intelligent yeoman’s guide to the progress of life.”—Kirkus Reviews“Magisterial . . . part historical account, part scientific detective story. Switek’s elegant prose and thoughtful scholarship will change the way you see life on our planet. This book marks the debut of an important new voice.”—Neil Shubin“Elegantly and engagingly crafted, Brian Switek’s narrative interweaves stories and characters not often encountered in books on paleontology—at once a unique, informative and entertaining read.”—Niles Eldredge“If you want to read one book to get up to speed on evolution, read Written in Stone. Brian Switek’s clear and compelling book is full of fascinating stories about how scientists have read the fossil record to trace the evolution of life on Earth.”—Ann Gibbons“[Switek's] accounts of dinosaurs, birds, whales, and our own primate ancestors are not just fascinating for their rich historical detail, but also for their up-to-date reporting on paleontology’s latest discoveries.”—Carl Zimmer"After reading this book, you will have a totally new context in which to interpret the evolutionary history of amphibians, mammals, whales, elephants, horses, and especially humans.”—Donald R. ProtheroSpectacular fossil finds make today's headlines; new technology unlocks secrets of skeletons unearthed a hundred years ago. Still, evolution is often poorly represented by the media and misunderstood by the public. A potent antidote to pseudoscience, Written in Stone is an engrossing history of evolutionary discovery for anyone who has marveled at the variety and richness of life.

    Building a house would entail no more work than planting a seed in the ground. These scenarios may seem far-fetched, but pioneering geneticist George Church and science writer Ed Regis show that synthetic biology is bringing us ever closer to making such visions a reality. In Regenesis, Church and Regis explore the possibilities—and perils—of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. Until now, nature has been the exclusive arbiter of life, death, and evolution; with synthetic biology, we now have the potential to write our own biological future. Indeed, as Church and Regis show, it even enables us to revisit crucial points in the evolution of life and, through synthetic biological techniques, choose different paths from those nature originally took. Such exploits will involve far more than just microbial tinkering. Full-blown genomic engineering will make possible incredible feats, from resurrecting woolly mammoths and other extinct organisms to creating mirror life forms with a molecular structure the opposite of our own. These technologies—far from the out-of-control nightmare depicted in science fiction—have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span. A breathtaking look at the potential of this world-changing technology, Regenesis is nothing less than a guide to the future of life.

      In 1875, tuberculosis was the deadliest disease in the world, accountable for a third of all deaths. A diagnosis of TB—often called consumption—was a death sentence. Then, in a triumph of medical science, a German doctor named Robert Koch deployed an unprecedented scientific rigor to discover the bacteria that caused TB. Koch soon embarked on a remedy—a remedy that would be his undoing.   When Koch announced his cure for consumption, Arthur Conan Doyle, then a small-town doctor in England and sometime writer, went to Berlin to cover the event. Touring the ward of reportedly cured patients, he was horrified. Koch’s "remedy" was either sloppy science or outright fraud.   But to a world desperate for relief, Koch’s remedy wasn’t so easily dismissed. As Europe’s consumptives descended upon Berlin, Koch urgently tried to prove his case. Conan Doyle, meanwhile, returned to England determined to abandon medicine in favor of writing. In particular, he turned to a character inspired by the very scientific methods that Koch had formulated: Sherlock Holmes.   Capturing the moment when mystery and magic began to yield to science, The Remedy chronicles the stunning story of how the germ theory of disease became a true fact, how two men of ambition were emboldened to reach for something more, and how scientific discoveries evolve into social truths.

    Chemistry professor and syndicated Washington Post food columnist Robert L. Wolke provides over 100 reliable and witty explanations, while debunking misconceptions and helping you to see through confusing advertising and labeling.

    He begins with Copernicus, during the Renaissance, when science replaced mysticism as a means of explaining the workings of the world, and he continues through the centuries, creating an unbroken genealogy of not only the greatest but also the more obscure names of Western science, a dot-to-dot line linking amateur to genius, and accidental discovery to brilliant deduction.By focusing on the scientists themselves, Gribbin has written an anecdotal narrative enlivened with stories of personal drama, success and failure. A bestselling science writer with an international reputation, Gribbin is among the few authors who could even attempt a work of this magnitude. Praised as “a sequence of witty, information-packed tales” and “a terrifi c read” by The Times upon its recent British publication, The Scientists breathes new life into such venerable icons as Galileo, Isaac Newton, Albert Einstein and Linus Pauling, as well as lesser lights whose stories have been undeservedly neglected. Filled with pioneers, visionaries, eccentrics and madmen, this is the history of science as it has never been told before.From the Hardcover edition.

    In the last century, there have been massive breakthroughs that have rewritten the science of the brain, and yet the puzzles faced by the ancient Greeks are still present. In The Consciousness Instinct, the neuroscience pioneer Michael S. Gazzaniga puts the latest research in conversation with the history of human thinking about the mind, giving a big-picture view of what science has revealed about consciousness.The idea of the brain as a machine, first proposed centuries ago, has led to assumptions about the relationship between mind and brain that dog scientists and philosophers to this day. Gazzaniga asserts that this model has it backward--brains make machines, but they cannot be reduced to one. New research suggests the brain is actually a confederation of independent modules working together. Understanding how consciousness could emanate from such an organization will help define the future of brain science and artificial intelligence and close the gap between brain and mind.Captivating and accessible, with insights drawn from a lifetime at the forefront of the field, The Consciousness Instinct sets the course for the neuroscience of tomorrow.

    This adventure in science and imagination, which the Medical Tribune said might herald "a Copernican revolution for the life sciences," leads the reader through unexplored jungles and uncharted aspects of mind to the heart of knowledge.In a first-person narrative of scientific discovery that opens new perspectives on biology, anthropology, and the limits of rationalism, The Cosmic Serpent reveals how startlingly different the world around us appears when we open our minds to it.

    Some of their responses to those outbreaks are almost too strange to believe in hindsight. Get Well Soon delivers the gruesome, morbid details of some of the worst plagues we’ve suffered as a species, as well as stories of the heroic figures who selflessly fought to ease the suffering of their fellow man. With her signature mix of in-depth research and storytelling, and not a little dark humor, Jennifer Wright explores history’s most gripping and deadly outbreaks, and ultimately looks at the surprising ways they’ve shaped history and humanity for almost as long as anyone can remember.

    The media seized hold of the story and, in the process, helped to launch one of the most devastating health scares ever. In the years to come Wakefield would be revealed as a profiteer in league with class-action lawyers, and he would eventually lose his medical license. Meanwhile, one study after another failed to find any link between childhood vaccines and autism. Yet the myth that vaccines somehow cause developmental disorders lives on. Despite the lack of corroborating evidence, it has been popularized by media personalities such as Oprah Winfrey and Jenny McCarthy and legitimized by journalists who claim that they are just being fair to “both sides” of an issue about which there is little debate. Meanwhile, millions of dollars have been diverted from potential breakthroughs in autism research; families have spent their savings on ineffective “miracle cures"; and declining vaccination rates have led to outbreaks of deadly illnesses like Hib, measles, and whooping cough. Most tragic of all is the increasing number of children dying from vaccine-preventable diseases. In The Panic Virus Seth Mnookin draws on interviews with parents, public-health advocates, scientists, and anti-vaccine activists to tackle a fundamental question: How do we decide what the truth is? The fascinating answer helps explain everything from the persistence of conspiracy theories about 9/11 to the appeal of talk-show hosts who demand that President Obama “prove” he was born in America. The Panic Virus is the ultimate cautionary tale for our time.

    Like when doctors prescribed morphine for crying infants. When snorting skull moss was a cure for a bloody nose. When consuming mail-order tapeworms was a latter-day fad diet. Or when snake oil salesmen peddled strychnine (used in rat poison) as an aphrodisiac in the '60s. Seamlessly combining macabre humor with hard science and compelling storytelling, Quackery is a visually rich and information-packed exploration of history's most outlandish cures, experiments, and scams.A humorous book that delves into some of the wacky but true ways that humans have looked to cure their ills. Leeches, mercury, strychnine, and lobotomies are a few of the topics that explore the lengths society has gone in the search for health.

    Days later, the madman was dead and Denis was framed for murder. A riveting exposé of the fierce debates, deadly politics, and cutthroat rivalries behind the first transfusion experiments, Blood Work takes us from dissection rooms in palaces to the streets of Paris, providing an unforgettable portrait of an era that wrestled with the same questions about morality and experimentation that haunt medical science today.

    With his classic Why We Get Sick, Dr. Randolph Nesse helped to establish the field of evolutionary medicine. Now he returns with a book that transforms our understanding of mental disorders by exploring a fundamentally new question. Instead of asking why certain people suffer from mental illness, Nesse asks why natural selection has left us all with fragile minds.Drawing on revealing stories from his own clinical practice and insights from evolutionary biology, Nesse shows how negative emotions are useful in certain situations, yet can become overwhelming. Anxiety protects us from harm in the face of danger, but false alarms are inevitable. Low moods prevent us from wasting effort in pursuit of unreachable goals, but they often escalate into pathological depression. Other mental disorders, such as addiction and anorexia, result from the mismatch between modern environment and our ancient human past. And there are good evolutionary reasons for sexual disorders and for why genes for schizophrenia persist. Taken together, these and many more insights help to explain the pervasiveness of human suffering, and show us new paths for relieving it by understanding individuals as individuals.

    In fact, your body is actually endowed with many self-defense measures to hold on to fat. For example, fat can use stem cells to regenerate; increase our appetite if it feels threatened; and use bacteria, genetics, and viruses to expand itself. The secret to losing twenty pounds? You have to work with your fat, not against it. Tara explains how your fat influences your appetite and willpower, how it defends itself when attacked, and why it grows back so quickly. The Secret Life of Fat brings cutting-edge research together with historical perspectives to reveal fat’s true identity: an endocrine organ that, in the right amount, is critical to our health. Fat triggers puberty, enables our reproductive and immune systems, and even affects brain size.Although we spend $60 billion annually fighting fat, our efforts are often misinformed and misdirected. Tara expertly illustrates the complex role that genetics, hormones, diet, exercise, and history play in our weight, and The Secret Life of Fat sets you on the path to beat the bulge once and for all.

    Every new reader's brain possesses the extraordinary capacity to rearrange itself beyond its original abilities in order to understand written symbols. But how does the brain learn to read? As world-renowned cognitive neuroscientist and scholar of reading Maryanne Wolf explains in this impassioned book, we taught our brain to read only a few thousand years ago, and in the process changed the intellectual evolution of our species.Wolf tells us that the brain that examined tiny clay tablets in the cuneiform script of the Sumerians is configured differently from the brain that reads alphabets or of one literate in today's technology.There are critical implications to such an evolving brain. Just as writing reduced the need for memory, the proliferation of information and the particular requirements of digital culture may short-circuit some of written language's unique contributions—with potentially profound consequences for our future.Turning her attention to the development of the individual reading brain, Wolf draws on her expertise in dyslexia to investigate what happens when the brain finds it difficult to read. Interweaving her vast knowledge of neuroscience, psychology, literature, and linguistics, Wolf takes the reader from the brains of a pre-literate Homer to a literacy-ambivalent Plato, from an infant listening to Goodnight Moon to an expert reader of Proust, and finally to an often misunderstood child with dyslexia whose gifts may be as real as the challenges he or she faces.As we come to appreciate how the evolution and development of reading have changed the very arrangement of our brain and our intellectual life, we begin to realize with ever greater comprehension that we truly are what we read. Ambitious, provocative, and rich with examples, Proust and the Squid celebrates reading, one of the single most remarkable inventions in history. Once embarked on this magnificent story of the reading brain, you will never again take for granted your ability to absorb the written word.

    Francis Collins, director of the National Institute of Health, 2007 recipient of the Presidential Medal of Freedom, and 15-year head of the Human Genome Project, comes one of the most important medical books of the year: The Language of Life. With accessible, insightful prose, Dr. Collins describes the medical, scientific, and genetic revolution that is currently unlocking the secrets of “personalized medicine,” and offers practical advice on how to utilize these discoveries for you and your family’s current and future health and well-being. In the words of Dr. Jerome Groopman (How Doctors Think), The Language of Life “sets out hope without hype, and will enrich the mind and uplift the heart.”