These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    His contribution to our understanding not only of mental illness but also of the human condition is truly stunning.The Noonday Demon examines depression in personal, cultural, and scientific terms. Drawing on his own struggles with the illness and interviews with fellow sufferers, doctors and scientists, policymakers and politicians, drug designers and philosophers, Solomon reveals the subtle complexities and sheer agony of the disease. He confronts the challenge of defining the illness and describes the vast range of available medications, the efficacy of alternative treatments, and the impact the malady has had on various demographic populations around the world and throughout history. He also explores the thorny patch of moral and ethical questions posed by emerging biological explanations for mental illness.The depth of human experience Solomon chronicles, the range of his intelligence, and his boundless curiosity and compassion will change the reader's view of the world.

    With We Are Never Meeting in Real Life., "bitches gotta eat" blogger and comedian Samantha Irby turns the serio-comic essay into an art form. Whether talking about how her difficult childhood has led to a problem in making "adult" budgets, explaining why she should be the new Bachelorette--she's "35-ish, but could easily pass for 60-something"--detailing a disastrous pilgrimage-slash-romantic-vacation to Nashville to scatter her estranged father's ashes, sharing awkward sexual encounters, or dispensing advice on how to navigate friendships with former drinking buddies who are now suburban moms--hang in there for the Costco loot--she's as deft at poking fun at the ghosts of her past self as she is at capturing powerful emotional truths.Chapter titles:My Bachelorette application --A blues for Fred --The miracle porker --Do you guys pay your fucking bills or what? --You don't have to be grateful for sex --A Christmas carol --Happy birthday --A case for remaining indoors --A total attack of the heart --A civil union --Mavis --Fuck it, bitch. Stay fat --Nashville hot chicken --I'm in love and it's boring --A bomb, probably --The real housewife of Kalamazoo --Thirteen questions to ask before getting married --Yo, I need a job --Feelings are a mistake --We are never meeting in real life

    After two broken marriages, this third, she believed, was her lucky charm. But within a few years, Debbie discovered that he had betrayed her emotionally and financially, nearly destroying her life.Today, she writes, "When I read the optimistic ending of my last memoir now, I can't believe how naive I was when I wrote it. In Unsinkable, I look back at the many years since then, and share my memories of a film career that took me from the Miss Burbank Contest of 1948 to the work I did in 2012. . . . To paraphrase Bette Davis: Fasten your seatbelts, I've had a bumpy ride."Unsinkable shines a spotlight on the resilient woman whose talent and passion for her work have endured for more than six decades. In her engaging, down-to-earth voice, Debbie shares private details about her man and money troubles, including building and losing her Las Vegas dream hotel and her treasured Hollywood memorabilia collection. Yet no matter how difficult the problems, the show always goes on.Debbie also invites us into the close circle of her family, speaking with deep affection and honesty about her relationships with her children, Carrie and Todd Fisher. She looks back at her life as an actress during Hollywood's Golden Age—"the most magical time you could imagine"—including her lifelong friendship with (and years-long estrangement from) the legendary Elizabeth Taylor. Here, too, are stories that never reached the tabloids about numerous celebrities, such as Ava Gardner, Clark Gable, Frank Sinatra, Mick Jagger, Gene Kelly, and many more. She takes us on a guided tour through her movies with delightful, often hilarious behind-the-scenes anecdotes about every film in which she was involved, from 1948 to the present.Frank and forthright, and featuring dozens of previously unseen photos from Debbie's personal collection, Unsinkable is a poignant reminder that there is light in the darkest times. It is a revealing portrait of a woman whose determination is an inspiration.

    In her book Self-Inflicted Wounds, comedian, actress, and cohost of CBS’s daytime hit show The Talk, Aisha Tyler recounts a series of epic mistakes and hilarious stories of crushing personal humiliation, and the personal insights and authentic wisdom she gathered along the way. The essays in Self-Inflicted Wounds are refreshingly and sometimes brutally honest, surprising, and laugh-out-loud funny, vividly translating the brand of humor Tyler has cultivated through her successful standup career, as well as the strong voice and unique point of view she expresses on her taste-making comedy podcast Girl on Guy. Riotous, revealing, and wonderfully relatable, Aisha Tyler’s Self-Inflicted Wounds: Heartwarming Tales of Epic Humiliation is about the power of calamity to shape life, learning, and success.

    Now, at last, the man himself tells us the story of life in the crossfire hurricane.

    The niece of Theodore Roosevelt, she married a distant relative and Columbia University law student named Franklin Delano Roosevelt; he gradually ascended throughout the world of New York politics to reach the U.S. presidency in 1932. Throughout his three terms, Eleanor Roosevelt was not only intimately involved in FDR’s personal and political life, but led women’s organizations and youth movements and fought for consumer welfare, civil rights, and improved housing. During World War II she traveled with her husband to meet leaders of many powerful nations; after his death in 1945 she worked as a UN delegate, chairman of the Commission on Human Rights, newspaper columnist, Democratic party activist, world-traveler, and diplomat. By the end of her life, Eleanor Roosevelt was recognized throughout the world for her fortitude and commitment to the ideals of liberty and human rights. Her autobiography constitutes a self-portrait no biography can match for its candor and liveliness, its wisdom, tolerance, and breadth of view—a self-portrait of one of the greatest American humanitarians of our time.

    "I was born in a harem in 1940 in Fez, Morocco . . . " So begins Fatima Mernissi in this illuminating narrative of a childhood behind the iron gates of a domestic harem. In Dreams of Trespass, Mernissi weaves her own memories with the dreams and memories of the women who surrounded her in the courtyard of her youth -- women who, without access to the world outside, recreated it from sheer imagination. A beautifully written account of a girl confronting the mysteries of time and place, gender and sex, Dreams of Trespass illuminates what it was like to be a modern Muslim woman in a place steeped in tradition.

    In the decades since his death in September 1973, millions have read THE HOBBIT, THE LORD OF THE RINGS, and THE SILMARILLION and become fascinated about the very private man behind the books. Born in South Africa in January 1892, John Ronald Reuel Tolkien was orphaned in childhood and brought up in near-poverty. He served in the first World War, surviving the Battle of the Somme, where he lost many of the closest friends he'd ever had. After the war he returned to the academic life, achieving high repute as a scholar and university teacher, eventually becoming Merton Professor of English at Oxford where he was a close friend of C.S. Lewis and the other writers known as The Inklings.Then suddenly his life changed dramatically. One day while grading essay papers he found himself writing 'In a hole in the ground there lived a hobbit' -- and worldwide renown awaited him. Humphrey Carpenter was given unrestricted access to all Tolkien's papers, and interviewed his friends and family. From these sources he follows the long and painful process of creation that produced THE LORD OF THE RINGS and THE SILMARILLION and offers a wealth of information about the life and work of the twentieth century's most cherished author.