We like to imagine that it’s based on evidence and the results of fair tests. In reality, those tests are often profoundly flawed. We like to imagine that doctors are familiar with the research literature surrounding a drug, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by industry. We like to imagine that regulators let only effective drugs onto the market, when in reality they approve hopeless drugs, with data on side effects casually withheld from doctors and patients.All these problems have been protected from public scrutiny because they’re too complex to capture in a sound bite. But Dr. Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct on a global scale affects us. In his own words, “the tricks and distortions documented in these pages are beautiful, intricate, and fascinating in their details.” With Goldacre’s characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for something to be done. This is the pharmaceutical industry as it has never been seen before.

    Today, says Dale Purves, the dominant research agenda may have taken us as far as it can--and neuroscientists may be approaching a paradigm shift. In this highly personal book, Purves reveals how we got to this point and offers his notion of where neuroscience may be headed next. Purves guides you through a half-century of the most influential ideas in neuroscience and introduces the extraordinary scientists and physicians who created and tested them. Purves offers a critical assessment of the paths that neuroscience research has taken, their successes and their limitations, and then introduces an alternative approach for thinking about brains. Building on new research on visual perception, he shows why common ideas about brain networks can't be right and uncovers the factors that determine our subjective experience. The resulting insights offer a deeper understanding of what it means to be human. - Why we need a better conception of what brains are trying to do and how they do it Approaches to understanding the brain over the past several decades may be at an impasse - The surprising lessons that can be learned from what we see How complex neural processes owe more to trial-and-error experience than to logical principles - Brains--and the people who think about them Meet some of the extraordinary individuals who've shaped neuroscience - The -ghost in the machine- problem The ideas presented further undermine the concept of free will

    Lehninger Principles of Biochemistry, Fourth Edition brings clarity and coherence to an often unwieldy discipline, while incorporating the field's most important recent developments and applications.

    A new mother is admitted with incessant visions of harming her child. A recent graduate, dressed in a tunic and declaring that love emanates from everything around him, is brought to A&E by his alarmed girlfriend. These are among the patients new physician Christine Montross meets during rounds at her hospital’s locked inpatient ward – and who we meet as she struggles to understand the mysteries of the mind, most especially when the tools of modern medicine are failing us. Beautifully written and deeply felt, Falling into the Fire is an intimate portrait of psychiatry and a moving reminder, in the words of the New York Times, of 'our fragile, shared humanity'

    Medication Madness is a fascinating, frightening, and dramatic look at the role that psychiatric medications have played in fifty cases of suicide, murder, and other violent, criminal, and bizarre behaviors.  As a psychiatrist who believes in holding people responsible for their conduct, the weight of scientific evidence and years of clinical experience eventually convinced Dr. Breggin that psychiatric drugs frequently cause individuals to lose their judgment and their ability to control their emotions and actions. Medication Madness raises and examines the issues surrounding personal responsibility when behavior seems driven by drug-induced adverse reactions and intoxication. Dr. Breggin personally evaluated the cases in the book in his role as a treating psychiatrist, consultant or medical expert.  He interviewed survivors and witnesses, and reviewed extensive medical, occupational, educational and police records. The great majority of individuals lived exemplary lives and committed no criminal or bizarre actions prior to taking the psychiatric medications. Medication Madness reads like a medical thriller, true crime story, and courtroom drama; but it is firmly based in the latest scientific research and dozens of case studies. The lives of the children and adults in these stories, as well as the lives of their families and their victims, were thrown into turmoil and sometimes destroyed by the unanticipated effects of psychiatric drugs.  In some cases our entire society was transformed by the tragic outcomes. Many categories of psychiatric drugs can cause potentially horrendous reactions. Prozac, Paxil, Zoloft, Adderall, Ritalin, Concerta, Xanax, lithium, Zyprexa and other psychiatric medications may spellbind patients into believing they are improved when too often they are becoming worse.  Psychiatric drugs drive some people into psychosis, mania, depression, suicide, agitation, compulsive violence and loss of self-control without the individuals realizing that their medications have deformed their way of thinking and feeling.  This book documents how the FDA, the medical establishment and the pharmaceutical industry have over-sold the value of psychiatric drugs.  It serves as a cautionary tale about our reliance on potentially dangerous psychoactive chemicals to relieve our emotional problems and provides a positive approach to taking personal charge of our lives.

    And yet, the 1949 discovery of lithium as a cure for bipolar disorder is perhaps one of the most important—yet largely unsung—breakthroughs of the modern era. In Lithium, Walter Brown, a practicing psychiatrist and professor at Brown, reveals two unlikely success stories: that of John Cade, the physician whose discovery would come to save an untold number of lives and launch a pharmacological revolution, and that of a miraculous metal rescued from decades of stigmatization.From insulin comas and lobotomy to incarceration to exile, Brown chronicles the troubling history of the diagnosis and (often ineffective) treatment of bipolar disorder through the centuries, before the publication of a groundbreaking research paper in 1949. Cade’s “Lithium Salts in the Treatment of Psychotic Excitement” described, for the first time, lithium’s astonishing efficacy at both treating and preventing the recurrence of manic-depressive episodes, and would eventually transform the lives of patients, pharmaceutical researchers, and practicing physicians worldwide. And yet, as Brown shows, it would be decades before lithium would overcome widespread stigmatization as a dangerous substance, and the resistance from the pharmaceutical industry, which had little incentive to promote a naturally occurring drug that could not be patented.With a vivid portrait of the story’s unlikely hero, John Cade, Brown also describes a devoted naturalist who, unlike many modern medical researchers, did not benefit from prestigious research training or big funding sources (Cade’s “laboratory” was the unused pantry of an isolated mental hospital). As Brown shows, however, these humble conditions were the secret to his historic success: Cade was free to follow his own restless curiosity, rather than answer to an external funding source. As Lithium makes tragically clear, medical research—at least in America—has transformed in such a way that serendipitous discoveries like Cade’s are unlikely to occur ever again.Recently described by the New York Times as the “Cinderella” of psychiatric drugs, lithium has saved countless of lives and billions of dollars in healthcare costs. In this revelatory biography of a drug and the man who fought for its discovery, Brown crafts a captivating picture of modern medical history—revealing just how close we came to passing over this extraordinary cure.

    It discusses neuroanatomy, cell and molecular mechanisms and signaling through a cognitive approach to behaviour. It features an expanded treatment of the nervous system, neurological and psychiatric diseases and perception.

    In this newly revised edition, chapters have been rewritten to accommodate the impact of computer technology and the Internet, not only on the acquisition and analysis of data, but also on its organization and presentation. Alternatives to the use of radiation have been expanded, and figures and illustrations have been redrawn to reflect changes in laboratory equipment and procedures.

    Hailed as the most outstanding book in the biomedical sciences when it was originally published in 1990, Manic-Depressive Illness was the first to survey this massive body of evidence comprehensively and to assess its meaning for both clinician and scientist. It also vividly portrayed the experience of manic-depressive illness from the perspective of patients, their doctors, and researchers. Encompassing an understanding about the illness as Kraeplin conceived of it- about its cyclical course and about the essential unity of its bipolar and recurrent unipolar forms- the book has become the definitive work on the topic, revered by both specialists and nonspecialists alike. Now, in this magnificent second edition, Drs. Frederick Goodwin and Kay Redfield Jamison bring their unique contribution to mental health science into the 21st century. In collaboration with a team of other leading scientists, a collaboration designed to preserve the unified voice of the two authors, they exhaustively review the biological and genetic literature that has dominated the field in recent years and incorporate cutting-edge research conducted since publication of the first edition. They also update their surveys of psychological and epidemiological evidence, as well as that pertaining to diagnostic issues, course, and outcome, and they offer practical guidelines for differential diagnosis and clinical management. The medical treatment of manic and depressive episodes is described, strategies for preventing future episodes are given in detail, and psychotherapeutic issues common in this illness are considered. Special emphasis is given to fostering compliance with medication regimens and treating patients who abuse drugs and alcohol or who pose a risk of suicide. This book, unique in the way that it retains the distinct perspective of its authors while assuring the maximum in-depth coverage of a vastly expanded base of scientific knowledge, will be a valuable and necessary addition to the libraries of psychiatrists and other physicians, psychologists, clinical social workers, neuroscientists, pharmacologists, and the patients and families who live with manic-depressive illness.

    

    The text covers the neuroanatomy that medical and other healthcare students need, with expanded coverage of neurophysiology and inclusion of clinical content providing real-life application of neuroanatomy and neurophysiologic concepts to clinical neurologic disorders. Its readability and enhanced full-color illustrations make it a favorite among both students and faculty.Provides a single-author approach for a more consistent, readable text.Contains summary statement headings to help you find what you're looking for within the text.Provides an outline introducing each chapter to help students organize and stay focused as they learn.Includes appealing four-color, computerized three-dimensional images of the brain and brain structures fully integrated with the text.Complements an Electronic Image Bank that is also available separately.Includes more coverage of neurobiology and neurophysiology.Gives more clinical content, including many images depicting neurologic disorders.Features an expanded section on higher cortical function.Features an expanded section on learning and memory.Contains a new chapter on the development, maintenance, and repair of neural connections-an explosive area of research in neuroscience.Supplies a glossary of key terms.Replaces many of the older figures with new, computer-generated illustrations.

    However, as the authors of this accessible guide demonstrate, there are at least some things we do understand about the brain, things which may lead us to think quite differently about the way we view ourselves and workings of our minds. Starting off with a brief tour of the history of neuroscience, from Aristotle's view that the function of the brain was to cool the heart to the ancient practice of drilling a hole in the skull to relieve headaches, the book covers all of the key areas - including the anatomy and development of the brain, the workings of the sensory and nervous systems, the function of sleep and the capacity for language - in a clear and comprehensible manner. The authors also consider the roots - and possible treatments - of some of the most common psychological disorders, and examine the way in which science may help us to find answers to philosophical questions about the nature of consciousness and the identity of the self. to be able to extend life well beyond the standard three score years and ten, this lively and entertaining introduction assumes no previous scientific knowledge and will be suitable for readers of all backgrounds.

    This began to change with the devising of methods to try to tap into what was going on in the 'black box' of the mind, and the development of 'cognitive psychology'. With the study of patients who had suffered brain damage or injury to limited parts of the brain, outlines of brain components and processes began to take shape, and by the end of the 1970s, a new science, cognitive neuroscience, was born. But it was with the development of ways of accessing activation of the working brain using imaging techniques such as PET and fMRI that cognitive neuroscience came into its own, as a science cutting across psychology and neuroscience, with strong connections to philosophy of mind. Experiments involving subjects in scanners while doing various tasks, thinking, problem solving, and remembering are shedding light on the brain processes involved. The research is exciting and new, and often makes media headlines. But there is much misunderstanding about what brain imaging tells us, and the interpretation of studies on cognition.In this Very Short Introduction Richard Passingham, a distinguished cognitive neuroscientist, gives a provocative and exciting account of the nature and scope of this relatively new field, and the techniques available to us, focusing on investigation of the human brain. He explains what brain imaging shows, pointing out common misconceptions, and gives a brief overview of the different aspects of human cognition: perceiving, attending, remembering, reasoning, deciding, and acting. Passingham concludes with a discussion of the exciting advances that may lie ahead.ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

     Her pioneering research on how the chemicals inside our bodies form a dynamic information network, linking mind and body, is not only provocative, it is revolutionary. By establishing the biomolecular basis for our emotions and explaining these new scientific developments in a clear and accessible way, Pert empowers us to understand ourselves, our feelings, and the connection between our minds and our bodies -- body-minds -- in ways we could never possibly have imagined before. Molecules of Emotion is a landmark work, full of insight and wisdom and possessing that rare power to change the way we see the world and ourselves.

    This complete, concise overview of the entire field of psychiatry is a staple board review text for psychiatry residents and is popular with a broad range of students in medicine, clinical psychology, social work, and occupational therapy. This edition includes new chapters on health care delivery systems and end-of-life care and palliative medicine. Coverage of psychotropic drugs and neuropsychiatric foundations of biological psychiatry has been significantly updated. The book is DSM-IV-TR compatible and replete with case studies and tables, including ICD-10 diagnostic coding tables.