As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    Rules for being a man:Don't Cry; Love Sport; Play Rough; Drink Beer; Don't Talk About FeelingsBut Robert Webb has been wondering for some time now: are those rules actually any use? To anyone?Looking back over his life, from schoolboy crushes (on girls and boys) to discovering the power of making people laugh (in the Cambridge Footlights with David Mitchell), and from losing his beloved mother to becoming a husband and father, Robert Webb considers the absurd expectations boys and men have thrust upon them at every stage of life.Hilarious and heartbreaking, How Not To Be a Boy explores the relationships that made Robert who he is as a man, the lessons we learn as sons and daughters, and the understanding that sometimes you aren't the Luke Skywalker of your life - you're actually Darth Vader.

    Worse, as they failed to cure her, they hinted that her devastating symptoms were psychological.The Lady's Handbook for Her Mysterious Illness is a memoir with a mission, to help the millions of (mostly) women who suffer from unnamed or misunderstood conditions.Ramey's pursuit of a diagnosis and cure for her own mysterious illness is a medical mystery that she says reveals a new understanding of today's chronic illnesses as ecological in nature, driven by modern changes to the basic foundations of health, from the quality of our sleep, diet, and social connection to the state of our microbiomes.

    "Go ahead, ask your question," her father urged, nudging her forward. She smiled shyly and said, "You're my hero. Who's yours?" Many people - especially girls - have asked us that same question over the years. It's one of our favourite topics.HILLARY: Growing up, I knew hardly any women who worked outside the home. So I looked to my mother, my teachers, and the pages of Life magazine for inspiration. After learning that Amelia Earhart kept a scrapbook with newspaper articles about successful women in male-dominated jobs, I started a scrapbook of my own. Long after I stopped clipping articles, I continued to seek out stories of women who seemed to be redefining what was possible.CHELSEA: This book is the continuation of a conversation the two of us have been having since I was little. For me, too, my mom was a hero; so were my grandmothers. My early teachers were also women. But I grew up in a world very different from theirs. My pediatrician was a woman, and so was the first mayor of Little Rock who I remember from my childhood. Most of my close friends' moms worked outside the home as nurses, doctors, teachers, professors, and in business. And women were going into space and breaking records here on Earth.Ensuring the rights and opportunities of women and girls remains a big piece of the unfinished business of the twenty-first century. While there's a lot of work to do, we know that throughout history and around the globe women have overcome the toughest resistance imaginable to win victories that have made progress possible for all of us. That is the achievement of each of the women in this book.So how did they do it? The answers are as unique as the women themselves. Civil rights activist Dorothy Height, LGBTQ trailblazer Edie Windsor, and swimmer Diana Nyad kept pushing forward, no matter what. Writers like Rachel Carson and Chimamanda Ngozi Adichie named something no one had dared talk about before. Historian Mary Beard used wit to open doors that were once closed, and Wangari Maathai, who sparked a movement to plant trees, understood the power of role modeling. Harriet Tubman and Malala Yousafzai looked fear in the face and persevered. Nearly every single one of these women was fiercely optimistic - they had faith that their actions could make a difference. And they were right.To us, they are all gutsy women - leaders with the courage to stand up to the status quo, ask hard questions, and get the job done. So in the moments when the long haul seems awfully long, we hope you will draw strength from these stories. We do. Because if history shows one thing, it's that the world needs gutsy women.

    Selling the shoes from the trunk of his lime green Plymouth Valiant, Knight grossed $8,000 his first year. Today, Nike’s annual sales top $30 billion. In an age of startups, Nike is the ne plus ultra of all startups, and the swoosh has become a revolutionary, globe-spanning icon, one of the most ubiquitous and recognizable symbols in the world today.But Knight, the man behind the swoosh, has always remained a mystery. Now, for the first time, in a memoir that is candid, humble, gutsy, and wry, he tells his story, beginning with his crossroads moment. At 24, after backpacking around the world, he decided to take the unconventional path, to start his own business—a business that would be dynamic, different.Knight details the many risks and daunting setbacks that stood between him and his dream—along with his early triumphs. Above all, he recalls the formative relationships with his first partners and employees, a ragtag group of misfits and seekers who became a tight-knit band of brothers. Together, harnessing the transcendent power of a shared mission, and a deep belief in the spirit of sport, they built a brand that changed everything.

    She could barely find the strength to get off the sofa, let alone piece her life back together. Until one day she did something she had never done of her own free will – she pulled on a pair of trainers and went for a run.That first attempt didn’t last very long. But to her surprise, she was back out there the next day. And the day after that. She began to set herself achievable goals – to run 5k in under 30 minutes, to walk to work every day for a week, to attempt 10 push-ups in a row. Before she knew it, her mood was lifting for the first time in years.In Jog On, Bella explains with hilarious and unfiltered honesty how she used running to battle crippling anxiety and depression, without having to sacrifice her main loves: booze, cigarettes and ice cream. With the help of a supporting cast of doctors, psychologists, sportspeople and friends, she shares a wealth of inspirational stories, research and tips that show how exercise often can be the best medicine. This funny, moving and motivational book will encourage you to say ‘jog on’ to your problems and get your life back on track – no matter how small those first steps may be.

    Jon Benjamin--the lead voice behind Archer and Bob's Burgers--helps us all feel a little better about our own failures by sharing his own in a hilarious memoir-ish chronicle of failure.Most people would consider H. Jon Benjamin a comedy show business success. But he'd like to remind everyone that as great as success can be, failure is also an option. And maybe the best option. In this book, he tells stories from his own life, from his early days ("wherein I'm unable to deliver a sizzling fajita") to his romantic life ("how I failed to quantify a threesome") to family ("wherein a trip to P.F. Chang's fractures a family") to career ("how I failed at launching a kid's show").As Jon himself says, breaking down one's natural ability to succeed is not an easy task, but also not an insurmountable one. Society as we know it is, sadly, failure averse. But more acceptance of failure, as Jon sees it, will go a long way to making this world a different place . . . a kinder, gentler place, where gardens are overgrown and most people stay home with their pets. A vision of failure, but also a vision of freedom.With stories, examples of artistic and literary failure, and a powerful can't-do attitude, Failure Is an Option is the book the world doesn't need right now but will get regardless.

    It's odd when I think of the arc of my life, from child to young woman to aging adult. First I was who I was. Then I didn't know who I was. Then I invented someone, and became her. Then I began to like what I'd invented. And finally I was what I was again. It turned out I wasn't alone in that particular progression. As she did in her beloved New York Times columns, and in A Short Guide to a Happy Life, Quindlen says for us here what we may wish we could have said ourselves. Using her past, present, and future to explore what matters most to women at different ages, Quindlen talks aboutMarriage: "A safety net of small white lies can be the bedrock of a successful marriage. You wouldn't believe how cheaply I can do a kitchen renovation."Girlfriends: "Real friends offer both hard truths and soft landings and realize that it's sometimes more important to be nice than to be honest." Our bodies: "I've finally recognized my body for what it is, a personality-delivery system, designed expressly to carry my character from place to place, now and in the years to come. It's like a car, and while I like a red convertible or even a Bentley as well as the next person, what I really need are four tires and an engine."Parenting: "Being a parent is not transactional. We do not get what we give. It is the ultimate pay-it-forward: We are good parents, not so they will be loving enough to stay with us, but so they will be strong enough to leave us." From childhood memories to manic motherhood to middle age, Quindlen uses the events of her own life to illuminate our own. Along with the downsides of age, she says, can come wisdom, a perspective on life that makes it both satisfying and even joyful. So here's to lots of candles, plenty of cake.

    With remarkable honesty and wisdom, von Furstenberg mines the rich territory of what it means to be a woman. She opens up about her family and career, overcoming cancer, building a global brand, and devoting herself to empowering other women, writing, "I want every woman to know that she can be the woman she wants to be."

    For most of that time, she didn't know why. All of her trips to the ER and her daily anguish, pain, and lethargy only ever resulted in one question: How could any one person be this sick? Several drug addictions, three major hospitalizations, and over $100,000 later, she finally had a diagnosis: late-stage Lyme disease. Sick is Khakpour's arduous, emotional journey—as a woman, a writer, and a lifelong sufferer of undiagnosed health problems—through the chronic illness that perpetually left her a victim of anxiety, living a life stymied by an unknown condition.Divided by settings, Khakpour guides the reader through her illness by way of the locations that changed her course—New York, LA, New Mexico, and Germany—as she meditates on both the physical and psychological impacts of uncertainty, and the eventual challenge of accepting the diagnosis she had searched for over the course of her adult life. With candor and grace, she examines her subsequent struggles with mental illness, her addiction to the benzodiazepines prescribed by her psychiatrists, and her ever-deteriorating physical health. A story about survival, pain, and transformation, Sick is a candid, illuminating narrative of hope and uncertainty, boldly examining the deep impact of illness on one woman's life.

    After the birth of their first son, she and her husband Jeffrey Dean Morgan, the star of The Walking Dead, decided to make a major change: they bought a working farm in Rhinebeck, New York, and began a new chapter in their lives.The Rural Diaries chronicles her inspiring story of farm life: chopping wood, making dandelion wine, building chicken coops. Burton looks back at her transition from urban to country living—discovering how to manage a farm while raising her son and making friends with her new neighbors. She mixes charming stories of learning to raise alpacas and buying and revitalizing the town’s beloved candy store, Samuel’s Sweet Shop, with raw observations on the ups and downs of marriage and her struggles with secondary infertility. Burton also includes delicious recipes that can be made with fresh ingredients at home, as well as home renovation and gardening tips.Burton’s charisma, wide eyed attitude, and fortitude—both internal and physical—propels this moving story of transformation and self-discovery. The Rural Diaries honors the values and lifestyle of small-town America and offers inspiration for anyone longing to embark on their own unconventional journey.

    64% of Brits want to drink less.Catherine Gray was stuck in a hellish whirligig of Drink, Make horrible decisions, Hangover, Repeat. She had her fair share of 'drunk tank' jail cells and topless-in-a-hot-tub misadventures. But this book goes beyond the binges and blackouts to deep-dive into uncharted territory: What happens after you quit drinking? This gripping, heart-breaking and witty book takes us down the rabbit-hole of an alternative reality. A life with zero hangovers, through sober weddings, sex, Christmases and breakups.In The Unexpected Joy of Being Sober, Catherine Gray shines a light on society's drink-pushing and talks to top neuroscientists and psychologists about why we drink, delving into the science behind what it does to our brains and bodies. Much more than a tale from the netherworld of addicted drinking, this book is about the escape, and why a sober life can be more intoxicating than you ever imagined. Whether you're a hopelessly devoted drinker, merely sober-curious, or you've already ditched the drink, you will love this book.

    By the time he turned sixty, he had lost everything except his Ivy League education and his sense of entitlement. First, he was downsized at work. Next, an affair ended his twenty-year marriage. Then, he was diagnosed with a slow-growing brain tumor, prognosis undetermined. Around the same time, his girlfriend gave birth to a son. Gill had no money, no health insurance, and no prospects. One day as Gill sat in a Manhattan Starbucks with his last affordable luxury—a latté—brooding about his misfortune and quickly dwindling list of options, a 28-year-old Starbucks manager named Crystal Thompson approached him, half joking, to offer him a job. With nothing to lose, he took it, and went from drinking coffee in a Brooks Brothers suit to serving it in a green uniform. For the first time in his life, Gill was a minority--the only older white guy working with a team of young African-Americans. He was forced to acknowledge his ingrained prejudices and admit to himself that, far from being beneath him, his new job was hard. And his younger coworkers, despite having half the education and twice the personal difficulties he’d ever faced, were running circles around him. The other baristas treated Gill with respect and kindness despite his differences, and he began to feel a new emotion: gratitude. Crossing over the Starbucks bar was the beginning of a dramatic transformation that cracked his world wide open. When all of his defenses and the armor of entitlement had been stripped away, a humbler, happier and gentler man remained. One that everyone, especially Michael’s kids, liked a lot better. The backdrop to Gill's story is a nearly universal cultural phenomenon: the Starbucks experience. In How Starbucks Saved My Life, we step behind the counter of one of the world's best-known companies and discover how it all really works, who the baristas are and what they love (and hate) about their jobs. Inside Starbucks, as Crystal and Mike’s friendship grows, we see what wonders can happen when we reach out across race, class, and age divisions to help a fellow human being.

     “If you’re kicking yourself for not having accomplished all you should have by now, don’t worry about it. Even without any ‘big’ accomplishments yet to your name, you are enough.”   In this expansion of the 2017 commencement speech she gave at her hometown Langley High, Lauren Graham, the beloved star of Gilmore Girls and Parenthood, reflects on growing up, pursuing your dreams, and living in the here and now. “Whatever path you choose, whatever career you decide to go after, the important thing is that you keep finding joy in what you’re doing, especially when the joy isn’t finding you.” In her hilarious, relatable voice, Graham reminds us to be curious and compassionate, no matter where life takes us or what we’ve yet to achieve. Grounded and inspiring—and illustrated throughout with drawings by Graham herself—here is a comforting road map to a happy life.   “I’ve had ups and downs. I’ve had successes and senior slumps. I’ve been the girl who has the lead, and the one who wished she had the bigger part. The truth? They don’t feel that different from each other.”

    In her brutally honest, hilarious, heartbreaking memoir, she reveals what was going on behind the scenes of her sometimes tumultuous personal and professional life - a story she’s never shared, until now. Of the medium she loves, the one that made her a household name, she says, “Television can put you in a box; the flat-screen can flatten. On TV, you are larger than life but smaller, too. It is not the whole story, and it is not the whole me. This book is.”Beginning in early childhood, Couric was inspired by her journalist father to pursue the career he loved but couldn’t afford to stay in. Balancing her vivacious, outgoing personality with her desire to be taken seriously, she overcame every obstacle in her way: insecurity, an eating disorder, being typecast, sexism . . . challenges, and how she dealt with them, setting the tone for the rest of her career. Couric talks candidly about adjusting to sudden fame after her astonishing rise to co-anchor of the TODAY show, and guides us through the most momentous events and news stories of the era, to which she had a front-row seat:  Rodney King, Anita Hill, Columbine, the death of Princess Diana, 9/11, the Iraq War . . . In every instance, she relentlessly pursued the facts, ruffling more than a few feathers along the way.  She also recalls in vivid and sometimes lurid detail the intense pressure on female anchors to snag the latest “get”—often sensational tabloid stories like Jon Benet Ramsey, Tonya Harding, and OJ Simpson.Couric’s position as one of the leading lights of her profession was  shadowed by the shock and trauma of losing her husband to stage 4 colon cancer when he was just 42, leaving her a widow and single mom to two daughters, 6 and 2. The death of her sister Emily, just three years later, brought yet more trauma—and an unwavering commitment to cancer awareness and research, one of her proudest accomplishments. Couric is unsparing in the details of her historic move to the anchor chair at the CBS Evening News—a world rife with sexism and misogyny.  Her “welcome” was even more hostile at 60 Minutes, an unrepentant boys club that engaged in outright hazing of even the most established women.  In the wake of the MeToo movement, Couric shares her clear-eyed reckoning with gender inequality and predatory behavior in the workplace, and downfall of Matt Lauer—a colleague she had trusted and respected for more than a decade.Couric also talks about the challenge of finding love again, with all the hilarity, false-starts, and drama that search entailed, before finding her midlife Mr. Right.  Something she has never discussed publicly—why her second marriage almost didn’t happen. If you thought you knew Katie Couric, think again. Going There is the fast-paced, emotional, riveting story of a thoroughly modern woman, whose journey took her from humble origins to superstardom. In these pages, you will find a friend, a confidante, a role model, a survivor whose lessons about life will enrich your own.