This fascinating collection of historical curiosities explores some of the strangest cases that have perplexed doctors across the world.From seventeenth-century Holland to Tsarist Russia, from rural Canada to a whaler in the Pacific, many are monuments to human stupidity – such as the sailor who swallowed dozens of penknives to amuse his shipmates, or the chemistry student who in 1850 arrived at a hospital in New York with his penis trapped inside a bottle, having unwisely decided to relieve himself into a vessel containing highly reactive potassium. Others demonstrate exceptional surgical ingenuity long before the advent of anaesthesia – such as a daring nineteenth-century operation to remove a metal fragment from beneath a conscious patient’s heart. We also hear of the weird, often hilarious remedies employed by physicians of yore – from crow’s vomit to port-wine enemas – the hazards of such everyday objects as cucumbers and false teeth, and miraculous recovery from apparently terminal injuries.

    More than 1,000 questions cover everything from the fundamentals of gross and microscopic pathology to the latest findings in molecular biology and genetics. Based on two of the best-selling, most authoritative pathology textbooks-Robbins and Cotran Pathologic Basis of Disease, 7th Edition and Basic Pathology, 7th Edition-Robbins and Cotran Review of Pathology, 2nd Edition is an ideal aid for coursework, self-assessment, and examinations in pathology.Offers more than 1,000 questions that follow the clinical vignette style, emphasizing problem solving over rote memorization. Presented in both single-best-answer and extended-matching formats, they reflect levels of difficulty that prepare students for both examinations and the practice of medicine.Provides an answer and a detailed explanation for every question at the end of each chapter.Includes page references and a parallel organization to both Robbins and Cotran Pathologic Basis of Disease and Basic Pathology, making additional information easy to locate.Presents correlative laboratory, radiologic, and physical diagnostic data to enhance readers' understanding of pathophysiology and to integrate pathology with other medical disciplines.Uses numerous full-color illustrations to test readers' diagnostic skills.Delivers a 73-question chapter covering all subjects that mimics a comprehensive final examination.

    Eventually, the barkeep-turned-actor would grace the small screen opposite Cybill Shepherd in the ABC series "Moonlighting" and, with a few turns of luck, the big screen in the unlikely role of John McClane. Bruce Willis would then forever be recognized as the world's ultimate anti-hero, a blue-collar Everyman with the worst luck, always surrounded by terrorists taking over something or other. And, in this definitive oral history of "Die Hard," writers, actors, producers, and studio executives reveal behind-the-scenes stories, from the curious origins of the film's title, to the script's evolution from a depressing ‘70s character study to an optimistic Reagan-era blockbuster, to the seminal negotiations between 20th Century Fox and Willis's then-agent which sent his client's career into the stratosphere, to details of moguls Lawrence Gordon and Joel Silver’s famously tumultuous relationship while developing some of the '80s most successful franchises. Brian Abrams’ first book, "Party Like a President: True Tales of Inebriation, Lechery, and Mischief from the Oval Office" (Workman Publishing), was released in February 2015 and earned attention from The Tonight Show Starring Jimmy Fallon, NPR, and Vanity Fair. His Kindle Singles, "AND NOW...An Oral History of 'Late Night with David Letterman,' 1982-1993" and "Gawker: An Oral History" became #1 bestsellers in 2014 and in 2015. He is editor-in-chief of the news and culture site Death and Taxes Magazine and lives in New York City. Cover design by Adil Dara.

    By extracting the fundamental concepts from this enormous and ever-growing field, the authors tell the story of cell biology, and create a coherent framework through which non-expert readers may approach the subject. Written in clear and concise language, and beautifully illustrated, the book is enjoyable to read, and it provides a clear sense of the excitement of modern biology. Molecular Biology of the Cell sets forth the current understanding of cell biology (completely updated as of Autumn 2001), and it explores the intriguing implications and possibilities of the great deal that remains unknown. The hallmark features of previous editions continue in the Fourth Edition. The book is designed with a clean and open, single-column layout. The art program maintains a completely consistent format and style, and includes over 1,600 photographs, electron micrographs, and original drawings by the authors. Clear and concise concept headings introduce each section. Every chapter contains extensive references. Most important, every chapter has been subjected to a rigorous, collaborative revision process where, in addition to incorporating comments from expert reviewers, each co-author reads and reviews the other authors' prose. The result is a truly integrated work with a single authorial voice. Features : - Places the latest hot topics sensibly in context - including genomics, protein structure, array technology, stem cells and genetics diseases. - Incorporates and emphasises new genomic data. - All of molecular biology is brought together into one section (chapters 4-7) covering classically defined molecular biology and molecular genetics. - Two chapters deal exclusively with methods and contain information on the latest tools and techniques. - New chapters on "Pathogens, Infection, and Innate Immunity". - Cell Biology Interactive CD-ROM is packaged with every copy of the book. - Contains over 1,600 illustrations, electron micrographs and photographs, of which over 1,000 are originally conceived by the authors.

    Operations on the brain carry grave risks. Every day, leading neurosurgeon Henry Marsh must make agonizing decisions, often in the face of great urgency and uncertainty.If you believe that brain surgery is a precise and exquisite craft, practiced by calm and detached doctors, this gripping, brutally honest account will make you think again. With astonishing compassion and candor, Marsh reveals the fierce joy of operating, the profoundly moving triumphs, the harrowing disasters, the haunting regrets, and the moments of black humor that characterize a brain surgeon's life.Do No Harm provides unforgettable insight into the countless human dramas that take place in a busy modern hospital. Above all, it is a lesson in the need for hope when faced with life's most difficult decisions.

    These dramatic first-person essays detail spectacular serendipities, impossible cures, breathtaking resuscitations, extraordinary awakenings, and recovery from unimaginable disasters. Still other essays give voice to cases in which the physical aspects were less dramatic than the emotional aspects, yet miraculous and transformational for everyone involved. Positive impacts left in the wake of even the gravest of tragedies, profound triumphs of heart and spirit. Preeminent physicians in many specialties, including deans and department heads on the faculties of the top university medical schools in the country describe, in everyday language and with moving testimony, their very personal reactions to these remarkable clinical experiences. Among the extraordinary cases poignantly recounted by the physicians witnessing them: A priest visiting a hospitalized patient went into cardiac arrest on the elevator, which opened up on the cardiac floor, right at the foot of the cardiac specialist, at just the right moment.A tiny premature baby dying from irreversible lung disease despite the most intensive care who recovered almost immediately after being taken from his hospital bed and placed on his mother's chest.President John F. Kennedy's son Patrick, who died shortly after birth, and whose disease eventually led to research that saved generations of babies.A nine-year-old boy who was decapitated in a horrific car accident but survived without neurological damage.A woman who conceived and delivered a healthy baby—despite having had both of her fallopian tubes surgically removed.A young man whose only hope for survival was a heart transplant, but just at the moment he developed a potentially fatal complication making a transplant impossible, his own heart began healing itself.A teenage girl near death after contracting full-blown rabies who became the first patient ever to recover from that disease after an unexpected visit by Timothy Dolan, the man who would go on to become the Archbishop of New York.A Manhattan window-washer who fell 47 stories—and not only became the only person ever to survive a fall from that height, but went on to make a full recovery. Miracles We Have Seen is a book of inspiration and optimism, and a compelling glimpse into the lives of physicians—their humanity and determined devotion to their patients and their patients' families. It reminds us that what we don't know or don't understand isn‘t necessarily cause for fear, and can even be reason for hope

    Throughout our life, we look for ways to keep our mind sharp and effortlessly productive. Now, globetrotting neurosurgeon Dr. Sanjay Gupta offers insights from top scientists all over the world, whose cutting-edge research can help you heighten and protect brain function and maintain cognitive health at any age. Keep Sharp debunks common myths about aging and cognitive decline, explores whether there’s a “best” diet or exercise regimen for the brain, and explains whether it’s healthier to play video games that test memory and processing speed, or to engage in more social interaction. Discover what we can learn from “super-brained” people who are in their eighties and nineties with no signs of slowing down—and whether there are truly any benefits to drugs, supplements, and vitamins. Dr. Gupta also addresses brain disease, particularly Alzheimer’s, answers all your questions about the signs and symptoms, and shows how to ward against it and stay healthy while caring for a partner in cognitive decline. He likewise provides you with a personalized twelve-week program featuring practical strategies to strengthen your brain every day. Keep Sharp is the only owner’s manual you’ll need to keep your brain young and healthy regardless of your age!

    Our looks, longevity, as well as our physical and mental conditions result from the way we eat, breathe, and take care of all our physical and psychological needs. The question is not limited to nutrition only, as is the case of dieting programs.

    Chae Hyun Moon, a celebrated cardiologist in Redding, California. Corapi had been suffering from exhaustion and shortness of breath, and although a physical examination and a conventional stress test revealed nothing abnormal, Moon insisted that the calcium level in Corapi's coronary arteries called for a highly invasive diagnostic test: an angiogram. A chain-smoking Korean immigrant known for his gruff bedside manner, Moon performed the procedure briskly and immediately handed down a devastating diagnosis: "I'm sorry; there is nothing I can do for you. You need a triple bypass tomorrow morning." He then abruptly left the room.Several hours later, however, Moon inexplicably decided the surgery could wait until Corapi returned from a previously scheduled cross-country trip. Unnerved by the dire diagnosis and also by Moon's inconsistent statements, Corapi sought other opinions. To his amazement, a second, third, and fourth doctor found that his heart was perfectly healthy. In fact, for a man his age, Corapi's arteries were "remarkably free of disease."Sensing a cause more disturbing than human error, Corapi took his story to the FBI. As local agent Mike Skeen soon discovered, Corapi was one of a number of people who had suspicions about Moon and Moon's go-to cardiac surgeon, Dr. Fidel Realyvasquez, an equally respected member of the close-knit northern California community. Working ata hospital owned by Tenet Healthcare, Moon would make the diagnoses and Realyvasquez would perform the surgeries. Together, these leaders of the Redding medical establishment put hundreds of healthy people at risk, some of whom never recovered. Soon Skeen launched a major investigation, interviewing numerous doctors and patients, and forty federal agents raided the hospital where the doctors worked.A timely and provocative dissection of America's medical-industrial complex, "Coronary" lays bare the financial structures that drive the American healthcare system, and which precipitated Moon's and Realyvasquez's actions. In a scheme that placed the demands of Wall Street above the lives of its patients, Tenet Healthcare rewarded doctors based on how much revenue they generated for the corporation.A meticulous three-year FBI investigation and hundreds of civil suits culminated in no criminal charges but a series of settlements with Tenet Healthcare and the doctors that totaled more than $450 million and likely put an end to Moon's and Realyvasquez's medical careers. The case's every twist and turn is documented here.A riveting, character-rich narrative and a masterpiece of long-form journalism, "Coronary" is as powerful as it is alarming. This is a hair-raising story of the hundreds of men and women who went under the knife, not in the name of medicine, but of profit and prestige. Brilliantly told, Stephen Klaidman's "Coronary" is a cautionary tale in the age of miracle medicine, and a shocking reminder to always get a second opinion.

    And though we are rewarded with more time with the people we love, we are also faced with new sets of complications—more diseases, more disability, more need for support and careful judgments. Yet while our health care system may help people live to an older age, it doesn't perform so well when decline eventually sets in. We want to do the best thing but are overwhelmed with the staggering choices we face.Geriatrician Dennis McCullough has spent his life helping families to cope with their parents' aging and eventual final passage, experiences he faced with his own mother. In this comforting and much-needed book, he recommends a new approach, which he terms "Slow Medicine."Shaped by common sense and kindness, grounded in traditional medicine yet receptive to alternative therapies, Slow Medicine advocates for careful anticipatory "attending" to an elder's changing needs rather than waiting for crises that force acute medical interventions—an approach that improves the quality of elders' extended late lives without bankrupting their families financially or emotionally. As Dr. McCullough argues, we need to learn that time and kindness are sometimes more important and humane at these late stages than state-of-the-art medical interventions.My Mother, Your Mother will help you learn how to:—form an early and strong partnership with your parents and siblings;—strategize on connecting with doctors and other care providers;—navigate medical crises;—create a committed Advocacy Team;—reach out with greater empathy and awareness; and—face the end-of-life time with confidence and skill.Although taking care of those who have always cared for us is not an easily navigated time of life, My Mother, Your Mother will help you and your family to prepare for this complex journey. This is not a plan for getting ready to die; it is a plan for understanding, for caring, and for helping those you love live well during their final years. And the time to start is now.

    Texting while driving. Binge-drinking. Bullying. Unprotected sex. There are plenty of reasons for parents to worry about getting a late-night call about their teen. But most of the advice parents and educators hear about teens is outdated and unscientific--and based on the rates of teen pregnancy, accidents, addiction, and more.Acclaimed adolescent psychiatrist Jess P. Shatkin brings more than two decades' worth of research and clinical experience to the subject, along with cutting-edge findings from brain science, evolutionary psychology, game theory, and other disciplines -- plus a widely curious mind and the perspective of a concerned dad.Using science and stories, fresh analogies, clinical anecdotes, and research-based observations, Shatkin explains: Why "scared straight," adult logic, and draconian punishment don't work. Why the teen brain is "born to be wild"--shaped by evolution to explore and take risks.The surprising role of brain development, hormones, peer pressure, screen time, and other key factors.What parents and teachers can do--in everyday interactions, teachable moments, and specially chosen activities and outings--to work with teens' need for risk, rewards and social acceptance, not against it.

    Lorimer Moseley, is a compilation of hilarious stories and images intended to help explain the complexity of pain. These stories, while entertaining, are used as metaphors to explain key aspects of the biology of pain. 'Painful Yarns' is a perfect pre-read for 'Explain Pain'.

    Lisa Sanders, author of the monthly New York Times Magazine column "Diagnosis," the inspiration for the hit Fox TV series House, M.D.The experience of being ill can be like waking up in a foreign country. Life, as you formerly knew it, is on hold while you travel through this other world as unknown as it is unexpected. When I see patients in the hospital or in my office who are suddenly, surprisingly ill, what they really want to know is, ‘What is wrong with me?’ They want a road map that will help them manage their new surroundings. The ability to give this unnerving and unfamiliar place a name, to know it–on some level–restores a measure of control, independent of whether or not that diagnosis comes attached to a cure. Because, even today, a diagnosis is frequently all a good doctor has to offer.A healthy young man suddenly loses his memory–making him unable to remember the events of each passing hour. Two patients diagnosed with Lyme disease improve after antibiotic treatment–only to have their symptoms mysteriously return. A young woman lies dying in the ICU–bleeding, jaundiced, incoherent–and none of her doctors know what is killing her. In Every Patient Tells a Story, Dr. Lisa Sanders takes us bedside to witness the process of solving these and other diagnostic dilemmas, providing a firsthand account of the expertise and intuition that lead a doctor to make the right diagnosis.Never in human history have doctors had the knowledge, the tools, and the skills that they have today to diagnose illness and disease. And yet mistakes are made, diagnoses missed, symptoms or tests misunderstood. In this high-tech world of modern medicine, Sanders shows us that knowledge, while essential, is not sufficient to unravel the complexities of illness. She presents an unflinching look inside the detective story that marks nearly every illness–the diagnosis–revealing the combination of uncertainty and intrigue that doctors face when confronting patients who are sick or dying. Through dramatic stories of patients with baffling symptoms, Sanders portrays the absolute necessity and surprising difficulties of getting the patient’s story, the challenges of the physical exam, the pitfalls of doctor-to-doctor communication, the vagaries of tests, and the near calamity of diagnostic errors. In Every Patient Tells a Story, Dr. Sanders chronicles the real-life drama of doctors solving these difficult medical mysteries that not only illustrate the art and science of diagnosis, but often save the patients’ lives.

    Unlocking the secrets of our genomes opens the door to understanding why we are the way we are and potentially fixing what ails us, from cancer and diabetes to obesity and male pattern baldness. But what exactly will happen to this information? Will it be a boon or just another marketing tool?Here Is a Human Being is the first in-depth look at personal genomics—its larger-than-life research subjects; its entrepreneurs and do-it-yourselfers; its technology developers; and the bewildered physicians and regulators who must negotiate with it—and what it means to be a “public genome” in a world where privacy is already under siege.

    It takes as its starting point the sudden appearance of biology as a science in the nineteenth century and examines the conditions determining its particular makeup.Canguilhem analyzes the radically new way in which health and disease were defined in the early nineteenth century, showing that the emerging categories of the normal and the pathological were far from objective scientific concepts. He demonstrates how the epistemological foundations of modern biology and medicine were intertwined with political, economic, and technological imperatives.Canguilhem was an important influence on the thought of Michel Foucault and Louis Althusser, among others, in particular for the way in which he poses the problem of how new domains of knowledge come into being and how they are part of a discontinuous history of human thought.