What at first seemed like a case of food poisoning quickly turned critical, and by the time Tom had been transferred via emergency medevac to the world-class medical center at UC San Diego, where both he and Steffanie worked, blood work revealed why modern medicine was failing: Tom was fighting one of the most dangerous, antibiotic-resistant bacteria in the world.Frantic, Steffanie combed through research old and new and came across phage therapy: the idea that the right virus, aka "the perfect predator," can kill even the most lethal bacteria. Phage treatment had fallen out of favor almost 100 years ago, after antibiotic use went mainstream. Now, with time running out, Steffanie appealed to phage researchers all over the world for help. She found allies at the FDA, researchers from Texas A&M, and a clandestine Navy biomedical center -- and together they resurrected a forgotten cure.

    Beginning with the study of DNA in Egyptian mummies in the early 1980s and culminating in the sequencing of the Neanderthal genome in 2010, Neanderthal Man describes the events, intrigues, failures, and triumphs of these scientifically rich years through the lens of the pioneer and inventor of the field of ancient DNA.We learn that Neanderthal genes offer a unique window into the lives of our hominin relatives and may hold the key to unlocking the mystery of why humans survived while Neanderthals went extinct. Drawing on genetic and fossil clues, Pääbo explores what is known about the origin of modern humans and their relationship to the Neanderthals and describes the fierce debate surrounding the nature of the two species’ interactions. His findings have not only redrawn our family tree, but recast the fundamentals of human history—the biological beginnings of fully modern Homo sapiens, the direct ancestors of all people alive today.A riveting story about a visionary researcher and the nature of scientific inquiry, Neanderthal Man offers rich insight into the fundamental question of who we are.

    Read her work; you'll have a deeper appreciation for your every step, every bite, and every breath." --Bill NyeSasha Sagan was raised by secular parents, the astronomer Carl Sagan and the writer and producer Ann Druyan. They taught her that the natural world and vast cosmos are full of profound beauty, that science reveals truths more wondrous than any myth or fable.When Sagan herself became a mother, she began her own hunt for the natural phenomena behind our most treasured occasions--from births to deaths, holidays to weddings, anniversaries, and more--growing these roots into a new set of rituals for her young daughter that honor the joy and significance of each experience without relying on religious framework.As Sagan shares these rituals, For Small Creatures Such as We becomes a tribute to a father, a newborn daughter, a marriage, and the natural world--a celebration of life itself, and the power of our families and beliefs to bring us together.

    She had a play that was to be produced at the New York International Fringe Festival and a job waiting for her at the New Yorker. Tragically, five days after graduation, Marina died in a car crash.As her family, friends, and classmates, deep in grief, joined to create a memorial service for Marina, her unforgettable last essay for the Yale Daily News, “The Opposite of Loneliness,” went viral, receiving more than 1.4 million hits. She had struck a chord.Even though she was just twenty-two when she died, Marina left behind a rich, expansive trove of prose that, like her title essay, captures the hope, uncertainty, and possibility of her generation. The Opposite of Loneliness is an assem­blage of Marina’s essays and stories that, like The Last Lecture, articulates the universal struggle that all of us face as we figure out what we aspire to be and how we can harness our talents to make an impact on the world.

    From training to launch, from his historic spacewalk to re-entry, he reveals for readers of all ages the cutting-edge science behind his ground-breaking experiments, and the wonders of day-to-day life on board the International Space Station.The public were invited to submit questions using the hashtag #askanastronaut, and a selection are answered by Tim in the book, which will be accompanied with illustrations, diagrams and never-before-seen photos.Tim is pleased to announce that, as with his previous book, royalties received from the book will be donated to The Prince’s Trust.

    . . but rarely acknowledging.Filled with insights and observations that instantly ring true—and could have come only from Nora Ephron—I Remember Nothing is pure joy.

    When Matt Haig developed panic disorder, anxiety, and depression as an adult, it took him a long time to work out the ways the external world could impact his mental health in both positive and negative ways. Notes on a Nervous Planet collects his observations, taking a look at how the various social, commercial and technological "advancements" that have created the world we now live in can actually hinder our happiness. Haig examines everything from broader phenomena like inequality, social media, and the news; to things closer to our daily lives, like how we sleep, how we exercise, and even the distinction we draw between our minds and our bodies.

    It has been inspired by the scientific ferment that swept through Britain at the end of the 18th century, and which Holmes now radically redefines as 'the revolution of Romantic Science'.

    There was the location: an impoverished, nuclear waste-riddled area of the American Midwest. There was her mother, a woman who speaks almost entirely in strange koans and warnings of impending danger. Above all, there was her gun-toting, guitar-riffing, frequently semi-naked father, who underwent a religious conversion on a submarine and discovered a loophole which saw him approved for the Catholic priesthood by the future Pope Benedict XVI - despite already having a wife and children.When the expense of a medical procedure forces the 30-year-old Patricia to move back in with her parents, husband in tow, she must learn to live again with her family's simmering madness, and to reckon with the dark side of a childhood spent in the bosom of the Catholic Church. Told with the comic sensibility of a brasher, bluer Waugh or Wodehouse, this is at the same time a lyrical and affecting story of how, having ventured into the underworld, we can emerge with our levity and our sense of justice intact.

    But one particular string of bad news stories – and a terrifying brush with her own mortality – sent her looking for answers about how vulnerable each of us is to a life-changing event. What are our chances of actually experiencing one? What do we fear most and why? And when the worst does happen, what comes next?In this wise and layered book, Leigh talks intimately with people who’ve faced the unimaginable, from terrorism to natural disaster to simply being in the wrong place at the wrong time. Expecting broken lives, she instead finds strength, hope, even humour. Leigh brilliantly condenses the cutting-edge research on the way the human brain processes fear and grief, and poses the questions we too often ignore out of awkwardness. Along the way, she offers an unguarded account of her own challenges and what she’s learned about coping with life’s unexpected blows.Warm, candid and empathetic, this book is about what happens when ordinary people, on ordinary days, are forced to suddenly find the resilience most of us don’t know we have.

    In so doing, he reaches a provocative conclusion: science, the main tool we use to find answers, is fundamentally limited.These limits to our knowledge arise both from our tools of exploration and from the nature of physical reality: the speed of light, the uncertainty principle, the impossibility of seeing beyond the cosmic horizon, the incompleteness theorem, and our own limitations as an intelligent species. Recognizing limits in this way, Gleiser argues, is not a deterrent to progress or a surrendering to religion. Rather, it frees us to question the meaning and nature of the universe while affirming the central role of life and ourselves in it. Science can and must go on, but recognizing its limits reveals its true mission: to know the universe is to know ourselves.Telling the dramatic story of our quest for understanding, The Island of Knowledge offers a highly original exploration of the ideas of some of the greatest thinkers in history, from Plato to Einstein, and how they affect us today. An authoritative, broad-ranging intellectual history of our search for knowledge and meaning, The Island of Knowledge is a unique view of what it means to be human in a universe filled with mystery.

    At twenty-three, after leaving graduate school to pursue her dreams of becoming a poet, Joanna Rakoff moves to New York City and takes a job as assistant to the storied literary agent for J. D. Salinger. She spends her days in a plush, wood-paneled office, where Dictaphones and typewriters still reign and old-time agents doze at their desks after martini lunches. At night she goes home to the tiny, threadbare Williamsburg apartment she shares with her socialist boyfriend. Precariously balanced between glamour and poverty, surrounded by titanic personalities, and struggling to trust her own artistic instinct, Rakoff is tasked with answering Salinger’s voluminous fan mail. But as she reads the candid, heart-wrenching letters from his readers around the world, she finds herself unable to type out the agency’s decades-old form response. Instead, drawn inexorably into the emotional world of Salinger’s devotees, she abandons the template and begins writing back. Over the course of the year, she finds her own voice by acting as Salinger’s, on her own dangerous and liberating terms. Rakoff paints a vibrant portrait of a bright, hungry young woman navigating a heady and longed-for world, trying to square romantic aspirations with burgeoning self-awareness, the idea of a life with life itself. Charming and deeply moving, filled with electrifying glimpses of an American literary icon, My Salinger Year is the coming-of-age story of a talented writer. Above all, it is a testament to the universal power of books to shape our lives and awaken our true selves.

    Since its 2009 launch, the Kepler satellite has discovered more than two thousand exoplanets, or planets outside of our solar system. More and more exoplanets are being discovered all the time, and even more remarkable than the sheer number of exoplanets is their variety. In Exoplanets, astronomer Michael Summers and physicist James Trefil explore the unbelievable recent discoveries: planets revolving around pulsars, planets made out of diamond, planets that are mostly water, and numerous rogue planets wandering through the emptiness of space. This captivating book reveals the latest, greatest discoveries and argues that the incredible richness and complexity we are finding necessitates a change in the questions we ask and the mental paradigms we use. In short, we have to change how we think about the universe and our place in it, because it is stranger and more interesting than we can even begin to imagine.

    He describes the architecture of space and time, dark matter and dark energy, how galaxies form, why stars implode, how everything began, and how it's all going to end. He considers parallel universes, the fine-tuning of the cosmos for life, what forms extraterrestrial life might take, and the likelihood of life on Earth being snuffed out by an asteroid.Beginning with the Babylonian integration of mathematics into the study of astronomy and cosmology, Stewart traces the evolution of our understanding of the cosmos: How Kepler's laws of planetary motion led Newton to formulate his theory of gravity. How, two centuries later, tiny irregularities in the motion of Mars inspired Einstein to devise his general theory of relativity. How, eighty years ago, the discovery that the universe is expanding led to the development of the Big Bang theory of its origins. How single-point origin and expansion led cosmologists to theorize new components of the universe, such as inflation, dark matter, and dark energy. But does inflation explain the structure of today's universe? Does dark matter actually exist? Could a scientific revolution that will challenge the long-held scientific orthodoxy and once again transform our understanding of the universe be on the way? In an exciting and engaging style, Calculating the Cosmos is a mathematical quest through the intricate realms of astronomy and cosmology.

    But I was getting there. I wanted the world to know that all of this pain I had been feeling…that it was related to my vagina. Thus, Vagina Problems was born. It was a cutesy name. It was my way of taking this pain and saying, “Whatever. I’m here. I have it. It sucks. Let’s talk about it.”In April 2014, Deputy Editorial Director at BuzzFeed Lara Parker opened up to the world in an article on the website: she suffers from endometriosis. And beyond that? She let the whole world know that she wasn’t having any sex, as sex was excruciatingly painful. Less than a year before, she received not only the diagnosis of endometriosis, but also a diagnosis of pelvic floor dysfunction, vulvodynia, vaginismus, and vulvar vestibulitis. Combined, these debilitating conditions have wreaked havoc on her life, causing excruciating pain throughout her body since she was fourteen years old. These are her Vagina Problems. It was five years before Lara learned what was happening to her body. Five years of doctors insisting she just had “bad period cramps,” or implying her pain was psychological. Shamed and stigmatized, Lara fought back against a medical community biased against women and discovered that the ignorance of many doctors about women’s anatomy was damaging more than just her own life. One in ten women have endometriosis and it takes an average of seven years before they receive an accurate diagnosis—or any relief from this incurable illness’ chronic pain. With candid revelations about her vaginal physical therapy, dating as a straight woman without penetrative sex, coping with painful seizures while at the office, diet and wardrobe malfunctions when your vagina hurts all the time, and the depression and anxiety of feeling unloved, Lara tackles it all in Vagina Problems: Endometriosis, Painful Sex, and Other Taboo Topics with courage, wit, love, and a determination to live her best life."