Two scientists explore the potential of a revolutionary genetics technology capable of easily and affordably manipulating DNA in human embryos to prevent specific diseases, addressing key concerns about related ethical and societal repercussions.

    Based in the latest research in neuroscience, this audiobook offers dozens of little things you can do every day to rewire your brain and create an upward spiral towards a happier, healthier life.Depression doesn't happen all at once. It starts gradually and builds momentum over time. If you go through a difficult experience, you may stop taking care of yourself. You may stop exercising and eating healthy, which will end up making you feel even worse as time goes on. You are caught in a downward spiral, but you may feel too tired, too overwhelmed, and too scared to try and pull yourself back up. The good news is that just one small step can be a step in the right direction.In The Upward Spiral, neuroscientist Alex Korb demystifies the neurological processes in the brain that cause depression and offers effective ways to get better "one little step at a time". In the book, you'll discover that there isn't "one big solution" that will solve your depression. Instead, there are dozens of small, practical things you can do to alleviate your symptoms and start healing. Some are as simple as relaxing certain muscles to reduce feelings of anxiety, while others involve making small efforts toward more positive social interactions. Small steps in the right direction can have profound effects giving you the power to literally "reshape" your brain.Like most people, you probably didn't wake up one day and find yourself completely depressed. Instead, it probably happened over time, as a series of reactions to difficult situations and negative thinking. But if you are ready to reverse the trajectory of your depression and find lasting happiness, this book will show you how.

    Bitches are moody. To succeed in life, we are told, we must have it all under control. We have to tamp down our inherent shifts in favor of a more static way of being. But our bodies are wiser than we imagine. Moods are not an annoyance to be stuffed away. They are a finely-tuned feedback system that, if heeded, can tell us how best to manage our lives. Our changing moods let us know when our bodies are primed to tackle different challenges and when we should be alert to developing problems. They help us select the right tool for each of our many jobs. If we deny our emotionality, we deny the breadth of our talents. With the right care of our inherently dynamic bodies, we can master our moods to avail ourselves of this great natural strength.  Yet millions of American women are medicating away their emotions because our culture says that moodiness is a problem to be fixed. One in four of us takes a psychiatric drug. If you add sleeping pills to the mix, the statistics become considerably higher. Over-prescribed medications can have devastating consequences for women in many areas of our lives: sex, relationships, sleep, eating, focus, balance, and aging.  And even if we don’t pop a pill, women everywhere are numbing their emotions with food, alcohol, and a host of addictive behaviors that deny the wisdom of our bodies and keep us from addressing the real issues that we face. Dr. Julie Holland knows there is a better way. She’s been sharing her frank and funny wisdom with her patients for years, and in Moody Bitches Dr. Holland offers readers a guide to our bodies and our moodiness that includes insider information about the pros and cons of the drugs we’re being offered, the direct link between food and mood, an honest discussion about sex, practical exercise and sleep strategies, as well as some surprising and highly effective natural therapies that can help us press the reset button on our own bodies and minds. In the tradition of Our Bodies, Our Selves, this groundbreaking guide for women of all ages will forge a much needed new path in women’s health—and offer women invaluable information on how to live better, and be more balanced, at every stage of life.

    This book is the result of the authors' yearlong, world-wide exploration of magic and how its principles apply to our behavior. Magic tricks fool us because humans have hardwired processes of attention and awareness that are hackable—a good magician uses your mind's own intrinsic properties against you in a form of mental jujitsu. Now magic can reveal how our brains work in everyday situations. For instance, if you've ever bought an expensive item you'd sworn you'd never buy, the salesperson was probably a master at creating the "illusion of choice," a core technique of magic. The implications of neuromagic go beyond illuminating our behavior; early research points to new approaches for everything from the diagnosis of autism to marketing techniques and education. Sleights of Mind makes neuroscience fun and accessible by unveiling the key connections between magic and the mind.

    Stone—host of Discovery Channel’s former series Most Evil—uses this common emotional reaction to horrifying acts as his starting point to explore the concept and reality of evil from a new perspective. In an in-depth discussion of the personality traits and behavior that constitute evil across a wide spectrum, Dr. Stone takes a clarifying scientific approach to a topic that for centuries has been inadequately explained by religious doctrines.Basing his analysis on the detailed biographies of more than 600 violent criminals, Stone has created a 22-level hierarchy of evil behavior, which loosely reflects the structure of Dante’s Inferno. He traces two salient personality traits that run the gamut from those who commit crimes of passion to perpetrators of the worst crimes—sadistic torture and murder. One trait is narcissism, as exhibited in people who are so self-centered that they have little or no ability to care about their victims. The other is aggression, the use of power over another person to inflict humiliation, suffering, and death.Stone then turns to the various factors that, singly or intertwined, contribute to pushing certain people over the edge into committing heinous crimes. They include heredity, adverse environments, violence-prone cultures, mental illness or brain injury, and abuse of mind-altering drugs. All are considered in the search for the root causes of evil behavior.What do psychology, psychiatry, and neuroscience tell us about the minds of those whose actions could be described as evil? And what will that mean for the rest of us? Stone discusses how an increased understanding of the causes of evil will affect the justice system. He predicts a day when certain persons can safely be declared salvageable and restored to society and when early signs of violence in children may be corrected before potentially dangerous patterns become entrenched.

    The bestselling author of Shadow Divers returns with a riveting story of exploration, mystery, and the discovery of an unknown world--this time about one man's incredible odyssey from blindness into sight.

    Along the way, you’ll encounter Boschean beasts, giant squid, guitar-playing sea slugs, and the great pioneers of neuroscience. Hana Roš and Matteo Farinella provide an insight into the most complex thing in the universe.

    The truth is, there are untapped sources of meaning all around us right here, right now. Drawing on the latest research in positive psychology; on insights from George Eliot, Viktor Frankl, Aristotle, the Buddha, and other great minds; and on interviews with seekers of meaning, Emily Esfahani Smith lays out the four pillars upon which meaning rests. Belonging We all need to find our tribe and forge relationships in which we feel understood, recognized, and valued to know we matter to others.Purpose We all need a far-reaching goal that motivates us, serves as the organizing principle of our lives, and drives us to make a contribution to the world.Storytelling We are all storytellers, taking our disparate experiences and assembling them into a coherent narrative that allows us to make sense of ourselves and the world. Transcendence During a transcendent or mystical experience, we feel we have risen above the everyday world and are connected to something vast and meaningful. To bring those concepts to life, Smith visits a tight-knit fishing village on the Chesapeake Bay, stargazes in West Texas, attends a dinner where young people gather to share their experiences of untimely loss, and more. And she explores how we might begin to build a culture of meaning in our schools, our workplaces, and our communities. Inspiring and story-driven, The Power of Meaning will strike a profound chord in anyone seeking a richer, more satisfying life."

    Jacobs's hilarious, enlightening, and seemingly impossible quest to read the Encyclopaedia Britannica from A to Z. 33,000 Pages44 Million Words10 Billion Years Of History1 Obsessed ManTo fill the ever-widening gaps in his Ivy League education, A.J. Jacobs sets for himself the daunting task of reading all thirty-two volumes of the Encyclopaedia Britannica. His wife, Julie, tells him it's a waste of time, his friends believe he is losing his mind, and his father, a brilliant attorney who had once attempted the same feat and quit somewhere around Borneo, is encouraging but unconvinced. With self-deprecating wit and a disarming frankness, The Know-It-All recounts the unexpected and comically disruptive effects Operation Encyclopedia has on every part of Jacobs's life -- from his newly minted marriage to his complicated relationship with his father and the rest of his charmingly eccentric New York family to his day job as an editor at Esquire. Jacobs's project tests the outer limits of his stamina and forces him to explore the real meaning of intelligence as he endeavors to join Mensa, win a spot on Jeopardy!, and absorb 33,000 pages of learning. On his journey he stumbles upon some of the strangest, funniest, and most profound facts about every topic under the sun, all while battling fatigue, ridicule, and the paralyzing fear that attends his first real-life responsibility -- the impending birth of his first child. The Know-It-All is an ingenious, mightily entertaining memoir of one man's intellect, neuroses, and obsessions, and a struggle between the all-consuming quest for factual knowledge and the undeniable gift of hard-won wisdom.

    Sway introduces us to the Harvard Business School professor who got his students to pay $204 for a $20 bill, the head of airline safety whose disregard for his years of training led to the transformation of an entire industry, and the football coach who turned conventional strategy on its head to lead his team to victory. We also learn the curse of the NBA draft, discover why interviews are a terrible way to gauge future job performance, and go inside a session with the Supreme Court to see how the world’s most powerful justices avoid the dangers of group dynamics.Every once in a while, a book comes along that not only challenges our views of the world but changes the way we think. In Sway, Ori and Rom Brafman not only uncover rational explanations for a wide variety of irrational behaviors but also point readers toward ways to avoid succumbing to their pull.

    Hand argues that extraordinarily rare events are anything but. In fact, they’re commonplace. Not only that, we should all expect to experience a miracle roughly once every month.     But Hand is no believer in superstitions, prophecies, or the paranormal. His definition of “miracle” is thoroughly rational. No mystical or supernatural explanation is necessary to understand why someone is lucky enough to win the lottery twice, or is destined to be hit by lightning three times and still survive. All we need, Hand argues, is a firm grounding in a powerful set of laws: the laws of inevitability, of truly large numbers, of selection, of the probability lever, and of near enough.     Together, these constitute Hand’s groundbreaking Improbability Principle. And together, they explain why we should not be so surprised to bump into a friend in a foreign country, or to come across the same unfamiliar word four times in one day. Hand wrestles with seemingly less explicable questions as well: what the Bible and Shakespeare have in common, why financial crashes are par for the course, and why lightning does strike the same place (and the same person) twice. Along the way, he teaches us how to use the Improbability Principle in our own lives—including how to cash in at a casino and how to recognize when a medicine is truly effective.     An irresistible adventure into the laws behind “chance” moments and a trusty guide for understanding the world and universe we live in, The Improbability Principle will transform how you think about serendipity and luck, whether it’s in the world of business and finance or you’re merely sitting in your backyard, tossing a ball into the air and wondering where it will land.

    And yet, we are the safest and healthiest humans in history. Irrational fear seems to be taking over, often with tragic results. For example, in the months after 9/11, when people decided to drive instead of fly—believing they were avoiding risk—road deaths rose by more than 1,500. In this fascinating, lucid, and thoroughly entertaining examination of how humans process risk, journalist Dan Gardner had the exclusive cooperation of Paul Slovic, the world renowned risk-science pioneer, as he reveals how our hunter gatherer brains struggle to make sense of a world utterly unlike the one that made them. Filled with illuminating real world examples, interviews with experts, and fast-paced, lean storytelling, The Science of Fear shows why it is truer than ever that the worst thing we have to fear is fear itself.

    Now in paperback, Dr Jeffrey Schwartz and Sharon Begley's groundbreaking work, The Mind and the Brain, argues exactly the opposite: that the mind has a life of its own.Dr Schwartz, a leading researcher in brain dysfunctions, and Wall Street Journal science columnist Sharon Begley demonstrate that the human mind is an independent entity that can shape and control the functioning of the physical brain. Their work has its basis in our emerging understanding of adult neuroplasticity–the brain's ability to be rewired not just in childhood, but throughout life, a trait only recently established by neuroscientists.Through decades of work treating patients with obsessive–compulsive disorder (OCD), Schwartz made an extraordinary finding: while following the therapy he developed, his patients were effecting significant and lasting changes in their own neural pathways. It was a scientific first: by actively focusing their attention away from negative behaviors and toward more positive ones, Schwartz's patients were using their minds to reshape their brains–and discovering a thrilling new dimension to the concept of neuroplasticity.The Mind and the Brain follows Schwartz as he investigates this newly discovered power, which he calls self–directed neuroplasticity or, more simply, mental force. It describes his work with noted physicist Henry Stapp and connects the concept of 'mental force' with the ancient practice of mindfulness in Buddhist tradition. And it points to potential new applications that could transform the treatment of almost every variety of neurological dysfunction, from dyslexia to stroke–and could lead to new strategies to help us harness our mental powers. Yet as wondrous as these implications are, perhaps even more important is the philosophical dimension of Schwartz's work. For the existence of mental force offers convincing scientific evidence of human free will, and thus of man's inherent capacity for moral choice.

    But as the twins approached adolescence, Pamela began to succumb to schizophrenia, hearing disembodied voices and eventually suffering many breakdowns and hospitalizations.Divided Minds is a dual memoir of identical twins, one of whom faces a life sentence of schizophrenia, and the other who becomes a psychiatrist, after entering the spotlight that had for so long been focused on her sister. Told in the alternating voices of the sisters, Divided Minds is a heartbreaking account of the far reaches of madness, as well as the depths of ambivalence and love between twins. It is a true and unusually frank story of identical twins with very different identities and wildly different experiences of the world around them.

    Whether we're buying a pair of jeans, ordering a cup of coffee, selecting a long-distance carrier, applying to college, choosing a doctor, or setting up a 401K, everyday decisions have become increasingly complex due to the overwhelming abundance of choice with which we are presented. In The Paradox of Choice, Barry Schwartz explains why too much of a good thing has proven detrimental to our psychological and emotional well-being. In accessible, engaging, and anecdotal prose, Schwartz explains how a culture that thrives on the availability of constantly evolving options can also foster profound dissatisfaction and self-blame in individuals, which can lead to a paralysis in decision making and, in some cases, depression. With the latest studies on how we make choices in our personal and professional lives, Schwartz offers practical advice on how to focus on the right choices, and how to derive greater satisfaction from choices that we do make.