As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    She had killed someone with a thought, spread untold disease, and ogled the bodies of other children. Only by performing an exhausting series of secret routines could she make up for what she’d done. But no matter how intricate or repetitive, no act of penance was ever enough.Beautifully written and astonishingly intimate, Because We Are Bad recounts a childhood consumed by obsessive compulsive disorder. As a child, Bailey created a second personality inside herself—"I" became "we"—to help manifest compulsions that drove every minute of every day of her young life. Now she writes about the forces beneath her skin, and how they ordered, organized, and urged her forward. Lily charts her journey, from checking on her younger sister dozens of times a night, to "normalizing" herself at school among new friends as she grew older, and finally to her young adult years, learning—indeed, breaking through—to make a way for herself in a big, wide world that refuses to stay in check.Charming and raw, harrowing and redemptive, Because We Are Bad is an illuminating and uplifting look into the mind and soul of an extraordinary young woman, and a startling portrait of OCD that allows us to see and understand this condition as never before.

    On her blog, in her magazine, and on her cooking show, Ree shares recipes, tales of her adventures in the country, and stories of everyday life with her four children and cowboy/rancher husband.In this down-to-earth and charming book, Ree shares real-life anecdotes about parenting from her own unique vantage point. While her busy life is constantly full of new surprises, what's most important to her is family. Over the years she's learned a few things about balancing motherhood with a million other things, and now she offers the wisdom of her experiences; the ups, the downs, the bumps in the road, the laughter and the tears; in stories brimming with the relatable wit and humor found in her cookbooks and her bestselling love story, The Pioneer Woman: Black Heels to Tractor Wheels.A celebration of motherhood, family, love, and laughter, Frontier Follies is a keepsake to treasure and share with the wonderful women in your life

    Since then he’s covered more than a million miles as a mover, packing, loading, hauling people’s belongings all over America. In The Long Haul, Murphy recounts with wit, candor, and charm the America he has seen change over the decades and the poignant, funny, and often haunting stories of the people he encounters on the job.

    I wasn’t submissive or begging him to come back, I was kicking his ass, kicking him out, kicking my own ass too. My Blondie character was an inflatable doll but with a dark, provocative, aggressive side. I was playing it up, yet I was very serious.’ BRAVE, BEAUTIFUL AND BORN TO BE PUNK DEBBIE HARRY is a musician, actor, activist and the iconic face of New York City cool. As the front-woman of Blondie, she and the band forged a new sound that brought together the worlds of rock, punk, disco, reggae and hip-hop to create some of the most beloved pop songs of all time. As a muse, she collaborated with some of the boldest artists of the past four decades. The scope of Debbie Harry’s impact on our culture has been matched only by her reticence to reveal her rich inner life – until now.In an arresting mix of visceral, soulful storytelling and stunning visuals that includes never-before-seen photographs, bespoke illustrations and fan art installations, Face It upends the standard music memoir while delivering a truly prismatic portrait. With all the grit, grime, and glory recounted in intimate detail, Face It recreates the downtown scene of 1970s New York City, where Blondie played alongside the Ramones, Television, Talking Heads, Iggy Pop and David Bowie.Following her path from glorious commercial success to heroin addiction, the near-death of partner Chris Stein, a heart-wrenching bankruptcy, and Blondie’s break-up as a band to her multifaceted acting career in more than thirty films, a stunning solo career and the triumphant return of her band, and her tireless advocacy for the environment and LGBTQ rights, Face It is a cinematic story of a woman who made her own path, and set the standard for a generation of artists who followed in her footsteps – a memoir as dynamic as its subject.

     Elinor Cleghorn became an unwell woman ten years ago. She was diagnosed with an autoimmune disease after a long period of being told her symptoms were anything from psychosomatic to a possible pregnancy. As Elinor learned to live with her unpredictable disease she turned to history for answers, and found an enraging legacy of suffering, mystification, and misdiagnosis.In Unwell Women, Elinor Cleghorn traces the almost unbelievable history of how medicine has failed women by treating their bodies as alien and other, often to perilous effect. The result is an authoritative and groundbreaking exploration of the relationship between women and medical practice, from the wandering womb of Ancient Greece to the rise of witch trials across Europe, and from the dawn of hysteria as a catchall for difficult-to-diagnose disorders to the first forays into autoimmunity and the shifting understanding of hormones, menstruation, menopause, and conditions like endometriosis.Packed with character studies and case histories of women who have suffered, challenged, and rewritten medical orthodoxy--and the men who controlled their fate--this is a revolutionary examination of the relationship between women, illness, and medicine. With these case histories, Elinor pays homage to the women who suffered so strides could be made, and shows how being unwell has become normalized in society and culture, where women have long been distrusted as reliable narrators of their own bodies and pain. But the time for real change is long overdue: answers reside in the body, in the testimonies of unwell women--and their lives depend on medicine learning to listen.

    Her pioneering reseach was praised in People and Vanity Fair and hailed on TV shows including Today, The O’Reilly Factor, and CBS’s The Talk. On New Year’s Eve, journalist and former Parade Editor-in-Chief Janice Kaplan makes a promise to be grateful and look on the bright side of whatever happens. She realizes that how she feels over the next months will have less to do with the events that occur than her own attitude and perspective. Getting advice at every turn from psychologists, academics, doctors, and philosophers, she brings readers on a smart and witty journey to discover the value of appreciating what you have. Relying on both amusing personal experiences and extensive research, Kaplan explores how gratitude can transform every aspect of life including marriage and friendship, money and ambition, and health and fitness. She learns how appreciating your spouse changes the neurons of your brain and why saying thanks helps CEOs succeed. Through extensive interviews with experts and lively conversations with real people including celebrities like Matt Damon, Daniel Craig, and Jerry Seinfeld, Kaplan discovers the role of gratitude in everything from our sense of fulfillment to our children’s happiness.   With warmth, humor, and appealing insight, Janice’s journey will empower readers to think positively and start living their own best year ever.

    Yet somehow, this normal boy became one of the youngest people on whom Dr. Walter Freeman performed his barbaric transorbital—or ice pick—lobotomy.Abandoned by his family within a year of the surgery, Howard spent his teen years in mental institutions, his twenties in jail, and his thirties in a bottle. It wasn’t until he was in his forties that Howard began to pull his life together. But even as he began to live the “normal” life he had been denied, Howard struggled with one question: Why?“October 8, 1960. I gather that Mrs. Dully is perpetually talking, admonishing, correcting, and getting worked up into a spasm, whereas her husband is impatient, explosive, rather brutal, won’t let the boy speak for himself, and calls him numbskull, dimwit, and other uncomplimentary names.”There were only three people who would know the truth: Freeman, the man who performed the procedure; Lou, his cold and demanding stepmother who brought Howard to the doctor’s attention; and his father, Rodney. Of the three, only Rodney, the man who hadn’t intervened on his son’s behalf, was still living. Time was running out. Stable and happy for the first time in decades, Howard began to search for answers. “December 3, 1960. Mr. and Mrs. Dully have apparently decided to have Howard operated on. I suggested [they] not tell Howard anything about it.”Through his research, Howard met other lobotomy patients and their families, talked with one of Freeman’s sons about his father’s controversial life’s work, and confronted Rodney about his complicity. And, in the archive where the doctor’s files are stored, he finally came face to face with the truth.Revealing what happened to a child no one—not his father, not the medical community, not the state—was willing to protect, My Lobotomy exposes a shameful chapter in the history of the treatment of mental illness. Yet, ultimately, this is a powerful and moving chronicle of the life of one man. Without reticence, Howard Dully shares the story of a painfully dysfunctional childhood, a misspent youth, his struggle to claim the life that was taken from him, and his redemption.

    Joan Didion explores an intensely personal yet universal experience: a portrait of a marriage–and a life, in good times and bad–that will speak to anyone who has ever loved a husband or wife or child.Several days before Christmas 2003, John Gregory Dunne and Joan Didion saw their only daughter, Quintana, fall ill with what seemed at first flu, then pneumonia, then complete septic shock. She was put into an induced coma and placed on life support. Days later–the night before New Year's Eve–the Dunnes were just sitting down to dinner after visiting the hospital when John Gregory Dunne suffered a massive and fatal coronary. In a second, this close, symbiotic partnership of forty years was over. Four weeks later, their daughter pulled through. Two months after that, arriving at LAX, she collapsed and underwent six hours of brain surgery at UCLA Medical Center to relieve a massive hematoma.This powerful book is Didion's attempt to make sense of the "weeks and then months that cut loose any fixed idea I ever had about death, about illness . . . about marriage and children and memory . . . about the shallowness of sanity, about life itself."

    Instead, she discovered she’d been granted an invaluable chance to witness firsthand what she calls the “spiritual work of dying”—the work of finding or making meaning of one’s life, the experiences it’s contained and the people who have touched it, the betrayals, wounds, unfinished business, and unrealized dreams. Instead of talking, she mainly listened: to stories of hope and regret, shame and pride, mystery and revelation and secrets held too long. Most of all, though, she listened as her patients talked about love—love for their children and partners and friends; love they didn’t know how to offer; love they gave unconditionally; love they, sometimes belatedly, learned to grant themselves. This isn’t a book about dying—it’s a book about living. And Egan isn’t just passively bearing witness to these stories. An emergency procedure during the birth of her first child left her physically whole but emotionally and spiritually adrift. Her work as a hospice chaplain healed her, from a brokenness she came to see we all share. Each of her patients taught her something—how to find courage in the face of fear or the strength to make amends; how to be profoundly compassionate and fiercely empathetic; how to see the world in grays instead of black and white. In this poignant, moving, and beautiful book, she passes along all their precious and necessary gifts.

    The #1 "New York Times" Bestselling Author of "A Man Called Ove" shares an irresistible and moving collection of heartfelt, humorous essays about fatherhood, providing his newborn son with the perspective and tools he'll need to make his way in the world.

    From that day forward his life became a hell of uncontrollable tics, urges, and involuntary utterances. Eventually he is diagnosed with Tourette's Syndrome and Obsessive Compulsive disorder, and Cory embarks on an excruciating journey from specialist to specialist, enduring countless combinations of medications in wildly varying doses. Soon it becomes unclear what tics are symptoms of his disease and what are side effects of the drugs. The only certainty is that it kept getting worse. Despite his lack of control, Cory is aware of every embarrassing movement, and sensitive to every person's reaction to his often aggravating presence. Simply put: Cory Friedman's life is a living hell.Against Medical Advice is the true story of one family's decades-long battle for survival in the face of extraordinary difficulties and a rigid medical establishment.

    Le Guin, and with an introduction by Karen Joy Fowler, a collection of thoughts—always adroit, often acerbic—on aging, belief, the state of literature, and the state of the nation.Ursula K. Le Guin has taken readers to imaginary worlds for decades. Now she’s in the last great frontier of life, old age, and exploring new literary territory: the blog, a forum where her voice—sharp, witty, as compassionate as it is critical—shines. No Time to Spare collects the best of Ursula’s blog, presenting perfectly crystallized dispatches on what matters to her now, her concerns with this world, and her wonder at it.   On the absurdity of denying your age, she says, If I’m ninety and believe I’m forty-five, I’m headed for a very bad time trying to get out of the bathtub. On cultural perceptions of fantasy: The direction of escape is toward freedom. So what is ‘escapism’ an accusation of? On her new cat: He still won’t sit on a lap…I don’t know if he ever will. He just doesn’t accept the lap hypothesis. On breakfast: Eating an egg from the shell takes not only practice, but resolution, even courage, possibly willingness to commit crime. And on all that is unknown, all that we discover as we muddle through life: How rich we are in knowledge, and in all that lies around us yet to learn. Billionaires, all of us.

    A right wing survivalist amasses a cache of weapons and resists calls to surrender. A drug trafficker barricades himself and his family in a railroad car, and begins shooting. A cult leader in Waco, Texas faces the FBI in an armed stand-off that leaves many dead in a fiery blaze. A sniper, claiming to be God, terrorizes the DC metropolitan area. For most of us, these are events we hear about on the news. For Gary Noesner, head of the FBI’s groundbreaking Crisis Negotiation Unit, it was just another day on the job. In Stalling for Time, Noesner takes readers on a heart-pounding tour through many of the most famous hostage crises of the past thirty years. Specially trained in non-violent confrontation and communication techniques, Noesner’s unit successfully defused many potentially volatile standoffs, but perhaps their most hard-won victory was earning the recognition and respect of their law enforcement peers.Noesner pursued his dream of joining the FBI all the way to Quantico, where he not only became a Special Agent, but also—in the course of a distinguished thirty-year career—the FBI’s Chief Negotiator. Gaining respect for the fledgling art of crisis negotiation in the hard-boiled culture of The Bureau, where the shadow of J. Edgar Hoover still loomed large, was an uphill battle, educating FBI and law enforcement leaders on the job at an incident, and advocating the use of psychology rather than force whenever possible. Noesner’s many bloodless victories rarely garnered as much media attention as the notorious incident management blunders like the Branch Davidian disaster in Waco and the Ruby Ridge tragedy.Noesner offers a candid as well as fascinating look back at his years as a rebel in the ranks and a pioneer on the front lines. Whether vividly recounting showdowns with the radical Republic of Texas militia, the terrorist hijackers of the cruise ship Achille Lauro, and self-styled messiah David Koresh, or clashes with colleagues and superiors that expose the internal politics and power-plays of America’s premier law enforcement agency, Stalling for Time crackles with breathtaking suspense and insight in equal measure. Case by case, minute by minute, it’s a behind the scenes view of a visionary crime-fighter in action.

    Now Pollan turns his sharp insight to the craft of building, as he recounts the process of designing and constructing a small one-room structure on his rural Connecticut property--a place in which he hoped to read, write and daydream, built with his two own unhandy hands.Invoking the titans of architecture, literature and philosophy, from Vitrivius to Thoreau, from the Chinese masters of feng shui to the revolutionary Frank Lloyd Wright, Pollan brilliantly chronicles a realm of blueprints, joints and trusses as he peers into the ephemeral nature of "houseness" itself. From the spark of an idea to the search for a perfect site to the raising of a ridgepole, Pollan revels in the infinitely detailed, complex process of creating a finished structure. At once superbly written, informative and enormously entertaining, A Place of My Own is for anyone who has ever wondered how the walls around us take shape--and how we might shape them ourselves.A Place of My Own recounts his two-and-a-half-year journey of discovery in an absorbing narrative that deftly weaves the day-to-day work of design and building--from siting to blueprint, from the pouring of foundations to finish carpentry--with reflections on everything form the power of place to shape our lives to the question of what constitutes "real work" in a technological society.A book about craft that is itself beautifully crafted, linking the world of the body and material things with the realm of mind, heart, and spirit, A Place of My Own has received extraordinary praise.