Can a person think herself to orgasm? Why doesn't Viagra help women-or, for that matter, pandas? Can a dead man get an erection? Is vaginal orgasm a myth? Mary Roach shows us how and why sexual arousal and orgasm-two of the most complex, delightful, and amazing scientific phenomena on earth-can be so hard to achieve and what science is doing to make the bedroom a more satisfying place.

    Siegel has carved out a special niche in this area, having devoted his research, teaching and clinical and forensic career as a neuropsychiatrist to studying the phenomenon and trying to fathom the relationship of it to what is happening in the brain. No passive observer, he is himself an experienced ``psychonaut.'' Siegel presents 17 case studies, grouped under the headings of ``visionary drugs,'' ``dreams,'' ``imaginary companions,'' and ``life-threatening danger.''

    Kids typically no longer expect their lives to be better than their parents’ were. Dystopian scenarios loom ever larger in public consciousness as fisheries collapse, CO2 levels rise, and clouds of radioactive steam billow from “fail-safe” nuclear plants that failed. Despite the technological marvels of our age—or perhaps because of them—these are dark days.As comedian Louis C.K. put it, “Everything’s amazing, but nobody’s happy.”Even for the most fortunate among us, material abundance comes at a very high price. Facebook is a hollow replacement for face time. We produce more food than ever, but hunger and malnutrition are standard in most of the world while the rest of us stuff ourselves quite literally to death. Despair darkens ever more lives as rates of clinical depression and suicide continue their grim climb in the developed world. A third of all American children are obese or seriously overweight, and fifty four million of us are pre-diabetic. Pre-schoolers represent the fastest-growing market for anti-depressants, while the rate of increase of depression among children is over twenty percent, according to a recent Harvard study. Twenty four million American adults are thought to suffer from Post-Traumatic Stress Disorder—mostly attributable to the never-ending wars that have become part of modern life for the swelling underclass with few other employment opportunities.It’s common to wonder how an anthropologist from Mars would view our world or what sage advice an emissary from the future would bring back. But how would a time-traveler from our prehistoric past assess the lives we lead and the future prospects for the path we’re on? Such a visitor from 200 centuries ago would no doubt be impressed by much of what she found here. But once her amazement at iPhones, air travel, and liver transplants subsided, what would she make of our daily lives? Would she ultimately be more impressed by our advances or dismayed by what we’ve lost in our always accelerating rush toward the future?With faith in the future melting like an overheated glacier even as contentment with the present evaporates, it’s high time for a sober reassessment of the past. Ten thousand years since turning from the ancient path our ancestors trod forever, it’s time for a scientifically-informed, multidisciplinary look at the effects of this fateful divergence. It’s time to ask what may be the most subversive question of all: Are modern humans, even the most fortunate among us, living significantly better lives than our pre-civilized ancestors? Taken as a whole, is civilization a net gain for individual human beings?

    In this riveting investigative narrative, McKenna dives deep into the world of modern agriculture by way of chicken: from the farm where it's raised directly to your dinner table. Consumed more than any other meat in the United States, chicken is emblematic of today's mass food-processing practices and their profound influence on our lives and health. Tracing its meteoric rise from scarce treat to ubiquitous global commodity, McKenna reveals the astounding role of antibiotics in industrial farming, documenting how and why "wonder drugs" revolutionized the way the world eats--and not necessarily for the better. Rich with scientific, historical, and cultural insights, this spellbinding cautionary tale shines a light on one of America's favorite foods--and shows us the way to safer, healthier eating for ourselves and our children.

     Early studies of the functions of the human brain used a simple method: wait for misfortune to strike-strokes, seizures, infectious diseases, lobotomies, horrendous accidents-and see how the victim coped. In many cases survival was miraculous, and observers could only marvel at the transformations that took place afterward, altering victims' personalities. An injury to one section can leave a person unable to recognize loved ones; some brain trauma can even make you a pathological gambler, pedophile, or liar. But a few scientists realized that these injuries were an opportunity for studying brain function at its extremes. With lucid explanations and incisive wit, Sam Kean explains the brain's secret passageways while recounting forgotten stories of common people whose struggles, resiliency, and deep humanity made modern neuroscience possible.

    Tracing our culinary customs from the Stone Age to the stovetop range, he illuminates our complex and often contradictory eating habits, and suggests that perhaps we are what we eat.

    For every one of the cells that make up the vessel that you call your body, there are nine impostor cells hitching a ride. You are not just flesh and blood, muscle and bone, brain and skin, but also bacteria and fungi. Over your lifetime, you will carry the equivalent weight of five African elephants in microbes. You are not an individual but a colony.Until recently, we had thought our microbes hardly mattered, but science is revealing a different story, one in which microbes run our bodies and becoming a healthy human is impossible without them.In this riveting, shocking, and beautifully written book, biologist Alanna Collen draws on the latest scientific research to show how our personal colony of microbes influences our weight, our immune system, our mental health, and even our choice of partner. She argues that so many of our modern diseases—obesity, autism, mental illness, digestive disorders, allergies, autoimmunity afflictions, and even cancer—have their root in our failure to cherish our most fundamental and enduring relationship: that with our personal colony of microbes.Many of the questions about modern diseases left unanswered by the Human Genome Project are illuminated by this new science. And the good news is that unlike our human cells, we can change our microbes for the better. Collen's book is a revelatory and indispensable guide. It is science writing at its most relevant: life—and your body—will never seem the same again.

    The outcome was unexpected—when Henry awoke, he could no longer form new memories, and for the rest of his life would be trapped in the moment. But Henry’s tragedy would prove a gift to humanity. As renowned neuroscientist Suzanne Corkin explains in Permanent Present Tense, she and her colleagues brought to light the sharp contrast between Henry’s crippling memory impairment and his preserved intellect. This new insight that the capacity for remembering is housed in a specific brain area revolutionized the science of memory. The case of Henry—known only by his initials H. M. until his death in 2008—stands as one of the most consequential and widely referenced in the spiraling field of neuroscience. Corkin and her collaborators worked closely with Henry for nearly fifty years, and in Permanent Present Tense she tells the incredible story of the life and legacy of this intelligent, quiet, and remarkably good-humored man. Henry never remembered Corkin from one meeting to the next and had only a dim conception of the importance of the work they were doing together, yet he was consistently happy to see her and always willing to participate in her research. His case afforded untold advances in the study of memory, including the discovery that even profound amnesia spares some kinds of learning, and that different memory processes are localized to separate circuits in the human brain. Henry taught us that learning can occur without conscious awareness, that short-term and long-term memory are distinct capacities, and that the effects of aging-related disease are detectable in an already damaged brain.Undergirded by rich details about the functions of the human brain, Permanent Present Tense pulls back the curtain on the man whose misfortune propelled a half-century of exciting research. With great clarity, sensitivity, and grace, Corkin brings readers to the cutting edge of neuroscience in this deeply felt elegy for her patient and friend.

    

    But in the inevitable condition of aging and death, the goals of medicine seem too frequently to run counter to the interest of the human spirit. Nursing homes, preoccupied with safety, pin patients into railed beds and wheelchairs. Hospitals isolate the dying, checking for vital signs long after the goals of cure have become moot. Doctors, committed to extending life, continue to carry out devastating procedures that in the end extend suffering.Gawande, a practicing surgeon, addresses his profession's ultimate limitation, arguing that quality of life is the desired goal for patients and families. Gawande offers examples of freer, more socially fulfilling models for assisting the infirm and dependent elderly, and he explores the varieties of hospice care to demonstrate that a person's last weeks or months may be rich and dignified.

    What's the prescription for success? National Geographic Explorer Dan Buettner has traveled the globe to uncover the best strategies for longevity found in the Blue Zones: places in the world where higher percentages of people enjoy remarkably long, full lives. And in this dynamic book he discloses the recipe, blending this unique lifestyle formula with the latest scientific findings to inspire easy, lasting change that may add years to your life.Buettner's colossal research effort, funded in part by the National Institute on Aging, has taken him from Costa Rica to Italy to Japan and beyond. In the societies he visits, it's no coincidence that the way people interact with each other, shed stress, nourish their bodies, and view their world yields more good years of life. You'll meet a 94-year-old farmer and self-confessed "ladies man" in Costa Rica, an 102-year-old grandmother in Okinawa, a 102-year-old Sardinian who hikes at least six miles a day, and others. By observing their lifestyles, Buettner's teams have identified critical everyday choices that correspond with the cutting edge of longevity research-and distilled them into a few simple but powerful habits that anyone can embrace.

    Your body fights to keep you within a range of about 15 pounds -- also known as your "setpoint weight." New research reveals that you can lower your setpoint and end that battle for good by focusing on the quality of calories you eat, not the quantity. With The Setpoint Diet, you will reprogram your body with a 21-day plan to rev up your metabolism, eliminate inflammation, heal your hormones, repair your gut, and get your body working like that of a naturally thin person -- permanently. The Setpoint Diet is a lower-carb menu that focuses on specific anti-inflammatory whole foods, including tons of produce, nutritious proteins, and therapeutic fats. Its creator, Jonathan Bailor, founded SANESolution, a weight loss company that has reached millions of people. Proven to help you lose weight naturally and maintain it, The SetpointDiet is your new blueprint for healthy living.

    A hunting and gathering people who made a good living by working only as much as needed to exist in harmony with their hostile desert environment, the Bushmen have lived in southern Africa since the evolution of our species nearly two hundred thousand years ago.In Affluence Without Abundance, anthropologist James Suzman asks whether understanding how hunter-gatherers like the Bushmen found contentment by having few needs easily met might help us address some of the environmental and economic challenges we face today. Vividly bringing to life a proud and private people, introducing unforgettable members of their tribe, Affluence Without Abundance tells the story of the collision between the modern global economy and the oldest hunting and gathering society on earth. In rendering an intimate picture of a people coping with radical change, it asks profound questions about how we now think about matters such as work, wealth, equality, contentment, and even time.Not since Elizabeth Marshall Thomas's The Harmless People in 1959 has anyone provided a more intimate or insightful account of the Bushmen or of what we might learn about ourselves from our shared history as hunter-gatherers.

     It is a remarkable portrait, too, of the life of a psychiatric asylum--the sort of community in which, for better and for worse, hundreds of thousands of people lived out their lives.More than four hundred abandoned suitcases filled with patients’ belongings were found when Willard Psychiatric Center closed in 1995 after 125 years of operation. They are skillfully examined here and compared to the written record to create a moving—and devastating—group portrait of twentieth-century American psychiatric care.

    From blurry vision, to crooked teeth, ACLs that tear at alarming rates and spines that seem to spend a lifetime falling apart, it's a curious thing that human beings have beaten the odds as a species. After all, we're the only survivors on our branch of the tree of life. Why is it that human mothers have such a life-endangering experience giving birth? And why are there entire medical specialties for teeth and feet? In this funny, wide-ranging and often surprising book, biologist Alex Bezzerides tells us just where we inherited our adaptable, achy, brilliant bodies in the process of evolution.The book traces the delightfully unexpected answers to these questions and many more:Why do we blink?Why don't our teeth regularly fit in our mouths?Why do women menstruate when so many other mammals don't?Why did humans stand up on two legs in the first place?