But why are they on the rise?     Science writer Moises Velasquez-Manoff offers a new and controversial way of thinking about autoimmune disease—one that may foster a paradigm shift in the way we think about health and hygiene.     In the early twentieth century, the dawn of improved hygiene, water treatment, vaccines, and antibiotics saved countless lives, eradicating diseases that had plagued humanity for millennia. But in the wake of this triumph, a new threat arose: The human immune system began to malfunction.     A growing body of evidence suggests that the very steps we took to cure these maladies have also eradicated organisms that once kept our bodies in balance. To combat this “epidemic of absence,” a group of scientists has begun deliberately reintroducing parasitic worms—helminthes—to calm the immune system of their hosts. This book takes a close look at the scientists at the vanguard of “worm therapy,” which has been proven to not only preempt immune malfunction, but to send a number of disorders—from Crohn’s Disease to multiple sclerosis to asthma—into remission.     Exploring the greater context of rampant immune system dysfunction in the developed world, and its implications for developing countries, Velasquez-Manoff offers an eye-opening and elegant portrait of science’s new view of the human organism.

    . . a book that enriches our understanding of how the struggle to think new thoughts is shared across time and space and people.”—The Sunday Telegraph (London)Christmas, 1859. Just one month after the publication of On the Origin of Species, Charles Darwin received an unsettling letter. He had expected criticism; in fact, letters were arriving daily, most expressing outrage and accusations of heresy. But this letter was different. It accused him of failing to acknowledge his predecessors, of taking credit for a theory that had already been discovered by others. Darwin realized that he had made an error in omitting from Origin of Species any mention of his intellectual forebears. Yet when he tried to trace all of the natural philosophers who had laid the groundwork for his theory, he found that history had already forgotten many of them.Darwin’s Ghosts tells the story of the collective discovery of evolution, from Aristotle, walking the shores of Lesbos with his pupils, to Al-Jahiz, an Arab writer in the first century, from Leonardo da Vinci, searching for fossils in the mine shafts of the Tuscan hills, to Denis Diderot in Paris, exploring the origins of species while under the surveillance of the secret police, and the brilliant naturalists of the Jardin de Plantes, finding evidence for evolutionary change in the natural history collections stolen during the Napoleonic wars. Evolution was not discovered single-handedly, Rebecca Stott argues, contrary to what has become standard lore, but is an idea that emerged over many centuries, advanced by daring individuals across the globe who had the imagination to speculate on nature’s extraordinary ways, and who had the courage to articulate such speculations at a time when to do so was often considered heresy.With each chapter focusing on an early evolutionary thinker, Darwin’s Ghosts is a fascinating account of a diverse group of individuals who, despite the very real dangers of challenging a system in which everything was presumed to have been created perfectly by God, felt compelled to understand where we came from. Ultimately, Stott demonstrates, ideas—including evolution itself—evolve just as animals and plants do, by intermingling, toppling weaker notions, and developing over stretches of time. Darwin’s Ghosts presents a groundbreaking new theory of an idea that has changed our very understanding of who we are.

    For all of neuroscience's advances, we've made little progress on its biggest question: How do simple cells in the brain create intelligence? Jeff Hawkins and his team discovered that the brain uses maplike structures to build a model of the world-not just one model, but hundreds of thousands of models of everything we know. This discovery allows Hawkins to answer important questions about how we perceive the world, why we have a sense of self, and the origin of high-level thought.

    Drawing on recent scientific breakthroughs and the current cross-pollination among geology, biology, astrophysics, and cosmology, Origins explains the soul-stirring leaps in our understanding of the cosmos. From the first image of a galaxy birth to Spirit Rover's exploration of Mars, to the discovery of water on one of Jupiter's moons, coauthors Neil deGrasse Tyson and Donald Goldsmith conduct a galvanizing tour of the cosmos with clarity and exuberance.

    An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

    At the time, Watson was only 24, a young scientist hungry to make his mark. His uncompromisingly honest account of the heady days of their thrilling sprint against other world-class researchers to solve one of science's greatest mysteries gives a dazzlingly clear picture of a world of brilliant scientists with great gifts, very human ambitions & bitter rivalries. With humility unspoiled by false modesty, Watson relates his & Crick's desperate efforts to beat Linus Pauling to the Holy Grail of life sciences, the identification of the basic building block of life. Never has a scientist been so truthful in capturing in words the flavor of his work.

    November 2015 is the 100th anniversary of Einstein’s discovery of the General Theory of Relativity.Levenson, head of MIT’s Science Writing Program, tells the captivating, unusual, and nearly-forgotten backstory behind Einstein’s invention of the Theory of Relativity, which completely changed the course of science forever. For over 50 years before Einstein developed his theory, the world’s top astronomers spent countless hours and energy searching for a planet, which came to be named Vulcan, that had to exist, it was thought, given Isaac Newton’s theories of gravity. Indeed, in the two centuries since Newton’s death, his theory had essentially become accepted as fact. It took Einstein’s genius to realize the mystery of the missing planet wasn’t a problem of measurements or math but of Newton’s theory of gravity itself. Einstein’s Theory of Relativity proved that Vulcan did not and could not exist, and that the decades-long search for it had merely been a quirk of operating under the wrong set of assumptions about the universe. Thomas Levenson tells this unique story, one of the strangest episodes in the history of science, with elegant simplicity, fast-paced drama, and lively characters sure to capture the attention of a wide group of readers.

    As gripping as CSI and as eye-opening as Mary Roach’s Stiff, Carney’s The Red Market sheds a blazing new light on the disturbing, billion-dollar business of trading in human body parts, bodies, and child trafficking, raising issues and exposing corruptions almost too bizarre and shocking to imagine.

    It’s a fly-on-the-wall account of the titanic fight to pass a 961-page law aimed at fixing America’s largest, most dysfunctional industry. It’s a penetrating chronicle of how the profiteering that Brill first identified in his trailblazing Time magazine cover story continues, despite Obamacare. And it is the first complete, inside account of how President Obama persevered to push through the law, but then failed to deal with the staff incompetence and turf wars that crippled its implementation.   But by chance America’s Bitter Pill ends up being much more—because as Brill was completing this book, he had to undergo urgent open-heart surgery. Thus, this also becomes the story of how one patient who thinks he knows everything about healthcare “policy” rethinks it from a hospital gurney—and combines that insight with his brilliant reporting. The result: a surprising new vision of how we can fix American healthcare so that it stops draining the bank accounts of our families and our businesses, and the federal treasury. Praise for America’s Bitter Pill   “A tour de force . . . a comprehensive and suitably furious guide to the political landscape of American healthcare . . . persuasive, shocking.”—The New York Times   “An energetic, picaresque, narrative explanation of much of what has happened in the last seven years of health policy . . . [Brill] has pulled off something extraordinary.” —The New York Times Book Review   “A thunderous indictment of what Brill refers to as the ‘toxicity of our profiteer-dominated healthcare system.’ ”—Los Angeles Times  “A sweeping and spirited new book [that] chronicles the surprisingly juicy tale of reform.”—The Daily Beast  “One of the most important books of our time.”—Walter Isaacson   “Superb . . . Brill has achieved the seemingly impossible—written an exciting book about the American health system.”—The New York Review of Books

    F. Skinner and the legend of a child raised in a box, Slater takes us from a deep empathy with Stanley Milgram's obedience subjects to a funny and disturbing re-creation of an experiment questioning the validity of psychiatric diagnosis. Previously described only in academic journals and textbooks, these often daring experiments have never before been narrated as stories, chock-full of plot, wit, personality, and theme.

    In this selection from The Body, Bill Bryson introduces us to the mysterious, and often devastating, world of disease.

    Why is glass see-through? What makes elastic stretchy? Why does a paper clip bend? Why does any material look and behave the way it does? These are the sorts of questions that Mark Miodownik a globally-renowned materials scientist has spent his life exploring In this book he examines the materials he encounters in a typical morning, from the steel in his razor and the graphite in his pencil to the foam in his sneakers and the concrete in a nearby skyscraper.

    The epidemics of obesity, heart disease, and diabetes are not tied to the overabundance of fat or carbs or any other specific nutrient. Instead, we have been led astray by the growing divide between flavor - the tastes we crave - and the underlying nutrition. Since the late 1940s, we have been slowly leeching flavor out of the food we grow. Those perfectly round, red tomatoes that grace our supermarket aisles today are mostly water, and the big breasted chickens on our dinner plates grow three times faster than they used to, leaving them dry and tasteless. Simultaneously, we have taken great leaps forward in technology, allowing us to produce in the lab the very flavors that are being lost on the farm. Thanks to this largely invisible epidemic, seemingly healthy food is becoming more like junk food: highly craveable but nutritionally empty. We have unknowingly interfered with an ancient chemical language - flavor - that evolved to guide our nutrition, not destroy it.With in-depth historical and scientific research, The Dorito Effect casts the food crisis in a fascinating new light, weaving an enthralling tale of how we got to this point and where we are headed. We've been telling ourselves that our addiction to flavor is the problem, but it is actually the solution. We are on the cusp of a new revolution in agriculture that will allow us to eat healthier and live longer by enjoying flavor the way nature intended.

    A defiant atheist, Chapman is confronted not only by the fundamentalist beliefs that continue to banish the theory of evolution but by his own spiritual malaise as the outward journey becomes an inward quest, a tragicomic "accidental memoir"."First there was Charles Darwin, two yards long and nobody's fool. Then there was his son, my great-grandfather, Sir Francis Darwin, an eminent botanist. Then came my grandmother Frances, a modest poet who spent a considerable amount of time in rest-homes for depression From her issued my beloved mother, Clare, who was extremely short, failed to complete medical school, and eventually became an alcoholic. Then we get down to me. I'm in the movie business."Trials of the Monkey combines travel writing and reportage, as Chapman records his encounters in the South, with history and the accidental memoir of a man full of mid-life doubts in a genre-breaking first book that is darkly funny, provocative and poignant.

    When temperatures drop below 56°F, tin crumbles into powder. Were the soldiers of the Grande Armée acutee fatally weakened by cold because the buttons of their uniforms fell apart? How different our world might be if tin did not disintegrate at low temperatures and the French had continued their eastward expansion! This fascinating book tells the stories of seventeen molecules that, like the tin of those buttons, greatly influenced the course of history. These molecules provided the impetus for early exploration and made possible the ensuing voyages of discovery. They resulted in grand feats of engineering and spurred advances in medicine; lie behind changes in gender roles, in law, and in the environment; and have determined what we today eat, drink, and wear. Showing how a change as small as the position of an atom can lead to enormous differences in the properties of a substance, the authors reveal the astonishing chemical connections among seemingly unrelated events. Napoleon's Buttons offers a novel way to understand how our contemporary world works and how our civilization has been shaped over time.