Watson, the Nobel laureate whose pioneering work helped unlock the mystery of DNA's structure, charts the greatest scientific journey of our time, from the discovery of the double helix to today's controversies to what the future may hold. Updated to include new findings in gene editing, epigenetics, agricultural chemistry, as well as two entirely new chapters on personal genomics and cancer research. This is the most comprehensive and authoritative exploration of DNA's impact--practical, social, and ethical--on our society and our world.

    Prusiner received a Nobel Prize, the world's most prestigious award for achievement in physiology or medicine. That he was the sole recipient of the award for the year was entirely appropriate, for his struggle to identify the agent responsible for ravaging the brains of animals suffering from scrapie and mad cow disease, and of humans with Creutzfeldt-Jakob disease, had been waged largely alone and in some cases in the face of strenuous disagreement.   In this book, Prusiner tells the remarkable story of his discovery of prions—infectious proteins that replicate and cause disease but surprisingly contain no genetic material—and reveals how superb and meticulous science is actually practiced using talented teams of researchers who persevere. He recounts the frustrations and rewards of years of research and offers fascinating portraits of his peers as they raced to discover the causes of fatal brain diseases. Prusiner’s hypothesis, once considered heresy, now stands as accepted science and the basis for developing diagnoses and eventual cures. He closes with a meditation on the legacy of his discovery: What will it take to cure Alzheimer’s, Parkinson’s, Lou Gehrig’s and other devastating diseases of the brain?

    Cavalli-Sforza and others have answered this question—anticipated by Darwin—with a decisive yes. Genes, Peoples, and Languages comprises five lectures that serve as a summation of the author's work over several decades, the goal of which has been nothing less than tracking the past hundred thousand years of human evolution.Cavalli-Sforza raises questions that have serious political, social, and scientific import: When and where did we evolve? How have human societies spread across the continents? How have cultural innovations affected the growth and spread of populations? What is the connection between genes and languages? Always provocative and often astonishing, Cavalli-Sforza explains why there is no genetic basis for racial classification.

    This is the dream of Richard Ridley, founder of Manifold Genetics, and he has just discovered the key to eternal life: an ancient artifact buried beneath a Greek-inscribed stone in the Peruvian desert.When Manifold steals the artifact and abducts archaeologist Dr. George Pierce, United States Special Forces Delta operator Jack Sigler, call sign King, and his “Chess Team” —Queen, Knight, Rook, Bishop, and their handler, Deep Blue—give chase. Formed under special order from President Duncan, they are the best of America’s Special Forces, tasked with antiterrorism missions that take them around the world against any threat, ancient, modern, and at times, inhuman. With cutting-edge weapons, tough-as-nails tactics, and keen intellects, they stand alone on the brink, facing the world’s most dangerous threats.Ridley’s plan to create unstoppable soldiers has just made him threat number one. Tension soars along with the body count as the team faces high-tech security forces, hordes of “regens,” the horrific results of Manifold’s experiments, and a resurrected mythological predator complete with regenerative abilities, seven heads, and a savage appetite. The Chess Team races to save Pierce and stop Manifold before they change the face of genetics—and human history—forever.Heart-pounding action combines with adrenaline-charged suspense in the first of Jeremy Robinson’s smart, sharp series featuring the Chess Team.

    Explaining the nature of genetic variation in the human population, how hereditary factors were identified as molecules of DNA, and how certain specific mutations can lead to disease, Slack highlights how DNA variants are used to trace human ancestry and migration, and can also be used by forensic scientists to identify individuals in crime. Slack also explores issues such as the role of genetic heritability and IQ as well as the changes that occur in the genes of populations during evolution. An ideal guide for anyone curious about what genes are and how genetics can be put to use, this Very Short Introduction demonstrates the ways in which the gene concept has been understood and used by molecular biologists, population biologists, and social scientists around the world. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

    Is it in our genes? The structure of our brains? Our genome may determine our eye color and even aspects of our personality. But our friendships, failures, and passions also shape who we are. The question is: how?Sebastian Seung, a dynamic professor at MIT, is on a quest to discover the biological basis of identity. He believes it lies in the pattern of connections between the brain’s neurons, which change slowly over time as we learn and grow. The connectome, as it’s called, is where our genetic inheritance intersects with our life experience. It’s where nature meets nurture.Seung introduces us to the dedicated researchers who are mapping the brain’s connections, neuron by neuron, synapse by synapse. It is a monumental undertaking—the scientific equivalent of climbing Mount Everest—but if they succeed, it could reveal the basis of personality, intelligence, memory, and perhaps even mental disorders. Many scientists speculate that people with anorexia, autism, and schizophrenia are "wired differently," but nobody knows for sure. The brain’s wiring has never been clearly seen.In sparklingly clear prose, Seung reveals the amazing technological advances that will soon help us map connectomes. He also examines the evidence that these maps will someday allow humans to "upload" their minds into computers, achieving a kind of immortality.Connectome is a mind-bending adventure story, told with great passion and authority. It presents a daring scientific and technological vision for at last understanding what makes us who we are. Welcome to the future of neuroscience.

    Twenty-one-year-old Laura Rothenberg has always tried to live a normal life--even with lungs that betray her, and a sober awareness that she may not live to see her next birthday. Like most people born with cystic fibrosis, the chronic disease that affects lungs and other organs, Rothenberg struggles to come to grips with a life that has already been compromised in many ways. Sometimes healthy and able to go to school, other times hospitalized for months on end, Rothenberg finds solace in keeping a diary. In her writing, she can be open, honest, and irreverent, like the young person she is. Yet mixed in with this voice is an incredible maturity about her mortality. The memoir opens with Rothenberg's decision to accept a lung transplant. From the waiting--and all it implies to the surgery, recovery, and her new life, Rothenberg muses on mortality in journal entries and poetry. Through it all, she reveals a will and temperament that is strong and wise despite her years. Laura Rothenberg's story, recorded and shared on NPR's Radio Diaries, was awarded the prestigious Third Coast Audio Festival Award, it also received an unprecedented listener response and generated more e-mail than any other story the producers could recall. Rothenberg's story was also featured in the New York Times and U.S. News & World Report.

    John Lewis-Stempel succeeds in all these things triumphantly. From amorous toads to the eye-popping mating habits of water boatmen, a magical celebration of pond life by one of our finest, most evocative nature writers.' Daily MailPonds: small bodies of water, both naturally formed and artificial, home to wondrous, multitudinous life-forms. Ponds define our childhood: frogspawn, goldfish, feeding the ducks, but also our village life, our farms, our landscape. And they are multi-layered - from carp circling the bottom to water boatmen, coot, and birds dragonflies overhead. In Still Water, John immerses himself in the murky depths, both literarily and figuratively, to explore the still waters of the British countryside through each month of the year.

    He is wonderfully able to communicate the epic elements of the story – which matters because that’s precisely what man’s survival has been’ - David Robinson, The Scotsman‘I’ve been enjoyably immersed in it since it arrived on my doorstep last week...wonderfully readable. This is no dry, academic account, but it’s the most fascinating and thought-provoking treatment of interlocking aspects of our early history I’ve yet to read. I recommend it whole-heartedly’ - Colin Will, poet and publisher‘Alistair Moffat explores the history of where we all came from, with the help of new DNA science’ - BBC Radio Scotland‘In The Scots: A Genetic Journey, historian and broadcaster Alistair Moffat taps into the latest advances in DNA science to find that our origins lie not only deep in the mists of time, but right off the map... with the help of historical geneticist Jim Wilson, he finds that, post-Ice Age, Scotland's earliest settlers walked here from what is now Spain’ - Jim Gilchrist, Scotsman‘In The Scots: A Genetic Journey, Alistair Moffat and James F. Wilson explore the history that is printed in our genes, and in a remarkable new approach come to some fascinating conclusions about who we are and where we came from’ - The Orcadian‘The fusion of science and the physical history – like an abandoned croft – allows people to trace their Scots ancestry with precision’ - Sunday Herald‘The Scots: A Genetic Journey, a book and radio series based on Moffat and Wilson’s research, concludes that all Scots are immigrants by descent. Britain as a whole is a mongrel nation’ - Julian Baggini‘Skillfully written, weaving together genetics, archaeology, history, and topics of interest like red hair ‘ - James Honeychuck on AmazonHistory has always mattered to Scots, and rarely more so than now at the outset of a new century, with a new census appearing in 2011 and after more than ten years of a new parliament. An almost limitless archive of our history lies hidden inside our bodies and we carry the ancient story of Scotland around with us. The mushrooming of genetic studies, of DNA analysis, is rewriting our history in spectacular fashion. In The Scots: A Genetic Journey, Alistair Moffat explores the history that is printed on our genes, and in a remarkable new approach, uncovers the detail of where we are from, who we are and in so doing colour vividly a DNA map of Scotland.(less)

    Together–and with dire consequences–they bring back to the light something meant to be forgotten.A world away in London, an absent father, haunted by the voice of a banished angel, presents his daughter with an impossible friend–a clockwork ballerina.For two centuries, a bullet-removal specialist has wielded instruments of angel bone in service to a forgotten power . . . and now he vows to find someone else to shoulder the burden, someone with a conscience of their own, a strong mind, and a broken will. For a hundred years he has searched for the perfect contender, and now he has found two: a brother and a sister. Walter and Hope. Either will do.Last night something stepped from little Walter’s closet and he never woke up. Now he travels the dark road between worlds, no longer entirely boy nor wholly beast, but with one goal in mind: to prevent his sister from suffering the same fate as he. Only the creature he has become can save Hope. But is it too late to save himself?

    For this understandable reason, the idea has been banished from polite academic conversation. Arguing that race is more than just a social construct can get a scholar run out of town, or at least off campus, on a rail. Human evolution, the consensus view insists, ended in prehistory. Inconveniently, as Nicholas Wade argues in A Troublesome Inheritance, the consensus view cannot be right. And in fact, we know that populations have changed in the past few thousand years—to be lactose tolerant, for example, and to survive at high altitudes. Race is not a bright-line distinction; by definition it means that the more human populations are kept apart, the more they evolve their own distinct traits under the selective pressure known as Darwinian evolution. For many thousands of years, most human populations stayed where they were and grew distinct, not just in outward appearance but in deeper senses as well. Wade, the longtime journalist covering genetic advances for The New York Times, draws widely on the work of scientists who have made crucial breakthroughs in establishing the reality of recent human evolution. The most provocative claims in this book involve the genetic basis of human social habits. What we might call middle-class social traits—thrift, docility, nonviolence—have been slowly but surely inculcated genetically within agrarian societies, Wade argues. These “values” obviously had a strong cultural component, but Wade points to evidence that agrarian societies evolved away from hunter-gatherer societies in some crucial respects. Also controversial are his findings regarding the genetic basis of traits we associate with intelligence, such as literacy and numeracy, in certain ethnic populations, including the Chinese and Ashkenazi Jews. Wade believes deeply in the fundamental equality of all human peoples. He also believes that science is best served by pursuing the truth without fear, and if his mission to arrive at a coherent summa of what the new genetic science does and does not tell us about race and human history leads straight into a minefield, then so be it. This will not be the last word on the subject, but it will begin a powerful and overdue conversation.