Indeed, these tiny structures inside our cells are important beyond imagining. Without mitochondria, we would have no cell suicide, no sculpting of embryonic shape, no sexes, no menopause, no aging.In this fascinating and thought-provoking book, Nick Lane brings together the latest research in this exciting field to show how our growing insight into mitochondria has shed light on how complex life evolved, why sex arose (why don't we just bud?), and why we age and die. These findings are of fundamental importance, both in understanding life on Earth, but also in controlling our own illnesses, and delaying our degeneration and death. Readers learn that two billion years ago, mitochondria were probably bacteria living independent lives and that their capture within larger cells was a turning point in the evolution of life, enabling the development of complex organisms. Lane describes how mitochondria have their own DNA and that its genes mutate much faster than those in the nucleus. This high mutation rate lies behind our aging and certain congenital diseases. The latest research suggests that mitochondria play a key role in degenerative diseases such as cancer. We also discover that mitochondrial DNA is passed down almost exclusively via the female line. That's why it has been used by some researchers to trace human ancestry daughter-to-mother, to "Mitochondrial Eve," giving us vital information about our evolutionary history.Written by Nick Lane, a rising star in popular science, Power, Sex, Suicide is the first book for general readers on the nature and function of these tiny, yet fascinating structures.

    It also makes him enormously vulnerable. Eli lacks the innate skepticism that will help his peers navigate adolescence more safely—and vastly more successfully. Journalist Jennifer Latson follows Eli over three critical years of his life as his mother, Gayle, must decide whether to shield Eli entirely from the world and its dangers or give him the freedom to find his own way and become his own person. By intertwining Eli and Gayle’s story with the science and history of Williams syndrome, the book explores the genetic basis of behavior and the quirks of human nature. More than a case study of a rare disorder, however, The Boy Who Loved Too Much is a universal tale about the joys and struggles of raising a child, of growing up, and of being different.

    Far from inheriting the throne, the orphaned boy-king had to endure the hostility and abuse of a nation. Two years later, the revolutionary leaders declared the young Louis XVII dead, prompting rumors of murder. No grave was dug, no monument built to mark his passing. Soon thereafter, the theory circulated that the prince had in fact escaped from prison and was still alive. Others believed that he had been killed, his heart preserved as a relic. The quest for the truth continued into the twenty-first century when, thanks to DNA testing, a stolen heart found within the royal tombs brought an exciting conclusion to the two-hundred-year-old mystery.A fascinating blend of royalist plots, palace intrigue, and modern science, The Lost King of France is a moving and dramatic tale that interweaves a pivotal moment in France's history with a compelling detective story.

    Two years later, police found a boy abandoned outside a variety store in New Jersey. The FBI tracked down Dora Fronczak, the kidnapped infant’s mother, and she identified the abandoned boy as her son. The family spent the next fifty years believing they were whole again—but Paul was always unsure about his true identity. Then, four years ago—spurred on by the birth of his first child, Emma Faith—Paul took a DNA test. The test revealed that he was definitely not Paul Fronczak. From that moment on, Paul has been on a tireless mission to find the man whose life he’s been living—and to discover who abandoned him, and why. Poignant and inspiring, The Foundling is a story about a child lost and a faith found, about the permanence of families and the bloodlines that define you, and about the emotional toll of both losing your identity and rediscovering who you truly are.

    Giant corporations are creating designer crops with strange powers-from cholesterol-reducing soybeans to plants that act as miniature drug factories, churning out everything from vaccines to insulin. They promise great benefits: better health for consumers, more productive agriculture-even an end to world hunger. But the vision has a dark side, one of profit-driven tampering with life and the possible destruction of entire ecosystems. In Lords of the Harvest, Daniel Charles takes us deep inside research labs, farm sheds, and corporate boardrooms to reveal the hidden story behind this agricultural revolution. He tells how a handful of scientists at Monsanto drove biotechnology from the lab into the field, and how the company's opponents are fighting back with every tool available to them, including the cynical manipulation of public fears. A dramatic account of boundless ambition, political intrigue, and the quest for knowledge, Lords of the Harvest is ultimately a story of idealism and of conflicting dreams about the shape of a better world.

    With Mutant he has written one of his most gripping, utterly chilling novels to date.On an isolated stretch of highway in Oahu, a woman cradles her dying son in her arms. In the days that follow, an autopsy draws a shocking conclusion: the boy, his lungs filled with blood, died of a disease previously found only in birds. On the other side of the globe, Dr. Richard Steele, a burned-out ER doctor is being recruited into a movement to examine the hazards of genetically modified foods, a job that takes him to an explosive conference in Hawaii.Spearheaded by a charismatic female doctor, the anti-bioengineering movement is gathering steam. While a powerful company is using genetic breakthroughs to create disease-resistant super crops, activists warn that new DNA strains will wreak havoc on the environment. But no one suspects that the controversy is masking a far more frightening human threat–one that could lead to the deadliest weapon of mass destruction ever unleashed upon the world. . . .

    Leisha Camden was genetically modified at birth to require no sleep, and her normal twin Alice is the control. Problems and envy between the sisters mirror those in the larger world, as society struggles to adjust to a growing pool of people who not only have 30 percent more time to work and study than normal humans, but are also highly intelligent and in perfect health. The Sleepless gradually outgrow their welcome on Earth, and their children escape to an orbiting space station to set up their own society. But Leisha and a few others remain behind, preaching acceptance for all humans, Sleepless and Sleeper alike. With the conspiracy and revenge that unwinds, the world needs a little preaching on tolerance.

    Gases and dust particles ejected into the atmosphere changed weather patterns around the world, resulting in the infamous ''year without a summer'' in North America, food riots in Europe, and a widespread cholera epidemic. And the gloomy weather inspired Mary Shelley to write the gothic novel Frankenstein.This book tells the story of nine such epic volcanic events, explaining the related geology for the general reader and exploring the myriad ways in which the earth's volcanism has affected human history. Zeilinga de Boer and Sanders describe in depth how volcanic activity has had long-lasting effects on societies, cultures, and the environment. After introducing the origins and mechanisms of volcanism, the authors draw on ancient as well as modern accounts--from folklore to poetry and from philosophy to literature. Beginning with the Bronze Age eruption that caused the demise of Minoan Crete, the book tells the human and geological stories of eruptions of such volcanoes as Vesuvius, Krakatau, Mount Pel�e, and Tristan da Cunha. Along the way, it shows how volcanism shaped religion in Hawaii, permeated Icelandic mythology and literature, caused widespread population migrations, and spurred scientific discovery.From the prodigious eruption of Thera more than 3,600 years ago to the relative burp of Mount St. Helens in 1980, the results of volcanism attest to the enduring connections between geology and human destiny.

    Ben Lynch discovered the root cause—“dirty” genes. Genes can be “born dirty” or merely “act dirty” in response to your environment, diet, or lifestyle—causing lifelong, life-threatening, and chronic health problems, including cardiovascular disease, autoimmune disorders, anxiety, depression, digestive issues, obesity, cancer, and diabetes.Based on his own experience and successfully helping thousands of clients, Dr. Lynch shows you how to identify and optimize both types of dirty genes by cleaning them up with targeted and personalized plans, including healthy eating, good sleep, stress relief, environmental detox, and other holistic and natural means.Many of us believe our genes doom us to the disorders that run in our families. But Dr. Lynch reveals that with the right plan in place, you can eliminate symptoms, and optimize your physical and mental health—and ultimately rewrite your genetic destiny.

    The prolonged encounter between the Cro-Magnons and the archaic Neanderthals and between 45,000 and 30,000 years ago was one of the defining moments of history. The Neanderthals survived for some 15,000 years in the face of the newcomers, but were finally pushed aside by the Cro-Magnons' vastly superior intellectual abilities and cutting-edge technologies, which allowed them to thrive in the intensely challenging climate of the Ice Age.What do we know about this remarkable takeover? Who were the first modern Europeans and what were they like? How did they manage to thrive in such an extreme environment? And what legacy did they leave behind them after the cold millennia? The age of the Cro-Magnons lasted some 30,000 years?longer than all of recorded history. Cro-Magnon is the story of a little known, yet seminal, chapter of human experience.

    At age thirteen, he is mentally and developmentally between one and three years old and will need constant care for the rest of his life. Brown travels the globe, meeting with genetic scientists and neurologists as well as parents, to solve the questions Walker’s doctors can’t answer. In his journey, he offers an insightful critique of society’s assumptions about the disabled, and he discovers a connected community of families living with this illness. As Brown gradually lets go of his self-blame and hope for a cure, he learns to accept the Walker he loves, just as he is. Honest, intelligent, and deeply moving, The Boy in the Moon explores the value of a single human life.

    Written by an author team, including a Noble Prize winner, this text presents the integration of Mendelian and molecular principles, providing students with the links between early genetics understanding and the molecular discoveries that have changed the way the field of genetics is viewed.

    Now it could be the key to healing millions with genetic diseases of every type—from Alzheimer's and Parkinson's to diabetes and sickle cell anemia.In 1974, Joey O'Donnell was born with strange symptoms. His insatiable appetite, incessant vomiting, and a relentless cough—which shook his tiny, fragile body and made it difficult to draw breath—confounded doctors and caused his parents agonizing, sleepless nights. After six sickly months, his salty skin provided the critical clue: he was one of thousands of Americans with cystic fibrosis, an inherited lung disorder that would most likely kill him before his first birthday.The gene and mutation responsible for CF were found in 1989—discoveries that promised to lead to a cure for kids like Joey. But treatments unexpectedly failed and CF was deemed incurable. It was only after the Cystic Fibrosis Foundation, a grassroots organization founded by parents, formed an unprecedented partnership with a fledgling biotech company that transformative leaps in drug development were harnessed to produce groundbreaking new treatments: pills that could fix the crippled protein at the root of this deadly disease.From science writer Bijal P. Trivedi, Breath from Salt chronicles the riveting saga of cystic fibrosis, from its ancient origins to its identification in the dank autopsy room of a hospital basement, and from the CF gene's celebrated status as one of the first human disease genes ever discovered to the groundbreaking targeted genetic therapies that now promise to cure it.Told from the perspectives of the patients, families, physicians, scientists, and philanthropists fighting on the front lines, Breath from Salt is a remarkable story of unlikely scientific and medical firsts, of setbacks and successes, and of people who refused to give up hope—and a fascinating peek into the future of genetics and medicine.

    In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. In England, cows attack their owners in the milking parlors, while in the American West, thousands of deer starve to death in fields full of grass.What these strange conditions–including fatal familial insomnia, kuru, scrapie, and mad cow disease–share is their cause: prions. Prions are ordinary proteins that sometimes go wrong, resulting in neurological illnesses that are always fatal. Even more mysterious and frightening, prions are almost impossible to destroy because they are not alive and have no DNA–and the diseases they bring are now spreading around the world.In The Family That Couldn’t Sleep, essayist and journalist D. T. Max tells the spellbinding story of the prion’s hidden past and deadly future

    It says what most scientists and politicians are afraid to say about what research can and, perhaps more importantly, cannot deliver on topics ranging from sexuality, race and genetic modification to stem cells, cloning, modern medicine, fertility treatment, creationism and bioterrorism.Having worked at the heart of government science, at the most prestigious science publishing company in the world, and in one of the world's leading biology institutions the author has a unique view of the politics, culture and reach of science. He illustrates how we are facing dangerous times where political agendas and public misunderstanding are hobbling truly novel work and hence calls for wide reaching changes in science education, funding, publishing and promulgation.