But by itself, DNA is just an inert blueprint for life. It is the ribosome--an enormous molecular machine made up of a million atoms--that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases. But this is also a human story of Ramakrishnan's unlikely journey, from his first fumbling experiments in a biology lab to being the dark horse in a fierce competition with some of the world's best scientists. In the end, Gene Machine is a frank insider's account of the pursuit of high-stakes science.

    One of the greatest partnerships in the history of science, Kahneman and Tversky’s extraordinary friendship incited a revolution in Big Data studies, advanced evidence-based medicine, led to a new approach to government regulation, and made much of Michael Lewis’s own work possible. In The Undoing Project, Lewis shows how their Nobel Prize–winning theory of the mind altered our perception of reality.

    As one of the greatest NHL players of all time, he reflects on his 2005-06 rookie season with the Pittsburgh Penguins. From a Canadian phenom dubbed "the next Gretzky" to an 18-year-old carrying the burden of a struggling franchise, he talks candidly about the intense pressure he was under, the surreal experience of lacing up alongside his childhood idol Mario Lemieux and the truth about his rivalry with Alex Ovechkin. Sidney Crosby, with the help of his family, coaches and former teammates, gives listeners an all-access pass to one of the most scrutinized and tumultuous rookie seasons in the history of professional hockey. Hosted by Pittsburgh native and Penguins fan Joe Manganiello.

    We are a bombarded generation: Facebook, billboards, Twitter, Instagram, taxes, newspapers, watches monitoring our sleep, apps that read our pulse, terrorism. There's such an onslaught to the senses these days it's a marvel any of us manage to get out of bed. I love bed. While we are overwhelmed and confused by the miasmic cloud of information, there are those that seek to take advantage: there are parking fines, hate Tweets, Nigerian email scams and Christmas newsletters from old school friends about their ugly kids. And just as we're getting round to doing something about it, we're distracted again. I, Joe Lycett, comedian, wordsmith, and professional complainer, am here to help. During my short life of doing largely nothing I've discovered solutions to many of life's problems, which I impart to you, dear Reader. Containing a centurion of complaint letters to unsuspecting celebrities, companies and anyone brave enough to clog up my phone, as well as illustrations, one-liners , jokes and life hacks, this little gem offers you a collection of tips and advice* for all manner of modern woe. By the time you have finished reading this book you will have learnt how to: - Reverse a parking fine - Manipulate the tabloid press - Navigate social media - Respond to hate mail - Out-weird internet trolls - Contest a so-called ripe avocado - Send the perfect Christmas newsletter - Defeat ISIS - Take down multi-national companiesAND MUCH, MUCH MORE! Joe Lycett x * If you are looking for guidance with taxes, quitting smoking, moving house, love, divorce, education, healthcare or anything actually important may I recommend speaking to friends or family members and not consulting a book by a comedian who eats halloumi at least twice a day.

    Its mix of adventure narrative, survival science, and practical advice has inspired everyone from business leaders to military officers, educators, and psychiatric professionals on how to take control of stress, learn to assess risk, and make better decisions under pressure.

    It’s a journey deep within, in a way that’s respectful and non-invasive; a journey for which we will all pay a heavy price, even if you’ve waited for the smaller paperback edition.Ayoade argues for the canonisation of this brutal masterpiece, a film that celebrates capitalism in all its victimless glory; one we might imagine Donald Trump himself half-watching on his private jet’s gold-plated flat screen while his other puffy eye scans the cabin for fresh, young prey."

    This is a book for anyone who has ever failed. Which means it’s a book for everyone. If I have learned one thing from this shockingly beautiful venture called life, it is this: failure has taught me lessons I would never otherwise have understood. I have evolved more as a result of things going wrong than when everything seemed to be going right. Out of crisis has come clarity, and sometimes even catharsis.Part memoir, part manifesto, and including chapters on dating, work, sport, babies, families, anger and friendship, it is based on the simple premise that understanding why we fail ultimately makes us stronger. It's a book about learning from our mistakes and about not being afraid. Uplifting, inspiring and rich in stories from Elizabeth’s own life, How to Fail reveals that failure is not what defines us; rather it is how we respond to it that shapes us as individuals. Because learning how to fail is actually learning how to succeed better. And everyone needs a bit of that.

    Before Nic became addicted to crystal meth, he was a charming boy, joyous and funny, a varsity athlete and honor student adored by his two younger siblings. After meth, he was a trembling wraith who lied, stole, and lived on the streets. David Sheff traces the first warning signs: the denial, the three a.m. phone calls—is it Nic? the police? the hospital? His preoccupation with Nic became an addiction in itself. But as a journalist, he instinctively researched every treatment that might save his son. And he refused to give up on Nic.

    His debut stand-up DVD was the fastest selling of all time, only to be eclipsed by his second that sold over 1.4 million copies and was the 2009 Christmas number one. He hosts his own BAFTA nominated BBC1 series, Michael McIntyre’s Comedy Roadshow, and won the British Comedy Award for Best Live Stand-up in 2009 following his record breaking fifty-four date Arena tour.But how did he get there?Michael reveals all in his remarkably honest and hilarious autobiography Life and Laughing. His showbiz roots, his appalling attempts to attract the opposite sex, his fish-out-of-water move from public to state school and his astonishing journey from selling just one ticket at the Edinburgh Festival to selling half a million tickets on his last tour. Michael’s story is riveting, poignant, romantic and above all very, very funny.

    It contains 100,000 books, spread over a mile of shelving, with twisting corridors and roaring fires, and all set in a beautiful, rural town by the edge of the sea. A book-lover's paradise? Well, almost ... In these wry and hilarious diaries, Shaun provides an inside look at the trials and tribulations of life in the book trade, from struggles with eccentric customers to wrangles with his own staff, who include the ski-suit-wearing, bin-foraging Nicky. He takes us with him on buying trips to old estates and auction houses, recommends books (both lost classics and new discoveries), introduces us to the thrill of the unexpected find, and evokes the rhythms and charms of small-town life, always with a sharp and sympathetic eye.

    No academic analysis or bystander’s account can capture it. Now Doug Edwards, Employee Number 59, offers the first inside view of Google, giving readers a chance to fully experience the bizarre mix of camaraderie and competition at this phenomenal company. Edwards, Google’s first director of marketing and brand management, describes it as it happened. We see the first, pioneering steps of Larry Page and Sergey Brin, the company’s young, idiosyncratic partners; the evolution of the company’s famously nonhierarchical structure (where every employee finds a problem to tackle or a feature to create and works independently); the development of brand identity; the races to develop and implement each new feature; and the many ideas that never came to pass. Above all, Edwards—a former journalist who knows how to write—captures the “Google Experience,” the rollercoaster ride of being part of a company creating itself in a whole new universe. I’m Feeling Lucky captures for the first time the unique, self-invented, yet profoundly important culture of the world’s most transformative corporation.

    Starved for affection, Lina battles daily panic attacks and, after reconnecting with an old flame through social media, embarks on an affair that quickly becomes all-consuming. In North Dakota we meet Maggie, a seventeen-year-old high school student who allegedly has a clandestine physical relationship with her handsome, married English teacher; the ensuing criminal trial will turn their quiet community upside down. Finally, in an exclusive enclave of the Northeast, we meet Sloane—a gorgeous, successful, and refined restaurant owner—who is happily married to a man who likes to watch her have sex with other men and women.Based on years of immersive reporting and told with astonishing frankness and immediacy, Three Women is both a feat of journalism and a triumph of storytelling, brimming with nuance and empathy. “A work of deep observation, long conversations, and a kind of journalistic alchemy” (Kate Tuttle, NPR), Three Women introduces us to three unforgettable women—and one remarkable writer—whose experiences remind us that we are not alone.

    Brutally honest' Matt Haig'I love it' Jon Ronson**********************************************************So, this is me. Lily Allen.I am a woman.I am a mother.I was a wife.I drink.I have taken drugs.I have loved and been let down.I am a success and a failure.I am a songwriter.I am a singer.I am all these things and more.When women share their stories, loudly and clearly and honestly, things begin to change - for the better.This is my story.

    That's what Ben Lindbergh and Sam Miller got to do when the Sonoma Stompers, an independent minor-league team in California, offered them the chance to run the team's baseball operations according to the most advanced statistics. The Only Rule Is It Has to Work is unlike any other baseball tale you've ever read.We tag along as Lindbergh and Miller apply their number-crunching insights to all aspects of assembling and running a team. We meet colorful figures like general manager Theo Fightmaster and boundary-breakers like the first openly gay professional player and the first Japanese manager in American professional baseball. Even José Canseco makes a cameo appearance.Will sabermetrics bring the Stompers a championship, or will they fall on their face? Will the team have a competitive advantage or is the old folk wisdom really true after all? Will the players be able to maximize their talents and attract the attention of big-league scouts, or will this be a fast track to oblivion?It's a wild ride, as the authors' infectious enthusiasm and feel for the absurd make the Stompers' story one that will speak to numbers geeks and traditionalists alike. And it proves that you don't need a bat or a glove to make a genuine contribution to the game.

    It recounts the life histories of those who had been victims of the 1920s encephalitis lethargica epidemic. Sacks chronicles his efforts in the late 1960s to help these patients at the Beth Abraham Hospital in the Bronx, New York.