Many people think of microbes as germs to be eradicated, but those that live with us—the microbiome—build our bodies, protect our health, shape our identities, and grant us incredible abilities. In this astonishing book, Ed Yong takes us on a grand tour through our microbial partners, and introduces us to the scientists on the front lines of discovery. Yong, whose humor is as evident as his erudition, prompts us to look at ourselves and our animal companions in a new light—less as individuals and more as the interconnected, interdependent multitudes we assuredly are. The microbes in our bodies are part of our immune systems and protect us from disease. Those in cows and termites digest the plants they eat. In the deep oceans, mysterious creatures without mouths or guts depend on microbes for all their energy. Bacteria provide squids with invisibility cloaks, help beetles to bring down forests, and allow worms to cause diseases that afflict millions of people. I Contain Multitudes is the story of these extraordinary partnerships, between the creatures we are familiar with and those we are not. It reveals how we humans are disrupting these partnerships and how we might manipulate them for our own good. It will change both our view of nature and our sense of where we belong in it.

    She conjures up early operating theaters--no place for the squeamish--and surgeons, working before anesthesia, who were lauded for their speed and brute strength. These medical pioneers knew that the aftermath of surgery was often more dangerous than their patients' afflictions, and they were baffled by the persistent infections that kept mortality rates stubbornly high. At a time when surgery couldn't have been more hazardous, an unlikely figure stepped forward: a young, melancholy Quaker surgeon named Joseph Lister, who would solve the deadly riddle and change the course of history.Fitzharris dramatically recounts Lister's discoveries in gripping detail, culminating in his audacious claim that germs were the source of all infection--and could be countered by antiseptics. Focusing on the tumultuous period from 1850 to 1875, she introduces us to Lister and his contemporaries--some of them brilliant, some outright criminal--and takes us through the grimy medical schools and dreary hospitals where they learned their art, the deadhouses where they studied anatomy, and the graveyards they occasionally ransacked for cadavers.Eerie and illuminating, The Butchering Art celebrates the triumph of a visionary surgeon whose quest to unite science and medicine delivered us into the modern world.

    Joe, Florida and confessed that he’d shot and killed his parents in their family home in Silver Spring, Maryland. He said he’d been possessed by the devil. He was eventually diagnosed with schizophrenia and ruled “not criminally responsible” for the murders on grounds of insanity.But after the trial, where do the "criminally insane" go? Brottman reveals Brian's inner life leading up to the murder, as well as his complicated afterlife in a maximum security psychiatric hospital, where he is neither imprisoned nor free. During his 27 years at the hospital, Brian has tried to escape and been shot by police, and has witnessed three patient-on-patient murders. He’s experienced the drugging of patients beyond recognition, a sadistic system of rewards and punishments, and the short-lived reign of a crazed psychiatrist-turned-stalker. In the tradition of One Flew Over The Cuckoo’s Nest, Couple Found Slain is an insider’s account of life in the underworld of forensic psych wards in America and the forgotten lives of those held there, often indefinitely.

    Your head hurts. You're mildly annoyed as you get the kids ready for school and dress for work yourself. Meanwhile, an epic war is being fought, just below your skin. Millions are fighting and dying for you to be able to complain as you head out the door.So what, exactly, is your immune system?Second only to the human brain in its complexity, it is one of the oldest and most critical facets of life on Earth. Without it, you would die within days. In Immune, Philipp Dettmer, the brains behind the most popular science channel on YouTube, takes readers on a journey through the fortress of the human body and its defenses. There is a constant battle of staggering scale raging within us, full of stories of invasion, strategy, defeat, and noble self-sacrifice. In fact, in the time you've been reading this, your immune system has probably identified and eradicated a cancer cell that started to grow in your body.Each chapter delves into an element of the immune system, including defenses like antibodies and inflammation as well as threats like bacteria, allergies, and cancer, as Dettmer reveals why boosting your immune system is actually nonsense, how parasites sneak their way past your body's defenses, how viruses work, and what goes on in your wounds when you cut yourself.Enlivened by engaging graphics and immersive descriptions, Immune turns one of the most intricate, interconnected, and confusing subjects—immunology—into a gripping adventure through an astonishing alien landscape. Immune is a vital and remarkably fun crash course in what is arguably, and increasingly, the most important system in the body.

    That obsession led Renner to a successful career as an investigative journalist. It also gave him post-traumatic stress disorder. In 2011, Renner began researching the strange disappearance of Maura Murray, a University of Massachusetts student who went missing after wrecking her car in rural New Hampshire in 2004. Over the course of his investigation, he uncovered numerous important and shocking new clues about what may have happened to Murray but also found himself in increasingly dangerous situations with little regard for his own well-being. As his quest to find Murray deepened, the case started taking a toll on his personal life, which began to spiral out of control. The result is an absorbing dual investigation of the complicated story of the All-American girl who went missing and Renner's own equally complicated true-crime addiction.True Crime Addict is the story of Renner's spellbinding investigation, which has taken on a life of its own for armchair sleuths across the web. In the spirit of David Fincher's Zodiac, it's a fascinating look at a case that has eluded authorities and one man's obsessive quest for the answers.

    But if we are supposedly evolution’s greatest creation, why do we have such bad knees? Why do we catch head colds so often—two hundred times more often than a dog does? How come our wrists have so many useless bones? Why is the vast majority of our genetic code pointless? And are we really supposed to swallow and breathe through the same narrow tube? Surely there’s been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last. The human body is one big pile of compromises. But that is also a testament to our greatness: as Lents shows, humans have so many design flaws precisely because we are very, very good at getting around them.   A rollicking, deeply informative tour of humans’ four billion year long evolutionary saga, Human Errors both celebrates our imperfections and offers an unconventional accounting of the cost of our success.

    “I don’t know why I’m telling you this,” people say, spilling confessions. In fall 2002, Krouse accepts a new contract job investigating lawsuits as a private investigator. The role seems perfect for her, but she quickly realizes she has no idea what she’s doing. Then a lawyer named Grayson assigns her to investigate a sexual assault, a college student who was attacked by football players and recruits at a party a year earlier. Krouse knows she should turn the assignment down; her own history with sexual violence makes it all too personal. But she takes the job anyway, inspired by Grayson’s conviction that he could help change things forever--and maybe she could, too.Over the next five years, Krouse learns everything she can about P. I. technique, tracking down witnesses and investigating a culture of sexual assault and harassment ingrained in the university’s football program. But as the investigation grows into a national scandal and a historic civil rights case, she finds herself increasingly consumed. When the case and her life both implode at the same time, she must figure out how to help win the case without losing herself.

    But beginning in December 1884, Austin was terrorized by someone equally as vicious and, in some ways, far more diabolical than London's infamous Jack the Ripper. For almost exactly one year, the Midnight Assassin crisscrossed the entire city, striking on moonlit nights, using axes, knives, and long steel rods to rip apart women from every race and class. At the time the concept of a serial killer was unthinkable, but the murders continued, the killer became more brazen, and the citizens' panic reached a fever pitch.Before it was all over, at least a dozen men would be arrested in connection with the murders, and the crimes would expose what a newspaper described as "the most extensive and profound scandal ever known in Austin." And yes, when Jack the Ripper began his attacks in 1888, London police investigators did wonder if the killer from Austin had crossed the ocean to terrorize their own city.With vivid historical detail and novelistic flair, Texas Monthly journalist Skip Hollandsworth brings this terrifying saga to life.

    Communities where heroin had never been seen before—from Charlotte, NC and Huntington, WVA, to Salt Lake City and Portland, OR—were overrun with it. Local police and residents were stunned. How could heroin, long considered a drug found only in the dense, urban environments along the East Coast, and trafficked into the United States by enormous Colombian drug cartels, be so incredibly ubiquitous in the American heartland? Who was bringing it here, and perhaps more importantly, why were so many townspeople suddenly eager for the comparatively cheap high it offered?With the same dramatic drive of El Narco and Methland, Sam Quinones weaves together two classic tales of American capitalism: The stories of young men in Mexico, independent of the drug cartels, in search of their own American Dream via the fast and enormous profits of trafficking cheap black-tar heroin to America’s rural and suburban addicts; and that of Purdue Pharma in Stamford, Connecticut, determined to corner the market on pain with its new and expensive miracle drug, Oxycontin; extremely addictive in its own right. Quinones illuminates just how these two stories fit together as cause and effect: hooked on costly Oxycontin, American addicts were lured to much cheaper black tar heroin and its powerful and dangerous long-lasting high. Embroiled alongside the suppliers and buyers are DEA agents, local, small-town sheriffs, and the US attorney from eastern Virginia whose case against Purdue Pharma and Oxycontin made him an enemy of the Bush-era Justice Department, ultimately stalling and destroying his career in public service.Dreamland is a scathing and incendiary account of drug culture and addiction spreading to every part of the American landscape.

    Bill Bass, one of the world's leading forensic anthropologists, gained international attention when he built a forensic lab like no other: The Body Farm. Now, this master scientist unlocks the gates of his lab to reveal his most intriguing cases-and to revisit the Lindbergh kidnapping and murder, fifty years after the fact.

    His passing on March 6, 1900, would have been unremarkable if a city health officer hadn’t noticed a swollen black lymph node on his groin—a sign of bubonic plague. Empowered by racist pseudoscience, officials rushed to quarantine Chinatown while doctors examined Wong’s tissue for telltale bacteria. If the devastating disease was not contained, San Francisco would become the American epicenter of an outbreak that had already claimed ten million lives worldwide.To local press, railroad barons, and elected officials, such a possibility was inconceivable—or inconvenient. As they mounted a cover-up to obscure the threat, ending the career of one of the most brilliant scientists in the nation in the process, it fell to federal health officer Rupert Blue to save a city that refused to be rescued. Spearheading a relentless crusade for sanitation, Blue and his men patrolled the squalid streets of fast-growing San Francisco, examined gory black buboes, and dissected diseased rats that put the fate of the entire country at risk.In the tradition of Erik Larson and Steven Johnson, Randall spins a spellbinding account of Blue’s race to understand the disease and contain its spread—the only hope of saving San Francisco, and the nation, from a gruesome fate.

    Clara Blackstone has just been released after one year in a private asylum for the insane. Clara has two goals: to reunite with her husband, Henry, and to never—ever—return to the asylum. As she enters Durham, Clara finds her carriage surrounded by a mob gathered to witness the imprisonment of Mary Ann Cotton—England’s first female serial killer—accused of poisoning nearly twenty people, including her husbands and children.Clara soon finds the oppressive confinement of her marriage no less terrifying than the white-tiled walls of Hoxton. And as she grows increasingly suspicious of Henry’s intentions, her fascination with Cotton grows. Soon, Cotton is not just a notorious figure from the headlines, but an unlikely confidante, mentor—and perhaps accomplice—in Clara’s struggle to protect her money, her freedom and her life.In the lineage of Margaret Atwood's Alias Grace, The Savage Instinct is the chilling story of one woman's struggle for her sanity, set against the backdrop of the arrest and trial of Mary Ann Cotton, England’s first female serial killer.

    15,000 BC) to today. Delving further back into human history and deeper into the human psyche than Serial Killers--Vronsky's 2004 book, which has been called "the definitive history of the phenomenon of serial murder"--he focuses strictly on sexual serial killers: thrill killers who engage in murder, rape, torture, cannibalism and necrophilia, as opposed to for-profit serial killers, including hit men, or "political" serial killers, like terrorists or genocidal murderers.These sexual serial killers differ from all other serial killers in their motives and their foundations. They are uniquely human and--as popular culture has demonstrated--uniquely fascinating.

    Norco ’80 tells the story of how five heavily-armed young men—led by an apocalyptic born-again Christian—attempted a bank robbery that turned into one of the most violent criminal events in U.S. history, forever changing the face of American law enforcement. Part action thriller and part courtroom drama, Norco ’80 transports the reader back to the Southern California of the 1970s, an era of predatory evangelical gurus, doomsday predictions, megachurches, and soaring crime rates, with the threat of nuclear obliteration looming over it all. A group of landscapers transforms into a murderous gang of bank robbers armed to the teeth with military-grade weapons. Their desperate getaway turned the surrounding towns into war zones. When it was over, three were dead and close to twenty wounded; a police helicopter was forced down from the sky, and thirty-two police vehicles were destroyed by thousands of rounds of ammo. The resulting trials shook the community to the core, raising many issues that continue to plague society today: from racism and the epidemic of post-traumatic stress disorder within law enforcement to religious extremism and the militarization of local police forces.

    Judy Melinek began her training as a New York City forensic pathologist. With her husband T.J. and their toddler Daniel holding down the home front, Judy threw herself into the fascinating world of death investigation, performing autopsies, investigating death scenes, counseling grieving relatives. Working Stiff chronicles Judy's two years of training, taking readers behind the police tape of some of the most harrowing deaths in the Big Apple, including a firsthand account of the events of September 11, the subsequent anthrax bio-terrorism attack, and the disastrous crash of American Airlines flight 587.Lively, action-packed, and loaded with mordant wit, Working Stiff offers a firsthand account of daily life in one of America's most arduous professions, and the unexpected challenges of shuttling between the domains of the living and the dead. The body never lies, and through the murders, accidents, and suicides that land on her table, Dr. Melinek lays bare the truth behind the glamorized depictions of autopsy work on shows like CSI and Law and Order to reveal the secret story of the real morgue.