He is one of the foremost figures of contemporary neuroscience, and his decades-long quest to understand the inner workings of the brain’s memory machine has begun to pay off. Award-winning journalist Terry McDermott spent nearly two years observing Lynch at work and now gives us a fascinating and dramatic account of daily life in his lab—the highs and lows, the drudgery and eureka moments, the agonizing failures. He provides detailed, lucid explanations of the cutting-edge science that enabled Lynch to reveal the inner workings of the molecular machine that manufactures memory. After establishing the building blocks, Lynch then set his sights on uncovering the complicated structure of memory as it is stored across many neurons. Adding practical significance to his groundbreaking work, Lynch discovered a class of drugs that could fix the memory machine when it breaks, drugs that would enhance brain function during the memory process and that hold out the possibility of cures for a wide range of neurological conditions, including Alzheimer’s disease, Parkinson’s disease, and attention deficit hyperactivity disorder. Here is an essential story of science, scientists, and scientific achievement—galvanizing in the telling and thrilling in its far-reaching implications.

    Leslie Jamison deftly excavates the stories we tell about addiction--both her own and others'--and examines what we want these stories to do, and what happens when they fail us.All the while, she offers a fascinating look at the larger history of the recovery movement, and at the literary and artistic geniuses whose lives and works were shaped by alcoholism and substance dependence, including John Berryman, Jean Rhys, Raymond Carver, Billie Holiday, David Foster Wallace, and Denis Johnson, as well as brilliant figures lost to obscurity but newly illuminated here.For the power of her striking language and the sharpness of her piercing observations, Jamison has been compared to such iconic writers as Joan Didion and Susan Sontag. Yet her utterly singular voice also offers something new. With enormous empathy and wisdom, Jamison has given us nothing less than the story of addiction and recovery in America writ large, a definitive and revelatory account that will resonate for years to come.

    Her real identity was buried so deep it would take five years to unearth. Who was Lori Ruff?Maureen O’Hagan’s The Woman in the Strongbox is part of Missing, a collection of six true stories about finding, restoring, or accepting the losses that define our lives—from the mysterious to the inspiring. Each story can be read—or listened to—in a single sitting.

    She explores the culture of genealogy buffs, the science of DNA, and the business of companies like Ancestry and 23andMe, all while tracing the story of one woman, her unusual results, and a relentless methodical drive for answers that becomes a thoroughly modern genetic detective story.

    Best-selling author and Rolling Stone columnist Rob Sheffield explores the music and artistry of the rock goddess who has kept generations of music lovers totally bewitched and spellbound, with such classic rock hits as "Rhiannon" and "Gypsy". With her recent induction into the Rock & Roll Hall of Fame (the only female artist to be honored for both her group and solo work), Nicks, who turns 70 this month, is being celebrated for living the seasons of her life with ferocious wit, fierce honesty, unstoppable talent, and a lot of rock & roll. Drawing from Rolling Stone magazine’s extensive archives, and his long time appreciation of Nicks, Sheffield shares the stories behind the best-selling records and the spitfire 1997 Fleetwood Mac reunion show that put the band back on top of the charts—and why Stevie Nicks still speaks to us today. A dynamic, revelatory sketch of the one-of-a-kind icon, The Wild Heart of Stevie Nicks is a portrait as revealing as it is dazzling, as human as it is pure magic

    To say that it’s high time that it was defined by its women falls some way short of an understatement.Jenni Murray draws together the lives 21 women to shed light upon a variety of social, political, religious and cultural aspects of British history. In lively prose Murray reinvigorates the stories behind the names we all know and reveals the fascinating tales behind those less familiar, ultimately producing a unique history of Britain that is as long-overdue as it is absorbing. From famous queens to forgotten visionaries, and from great artists to our most influential political actors, A History of Britain in 21 Women is a veritable feast of page-turning history.A History of Britain in 21 Women will profile Boudicca, Aphra Behn, Elizabeth I (this chapter will also feature Anne Boleyn and Mary Queen of Scots), Fanny Burney, Jane Austen, Mary Wollstonecraft, Constance Markievicz, Nancy Astor, Ada Lovelace, Caroline Herschel, Elizabeth Garrett Anderson, Millicent Garrett Fawcett, Emmeline Pankhurst, Gwen John, Rosalind Franklin, Ethel Smyth, Margaret Thatcher, Nicola Sturgeon, Mary Quant, Barbara Castle and Mary Somerville.

    of Maryland School of Medicine), offers case histories of the health problems of a dozen long-dead famous figures diagnosed from modern medical perspectives. Illustrations depict patients including the odd-looking Pharaoh Akhenaten, C

    In his capital at Constantinople he built the world's most beautiful building, married its most powerful empress, and wrote its most enduring legal code, seemingly restoring Rome's fortunes for the next five hundred years. Then, in the summer of 542, he encountered a flea. The ensuing outbreak of bubonic plague killed five thousand people a day in Constantinople and nearly killed Justinian himself. In Justinian's Flea, William Rosen tells the story of history's first pandemic plague seven centuries before the Black Death that killed tens of millions, devastated the empires of Persia and Rome, left a path of victims from Ireland to Iraq, and opened the way for the armies of Islam. Weaving together evolutionary microbiology, economics, military strategy, ecology, and ancient and modern medicine, Rosen offers a sweeping narrative of one of the great hinge moments in history, one that will appeal to readers of John Kelly's The Great Mortality, John Barry's The Great Influenza, and Jared Diamond's Collapse .

    is the first deep-dive investigation of a hazardous and illicit industry that has created a worldwide epidemic, ravaging communities and overwhelming and confounding government agencies that are challenged to combat it. "A whole new crop of chemicals is radically changing the recreational drug landscape," writes Ben Westhoff. "These are known as Novel Psychoactive Substances (NPS) and they include replacements for known drugs like heroin, cocaine, ecstasy, and marijuana. They are synthetic, made in a laboratory, and are much more potent than traditional drugs"--and all-too-often tragically lethal. Drugs like fentanyl, K2, and Spice--and those with arcane acronyms like 25i-NBOMe-- were all originally conceived in legitimate laboratories for proper scientific and medicinal purposes. Their formulas were then hijacked and manufactured by rogue chemists, largely in China, who change their molecular structures to stay ahead of the law, making the drugs' effects impossible to predict. Westhoff has infiltrated this shadowy world, becoming the first journalist to report from inside an illicit Chinese fentanyls lab and providing startling and original reporting on how China's vast chemical industry operates, and how the Chinese government subsidizes it. He tracks down the little-known scientists who invented these drugs and inadvertently killed thousands, as well as a mysterious drug baron who turned the law upside down in his home country of New Zealand. Poignantly, Westhoff chronicles the lives of addicted users and dealers, families of victims, law enforcement officers, and underground drug awareness organizers in the U.S. and Europe. Together they represent the shocking and riveting full anatomy of a calamity we are just beginning to understand. From its depths, as Westhoff relates, are emerging new strategies that may provide essential long-term solutions to the drug crisis that has affected so many.

    Notwithstanding the great strengths of medical science, many people now have concerns about key features of our health-care system-among them, the widespread use of medical drugs and a relative deemphasis on preventive care. But traditional Western medicine is not the only healing system rooted in science. Medical systems from other cultures, including those of India and China, have used natural treatments for centuries, some of which are now directly influencing our own health-care professions. These approaches not only emphasize healing with natural substances, but devote considerable attention to illness prevention and healthful living by considering the whole person rather than just targeting a condition. What is the most effective way to nurture your own optimal health? Are there sound alternatives to the drugs so common in our health-care system, which can carry unwanted consequences and side effects? What about the range of natural methods, such as herbal medications, micronutrients, and the use of food itself as medicine? Are these approaches valid? And, if so, can we integrate the best of Western medicine with the best natural treatments to enjoy prime health and longevity?

    Their father had gone to sea the previous Friday, the boys told their neighbours, and their mother was visiting her family in Liverpool. Over the next ten days Robert and Nattie spent extravagantly, pawning their parents' valuables to fund trips to the theatre and the seaside. But as the sun beat down on the Coombes house, a strange smell began to emanate from the building. When the police were finally called to investigate, the discovery they made sent the press into a frenzy of horror and alarm, and Robert and Nattie were swept up in a criminal trial that echoed the outrageous plots of the 'penny dreadful' novels that Robert loved to read. In The Wicked Boy, Kate Summerscale has uncovered a fascinating true story of murder and morality - it is not just a meticulous examination of a shocking Victorian case, but also a compelling account of its aftermath, and of man's capacity to overcome the past.

    had a plan to invade Canada? And what actually happened to the flags left on the moon?Even if you think you have a handle on all things trivia, you're guaranteed a big surprise with Now I Know. From uncovering what happens to lost luggage to New York City's plan to crack down on crime by banning pinball, this book will challenge your knowledge of the fascinating stories behind the world's greatest facts.Covering 100 outrageous topics, Now I Know is the ultimate challenge for any know-it-all who thinks they have nothing left to learn.