It takes an average of seven and a half years to get a diagnosis in the UK and affects sufferers' capacity to work, their fertility and their ability to enjoy sex.What Eleanor Thom can tell you about endometriosis:You are so much more than the sum of your private parts.Part memoir, part guide book and part survival guide, Private Parts retraces Eleanor's own journey with endometriosis, offering readers practical, down-to-earth and friendly advice covering everything from what actually happens in an internal exam, to finding the right specialist for you, the perfect post-op wardrobe and to why you should look to Frida Kahlo for inspiration in your darkest moments.Written for those looking to live well with their endometriosis and for those who are looking for help to understand the disease and how it affects those with it, Private Parts is a call to action for people to speak up about an illness which is still so misunderstood.Will feature exclusive interviews with Hilary Mantel and Lena Dunham.

    In these essays, he grows from student to teacher, reader to writer, and reckons with his identities as a son, a gay man, a Korean American, an artist, an activist, a lover, and a friend. He examines some of the most formative experiences of his life and the nation’s history, including his father’s death, the AIDS crisis, 9/11, the jobs that supported his writing—Tarot-reading, bookselling, cater-waiting for William F. Buckley—the writing of his first novel, Edinburgh, and the election of Donald Trump.

    As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    Instead she travels the world at an observant pace, talking to strangers and introducing readers to an endearing assemblage of eccentric neighbors, Filipina faith healers, dry-cleaning proprietors, and other quirky characters.A Palestinian-American who lives in a Mexican-American neighborhood, Nye speaks for the mix of people and places that can be called the American Experience. From St. Louis, the symbolic Gateway to the West, she embarks on a westward migration to examine America, past and present, and to glimpse into the lives of its latest outsiders--illegal immigrants from Mexico and troubled inner-city children.In other essays Nye ventures beyond North America's bounds, telling of a year in her childhood spent in Palestine and of an adulthood filled with cross-cultural quests. Whether recounting the purchase of a car on the island of Oahu or a camel-back ride through India's Thar Desert, Nye writes in wry, refreshing tones about themes that transcend borders and about the journey that remains the greatest of all--the journey from outside to in as the world enters each one of us, as we learn to see.

    Inside you will find:× The smell of honeysuckle× Heartbreak× A French-kissing rabbit× A haunted house× Death× A vagina singing sad old songs× Young geraniums in an ancient castle× Birth× A dog who appears in dreams as a spiritual guide× Divorce× Electromagnetic energy fields× Emotional horniness× The ghost of a sea captain× And moreI hope you enjoy these little weirds.Love,Jenny Slate

    “Half memoir, half polemic, and entirely necessary,” (Elle UK), Moran’s debut was an instant runaway bestseller in England as well as an Amazon UK Top Ten book of the year; still riding high on bestseller lists months after publication, it is a bona fide cultural phenomenon. Now poised to take American womanhood by storm, here is a book that Vanity Fair calls “the U.K. version of Tina Fey’s Bossypants….You will laugh out loud, wince, and—in my case—feel proud to be the same gender as the author.”

    Julie Devaney takes us on a journey through the health care system as she is diagnosed and treated for ulcerative colitis. In and out of emergency rooms in Vancouver and Toronto, she’s poked, prodded, and abandoned to a closet at one point, bearing the helplessness and indignities of a system that at best confuses a patient into silence.Raw, harrowing, and darkly funny, Julie Devaney argues convincingly for fixes to the system and better training for all medical personnel. As she recovers, she sets out to do just that: setting up a gurney on stage at workshops and conferences across the country to teach Bedside Manners 101 and to advocate for repairs to the system.Part memoir, part love story, part revolutionary manifesto, My Leaky Body is politically astute, gooey like cake batter, and raw like ulcerated bowels. Devaney writes the book that will heal her aching heart and relax her strictured rectum as she weaves stories from professional and public interactions with tales from her gurney.

    Born to privilege as the daughter of one of Pakistan’s great feudal families, she was groomed for a diplomatic career and was thrust into the political arena when her father, Pakistan's charismatic and controversial prime minister, was executed. She then led Pakistan, one of the most turbulent and impoverished nations in the world, through two terms as prime minister in the 1980s and 1990s, but she struggled to ward off charges of corruption and retain her tenuous hold on power and was eventually forced into exile. Bhutto returned to Pakistan in 2007, only to be assassinated in Rawalpindi after a triumphant speech.Including interviews with key figures who knew Bhutto and have never before spoken on the record, Benazir Bhutto: Favored Daughter illuminates Bhutto’s tragic life as well as the role she played as the first female prime minister of Pakistan. Celebrated literary critic Brooke Allen approaches Bhutto in a way not many have done before in this taut biography of a figure who had a profound effect on the volatile politics of the Middle East, drawing on contemporary news sources and eyewitness reports, as well as accounts from her supporters and her enemies.

    She was a poor Southern tobacco farmer who worked the same land as her enslaved ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia — a land of wooden quarters for enslaved people, faith healings, and voodoo — to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family — past and present — is inextricably connected to the history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance?Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

    She had questions: Was she a monster? Would she ever be able to grow sideburns? And most importantly, where was her penis?The problem was, it was the 1970s, so there were no answers yet.Here, Lorka tells the story—by turns hilarious and poignant—of her romp through the first fifty years of her life searching for sex, love, acceptance, and answers to her questions. With a sharp wit, endearing innocence, and indelible sense of optimism, she struggles through the awkward years (spoiler: that’s all of them) and discovers that what she thought were mistakes are actually powerful tools to launch her into a magical—and ridiculous—life.Oh, and she discovers that she can buy a penis at the store, too.

    The actor shares his sixteen-year struggle to hide his multiple sclerosis from his wife, daughter, and the public from his first signs of vertigo five years after Laverne & Shirley until his decision to announce his illness.

    Clichés around marriage—eternal bliss, domestic harmony, soul mates—leave out the real stuff. After marriage you may still want to sleep with other people. Sometimes your partner will bore the hell out of you. And when stuck paying for your spouse’s mistakes, you might miss being single.In Wedding Toasts I’ll Never Give, Ada Calhoun presents an unflinching but also loving portrait of her own marriage, opening a long-overdue conversation about the institution as it truly is: not the happy ending of a love story or a relic doomed by high divorce rates, but the beginning of a challenging new chapter of which “the first twenty years are the hardest.”Calhoun’s funny, poignant personal essays explore the bedrooms of modern coupledom for a nuanced discussion of infidelity, existential anxiety, and the many other obstacles to staying together. Both realistic and openhearted, Wedding Toasts I’ll Never Give offers a refreshing new way to think about marriage as a brave, tough, creative decision to stay with another person for the rest of your life. “What a burden,” Calhoun calls marriage, “and what a gift.”

    What one does with this desire is what we call gender." So begins Andrea Long Chu's investigation into gender and desire, females and bodies, radical dreams and philosophical pessimism, and feminism as a form of political suicide. Feminism, Chu argues, is an untenable claim, and "when you make an untenable claim, your desire is showing, like a shy tattoo peeking out from a sleeve." Written in a series of linked theses, this is a provocative and searching text from our most exciting new public intellectual, a self described "sad trans girl in Brooklyn." Chu wears her heart on her sleeve with wit, style, and a manic searching grace.

    In this stunningly unusual prose debut, Doireann Ni Ghriofa sculpts essay and autofiction to explore inner life and the deep connection felt between two writers centuries apart. In the 1700s, an Irish noblewoman, on discovering her husband has been murdered, drinks handfuls of his blood and composes an extraordinary poem. In the present day, a young mother narrowly avoids tragedy. On encountering the poem, she becomes obsessed with its parallels with her own life, and sets out to track down the rest of the story. A devastating and timeless tale about one woman freeing her voice by reaching into the past and finding another's.

    Parents and family members who never thought they could get inside the head of their autistic loved one, at last, have a way to break through to the curious, subtle, and complex life within.Using an alphabet grid to painstakingly construct words, sentences, and thoughts that he is unable to speak out loud, Naoki answers even the most delicate questions that people want to know. Questions such as: “Why do people with autism talk so loudly and weirdly?” “Why do you line up your toy cars and blocks?” “Why don’t you make eye contact when you’re talking?” and “What’s the reason you jump?” (Naoki’s answer: “When I’m jumping, it’s as if my feelings are going upward to the sky.”) With disarming honesty and a generous heart, Naoki shares his unique point of view on not only autism but life itself. His insights—into the mystery of words, the wonders of laughter, and the elusiveness of memory—are so startling, so strange, and so powerful that you will never look at the world the same way again.