But in the inevitable condition of aging and death, the goals of medicine seem too frequently to run counter to the interest of the human spirit. Nursing homes, preoccupied with safety, pin patients into railed beds and wheelchairs. Hospitals isolate the dying, checking for vital signs long after the goals of cure have become moot. Doctors, committed to extending life, continue to carry out devastating procedures that in the end extend suffering.Gawande, a practicing surgeon, addresses his profession's ultimate limitation, arguing that quality of life is the desired goal for patients and families. Gawande offers examples of freer, more socially fulfilling models for assisting the infirm and dependent elderly, and he explores the varieties of hospice care to demonstrate that a person's last weeks or months may be rich and dignified.

    Joshua Mezrich creates life from loss, transplanting organs from one body to another. In this intimate, profoundly moving work, he illuminates the extraordinary field of transplantation that enables this kind of miracle to happen every day.When Death Becomes Life is a thrilling look at how science advances on a grand scale to improve human lives. Mezrich examines more than one hundred years of remarkable medical breakthroughs, connecting this fascinating history with the inspiring and heartbreaking stories of his transplant patients. Combining gentle sensitivity with scientific clarity, Mezrich reflects on his calling as a doctor and introduces the modern pioneers who made transplantation a reality—maverick surgeons whose feats of imagination, bold vision, and daring risk taking generated techniques and practices that save millions of lives around the world.Mezrich takes us inside the operating room and unlocks the wondrous process of transplant surgery, a delicate, intense ballet requiring precise timing, breathtaking skill, and at times, creative improvisation. In illuminating this work, Mezrich touches the essence of existence and what it means to be alive. Most physicians fight death, but in transplantation, doctors take from death. Mezrich shares his gratitude and awe for the privilege of being part of this transformative exchange as the dead give their last breath of life to the living. After all, the donors are his patients, too.When Death Becomes Life also engages in fascinating ethical and philosophical debates: How much risk should a healthy person be allowed to take to save someone she loves? Should a patient suffering from alcoholism receive a healthy liver? What defines death, and what role did organ transplantation play in that definition? The human story behind the most exceptional medicine of our time, Mezrich’s riveting book is a beautiful, poignant reminder that a life lost can also offer the hope of a new beginning.

    Most thieves, of course, steal for profit. John Charles Gilkey steals purely for the love of books. In an attempt to understand him better, journalist Allison Hoover Bartlett plunged herself into the world of book lust and discovered just how dangerous it can be.John Gilkey is an obsessed, unrepentant book thief who has stolen hundreds of thousands of dollars worth of rare books from book fairs, stores, and libraries around the country. Ken Sanders is the self-appointed "bibliodick" (book dealer with a penchant for detective work) driven to catch him. Bartlett befriended both outlandish characters and found herself caught in the middle of efforts to recover hidden treasure. A cat-and-mouse chase that not only reveals exactly how Gilkey pulled off his dirtiest crimes, where he stashed the loot, and how Sanders ultimately caught him but also explores the romance of books, the lure to collect them, and the temptation to steal them. Bartlett looks at the history of book passion, collection, and theft through the ages, to examine the craving that makes some people willing to stop at nothing to possess the books they love.

    Anthony Fauci a household name, he played a pivotal role in American medicine for over 50 years, as a physician trained in the crucible of medical crisis and an effective researcher who supported medical breakthroughs. Get to know the man behind the sobering and stabilizing presence on TV, and hear the fascinating personal history that equipped him to keep our nation informed about COVID-19.In the summer of 2019, Alan Alda, the acclaimed actor, author and host of the podcast, Clear+Vivid, interviewed Dr. Fauci for the upcoming audio Soldiers of Science. This Audible Original explores a little-known Vietnam-era program that brought the very best and brightest young doctors into government service. Dr. Fauci was one of an elite corps of medical school graduates whose time as clinical researchers at the National Institutes of Health paved the way for life-saving breakthroughs in heart disease, cancer, immunology and the AIDS crisis, not to mention nine Nobel-prize winning discoveries in science (at last count).While editing the full documentary, Alan and the team found themselves deeply moved by Dr. Fauci’s commitment to service, his recollections of his early days at the NIH, and how he coped with the tragedy of the AIDS pandemic. We want our listeners to feel the same sense of inspiration, hope, and the comfort of Dr. Fauci’s insights, so we put together this special preview of Soldiers of Science, highlighting Dr. Fauci’s history. Please enjoy this special excerpt as our salute to all the doctors, nurses, health professionals, first responders, and scientists on the frontlines of the coronavirus pandemic. Soldiers of Science, we thank you for your service.Photo Credit: NIAID©2020 Audible Originals, LLC (P)2020 Audible, Inc.

    Across five decades, Prine has created critically acclaimed albums--John Prine (one of Rolling Stone's 500 Greatest Albums of All Time), Bruised Orange, and The Missing Years--and earned many honors, including two Grammy Awards, a Lifetime Achievement Award for Songwriting from the Americana Music Association, and induction into the Nashville Songwriters Hall of Fame. His songs have been covered by scores of artists, from Johnny Cash and Miranda Lambert to Bette Midler and 10,000 Maniacs, and have influenced everyone from Roger McGuinn to Kacey Musgraves. Hailed in his early years as the "new Dylan," Prine still counts Bob Dylan among his most enthusiastic fans. In John Prine, Eddie Huffman traces the long arc of Prine's musical career, beginning with his early, seemingly effortless successes, which led paradoxically not to stardom but to a rich and varied career writing songs that other people have made famous. He recounts the stories, many of them humorous, behind Prine's best-known songs and discusses all of Prine's albums as he explores the brilliant records and the ill-advised side trips, the underappreciated gems and the hard-earned comebacks that led Prine to found his own successful record label, Oh Boy Records. This thorough, entertaining treatment gives John Prine his due as one of the most influential songwriters of his generation.

    Over the course of minutes, they would kill twelve students and a teacher and wound twenty-four others before taking their own lives.   For the last sixteen years, Sue Klebold, Dylan’s mother, has lived with the indescribable grief and shame of that day. How could her child, the promising young man she had loved and raised, be responsible for such horror? And how, as his mother, had she not known something was wrong? Were there subtle signs she had missed? What, if anything, could she have done differently?   These are questions that Klebold has grappled with every day since the Columbine tragedy. In A Mother’s Reckoning, she chronicles with unflinching honesty her journey as a mother trying to come to terms with the incomprehensible. In the hope that the insights and understanding she has gained may help other families recognize when a child is in distress, she tells her story in full, drawing upon her personal journals, the videos and writings that Dylan left behind, and on countless interviews with mental health experts.   Filled with hard-won wisdom and compassion, A Mother’s Reckoning is a powerful and haunting book that sheds light on one of the most pressing issues of our time. And with fresh wounds from the recent Newtown and Charleston shootings, never has the need for understanding been more urgent.  All author profits from the book will be donated to research and to charitable organizations focusing on mental health issues.

    By turns humorous and moving, Tales from Both Sides of the Brain interweaves Gazzaniga’s scientific achievements with his reflections on the challenges and thrills of working as a scientist.

    The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. This incredible discovery was sulfa, the first antibiotic. In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of the drug that shaped modern medicine.Sulfa saved millions of lives—among them those of Winston Churchill and Franklin Delano Roosevelt Jr.—but its real effects are even more far reaching. Sulfa changed the way new drugs were developed, approved, and sold; transformed the way doctors treated patients; and ushered in the era of modern medicine. The very concept that chemicals created in a lab could cure disease revolutionized medicine, taking it from the treatment of symptoms and discomfort to the eradication of the root cause of illness. A strange and colorful story, The Demon Under the Microscope illuminates the vivid characters, corporate strategy, individual idealism, careful planning, lucky breaks, cynicism, heroism, greed, hard work, and the central (though mistaken) idea that brought sulfa to the world. This is a fascinating scientific tale with all the excitement and intrigue of a great suspense novel. For thousands of years, humans had sought medicines with which they could defeat contagion, and they had slowly, painstakingly, won a few battles: some vaccines to ward off disease, a handful of antitoxins. A drug or two was available that could stop parasitic diseases once they hit, tropical maladies like malaria and sleeping sickness. But the great killers of Europe, North America, and most of Asia—pneumonia, plague, tuberculosis, diphtheria, cholera, meningitis—were caused not by parasites but by bacteria, much smaller, far different microorganisms. By 1931, nothing on earth could stop a bacterial infection once it started. . . .But all that was about to change. . . . —from The Demon Under the Microscope

    Anatomy matters, Alice Domurat Dreger tells us, because the senses we possess, the muscles we control, and the resources we require to keep our bodies alive limit and guide what we experience in any given context. Her deeply thought-provoking and compassionate work exposes the breadth and depth of that context--the extent of the social frame upon which we construct the normal. In doing so, the book calls into question assumptions about anatomy and normality, and transforms our understanding of how we are all intricately and inextricably joined.

    In 1887, 23-year-old reporter Nellie Bly had herself committed to a New York City asylum for 10 days to expose the horrific conditions for 19th-century century mental patients.

    When she opened it, an FBI agent informed her that her father had been arrested for murdering ten people, including two children. It was then that she learned her father was the notorious serial killer known as BTK, a name he’d given himself that described the horrific way he committed his crimes: bind, torture, kill. As news of his capture spread, Wichita celebrated the end of a thirty-one-year nightmare. For Kerri Rawson, another was just beginning. She was plunged into a black hole of horror and disbelief. The same man who had been a loving father, a devoted husband, church president, Boy Scout leader, and a public servant had been using their family as a cover for his heinous crimes since before she was born. Everything she had believed about her life had been a lie.Written with candor and extraordinary courage, A Serial Killer’s Daughter is an unflinching exploration of life with one of America’s most infamous killers and an astonishing tale of personal and spiritual transformation. For all who suffer from unhealed wounds or the crippling effects of violence, betrayal, and anger, Kerri Rawson’s story offers the hope of reclaiming sanity in the midst of madness, rebuilding a life in the shadow of death, and learning to forgive the unforgivable.

    In this extraordinary memoir, she opens a window into the experience of wordlessness—the language paralysis called aphasia. In narrating the recovery of her husband, Paul West, from a stroke that reduced his vast vocabulary to a single syllable, she evokes the joy and mystery of the brain’s ability to find and connect words. Deeply rewarding to readers of all kinds, Ackerman has given us a literary love story, accessible insight into the science and medicine of brain injury,and invaluable spiritual sustenance in the face of life’s myriad physical sufferings.

    Heath in the 1950s and '60s has been described as among the most controversial experiments in US history. His work was alleged at the time to be part of MKUltra, the CIA's notorious "mind control" project. His research subjects included incarcerated convicts and gay men who wished to be "cured" of their sexual preference. Yet his cutting-edge research and legacy were quickly buried deep in Tulane University's archives. Investigative science journalist Lone Frank now tells the complete sage of this passionate, determined doctor and his groundbreaking neuroscience.More than fifty years after Heath's experiments, this very same treatment is becoming mainstream practice in modern psychiatry for everything from schizophrenia, anorexia, and compulsive behavior to depression, Parkinson's, and even substance addiction.Lone Frank uncovered lost documents and accounts of Heath's trailblazing work. She tracked down surviving colleagues and patients, and she delved into the current support for deep brain stimulation by scientists and patients alike. What has changed? Why do we today unquestioningly embrace this technology as a cure? How do we decide what is a disease of the brain to be cured and what should be allowed to remain unprobed and unprodded? And how do we weigh the decades of criticism against the promise of treatment that could be offered to millions of patients?Elegantly written and deeply fascinating, The Pleasure Shock weaves together biography, scientific history, and medical ethics. It is an adventure into our ever-shifting views of the mind and the fateful power we wield when we tinker with the self.

    Over the next three months, he was seduced by the drug and descended into psychosis.This confronting and illuminating story charts Luke's recovery from the drug, and his investigation into its usage and prevalence in Australia and the western world. In examining what led to his addiction, Luke also explores the social problems that surround ice, scrutinising whether its abuse is in fact an epidemic, with what we're experiencing now merely the tip of the proverbial iceberg, or yet another moral panic about the underclass. Luke traces the history of methamphetamine from its legal usage in the early 20th century to its contemporary relevance as one of the most foreboding and talked-about illicit drugs in the world. His search for answers sees him exploring meth labs, interviewing addicts and law-enforcement officials, and witnessing firsthand the effects of the drug on individuals, families, and the healthcare system.Combining memoir with reportage, The Ice Age is a vital, compelling first-person account, and an investigation into a drug that is fast becoming the subject of national discussion throughout the western world.

    In Broken, Jenny brings readers along on her mental and physical health journey, offering heartbreaking and hilarious anecdotes along the way.With people experiencing anxiety and depression now more than ever, Jenny humanizes what we all face in an all-too-real way, reassuring us that we’re not alone and making us laugh while doing it. From the business ideas that she wants to pitch to Shark Tank to the reason why Jenny can never go back to the post office, Broken leaves nothing to the imagination in the most satisfying way. And of course, Jenny’s long-suffering husband Victor―the Ricky to Jenny’s Lucille Ball―is present throughout.A treat for Jenny Lawson’s already existing fans, and destined to convert new ones, Broken is a beacon of hope and a wellspring of laughter when we all need it most.