Richard Rhodes follows virus hunters on three continents as they track the emergence of a deadly new brain disease that first kills cannibals in New Guinea, then cattle and young people in Britain and France—and that has already been traced to food animals in the United States. In a new afterword for the paperback, Rhodes reports the latest US and worldwide developments of a burgeoning global threat.

    We like to imagine that it’s based on evidence and the results of fair tests. In reality, those tests are often profoundly flawed. We like to imagine that doctors are familiar with the research literature surrounding a drug, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by industry. We like to imagine that regulators let only effective drugs onto the market, when in reality they approve hopeless drugs, with data on side effects casually withheld from doctors and patients.All these problems have been protected from public scrutiny because they’re too complex to capture in a sound bite. But Dr. Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct on a global scale affects us. In his own words, “the tricks and distortions documented in these pages are beautiful, intricate, and fascinating in their details.” With Goldacre’s characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for something to be done. This is the pharmaceutical industry as it has never been seen before.

    Two scientists explore the potential of a revolutionary genetics technology capable of easily and affordably manipulating DNA in human embryos to prevent specific diseases, addressing key concerns about related ethical and societal repercussions.

    Some of their responses to those outbreaks are almost too strange to believe in hindsight. Get Well Soon delivers the gruesome, morbid details of some of the worst plagues we’ve suffered as a species, as well as stories of the heroic figures who selflessly fought to ease the suffering of their fellow man. With her signature mix of in-depth research and storytelling, and not a little dark humor, Jennifer Wright explores history’s most gripping and deadly outbreaks, and ultimately looks at the surprising ways they’ve shaped history and humanity for almost as long as anyone can remember.

    America faced a troubling question: What happened? How was this epidemic allowed to spread so far before it was taken seriously? In answering these questions, Shilts weaves the disparate threads into a coherent story, pinning down every evasion and contradiction at the highest levels of the medical, political, and media establishments. Shilts shows that the epidemic spread wildly because the federal government put budget ahead of the nation's welfare; health authorities placed political expediency before the public health; and scientists were often more concerned with international prestige than saving lives. Against this backdrop, Shilts tells the heroic stories of individuals in science and politics, public health and the gay community, who struggled to alert the nation to the enormity of the danger it faced. And the Band Played On is both a tribute to these heroic people and a stinging indictment of the institutions that failed the nation so badly.

    But we should--even those of us who take care of our business in pristine, sanitary conditions. For it's not only in developing countries that human waste is a major public health threat: population growth is taxing even the most advanced sewage systems, and the disease spread by waste kills more people worldwide every year than any other single cause of death. Even in America, 1.95 million people have no access to an indoor toilet. Yet the subject remains unmentionable."The Big Necessity "takes aim at the taboo, revealing everything that matters about how people do--and don't--deal with their own waste. Moving from the deep underground sewers of Paris, London, and New York--an infrastructure disaster waiting to happen--to an Indian slum where ten toilets are shared by 60,000 people, Rose George stops along the way to explore the potential saviors: China's five million biogas digesters, which produce energy from waste; the heroes of third world sanitation movements; the inventor of the humble Car Loo; and the U.S. Army's personal lasers used by soldiers to zap their feces in the field.With razor-sharp wit and crusading urgency, mixing levity with gravity, Rose George has turned the subject we like to avoid into a cause with the most serious of consequences.

    Result: The world's first vaccine. Experiment: A slave woman is forced to undergo more than thirty operations without anesthesia. Result: The beginnings of modern gynecology. Experiment: From 1946 to 1953, seventy-four boys are fed oatmeal laced with radioactive iron and calcium. Result: A better understanding of the effects of radioactivity on the human body. Experimental incidents such as these paved the way for crucial medical discoveries and lifesaving cures and procedures. But they also violated the rights of their subjects, many of whom did not give their consent to the experiments. The subjects suffered excruciating pain and humiliation. Some even died as a result of the procedures. Even in the twenty-first century—despite laws, regulations, and ethical conventions—the tension between medical experimentation and patient rights continues. How do doctors balance the need to test new medicines and procedures with their ethical and moral duty to protect the rights of human subjects? What price has been paid for medical knowledge? Can we learn from the broken oaths of the past? Take a harrowing journey through some of history's greatest medical advances—and its most horrifying medical atrocities. You'll read about orphans injected with lethal tuberculosis and concentration camp inmates tortured by Nazi doctors. You’ll also learn about radiation experimentation and present-day clinical trials that prove fatal. Through these stories, explore the human suffering that has gone hand in hand with medical advancement.

    Lab 257 blows the lid off the stunning true nature and checkered history of Plum Island. It shows that the seemingly bucolic island in the shadow of New York City is a ticking biological time bomb that none of us can safely ignore.Based on declassified government documents, in-depth interviews, and access to Plum Island itself, this is an eye-opening, suspenseful account of a federal government germ laboratory gone terribly wrong. For the first time, Lab 257 takes you deep inside this secret world and presents startling revelations on virus outbreaks, biological meltdowns, infected workers, the periodic flushing of contaminated raw sewage into area waters, and the insidious connections between Plum Island, Lyme disease, and the deadly West Nile virus. The book also probes what's in store for Plum Island's new owner, the Department of Homeland Security, in this age of bioterrorism.Lab 257 is a call to action for those concerned with protecting present and future generations from preventable biological catastrophes.

    In 1750, the anatomist John Hunter described it as “a humiliating spectacle of the futility of science”; yet, over the next 150 years the feared, practical men of medicine benefited from a revolution in scientific progress and the increased availability of instructional textbooks. Anesthesia and antisepsis were introduced. Newly established medical schools improved surgeons’ understanding of the human body. For the first time, surgical techniques were refined, illustrated in color, and disseminated on the printed page.Crucial Interventions follows this evolution, drawing from magnificent examples of rare surgical textbooks from the mid-nineteenth century. Graphic and sometimes unnerving yet beautifully rendered, these fascinating illustrations, acquired from the Wellcome Collection’s extensive archives, include step-by-step surgical techniques paired with depictions of medical instruments and depictions of operations in progress.Arranged for the layman (from head to toe) Crucial Interventions is a captivating look at the early history of one of the world’s most mysterious and macabre professions.

    Brenda Maddox tells a powerful story of a remarkably single-minded, forthright, and tempestuous young woman who, at the age of fifteen, decided she was going to be a scientist, but who was airbrushed out of the greatest scientific discovery of the twentieth century.

    Like when doctors prescribed morphine for crying infants. When snorting skull moss was a cure for a bloody nose. When consuming mail-order tapeworms was a latter-day fad diet. Or when snake oil salesmen peddled strychnine (used in rat poison) as an aphrodisiac in the '60s. Seamlessly combining macabre humor with hard science and compelling storytelling, Quackery is a visually rich and information-packed exploration of history's most outlandish cures, experiments, and scams.A humorous book that delves into some of the wacky but true ways that humans have looked to cure their ills. Leeches, mercury, strychnine, and lobotomies are a few of the topics that explore the lengths society has gone in the search for health.

    She was a poor Southern tobacco farmer who worked the same land as her enslaved ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia — a land of wooden quarters for enslaved people, faith healings, and voodoo — to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family — past and present — is inextricably connected to the history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance?Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

    Nestled in the Smoky Mountains of eastern Tennessee, the town of Johnson City had always seemed exempt from the anxieties of modern American life. But when the local hospital treated its first AIDS patient, a crisis that had once seemed an urban problem had arrived in the town to stay. Working in Johnson City was Abraham Verghese, a young Indian doctor specializing in infectious diseases. Dr. Verghese became by necessity the local AIDS expert, soon besieged by a shocking number of male and female patients whose stories came to occupy his mind, and even take over his life. Verghese brought a singular perspective to Johnson City: as a doctor unique in his abilities; as an outsider who could talk to people suspicious of local practitioners; above all, as a writer of grace and compassion who saw that what was happening in this conservative community was both a medical and a spiritual emergency."

    129 - ca. 216) began his remarkable career tending to wounded gladiators in provincial Asia Minor. Later in life he achieved great distinction as one of a small circle of court physicians to the family of Emperor Marcus Aurelius, at the very heart of Roman society. Susan Mattern's The Prince of Medicine offers the first authoritative biography in English of this brilliant, audacious, and profoundly influential figure. Like many Greek intellectuals living in the high Roman Empire, Galen was a prodigious polymath, writing on subjects as varied as ethics and eczema, grammar and gout. Indeed, he was (as he claimed) as highly regarded in his lifetime for his philosophical works as for his medical treatises. However, it is for medicine that he is most remembered today, and from the later Roman Empire through the Renaissance, medical education was based largely on his works. Even up to the twentieth century, he remained the single most influential figure in Western medicine. Yet he was a complicated individual, full of breathtaking arrogance, shameless self- promotion, and lacerating wit. He was fiercely competitive, once disemboweling a live monkey and challenging the physicians in attendance to correctly replace its organs. Relentless in his pursuit of anything that would cure the patient, he insisted on rigorous observation and, sometimes, daring experimentation. Even confronting one of history's most horrific events- a devastating outbreak of smallpox-he persevered, bearing patient witness to its predations, year after year. The Prince of Medicine gives us Galen as he lived his life, in the city of Rome at its apex of power and decadence, among his friends, his rivals, and his patients. It offers a deeply human and long- overdue portrait of one of ancient history's most significant and engaging figures.