Sip coconuts on a Caribbean beach; lay eyes on the awe-inspiring Panama Canal; or hike through sublime cloud forests; all with your trusted travel companion. Get to the heart of Panama and begin your journey now! Inside Lonely Planet Panama: Color maps and images throughout Highlights and itineraries help you tailor your trip to your personal needs and interests Insider tips to save time and money and get around like a local, avoiding crowds and trouble spots Essential info at your fingertips - hours of operation, phone numbers, websites, transit tips, prices Honest reviews for all budgets - eating, sleeping, sight-seeing, going out, shopping, hidden gems that most guidebooks miss Cultural insights give you a richer, more rewarding travel experience - land & wildlife, music, cuisine, arts, politics, history Over 46 maps Covers Panama City, Panama Province, Cocle Province, Peninsula deAzuero, Veraguas Province, Chiriqui Province, Bocas del Toro Province, Colon Province, Comarca de Kuna Yala, Darien Province and more eBook Features: (Best viewed on tablet devices and smartphones) Downloadable PDF and offline maps prevent roaming and data charges Effortlessly navigate and jump between maps and reviews Add notes to personalise your guidebook experience Seamlessly flip between pages Bookmarks and speedy search capabilities get you to key pages in a flash Embedded links to recommendations' websites Zoom-in maps and images Inbuilt dictionary for quick referencing The Perfect Choice: Lonely Planet Panama, our most comprehensive guide to Panama, is perfect for both exploring top sights and taking roads less traveled. Looking for more extensive coverage? Check out Lonely Planet Central America on a Shoestring. Authors: Written and researched by Lonely Planet. About Lonely Planet: Since 1973, Lonely Planet has become the world's leading travel media company with guidebooks to every destination, an award-winning website, mobile and digital travel products, and a dedicated traveler community. Lonely Planet covers must-see spots but also enables curious travelers to get off beaten paths to understand more of the culture of the places in which they find themselves. *Best-selling guide to Panama. Source: Nielsen BookScan. Australia, UK and USA Important Notice: The digital edition of this book may not contain all of the images found in the physical edition.

    This new edition, written with five new authors, has been brought fully up to date, and incorporates insights very recently derived from genome sequencing in a variety of organisms. The book is an authoritative and comprehensive survey of the fundamentals of molecular biology, from basic mechanisms to the elaborate role of gene regulation in embryonic development and evolution. Although updated, the twentyone chapters of the new edition retain the distinctive and celebrated features of the original work, including introductory chapters on the history of genetics and molecular biology and an emphasis throughout on the chemical underpinnings of molecular biology. The new team of authors brings to this edition awardwinning teaching experience and outstanding research achievements. By revealing the intellectual framework and experimental approaches that made new discoveries in the field possible, the new edition highlights the significance of the molecular approach for all of biology.

    Just a half century ago, this idea was revolutionary. In April 1953, James Watson and Francis Crick published in Nature their groundbreaking work revealing the double helix structure of DNA. While this discovery received wide attention from both mainstream media and the academic community, it was just one part of the bigger story in this history of molecular biology. By the mid-1950s, the scientific community confirmed that genes were indeed comprised of DNA; they just needed to crack the genetic code—and the race was on. Life’s Greatest Secret is the full and rich history of this challenge and the characters—many of whom were not biologists—whose work contributed to this grand scientific endeavor: mathematician and father of cybernetics Norbert Wiener, physicist Erwin Schrödinger, information theorist Claude Shannon, and biologists Jacques Monod and Marshall Nirenberg.In Life’s Greatest Secret, science historian and zoologist Matthew Cobb shows that the race to crack the genetic code was mostly a matter of craft—individuals or small groups struggling with ideas and concepts as much as they were with facts, trying to find the right experiment to answer the right questions, even if they didn’t know what the questions were, and finding that, even when the most definitive answer served mostly to reveal more ignorance, whether in 1953, with Watson and Crick, or in 1961, when Nirenberg and Matthaei showed how DNA codes for specific amino acids, and again and again thereafter, or in 2000, with the first publication of a human genome. Each discovery was a leap forward in our understanding of the natural world and our place within in, akin to the discoveries of Galileo and Einstein in the realm of physics, or the publication of Darwin’s On the Origin of Species. And each served to show how much bigger the problem was that anyone had previously imagined, a trend that continues, as Cobb shows, even today, whether we are discussing gene regulation, epigenetics, or GMOs.Life’s Greatest Secret is a story of ideas and of experimentation, of ingenuity, insight, and dead-ends, in the hunt to make the greatest discovery of twentieth century biology. Ultimately, though, this is a story of humans exploring what it is that makes us human.

    Complications lays bare a science not in its idealized form but as it actually is--uncertain, perplexing, and profoundly human.Complications is a 2002 National Book Award Finalist for Nonfiction.

    Edgar Hoover by a member of his personal staff—his former assistant, Paul Letersky—offers unprecedented, “clear-eyed and compelling” (Mark Olshaker, coauthor of Mindhunter) insight into an American legend.The 1960s and 1970s were arguably among America’s most turbulent post-Civil War decades. While the Vietnam War continued seemingly without end, protests and riots ravaged most cities, the Kennedys and MLK were assassinated, and corruption found its way to the highest levels of politics, culminating in Watergate. In 1965, at the beginning of the chaos, twenty-two-year-old Paul Letersky was assigned to assist the legendary FBI director J. Edgar Hoover who’d just turned seventy and had, by then, led the Bureau for an incredible forty-one years. Hoover was a rare and complex man who walked confidently among the most powerful. His personal privacy was more tightly guarded than the secret “files” he carefully collected—and that were so feared by politicians and celebrities. Through Letersky’s close working relationship with Hoover, and the trust and confidence he gained from Hoover’s most loyal senior assistant, Helen Gandy, Paul became one of the few able to enter the Director’s secretive—and sometimes perilous—world. Since Hoover’s death half a century ago, millions of words have been written about the man and hundreds of hours of TV dramas and A-list Hollywood films produced. But until now, there has been virtually no account from someone who, for a period of years, spent hours with the Director on a daily basis. Balanced, honest, and keenly observed, this “vivid, foibles-and-all portrait of the fabled scourge of gangsters, Klansmen, and communists” (The Wall Street Journal) sheds new light on one of the most powerful law enforcement figures in American history.

    In this sensational and macabre story, we meet the surgeon who counted not only luminaries Benjamin Franklin, Lord Byron, Adam Smith, and Thomas Gainsborough among his patients but also “resurrection men” among his close acquaintances. A captivating portrait of his ruthless devotion to uncovering the secrets of the human body, and the extraordinary lengths to which he went to do so—including body snatching, performing pioneering medical experiments, and infecting himself with venereal disease—this rich historical narrative at last acknowledges this fascinating man and the debt we owe him today.

    But AIDS is just one of the many emerging viruses for which we have, as yet, no cure. Even the old plagues – TB, cholera, bubonic plague – are making a comeback, resistant now to our drugs.Frank Ryan, a leading authority on disease, describes the groundbreaking research of the world’s leading experts in the field to show both where these viruses come from and why they prove to be so lethal, and advances a radical new biological theory for the origins and behaviour of plague viruses. Full of vivid despatches from the front line of research and medicine, 'Virus X' is terrifying and essential reading for anyone interested in the effects of plague viruses on human evolution.“Extremely well written…Frank Ryan has the page-turning and spine-chilling ability of a good novelist”MATT RIDLEY, 'Sunday Telegraph'“Compelling and frightening…the plot could not be bettered”MICHAEL SMITH, 'Scotsman'“Ryan is very good at making technical matters comprehensible to the lay reader but more impressive still is the way he conveys the intellectual excitement and elation of scientific discovery”ANTHONY DANIELS, 'Literary Review'“Ryan takes us through the drama of discovery and challenges the notion that certain questions are too appalling to contemplate”DAVID BRADLEY, 'New Scientist'“Dr Ryan writes well in a difficult technical field, weaving the technicalities of scientific history, medicine, molecular biology and evolution into the human narratives…very readable and disturbing”JOHN R.G. TURNER, 'New York Times'

    About The Author: Henry Gray, F.R.S., Fellow of the royal college of Surgeons: Lecturer on anatomy at St. George?s Hospital Medical School. Table Of Contents: Descriptive and Surgical Anatomy The Articulations Muscles and Fasclae The Blood-vascular system The Lymphatics The Nervous system The Organs of special sense The Organs of Digestion The Organs of voice and respiration The urinary organs The Male Organs of Generation The Female Organs of Generation The Surgical Anatomy of Hernia Surgical Anatomy of the Perinaeum General Anatomy or Histology Embryology

    In this selection from The Body, Bill Bryson introduces us to the mysterious, and often devastating, world of disease.

    You'll experience the rush of adrenaline and the pain of loss. You'll go beyond the lights and sirens to witness the instinct of intelligence, the courage and commitment that makes the EMT an unsung hero in one of the most vital and compelling medical dramas of our time.

    Many studies have supported this, proving that life expectancy is 75 to 90 percent due to habits and only 10 to 25 percent due to genetics. This means that someone who is genetically destined to die at age 100 may not live past age 60 because of poor habits and lifestyle choices that cause accelerated aging and premature death. Conversely, a person can live to 100 and be functionally healthy. In this highly anticipated follow-up, Diana Schwarzbein, M.D., goes beyond the diet she introduced in her first book—which literally helped thousands of people lose weight—and offers a personalized anti-aging program for readers to heal their metabolisms and stop advanced aging in its tracks. Weaving in groundbreaking research and provocative case studies—including her own regeneration and that of her clients—she leads readers through a series of eye-opening questionnaires, which identify where they are on their path to either accelerated or healthy aging. Based on readers’ answers, she leads them to the “how-to” sections, which explain, in easy-to-follow and personalized detail, the steps they need to take to restore healthy functioning. For each unique situation, she covers five areas: Nutrition , Hormone Replacement Therapy (if needed), Tapering Off Toxic Chemicals or Avoiding Them Completely , Cross-Training Exercises and Stress Management. The Schwarzbein Principle II is sure to follow the success of the first book and will help people live a more healthful lifestyle by embracing a regeneration process to prevent and reverse accelerated aging.

    He argues that these turning points in the country’s history were not the result of foresight or careful planning but were rather the accidental consequences of major crises that had to be resolved at any cost.

    Over three decades he has interviewed and investigated some of the most professional, dangerous and ruthless killers in Ireland. Now Dillon explores their personalities, motivations and bizarre crimes.Many of Ireland's assassins learned their trade in fields and on hillsides in remote parts of Ireland, while others were trained in the Middle East or with Basque separatist terrorists in Spain. Some were one-target-one-shot killers, like the sniper who terrorised the inhabitants of Washington State in the autumn of 2002, while others were bombers skilled in designing the most sophisticated explosive devices and booby traps. Another more powerful group of 'trigger men' were the influential figures in the shadows, who were experts in motivating the killers under their control. All of these men, whether they squeezed the trigger on a high-powered rifle, set the timer on a bomb or used their authority to send others out to commit horrific and unspeakable acts of cruelty, are featured in this book. The Trigger Men takes the reader inside the labyrinthine world of terrorist cells and highly classified counter-terrorism units of British Military Intelligence. The individual stories are described in gripping, unflinching detail and show how the terrorists carried out their ghastly work. Dillon also explores the ideology of the cult of the gunmen and the greed and hatred that motivated assassins in their killing sprees. There are penetrating insights into the mindset of the most infamous assassins: their social and historical conditioning, their callousness......

    The author of The Lives of a Cell and The Medusa and the Snail now raises challenging questions about some of the major issues of our time—AIDS, drug abuse, and aging.With extraordinary perception, author Lewis Thomas discusses topics such as evolutionary biology, the development of language, the therapeutic aspects of medicine, and his love for his profession.

    Ice hockey fans will pull on their skates and gear up for this Who HQ title about the Stanley Cup Finals--the National Hockey League's championship games.Out of the thirty-two pro hockey teams that compete, only one can call itself the champion and proudly hoist up the Stanley Cup--the oldest sports trophy in the world! From the formation of the leagues and the crowning of the first championship-winning team, to the Rangers' Stanley Cup curse and the uncertain fate of the teams during the Spanish flu epidemic, this book recounts the highs and lows of this exciting ice hockey series.