But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought - just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportionof DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'?Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact ofits 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes ofNeanderthals as well as that of chimps about the development our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.

    A good idea can inspire one commercial. But a good insight can fuel a thousand ideas, a thousand commercials. An insight gives you an entirely new way of thinking about your business. Consider just a few of the breakthrough insights that Dusenberry's agency, BBDO, has offered their clients over the years: That General Electric's unifying tagline should be ?We bring good things to life.? That Pepsi should be targeting the ?Pepsi Generation.? That Ronald Reagan's 1984 reelection theme should be ?Morning in America.? That Visa should compare itself with American Express, not MasterCard. Talk about moving the needle!Dusenberry argues that these brainstorms don?t come out of thin air, even at a world class organization like BBDO. They are actually the result of a rigorous and disciplined process of insight generation, one that any manager in any type of business can adopt. Dusenberry explains this process?Research, Analysis, Insight, Strategy, and Execution (RAISE)?in plain English. And he offers examples of some of the greatest business insights of our time, from the birth of Federal Express to the positioning of HBO."Moving the Needle" will help businesspeople get to the heart of their toughest problems.

    Lewis Dartnell considers some of the fascinating questions facing researchers today. Could life exist anywhere else in the universe? What might aliens really look like? Dartnell explains why Earth is uniquely suited for life and reveals our profound connection to the cosmos.

     Three and a half billion years ago, Mars resembled earth. It was warm and wet and could have supported primitive organisms. If life once existed on Mars, might it have originated there and traveled to earth inside meteorites blasted into space by cosmic impacts? Davies builds on recent scientific discoveries and theories to address larger questions of existence: What, exactly, is life? Is it the inevitable by-product of physical laws, as many scientists maintain, or an almost miraculous accident? Are we alone in the universe, or will life emerge on all earthlike planets? And if there is life elsewhere in the universe, is it preordained to evolve toward greater complexity and intelligence? Through his search for answers to these questions, Davies explores the ultimate mystery of mankind's existence -- who we are and what our place might be in the unfolding drama of the cosmos.

    All animals, human or otherwise, thrive when they mimic key elements of life in their natural habitat. From diet to movement to sleep, this evolutionary perspective sheds light on some of our most pressing health concerns. What is causing the rise of chronic conditions, such as obesity, diabetes, and depression? Is eating red meat going to kill you? Is avoiding the sun actually the best way to avoid skin cancer? Durant takes readers on a thrilling ride to the Paleolithic and beyond, unlocking the health secrets of our ancient ancestors. What do obese gorillas teach us about weight loss? How can Paleolithic skulls contain beautiful sets of teeth? Why is the Bible so obsessed with hygiene? What do NASA astronauts teach us about getting a good night’s sleep? And how are Silicon Valley techies hacking the human body? Blending science and culture, anthropology and philosophy, John Durant distills the lessons from his adventures and shows how to apply them to day-to-day life, teaching people how to construct their own personal “habitat” that will enable them to thrive. The book doesn’t just address what we eat, but why we eat it; not just how to exercise, but the purpose of functional movement; not just being healthy, but leading a purposeful life. Combining the best of ancient wisdom with cutting edge science, Durant crafts a vision of health that is both fresh and futuristic.

    Its accessible writing style appeals to students and instructors because of its brevity, simplicity of presentation, selective choice of content, and clear explanations.Comparative timelines appear at the end of each text part to show the relationship between the political and intellectual history of the West. A full-color map with an essay on physical geography appears at the beginning of each volume to help students orient themselves to European geography. Primary source excerpts integrated throughout the narrative show students the materials that historians work with every day.

    Being Mortal by Atul Gawande - A 20-minute Summary Inside this Instaread Summary: • Overview of the entire book• Introduction to the important people in the book• Summary and analysis of all the chapters in the book• Key Takeaways of the book• A Reader's Perspective Preview of this summary: Chapter 1 Gawande grew up in Ohio. His parents were immigrants from India and both were doctors. His grandparents stayed in India, and there were few older people in his neighborhood, so he had little experience with aging or death until he met his wife’s grandmother, Alice Hobson. Hobson was seventy-seven and living on her own in Virginia. She was a spirited widow who fixed her own plumbing and volunteered with Meals On Wheels. However, Hobson was losing strength and height steadily each year as her arthritis worsened.Gawande’s father enthusiastically adopted the customs of his new country, but he could not understand the way in which seniors were treated in the US. In India, the elderly were treated with great respect and lived out their lives with family.In the United States, Sitaram Gawande, Gawande’s grandfather, likely would have been sent to a nursing home like most of the elderly who cannot handle the basics of daily living by themselves. However, in India, Sitaram Gawande was able to live in his own home and manage his own affairs, with family constantly around him. He died at the age of one hundred and ten when he fell off a bus during a business trip.Until recently, most elderly people stayed with their families. Even as the nuclear family unit became predominant, replacing the multi-generational family unit, people cared for their elderly relatives. Families were large and one child, usually a daughter, would not marry in order to take care of the parents.This has changed in much of the world, where elderly people end up struggling to live alone, like Hobson, rather than living with dignity amid family, like Sitaram Gawande.One cause of this change can be found in the nature of knowledge. When few people lived to be very old, elders were honored. Their store of knowledge was greatly useful. People often portrayed themselves as older to command respect. Modern society’s emphasis on youth is a complete reversal of this attitude. Technological advances are perceived as the territory of the young, and everyone wants to be younger. High-tech job opportunities are all over the world, and young people do not hesitate to leave their parents behind to pursue them.In developed countries, parents embrace the concept of a retirement filled with leisure activities. Parents are happy to begin living for themselves once children are grown. However, this system only works for young, healthy retirees, but not for those who cannot continue to be independent. Hobson, for example, was falling frequently and suffering memory lapses. Her doctor did tests and wrote prescriptions, but did not know what to do about her deteriorating condition. Neither did her family… About the Author With Instaread Summaries, you can get the summary of a book in 30 minutes or less. We read every chapter, summarize and analyze it for your convenience.

    But Vidal was also a terrific conversationalist; indeed Dick Cavett once described him as “the best talker since Oscar Wilde.” Vidal was never more eloquent, or caustic, than when let loose on his favorite topic: the history and politics of the United States.This book is made up from four interviews conducted with his long-time interlocutor, the writer and radio host Jon Wiener, in which Vidal grapples with matters evidently close to his heart: the history of the American Empire, the rise of the National Security State, and his own life in politics, both as a commentator and candidate.The interviews cover a twenty-year span, from 1988 to 2008, when Vidal was at the height of his powers. His extraordinary facility for developing an argument, tracing connections between past and present, and drawing on an encyclopedic knowledge of America’s place in the world, are all on full display. And, of course, it being Gore Vidal, an ample sprinkling of gloriously acerbic one-liners is also provided.

    Every day, we break our fast. Hunger explores the range of this primal experience. Sharman Apt Russell, the highly acclaimed author of Anatomy of a Rose and An Obsession with Butterflies, here takes us on a tour of hunger, from eighteen hours without food to thirty-six hours to seven days and beyond. What Russell finds-both in our bodies and in cultures around the world-is extraordinary. It is a biological process that transcends nature to shape the very of fabric of societies. In a fascinating survey of centuries of thought on hunger's unique power, she discovers an ability to adapt to it that is nothing short of miraculous. From the fasting saints of the early Christian church to activists like Mahatma Gandhi, generations have used hunger to make spiritual and political statements. Russell highlights these remarkable cases where hunger can inspire and even heal, but she also addresses the devastating impact of starvation on cultures around the world today. Written with consummate skill, a compassionate heart, and stocked with facts, figures, and fascinating lore, Hunger is an inspiring window on history and the human spirit.

    But what if we could escape these trappings? With The Possibility Principle, Mel Schwartz emerges as one of the first psychotherapists to distill the basic premises of quantum theory into an empowering and practical system for transcending limitations and opening to infinite possibility. New discoveries in quantum physics are revolutionizing the way we understand our world, but we're often unclear about how this applies to our own experience. Using three core tenets of quantum physics--inseparability, potentiality, and uncertainty--Schwartz demonstrates how each of us can overcome difficulties and live our fullest potential, so long as we are willing to challenge our operating beliefs. Drawing from his vast body of research and dozens of client success stories, Schwartz shows us how to break through communication impasses, create resilient relationships, build authentic self-esteem, overcome anxiety and depression, and catalyze our defining moments so we can live more fearless and expansive lives.

    Sutter emphasizes how amazing it is that we are part of such a huge, complex, and mysterious place. Through metaphors and uncomplicated language, Sutter breathes life into the science of astrophysics, unveiling how particles, forces, and fields interplay to create the greatest of cosmic dramas. Touched with the author's characteristic breezy, conversational style--which has made him a breakout hit on venues such as The Weather Channel, the Science Channel, and his own popular Ask a Spaceman! podcast--he conveys the fun and wonder of delving deeply into the physical processes of the natural universe. He weaves together the past and future histories of our universe with grounded descriptions of essential modern-day physics as well as speculations based on the latest research in cosmology. Topics include our place in the Milky Way galaxy; the cosmic web--a vast web-like pattern in which galaxies are arranged; the origins of our universe in the big bang; the mysteries of dark matter and dark energy; how science has dramatically changed our relationship to the cosmos; conjectures about the future of reality as we know it; and more.For anyone who has ever stared at the starry night sky and wondered how we humans on Earth fit into the big picture, this book is an essential roadmap.

    The nation’s most trusted authority on heart-healthy living presents the fourth edition of this classic cookbook, with the most up-to-date information on heart health and nutrition—including the effects of saturated and trans fats and cholesterol—and 50 exciting new recipes.American Heart Association Low-Fat, Low-Cholesterol Cookbook offers more than 200 delicious, easy-to-prepare dishes, including:•Fresh Basil and Kalamata Hummus•Elegant Beef Tenderloin •Tilapia Tacos with Fresh Salsa•Garlic Chicken Fillets in Balsamic Vinegar •Peppery Beef with Blue Cheese Sauce•Thai Coconut Curry with Vegetables•Sweet Potatoes in Creamy Cinnamon Sauce•Pumpkin-Pie Coffeecake•Streusel-Topped Blueberry Bars•Key Lime Tart with Tropical FruitThe perfect companion for today’s healthy cook, this indispensable cookbook will help you put delicious food on the table and make the best choices for your heart’s health.From the Hardcover edition.

    Long-established techniques are carefully explained as well as exciting new methods as the authors describe the ways in which archaeologists seek to explain and interpret the remote past of humankind

    Squirming parasites, bursting pustules, rotting limbs, and cascading diarrhea: it's all depicted here in vivid detail. Sometimes the remedy proved as unbearable as the sickness itself. Whether performing dire dentistry or ice-pick lobotomies, bloodletting or blistering, the medical practitioners of history were ever inventive, if not effective. Disease played a role in shaping human history, too: read how measles and smallpox hastened the decline of the native peoples of the Americas, and how typhus helped to defeat Napoleon. Extraordinary anecdotes abound, such as the cautionary tale of Typhoid Mary and how a cow called Blossom saved the day. Packed with startling medical illustrations, this morbidly fascinating study of all that ails is bound to grip you from page one and leave you reaching for the disinfectant."

    Excellent Board review.