These areas of knowledge have converged into a modern theory of epidemiology that has been slow to penetrate into textbooks, particularly at the introductory level. Epidemiology: An Introduction closes the gap. It begins with a brief, lucid discussion of causal thinking and causal inference and then takes the reader through the elements of epidemiology, focusing on the measures of disease occurrence and causal effects. With these building blocks in place, the reader learns how to design, analyze and interpret problems that epidemiologists face, including confounding, the role of chance, and the exploration of interactions. All these topics are layered on the foundation of basic principles presented in simple language, with numerous examples and questions for further thought.

    Today, more than sixty years later, members of a new generation of scientists are attempting to create life from the ground up. Science has moved forward in leaps and bounds since Schrodinger's time, but our understanding of what does and does not constitute life has only grown more complex. An era that has already seen computer chip-implanted human brains, genetically engineered organisms, genetically modified foods, cloned mammals, and brain-dead humans kept alive by machines is one that demands fresh thinking about the concept of life. While a segment of our national debate remains stubbornly mired in moral quandaries over abortion, euthanasia, and other right to life issues, the science writer Ed Regis demonstrates how science can and does provide us with a detailed understanding of the nature of life. Written in a lively and accessible style, and synthesizing a wide range of contemporary research, What Is Life? is a brief and illuminating contribution to an age-old debate.

    They force us to confront a fundamental biological problem: how can something as large and complex as a human body organize itself from the simplicity of a fertilized egg? A convergence of ideas from embryology, genetics, physics, networks, and control theory has begun to provide real answers. Based on the central principle of 'adaptive self-organization, ' it explains how the interactions of many cells, and of the tiny molecular machines that run them, can organize tissue structures vastly larger than themselves, correcting errors as they go along and creating new layers of complexity where there were none before.Life Unfolding tells the story of human development from egg to adult, from this perspective, showing how our whole understanding of how we come to be has been transformed in recent years. Highlighting how embryological knowledge is being used to understand why bodies age and fail, Jamie A. Daviesexplores the profound and fascinating impacts of our newfound knowledge.

    By some estimates, we may already have lost almost half of the songbirds that filled the skies only forty years ago. Renowned biologist Bridget Stutchbury convincingly argues that songbirds truly are the "canaries in the coal mine"--except the coal mine looks a lot like Earth and we are the hapless excavators.Following the birds on their six-thousand-mile migratory journey, Stutchbury leads us on an ecological field trip to explore firsthand the major threats to songbirds: pesticides, still a major concern decades after Rachel Carson first raised the alarm; the destruction of vital habitat, from the boreal forests of Canada to the diminishing continuous forests of the United States to the grasslands of Argentina; coffee plantations, which push birds out of their forest refuges so we can have our morning fix; the bright lights and structures in our cities, which prove a minefield for migrating birds; and global warming. We could well wake up in the near future and hear no songbirds singing. But we won't just be missing their cheery calls, we'll be missing a vital part of our ecosystem. Without songbirds, our forests would face uncontrolled insect infestations, and our trees, flowers, and gardens would lose a crucial element in their reproductive cycle. As Stutchbury shows, saving songbirds means protecting our ecosystem and ultimately ourselves.Some of the threats to songbirds: - The U.S. annually uses 4-5 million pounds of active ingredient acephate, an insecticide that, even in small quantities, throws off the navigation systems of White-throated sparrows and other songbirds, making them unable to tell north from south. - The U.S. Fish and Wildlife Service conservatively estimated that 4-5 million birds are killed by crashing into communication towers each year.- A Michigan study found that 600 domestic cats killed more than 6,000 birds during a typical 10-week breeding season. Wood thrush, Kentucky warbler, the Eastern kingbird--migratory songbirds are disappearing at a frightening rate. By some estimates, we may already have lost almost half of the songbirds that filled the skies only forty years ago. Renowned biologist Bridget Stutchbury convincingly argues that songbirds truly are the "canaries in the coal mine"--except the coal mine looks a lot like Earth and we are the hapless excavators.Following the birds on their six-thousand-mile migratory journey, Stutchbury leads us on an ecological field trip to explore firsthand the major threats to songbirds: pesticides, still a major concern decades after Rachel Carson first raised the alarm; the destruction of vital habitat, from the boreal forests of Canada to the diminishing continuous forests of the United States to the grasslands of Argentina; coffee plantations, which push birds out of their forest refuges so we can have our morning fix; the bright lights and structures in our cities, which prove a minefield for migrating birds; and global warming. We could well wake up in the near future and hear no songbirds singing. But we won't just be missing their cheery calls, we'll be missing a vital part of our ecosystem. Without songbirds, our forests would face uncontrolled insect infestations, and our trees, flowers, and gardens would lose a crucial element in their reproductive cycle. As Stutchbury shows, saving songbirds means protecting our ecosystem and ultimately ourselves.Some of the threats to songbirds: - The U.S. annually uses 4-5 million pounds of active ingredient acephate, an insecticide that, even in small quantities, throws off the navigation systems of White-throated sparrows and other songbirds, making them unable to tell north from south. - The U.S. Fish and Wildlife Service conservatively estimated that 4-5 million birds are killed by crashing into communication towers each year.- A Michigan study found that 600 domestic cats killed more than 6,000 birds during a typical 10-week breeding season.

    The word conjures up images of horrific diseases sweeping the globe and killing everyone in their path. But such highly lethal illnesses almost never create pandemics. The reality is deadly serious but far more subtle.In Pandemics: What Everyone Needs to Know�, Peter Doherty, who won the Nobel Prize for his work on how the immune system recognizes virus-infected cells, offers an essential guide to one of the truly life-or-death issues of our age. In concise, question-and-answer format, he explains the causes of pandemics, how they can be counteracted with vaccines and drugs, and how we can better prepare for them in the future. Doherty notes that the term "pandemic" refers not to a disease's severity but to its ability to spread rapidly over a wide geographical area. Extremely lethal pathogens are usually quickly identified and confined. Nevertheless, the rise of high-speed transportation networks and the globalization of trade and travel have radically accelerated the spread of diseases. A traveler from Africa arrived in New York in 1999 carrying the West Nile virus; one mosquito bite later, it was loose in the ecosystem. Doherty explains how the main threat of a pandemic comes from respiratory viruses, such as influenza and SARS, which disseminate with incredible speed through air travel. The climate disruptions of global warming, rising population density, and growing antibiotic resistance all complicate efforts to control pandemics. But Doherty stresses that pandemics can be fought effectively. Often simple health practices, especially in hospitals, can help enormously. And research into the animal reservoirs of pathogens, from SARS in bats to HIV in chimpanzees, show promise for our prevention efforts.Calm, clear, and authoritative, Peter Doherty's Pandemics is one of the most critically important additions to the What Everyone Needs to Know� series.What Everyone Needs to Know� is a registered trademark of Oxford University Press.

    We have all benefited from the medical discoveries of primate research--vaccines for polio, rubella, and hepatitis B are just a few. But we have also learned more in recent years about how intelligent apes and monkeys really are: they can speak to us with sign language, they can even play video games (and are as obsessed with the games as any human teenager). And activists have also uncovered widespread and unnecessarily callous treatment of animals by researchers (in 1982, a Silver Spring lab was charged with 17 counts of animal cruelty). It is a complex issue, made more difficult by the combative stance of both researchers and animal activists. In The Monkey Wars, Deborah Blum gives a human face to this often caustic debate--and an all-but-human face to the subjects of the struggle, the chimpanzees and monkeys themselves. Blum criss-crosses America to show us first hand the issues and personalities involved. She offers a wide-ranging, informative look at animal rights activists, now numbering some twelve million, from the moderate Animal Welfare Institute to the highly radical Animal Liberation Front (a group destructive enough to be placed on the FBI's terrorist list). And she interviews a wide variety of researchers, many forced to conduct their work protected by barbed wire and alarm systems, men and women for whom death threats and hate mail are common. She takes us to Roger Fouts's research center in Ellensburg, Washington, where we meet five chimpanzees trained in human sign language, and we visit LEMSIP, a research facility in New York State that has no barbed wire, no alarms--and no protesters chanting outside--because its director, Jan Moor-Jankowski, listens to activists with respect and treats his animals humanely. And along the way, Blum offers us insights into the many side-issues involved: the intense battle to win over school kids fought by both sides, and the danger of transplanting animal organs into humans. As it stands now, Blum concludes, the research community and its activist critics are like two different nations, nations locked in a long, bitter, seemingly intractable political standoff....But if you listen hard, there really are people on both sides willing to accept and work within the complex middle. When they can be freely heard, then we will have progressed to another place, beyond this time of hostilities. In The Monkey Wars, Deborah Blum gives these people their voice.

    Is the apple sitting on your kitchen counter alive, or is only the apple tree it came from deserving of the word? If we can't answer that question here on earth, how will we know when and if we discover alien life on other worlds? The question hangs over some of society's most charged conflicts--whether a fertilized egg is a living person, for example, and when we ought to declare a person legally dead.Charting the obsession with Dr. Frankenstein's monster and how Coleridge came to believe the whole universe was alive, Zimmer leads us all the way into the labs and minds of researchers working on engineering life from the ground up.

    Jack Kruse gives us his first book, Epi-paleo Rx: The Prescription for Disease Reversal and Optimal Health. Kruse, who used his findings to lose 140 pounds and pack on muscle, takes the reader through his prescriptions for obesity, diabetes, heart disease, osteoporosis, autoimmunity, brain health, and aging. The material weaves together surprises from our Ice Age origins with the new science of epigenetics, or the effect of diet and environment on gene expression.A champion of “biohacking,” the art of tinkering with one’s own biology, Kruse pounces on his own profession’s ineptness when it comes to chronic conditions and urges readers to take health care into their own hands. He discusses which labs to order and why, why your doctor is obligated to write you a prescription you don’t need, the vital roles daylight and darkness play in metabolism, and the optimal diet for different stages of health and different times of year. Perhaps Kruse’s more fascinating contributions to Paleo literature are his findings on cold therapy—the effect of cold environments, immersion in cold water, and ice pack therapy on disease reversal, pain, and optimal living. Kruse explains how our origins as cold-adapted mammals hold the key to disease reversal, using a shocking biohack to prove his theory.The Epi-paleo Rx is the result of Kruse’s abundant research and clinical application in his practice as a neurosurgeon. Kruse questions conventional wisdom about human metabolism and chronic disease, arguing science has incomplete information when it comes to insulin resistance, diabetes, obesity, and their related illnesses. By examining the human body through the prism of our early beginnings and the science of epigenetics, we find each of us already possesses the “owner’s manual” to reverse disease and live optimally.

    Mary T. Newport has demonstrated through her care for her husband that there is hope, relief, and perhaps a cure.

    Illustrations of cones, catkins, nuts and fruits allow you to distinguish between similar species at a glance.This new edition builds on the strengths of the unrivalled original, now expanded to include over 220 trees and shrubs that are native to or flourish in Britain and northern Europe.

    I know tomorrow.” This inscription in Tutankhamun’s tomb summarizes The Fifth Beginning. Here, archaeologist Robert L. Kelly explains how the study of our cultural past can predict the future of humanity.   In an eminently readable style, Kelly identifies four key pivot points in the six-million-year history of human development: the emergence of technology, culture, agriculture, and the state. In each example, the author examines the long-term processes that resulted in a definitive, no-turning-back change for the organization of society. Kelly then looks ahead, giving us evidence for what he calls a fifth beginning, one that started about AD 1500. Some might call it “globalization,” but the author places it in its larger context: a five-thousand-year arms race, capitalism’s global reach, and the cultural effects of a worldwide communication network.   Kelly predicts that the emergent phenomena of this fifth beginning will include the end of war as a viable way to resolve disputes, the end of capitalism as we know it, the widespread shift toward world citizenship, and the rise of forms of cooperation that will end the near-sacred status of nation-states. It’s the end of life as we have known it. However, the author is cautiously optimistic: he dwells not on the coming chaos, but on humanity’s great potential.

    Jonathan Reiner, share the story of Cheney’s thirty-five-year battle with heart disease—providing insight into the incredible medical breakthroughs that have changed cardiac care over the last four decades. For as long as he has served at the highest levels of business and government, Vice President Dick Cheney has also been one of the world’s most prominent heart patients. Now, for the first time ever, Cheney, together with his longtime cardiologist, Jonathan Reiner, MD, shares the very personal story of his courageous thirty-five-year battle with heart disease, from his first heart attack in 1978 to the heart transplant he received in 2012.In 1978, when Cheney suffered his first heart attack, he received essentially the same treatment President Eisenhower had had in 1955. Since then, cardiac medicine has been revolutionized, and Cheney has benefitted from nearly every medical breakthrough. At each juncture, when Cheney faced a new health challenge, the technology was one step ahead of his disease. Cheney’s story is in many ways the story of the evolution of modern cardiac care.Heart is the riveting, singular memoir of both doctor and patient. Like no US politician has before him, Cheney opens up about his health struggles, sharing harrowing, never-before-told stories about the challenges he faced during a perilous time in our nation’s history. Dr. Reiner provides his perspective on Cheney’s case and also gives readers a fascinating glimpse into his own education as a doctor and the history of our understanding of the human heart. He masterfully chronicles the important discoveries, radical innovations, and cutting-edge science that have changed the face of medicine and saved countless lives.Powerfully braiding science with story and the personal with the political, Heart is a sweeping, inspiring, and ultimately optimistic book that will give hope to the millions of Americans affected by heart disease.

    In a sequel to White Wolf, award-winning nature photographer Jim Brandenburg's powerful narrative--and 140 color photos of timber wolves in their natural habitat--will revolutionize our thinking about wolves, human nature, our primeval past, and the survival of our planet.

    Devlin's Textbook of Biochemistry with Clinical Correlations presents the biochemistry of mammalian cells, relates events at a cellular level to the subsequent physiological processes in the whole animal, and cites examples of human diseases derived from aberrant biochemical processes. The organization and content are tied together to provide students with the complete picture of biochemistry and how it relates to humans. Loaded with new material and chapters and brimming with detailed, full-color illustrations that clearly explain associated concepts, this sixth edition is an indispensable tool for students and professionals in the medical or health sciences. Key Features of the Sixth Edition Over 250 Clinical Correlations highlighting the significance of the biochemistry to clinical conditions and diseases MCAT-Style Questions with annontated answers in every chapter - in a format similar to that used by the National Board of Medical Examiners More than 1,200 high-quality, full-color illustrations A concise appendix reviewing important Organic Chemistry Concepts New to the Sixth Edition: Fully Updated with a significant revision of all chapters and major topics Two new chapters: Fundamentals of Signal Transduction and Cell Cycle, Programmed Cell Death, and Cancer A Glossary that explains important biochemical terms New sections on the Basal Lamina Protein Complex and Molecular Motors

    Join her on a comical, insightful and, at times, shocking nature trail around the world. In this mad-cap adventure, she introduces us to the amazing, surprising and hysterical truth about all creatures great and small. From the African lungfish to the kangaroo, get ready for an irreverent, funny and often furry journey of discovery.