Dr. Hermann Reuter, a son of old South West African stock, wants to show the world that if you provide decent treatment, people will come and get it, no matter their circumstances. Sizwe and Hermann live at the epicenter of the greatest plague of our times, the African AIDS epidemic. In South Africa alone, nearly 6 million people in a population of 46 million are HIV-positive. Already, Sizwe has watched several neighbors grow ill and die, yet he himself has pushed AIDS to the margins of his life and associates it obliquely with other people's envy, with comeuppance, and with misfortune. When Hermann Reuter establishes an antiretroviral treatment program in Sizwe's district and Sizwe discovers that close family members have the virus, the antagonism between these two figures from very different worlds -- one afraid that people will turn their backs on medical care, the other fearful of the advent of a world in which respect for traditional ways has been lost and privacy has been obliterated -- mirrors a continent-wide battle against an epidemic that has corrupted souls as much as bodies. A heartbreaking tale of shame and pride, sex and death, and a continent's battle with its demons, Steinberg's searing account is a tour-de-force of literary journalism.

    Drawing on exclusive accounts from whistleblowers and regulators, as well as thousands of pages of confidential FDA documents, Eban reveals an industry where fraud is rampant, companies routinely falsify data, and executives circumvent almost every principle of safe manufacturing to minimize cost and maximize profit, confident in their ability to fool inspectors. Meanwhile, patients unwittingly consume medicine with unpredictable and dangerous effects.The story of generic drugs is truly global. It connects middle America to China, India, sub-Saharan Africa and Brazil, and represents the ultimate litmus test of globalization: what are the risks of moving drug manufacturing offshore, and are they worth the savings? A decade-long investigation with international sweep, high-stakes brinkmanship and big money at its core, Bottle of Lies reveals how the world’s greatest public-health innovation has become one of its most astonishing swindles.

    A writer for The New Yorker and The Atlantic Monthly, Carl Elliott ventures into the uncharted dark side of medicine, shining a light on the series of social and legislative changes that have sacrificed old-style doctoring to the values of consumer capitalism. Along the way, he introduces us to the often shifty characters who work the production line in Big Pharma: from the professional guinea pigs who test-pilot new drugs and the ghostwriters who pen “scientific” articles for drug manufacturers to the PR specialists who manufacture “news” bulletins. We meet the drug reps who will do practically anything to make quota in an ever-expanding arms race of pharmaceutical gift-giving; the “thought leaders” who travel the world to enlighten the medical community about the wonders of the latest release; even, finally, the ethicists who oversee all that commercialized medicine has to offer from their pharma-funded perches.   Taking the pulse of the medical community today, Elliott discovers the culture of deception that has become so institutionalized many people do not even see it as a problem. Head-turning stories and a rogue’s gallery of colorful characters become his springboard for exploring larger ethical issues surrounding money. Are there certain things that should not be bought and sold? In what ways do the ethics of business clash with the ethics of medical care? And what is wrong with medical consumerism anyway? Elliott asks all these questions and more as he examines the underbelly of medicine.

    Here, nurses remember their first “sticks,” first births, and first deaths, and reflect on what gets them though long, demanding shifts, and keeps them in the profession. The stories reveal many voices from nurses at different stages of their careers: One nurse-in-training longs to be trusted with more “important” procedures, while another questions her ability to care for nursing home residents. An efficient young emergency room nurse finds his life and career irrevocably changed by a car accident. A nurse practitioner wonders whether she has violated professional boundaries in her care for a homeless man with AIDS, and a home care case manager is the sole attendee at a funeral for one of her patients. What connects these stories is the passion and strength of the writers, who struggle against burnout and bureaucracy to serve their patients with skill, empathy, and strength.

    What is going on? Anatomy of an Epidemic challenges readers to think through that question themselves. First, Whitaker investigates what is known today about the biological causes of mental disorders. Do psychiatric medications fix “chemical imbalances” in the brain, or do they, in fact, create them? Researchers spent decades studying that question, and by the late 1980s, they had their answer. Readers will be startled—and dismayed—to discover what was reported in the scientific journals. Then comes the scientific query at the heart of this book: During the past fifty years, when investigators looked at how psychiatric drugs affected long-term outcomes, what did they find? Did they discover that the drugs help people stay well? Function better? Enjoy good physical health? Or did they find that these medications, for some paradoxical reason, increase the likelihood that people will become chronically ill, less able to function well, more prone to physical illness?  This is the first book to look at the merits of psychiatric medications through the prism of long-term results. Are long-term recovery rates higher for medicated or unmedicated schizophrenia patients? Does taking an antidepressant decrease or increase the risk that a depressed person will become disabled by the disorder? Do bipolar patients fare better today than they did forty years ago, or much worse? When the National Institute of Mental Health (NIMH) studied the long-term outcomes of children with ADHD, did they determine that stimulants provide any benefit?  By the end of this review of the outcomes literature, readers are certain to have a haunting question of their own: Why have the results from these long-term studies—all of which point to the same startling conclusion—been kept from the public?  In this compelling history, Whitaker also tells the personal stories of children and adults swept up in this epidemic. Finally, he reports on innovative programs of psychiatric care in Europe and the United States that are producing good long-term outcomes. Our nation has been hit by an epidemic of disabling mental illness, and yet, as Anatomy of an Epidemic reveals, the medical blueprints for curbing that epidemic have already been drawn up.

    The Tuskegee Study had nothing to do with treatment. Its purpose was to trace the spontaneous evolution of the disease in order to learn how syphilis affected black subjects.The men were not told they had syphilis; they were not warned about what the disease might do to them; and, with the exception of a smattering of medication during the first few months, they were not given health care. Instead of the powerful drugs they required, they were given aspirin for their aches and pains. Health officials systematically deceived the men into believing they were patients in a government study of “bad blood”, a catch-all phrase black sharecroppers used to describe a host of illnesses. At the end of this 40 year deathwatch, more than 100 men had died from syphilis or related complications.“Bad Blood” provides compelling answers to the question of how such a tragedy could have been allowed to occur. Tracing the evolution of medical ethics and the nature of decision making in bureaucracies, Jones attempted to show that the Tuskegee Study was not, in fact, an aberration, but a logical outgrowth of race relations and medical practice in the United States.Now, in this revised edition of “Bad Blood”, Jones traces the tragic consequences of the Tuskegee Study over the last decade. A new introduction explains why the Tuskegee Study has become a symbol of black oppression and a metaphor for medical neglect, inspiring a prize-winning play, a Nova special, and a motion picture. A new concluding chapter shows how the black community's wide-spread anger and distrust caused by the Tuskegee Study has hampered efforts by health officials to combat AIDS in the black community. “Bad Blood” was nominated for the Pulitzer Prize and was one of the “N.Y. Times” 12 best books of the year.

    A clear, concise writing style and just the right dose of humor explain the role of epidemiology in measuring disease in a community, estimating risks, and influencing public policy and ethical concerns. Line diagrams, cartoons, and review questions with answers reinforce the text.The smart way to study!Elsevier titles with STUDENT CONSULT will help you master difficult concepts and study more efficiently in print and online! Perform rapid searches. Integrate bonus content from other disciplines. Download text to your handheld device. And a lot more. Each STUDENT CONSULT title comes with full text online, a unique image library, case studies, USMLE style questions, and online note-taking to enhance your learning experience.Your purchase of this book entitles you to access www.studentconsult.com at no extra charge. This innovative web site offers you... Access to the complete text and illustrations of this book. Integration links to bonus content in other STUDENT CONSULT titles.Content clipping for your handheld.An interactive community center with a wealth of additional resources. The more STUDENT CONSULT titles you buy, the more resources you can access online! Look for the STUDENT CONSULT logo on your favorite Elsevier textbooks!

    There is every reason to believe that, within a few weeks of its onset, the infection was universally present in the nose and throat of the people, disseminated by mouth spray given off on talking by innumerable carriers and, in addition, by the coughing and sneezing of the sick. Susceptibility was very general, though it varied greatly in degree. Among those who escaped well marked sickness there are few who could not recall having had an occluded or running nose, or a raw feeling in the throat, or a cough, or aches and pains, at some time during the period of the prevalence of the disease, these probably representing the price such persons paid for their immunization." - Dr. Bernard Fantus In many ways, it is hard for modern people living in First World countries to conceive of a pandemic sweeping around the world and killing millions of people, and it is even harder to believe that something as common as influenza could cause such widespread illness and death. Although the flu still takes hundreds of lives each year, most of those lost are very young or old or ill with something else that had already weakened them. In fact, most people contract influenza at least once, and many suffer from the flu several times in their lives and survive it with a minimum amount of medical attention. In 1918, the world was still in the throes of the Great War, the deadliest conflict in human history at that point, but while World War I would be a catastrophic war surpassed only by World War II, an unprecedented influenza outbreak that same year inflicted casualties that would make both wars pale in comparison. An illness, or more likely a collection of illnesses, Spanish influenza quickly spread across the world and may have killed upwards of 100 million people, decimating populations across developed nations and possibly wiping out as much as 5% of the world’s population. If anything, the ongoing war and the censorship maintained by the countries fighting it may have resulted in the actual toll of the outbreak being underestimated based on the way soldiers’ deaths were categorized. World War I may have distracted people about the unprecedented nature of the outbreak, but the most alarming aspect of the outbreak in 1918 was the indiscriminate nature in which the scourge attacked young and old, healthy and unhealthy, and rich and poor alike. In fact, the popular name for the outbreak was a reference to the fact that Spain’s own king was stricken with the disease. While he and President Woodrow Wilson ended up surviving it, former First Lady Rose Cleveland did not. The staggering number of fatalities, and the way in which seemingly anybody could suffer during the outbreak, taught people in the early 20th century that regardless of the tremendous strides made by technology, and no matter how stalemated the war was, nobody was safe from nature itself. Of course, it also demonstrated how much more work could be done to prevent similar occurrences. The 1918 pandemic was neither the first nor the last outbreak of the flu, but it was by far the worst, and it forever changed the face of medicine and public health care in both North America and Europe. The 1918 Spanish Flu Pandemic: The History and Legacy of the World’s Deadliest Outbreak chronicles the devastating disease and the damage it wrought across the globe.

    Its defeat was a reflection not only of progress in medical knowledge but of enduring changes in American social thought. Rosenberg has focused his study on New York City, the most highly developed center of this new society. Carefully documented, full of descriptive detail, yet written with an urgent sense of the drama of the epidemic years, this narrative is as absorbing for general audiences as it is for the medical historian. In a new Afterword, Rosenberg discusses changes in historical method and concerns since the original publication of The Cholera Years."A major work of interpretation of medical and social thought . . . this volume is also to be commended for its skillful, absorbing presentation of the background and the effects of this dread disease."—I.B. Cohen, New York Times"The Cholera Years is a masterful analysis of the moral and social interest attached to epidemic disease, providing generally applicable insights into how the connections between social change, changes in knowledge and changes in technical practice may be conceived."—Steven Shapin, Times Literary Supplement"In a way that is all too rarely done, Rosenberg has skillfully interwoven medical, social, and intellectual history to show how medicine and society interacted and changed during the 19th century. The history of medicine here takes its rightful place in the tapestry of human history."—John B. Blake, Science

    Debates around vaccines' necessity -- along with questions around their side effects -- have gone mainstream, blending with geopolitical conflicts, political campaigns, celebrity causes, and "natural" lifestyles to win a growing number of hearts and minds. Today's anti-vaccine positions find audiences where they've never existed previously.Stuck examines how the issues surrounding vaccine hesitancy are, more than anything, about people feeling left out of the conversation. A new dialogue is long overdue, one that addresses the many types of vaccine hesitancy and the social factors that perpetuate them. To do this, Stuck provides a clear-eyed examination of the social vectors that transmit vaccine rumors, their manifestations around the globe, and how these individual threads are all connected.

    We ignore this reality most of the time, but when a new threat (Ebola, SARS, Zika) seems imminent, we send our best and bravest doctors to contain it--people like Dr. Ali S. Khan.In his long career as a public health first responder—protected by a thin mask from infected patients, napping under nets to keep out scorpions, making life-and-death decisions on limited, suspect information—Khan has found that rogue microbes will always be a problem, but outbreaks are often caused by people. We make mistakes, politicize emergencies, and, too often, fail to imagine the consequences of our actions.The Next Pandemic is a firsthand account of disasters like anthrax, bird flu, and others and how we could do more to prevent their return. It's both a gripping story of our brushes with fate and an urgent lesson on how we can keep ourselves safe from the inevitable next pandemic.

    But when we look into the past, our sense of reality wavers: accounts of the body in diverse medical traditions often seem to describe mutually alien, almost unrelated worlds. How can perceptions of something as basic and intimate as the body differ so? In this book, Shigehisa Kuriyama explores this fundamental question, elucidating the fascinating contrasts between the human body described in classical Greek medicine and the body as envisaged by physicians in ancient China. Revealing how perceptions of the body and conceptions of personhood are intimately linked, his comparative inquiry invites us, indeed compels us, to reassess our own habits of feeling and perceiving.The Expressiveness of the Body was awarded the 2001 Welch Medal by the American Association for the History of Medicine.

    Among the most compelling and perplexing of these symptoms are the strange visual hallucinations and distortions of space, time, and body image which migraineurs sometimes experience. Portrayals of these uncanny states have found their way into many works of art, from the heavenly visions of Hildegard von Bingen to Alice in Wonderland. Dr. Oliver Sacks argues that migraine cannot be understood simply as an illness, but must be viewed as a complex condition with a unique role to play in each individual's life.

    microbe.” —The Wall Street Journal   Did the Black Death destroy medieval Europe? Did cholera pave the way for modern Manhattan? Did yellow fever help end the slave trade? Remarkably, the answer to all of these questions is yes. Time and again, diseases have impacted the course of human history in surprisingly powerful ways. From influenza to smallpox, from tuberculosis to yellow fever, Bryn Barnard describes the symptoms and paths of the world’s worst diseases—and how the epidemics they spawned have changed history forever.   Filled with fascinating, often gory details about disease and history, Outbreak! is a wonderful combination of science and history.

    Dr. Jeremy Brown, currently Director of Emergency Care Research at the National Institutes of Health, expounds on the flu's deadly past to solve the mysteries that could protect us from the next outbreak. In Influenza, he talks with leading epidemiologists, policy makers, and the researcher who first sequenced the genetic building blocks of the original 1918 virus to offer both a comprehensive history and a roadmap for understanding what’s to come.Dr. Brown digs into the discovery and resurrection of the flu virus in the frozen victims of the 1918 epidemic, as well as the bizarre remedies that once treated the disease, such as whiskey and blood-letting. Influenza also breaks down the current dialogue surrounding the disease, explaining the controversy over vaccinations, antiviral drugs like Tamiflu, and the federal government’s role in preparing for pandemic outbreaks. Though 100 years of advancement in medical research and technology have passed since the 1918 disaster, Dr. Brown warns that many of the most vital questions about the flu virus continue to confound even the leading experts.Influenza is an enlightening and unnerving look at a shapeshifting deadly virus that has been around long before people—and warns us that it may be many more years before we are able to conquer it for good.