It is too bad, write scientist-historian couple Robert and Michèle Root-Bernstein, who deplore the loss of proven methods developed without the blessing of the academy, noting that "formal academic systems are only one of many ways in which knowledge is discovered, accumulated, and transmitted." Many scientists are now coming to agree with this view, they write in this fascinating collection of case studies. Researchers have showed that black tea, for instance, has powerful antibiotic properties and that maggots do an extraordinary job of cleaning wounds--as traditional healers have known all along.

    Taking us on a journey through every fundamental field of science, as well as the history of civilization, art, moral values, and the theory of political institutions, Deutsch tracks how we form new explanations and drop bad ones, explaining the conditions under which progress—which he argues is potentially boundless—can and cannot happen. Hugely ambitious and highly original, The Beginning of Infinity explores and establishes deep connections between the laws of nature, the human condition, knowledge, and the possibility for progress.

    For two decades, historian Alice Dreger has led a life of extraordinary engagement, combining activist service to victims of unethical medical research with defense of scientists whose work has outraged identity politics activists. With spirit and wit, Dreger offers in Galileo’s Middle Finger an unforgettable vision of the importance of rigorous truth seeking in today’s America, where both the free press and free scholarly inquiry struggle under dire economic and political threats.This illuminating chronicle begins with Dreger’s own research into the treatment of people born intersex (once called hermaphrodites). Realization of the shocking surgical and ethical abuses conducted in the name of “normalizing” intersex children’s gender identities moved Dreger to become an internationally recognized patient rights’ activist. But even as the intersex rights movement succeeded, Dreger began to realize how some fellow progressive activists were employing lies and personal attacks to silence scientists whose data revealed uncomfortable truths about humans. In researching one such case, Dreger suddenly became the target of just these kinds of attacks.Troubled, she decided to try to understand more—to travel the country to ferret out the truth behind various controversies, to obtain a global view of the nature and costs of these battles. Galileo’s Middle Finger describes Dreger’s long and harrowing journeys between the two camps for which she felt equal empathy: social justice activists determined to win and researchers determined to put hard truths before comfort. Ultimately what emerges is a lesson about the intertwining of justice and of truth—and a lesson of the importance of responsible scholars and journalists to our fragile democracy.

    Indeed, no artistic movement has ever been quite so controversial. The drama of its birth, played out on canvas and against the backdrop of the Franco-Prussian War and the Commune, would at times resemble a battlefield; and as Ross King reveals, it would reorder both history and culture, and resonate around the world.

    Barron Lerner thought he had heard it all. But in the mid-1990s, his father, an infectious diseases physician, told him a stunning story: he had physically placed his body over an end-stage patient who had stopped breathing, preventing his colleagues from performing cardiopulmonary resuscitation, even though CPR was the ethically and legally accepted thing to do. Over the next few years, the senior Dr. Lerner tried to speed the deaths of his seriously ill mother and mother-in-law to spare them further suffering.These stories angered and alarmed the younger Dr. Lerner—an internist, historian of medicine and bioethicist—who had rejected physician-based paternalism in favor of informed consent and patient autonomy. The Good Doctor is a fascinating and moving account of how Dr. Lerner came to terms with two very different images of his father: a revered clinician, teacher and researcher who always put his patients first, but also a physician willing to “play God,” opposing the very revolution in patients' rights that his son was studying and teaching to his own medical students.But the elder Dr. Lerner’s journals, which he had kept for decades, showed his son how his outdated paternalism had grown out of a fierce devotion to patient-centered medicine that was rapidly disappearing in a world of managed care, spiraling costs and health care reform. And they raised questions: Are paternalistic doctors just relics or should their expertise be used to overrule patients and families that make ill-advised choices? Does the growing use of personalized medicine—in which specific interventions may be best for specific patients—change the calculus between autonomy and paternalism? And how can we best use technologies that were invented to save lives but now too often prolong death? In an era of high-technology medicine, spiraling costs and healthcare reform, these questions could not be more relevant. As his father slowly died of Parkinson’s disease, Dr. Lerner faced these questions both personally and professionally. He found himself being pulled into his dad’s medical care, even though he had criticized his father for making medical decisions for his relatives. Did playing God—at least in some situations—actually make sense? Did doctors sometimes “know best?” A timely and compelling story of one family’s engagement with medicine over the last half century, The Good Doctor is an important book for those who treat illness—and those who struggle to overcome it.

    From the blue-blooded pockets of old-WASP New England to the vast tribal lands of the Navajo, Bryan Sykes takes us on a historical genetic tour, interviewing genealogists, geneticists, anthropologists, and everyday Americans with compelling ancestral stories. His findings suggest:• Of Americans whose ancestors came as slaves, virtually all have some European DNA.• Racial intermixing appears least common among descendants of early New England colonists.• There is clear evidence of Jewish genes among descendants of southwestern Spanish Catholics.• Among white Americans, evidence of African DNA is most common in the South.• European genes appeared among Native Americans as early as ten thousand years ago.An unprecedented look into America's genetic mosaic and an impressive contribution to how we perceive race, this is a fascinating book about what it means to be American.

    In June 1962, a young biologist in Philadelphia, using tissue extracted from an aborted fetus from Sweden, produced safe, clean cells that allowed the creation of vaccines against rubella and other common childhood diseases. Two years later, in the midst of a devastating German measles epidemic, his colleague developed the vaccine that would one day wipe out homegrown rubella. The rubella vaccine and others made with those fetal cells have protected more than 150 million people in the United States, the vast majority of them preschoolers. The new cells and the method of making them also led to vaccines that have protected billions of people around the world from polio, rabies, chicken pox, measles, hepatitis A, shingles and adenovirus. Meredith Wadman’s masterful account recovers not only the science of this urgent race, but also the political roadblocks that nearly stopped the scientists. She describes the terrible dilemmas of pregnant women exposed to German measles and recounts testing on infants, prisoners, orphans, and the intellectually disabled, which was common in the era. These events take place at the dawn of the battle over using human fetal tissue in research, during the arrival of big commerce in campus labs, and as huge changes take place in the laws and practices governing who “owns” research cells and the profits made from biological inventions. It is also the story of yet one more unrecognized woman whose cells have been used to save countless lives. With another frightening virus imperiling pregnant women on the rise today, no medical story could have more human drama, impact, or urgency today than The Vaccine Race.

    But having developed that power, humans are also able to leave Earth and voyage into the vastness of space. After millions of years of evolution, we’ve arrived at the point where we can settle other worlds and begin the process of becoming multi-planetary. How did we get here? What does the future hold for us? Divided into four accessible sections, Beyond the Known examines major periods of discovery and rediscovery, from Classical Times, when Phoenicians, Persians and Greeks ventured forth; to The Age of European Exploration, which saw colonies sprout on nearly continent; to The Era of Scientific Inquiry, when researchers developed brand new tools for mapping and traveling farther; to Our Spacefaring Future, which unveils plans currently underway for settling other planets and, eventually, traveling to the stars. A Mission Manager at SpaceX with a light, engaging voice, Andrew Rader is at the forefront of space exploration. As a gifted historian, Rader, who has won global acclaim for his stunning breadth of knowledge, is singularly positioned to reveal the story of human exploration that is also the story of scientific achievement. Told with an infectious zeal for traveling beyond the known, Beyond the Known illuminates how very human it is to emerge from the cave and walk toward an infinitely expanding horizon.

    A hijacking, several nuclear explosions and a religious experience ... just some of the ingredients in the latest tour de force from the bestselling author of the Carpet Wars. In the searing summer of 2004, Christopher Kremmer returns to India, a country in the grip of enormous and sometimes violent change. As a young reporter in the 1990s, he first encountered this ancient and complex civilisation. Now, embarking on a yatra, or pilgrimage, he travels the dangerous frontier where religion and politics face off. tracking down the players in a decisive decade, he takes us inside the enigmatic Gandhi dynasty, and introduces an operatic cast of political Brahmins, 'cyber coolies', low-caste messiahs and wrestling priests. A sprawling portrait of India at the crossroads, Inhaling the Mahatma is also an intensely personal story about coming to terms with a dazzlingly different culture, as the author's fate is entwined with a cosmopolitan Hindu family of Old Delhi, and a guru who might just change his life.

    That's taught as fact in psychology textbooks, academic journals, and bestselling books. And these hardwired differences explain everything from sexual orientation to gender identity, to why there aren't more women physicists or more stay-at-home dads.In this compelling book, Rebecca Jordan-Young takes on the evidence that sex differences are hardwired into the brain. Analyzing virtually all published research that supports the claims of "human brain organization theory," Jordan-Young reveals how often these studies fail the standards of science. Even if careful researchers point out the limits of their own studies, other researchers and journalists can easily ignore them because brain organization theory just sounds so right. But if a series of methodological weaknesses, questionable assumptions, inconsistent definitions, and enormous gaps between ambiguous findings and grand conclusions have accumulated through the years, then science isn't scientific at all.Elegantly written, this book argues passionately that the analysis of gender differences deserves far more rigorous, biologically sophisticated science. "The evidence for hormonal sex differentiation of the human brain better resembles a hodge-podge pile than a solid structure... Once we have cleared the rubble, we can begin to build newer, more scientific stories about human development."

    We will soon be able to meet and exceed the basic needs of every man, woman and child on the planet. Abundance for all is within our grasp. This bold, contrarian view, backed up by exhaustive research, introduces our near-term future, where exponentially growing technologies and three other powerful forces are conspiring to better the lives of billions. An antidote to pessimism by tech entrepreneur turned philanthropist, Peter H. Diamandis and award-winning science writer Steven Kotler. Since the dawn of humanity, a privileged few have lived in stark contrast to the hardscrabble majority. Conventional wisdom says this gap cannot be closed. But it is closing—fast. The authors document how four forces—exponential technologies, the DIY innovator, the Technophilanthropist, and the Rising Billion—are conspiring to solve our biggest problems. Abundance establishes hard targets for change and lays out a strategic roadmap for governments, industry and entrepreneurs, giving us plenty of reason for optimism.Examining human need by category—water, food, energy, healthcare, education, freedom—Diamandis and Kotler introduce dozens of innovators making great strides in each area: Larry Page, Steven Hawking, Dean Kamen, Daniel Kahneman, Elon Musk, Bill Joy, Stewart Brand, Jeff Skoll, Ray Kurzweil, Ratan Tata, Craig Venter, among many, many others.

    If reason is so useful, why didn't it also evolve in other animals? If reason is that reliable, why do we produce so much thoroughly reasoned nonsense? In their groundbreaking account of the evolution and workings of reason, Hugo Mercier and Dan Sperber set out to solve this double enigma. Reason, they argue with a compelling mix of real-life and experimental evidence, is not geared to solitary use, to arriving at better beliefs and decisions on our own. What reason does, rather, is help us justify our beliefs and actions to others, convince them through argumentation, and evaluate the justifications and arguments that others address to us.In other words, reason helps humans better exploit their uniquely rich social environment. This interactionist interpretation explains why reason may have evolved and how it fits with other cognitive mechanisms. It makes sense of strengths and weaknesses that have long puzzled philosophers and psychologists--why reason is biased in favor of what we already believe, why it may lead to terrible ideas and yet is indispensable to spreading good ones.Ambitious, provocative, and entertaining, The Enigma of Reason will spark debate among psychologists and philosophers, and make many reasonable people rethink their own thinking.

    From the conquest of Mexico by smallpox as much as by the Spanish, to the bubonic plague in China, to the typhoid epidemic in Europe, the history of disease is the history of humankind. With the identification of AIDS in the early 1980s, another chapter has been added to this chronicle of events, which William McNeill explores in his new introduction to this updated editon.Thought-provoking, well-researched, and compulsively readable, Plagues and Peoples is that rare book that is as fascinating as it is scholarly, as intriguing as it is enlightening. "A brilliantly conceptualized and challenging achievement" (Kirkus Reviews), it is essential reading, offering a new perspective on human history.

    But American Overdose exposes the powerful forces they were up against, including the pharmaceutical industry's coopting of the Food and Drug Administration and Congress in the drive to push painkillers--resulting in the resurgence of heroin cartels in the American heartland. McGreal tells the story, in terms both broad and intimate, of people hit by a catastrophe they never saw coming. Years in the making, its ruinous consequences will stretch years into the future.

    In The Demon in the Freezer, his first nonfiction book since The Hot Zone, a #1 New York Times bestseller, Richard Preston takes us into the heart of Usamriid, the United States Army Medical Research Institute of Infectious Diseases at Fort Detrick, Maryland, once the headquarters of the U.S. biological weapons program and now the epicenter of national biodefense.Peter Jahrling, the top scientist at Usamriid, a wry virologist who cut his teeth on Ebola, one of the world’s most lethal emerging viruses, has ORCON security clearance that gives him access to top secret information on bioweapons. His most urgent priority is to develop a drug that will take on smallpox-and win. Eradicated from the planet in 1979 in one of the great triumphs of modern science, the smallpox virus now resides, officially, in only two high-security freezers-at the Centers for Disease Control in Atlanta and in Siberia, at a Russian virology institute called Vector. But the demon in the freezer has been set loose. It is almost certain that illegal stocks are in the possession of hostile states, including Iraq and North Korea. Jahrling is haunted by the thought that biologists in secret labs are using genetic engineering to create a new superpox virus, a smallpox resistant to all vaccines.Usamriid went into a state of Delta Alert on September 11 and activated its emergency response teams when the first anthrax letters were opened in New York and Washington, D.C. Preston reports, in unprecedented detail, on the government’s response to the attacks and takes us into the ongoing FBI investigation. His story is based on interviews with top-level FBI agents and with Dr. Steven Hatfill.Jahrling is leading a team of scientists doing controversial experiments with live smallpox virus at CDC. Preston takes us into the lab where Jahrling is reawakening smallpox and explains, with cool and devastating precision, what may be at stake if his last bold experiment fails.