Now it could be the key to healing millions with genetic diseases of every type—from Alzheimer's and Parkinson's to diabetes and sickle cell anemia.In 1974, Joey O'Donnell was born with strange symptoms. His insatiable appetite, incessant vomiting, and a relentless cough—which shook his tiny, fragile body and made it difficult to draw breath—confounded doctors and caused his parents agonizing, sleepless nights. After six sickly months, his salty skin provided the critical clue: he was one of thousands of Americans with cystic fibrosis, an inherited lung disorder that would most likely kill him before his first birthday.The gene and mutation responsible for CF were found in 1989—discoveries that promised to lead to a cure for kids like Joey. But treatments unexpectedly failed and CF was deemed incurable. It was only after the Cystic Fibrosis Foundation, a grassroots organization founded by parents, formed an unprecedented partnership with a fledgling biotech company that transformative leaps in drug development were harnessed to produce groundbreaking new treatments: pills that could fix the crippled protein at the root of this deadly disease.From science writer Bijal P. Trivedi, Breath from Salt chronicles the riveting saga of cystic fibrosis, from its ancient origins to its identification in the dank autopsy room of a hospital basement, and from the CF gene's celebrated status as one of the first human disease genes ever discovered to the groundbreaking targeted genetic therapies that now promise to cure it.Told from the perspectives of the patients, families, physicians, scientists, and philanthropists fighting on the front lines, Breath from Salt is a remarkable story of unlikely scientific and medical firsts, of setbacks and successes, and of people who refused to give up hope—and a fascinating peek into the future of genetics and medicine.

    In fact, a plethora of parasites affect our behavior in ways we have barely begun to understand.  In this mind-bending book, McAuliffe reveals the eons-old war between parasites and other creatures that is playing out in our very own bodies. And more surprising still, she uncovers the decisive role that parasites may have played in the rise and demise of entire civilizations. Our obsession with cleanliness and our experience of disgust are both evolutionary tools for avoiding infection, but they evolved differently for different populations. Political, social, and religious differences among societies may be caused, in part, by the different parasites that prey on us. In the tradition of Jared Diamond’s Guns, Germs, and Steel and Neil Shubin’s Your Inner Fish, This Is Your Brain on Parasites is both a journey into cutting-edge science and a revelatory examination of what it means to be human.

    Each page offers simple activities that help you understand the roles of your “happy chemicals”—serotonin, dopamine, oxytocin, and endorphin. You’ll also learn how to build new habits by rerouting the electricity in your brain to flow down a new pathway, making it even easier to trigger these happy chemicals and increase feelings of satisfaction when you need them most. Filled with dozens of exercises that will help you reprogram your brain, Habits of a Happy Brain shows you how to live a happier, healthier life!

    But how do we know what today's learners will really need to know in the future? Future Wise: Educating Our Children for a Changing World is a toolkit for approaching that question with new insight. There is no one answer to the question of what's worth teaching, but with the tools in this book, you'll be one step closer to constructing a curriculum that prepares students for whatever situations they might face in the future.K-12 teachers and administrators play a crucial role in building a thriving society. David Perkins, founding member and co-director of Project Zero at Harvard's Graduate School of Education, argues that curriculum is one of the most important elements of making students ready for the world of tomorrow. In Future Wise, you'll learn concepts, curriculum criteria, and techniques for prioritizing content so you can guide students toward the big understandings that matter.Understand how learners use knowledge in life after graduation Learn strategies for teaching critical thinking and addressing big questions Identify top priorities when it comes to disciplines and content areas Gain curriculum design skills that make the most of learning across the years of education Future Wise presents a brand new framework for thinking about education. Curriculum can be one of the hardest things for teachers and administrators to change, but David Perkins shows that only by reimagining what we teach can we lead students down the road to functional knowledge. Future Wise is the practical guidebook you need to embark on this important quest.

    Is it in our genes? The structure of our brains? Our genome may determine our eye color and even aspects of our personality. But our friendships, failures, and passions also shape who we are. The question is: how?Sebastian Seung, a dynamic professor at MIT, is on a quest to discover the biological basis of identity. He believes it lies in the pattern of connections between the brain’s neurons, which change slowly over time as we learn and grow. The connectome, as it’s called, is where our genetic inheritance intersects with our life experience. It’s where nature meets nurture.Seung introduces us to the dedicated researchers who are mapping the brain’s connections, neuron by neuron, synapse by synapse. It is a monumental undertaking—the scientific equivalent of climbing Mount Everest—but if they succeed, it could reveal the basis of personality, intelligence, memory, and perhaps even mental disorders. Many scientists speculate that people with anorexia, autism, and schizophrenia are "wired differently," but nobody knows for sure. The brain’s wiring has never been clearly seen.In sparklingly clear prose, Seung reveals the amazing technological advances that will soon help us map connectomes. He also examines the evidence that these maps will someday allow humans to "upload" their minds into computers, achieving a kind of immortality.Connectome is a mind-bending adventure story, told with great passion and authority. It presents a daring scientific and technological vision for at last understanding what makes us who we are. Welcome to the future of neuroscience.

    Between the ages of 12 and 24, the brain changes in important and often maddening ways. It's no wonder that many parents approach their child's adolescence with fear and trepidation. According to renowned neuropsychiatrist Daniel Siegel, however, if parents and teens can work together to form a deeper understanding of the brain science behind all the tumult, they will be able to turn conflict into connection and form a deeper understanding of one another. In *Brainstorm*, Siegel illuminates how brain development affects teenagers' behaviour and relationships. Drawing on important new research in the field of interpersonal neurobiology, he explores exciting ways in which understanding how the teenage brain functions can help parents make what is in fact an incredibly positive period of growth, change, and experimentation in their children's lives less lonely and distressing on both sides of the generational divide.

    He studied physics and philosophy at the University of Tübingen in Germany and was awarded his Ph.D. in biophysics in 1982. He is now the Lois and Victor Troendle Professor of Cognitive and Behavioral Biology at the California Institute of Technology. The author of several books, Dr. Koch studies the biophysics of computation, and the neuronal basis of visual perception, attention, and consciousness. Together with Francis Crick, his long-time collaborator, he has pioneered the scientific study of consciousness.

    Scientists have long supported this assumption by claiming that emotions are hardwired in the body or the brain. Today, however, the science of emotion is in the midst of a revolution on par with the discovery of relativity in physics and natural selection in biology—ans this paradigm shift has far-reaching implications for us all.Leading the charge is psychologist and neuroscientist Lisa Feldman Barrett, whose theory of emotion is driving a deeper understanding of the mind and brain, and shedding new light on what it means to be human. Her research overturns the widely held belief that emotions are housed in different parts of the brain and are universally expressed and recognized. Instead, she has shown that emotion is constructed in the moment, by core systems that interact across the whole brain, aided by a lifetime of learning. This new theory means that you play a much greater role in your emotional life than you ever thought. Its repercussions are already shaking the foundations not only of psychology but also of medicine, the legal system, child-rearing, meditation, and even airport security.Why do emotions feel automatic? Does rational thought really control emotion? How does emotion affect disease? How can you make your children more emotionally intelligent? How Emotions Are Made answers these questions and many more, revealing the latest research and intriguing practical applications of the new science of emotion, mind, and brain.

    But as amazing as these abilities are, they are not mysterious. Our brains constantly process a huge amount of information below our awareness, and what these gifted individuals have in common is that through practice, injury, an innate brain disorder, or even more unusual circumstances, they have managed to gain a degree of conscious access to this potent processing power. The Superhuman Mind takes us inside the lives and brains of geniuses, savants, virtuosos, and a wide variety of ordinary people who have acquired truly extraordinary talents, one way or another. Delving into the neurological underpinnings of these abilities, the authors even reveal how we can acquire some of them ourselves—from perfect pitch and lightning fast math skills to supercharged creativity. The Superhuman Mind is a book full of the fascinating science readers look for from the likes of Oliver Sacks, combined with the exhilarating promise of Moonwalking with Einstein.

    Its greatest detriment to the world has been its unfettered desire to play with and alter them: science for science's sake, as if it offered the only path to knowledge.According to Lehrer, when it comes to the human brain, the world of art unraveled such mysteries long before the neuroscientists: "This book is about artists who anticipated the discoveries of science who discovered truths about the human mind that science is only now discovering." 'Proust Was a Neuroscientist' is a dazzling inquiry into the nature of the mind and of the truths harvested by its first explorers: artists like Walt Whitman, George Eliot, Auguste Escoffier, Marcel Proust, Paul Cozanne, Igor Stravinsky, Gertrude Stein, and Virginia Woolf. What they understood intuitively and expressed through their respective art forms -- the fallibility of memory, the malleability of the brain, the subtleties of vision, and the deep structure of language -- science has only now begun to measure and confirm. Blending biography, criticism, and science writing, Lehrer offers a lucid examination of eight artistic thinkers who lit the path toward a greater understanding of the human mind and a deeper appreciation of the ineffable mystery of life.

    Always timely, topical, and distinctively “useful, with a pleasant degree of humor,” the Almanac is consulted daily by users from all walks of life, throughout the year.   The 2021 edition contains the fun facts, predictions, and feature items that have made it a cultural icon: traditionally 80 percent–accurate weather forecasts; notable astronomical events and time-honored astrological dates; horticultural, culinary, fashion, and other trends; historical hallmarks; best fishing days; time- and money-saving garden advice; recipes for refreshment; facts on folklore, farmers, home remedies, and husbandry; amusements and contests, plus too much more to mention—all in the inimitable way that the Almanac has done since 1792.   • Beloved by generations for being “useful, with a pleasant degree of humor,” The Old Farmer’s Almanac features everything under the Sun, including its much-in-demand long-range weather predictions, essential astronomical timetables, 2021 holidays, fascinating trends, best fishing days, valuable gardening information, tantalizing recipes, fun folklore, amusements, contests, and much more! • Exclusive: 32 reference pages, covering such popular topics as full Moon names, hurricane names, flowers that attract birds and butterflies, U.S./metric measurement conversions, and many more! • Easy-to-read edition, with crisp, white paper and larger type than the regular paperback version • Includes 112 full-color pages • Hard cover with dust jacket helps to protect the pages—a plus for those who collect the Almanac each year!

    Parlez-vous Doggish? At long last, dogs will know just how smart their owners can be. By unlocking the secrets of the hidden language of dogs, psychologist Stanley Coren allows us into the doggy dialogue, or “Doggish,” and makes effective communication a reality. Drawing on substantial research in animal behavior, evolutionary biology, and years of personal experience, Coren demonstrates that the average house dog can understand language at about the level of a two-year-old human. While actual conversation of the sort Lassie seemed capable of in Hollywood mythmaking remains forever out of reach, Coren shows us that a great deal of real communication is possible beyond the giving and obeying of commands. How to Speak Dog not only provides the sounds, words, actions, and movements with which we can effectively communicate with our dogs, but also deciphers the signs that our dogs give to us. With easy-to-follow tips on how humans can mimic the language dogs use to talk with one another, original drawings illustrating the subtleties of their body language, and a handy visual glossary and “Doggish” phrasebook, How to Speak Dog gives dog lovers the skills they need to improve their relationships with their pets.

    In this short, provocative, and useful HBR Single, motivational psychologist Heidi Grant Halvorson translates the psychological secrets of these winning human beings for your use. Halvorson expands on her immensely popular blog post to give more detail on each of her nine suggested actions-from getting specific about goals and aggressively monitoring your achievements to understanding the importance of having "grit." By emphasizing what successful people do consistently and effectively, Halvorson provides the path to help you accomplish your goals, once and for all.

    Noted science writer Nicholas Wade offers for the first time a convincing case based on a broad range of scientific evidence for the evolutionary basis of religion.

    This is a hypnotizing narrative, a brilliant study of money's power to corrupt absolutely. It's a crime not to publish it." -- Robert Kirsch, Los Angeles Times Immense wealth. Corrupt political power. Scientific genius. Sexual kinkiness. Howard Hughes, the legendary Texas billionaire, exemplified all these qualities. Oil tycoon, record-breaking aviator, Oscar-winning moviemaker, and the shy lover of dozens of Hollywood movie stars, he bought the favors of U.S. presidents and even tried to buy Las Vegas. In his twilight years he became a recluse, hiding in shadowed hotel suites. Many believed that he had died and his business associates had stolen his billions. Enter author and adventurer Clifford Irving. "Howard Hughes is alive and he's alive, and wants me to help him write the story of his life. He's going to tell a more shocking story than anyone could have foreseen." The book was called "a stunning hoax," but many believe that Richard Nixon's fear of the truths in the manuscript caused him to order the burglary of Democratic Party headquarters at the Watergate. For what he had done, Clifford Irving was sentenced to 2 ½ years in federal prison. Except for a small private 1998 edition, this is the Hughes Autobiography's first publication in the United States. "Until now, the most famous unpublished book of the 20th century." -- International Herald Tribune.