Keenly aware that the course of the nation's destiny lay westward—and that a "Voyage of Discovery" would be necessary to determine the nature of the frontier—President Thomas Jefferson commissioned Meriwether Lewis to lead an expedition from the Missouri River to the northern Pacific coast and back. From 1804 to 1806, accompanied by co-captain William Clark, the Shoshone guide Sacajawea, and thirty-two men, Lewis mapped rivers, traced the principal waterways to the sea, and established the American claim to the territories of Idaho, Washington, and Oregon. Together the captains kept this journal: a richly detailed record of the flora and fauna they sighted, the native tribes they encountered, and the awe-inspiring landscape they traversed, from their base camp near present-day St. Louis to the mouth of the Columbia River, that has become an incomparable contribution to the literature of exploration and the writing of natural history.

    Linda Peavy and Ursula Smith vividly describe the hardships such women endured journeying west and making homes and communities on the frontier. Their hopes and fears and, most of all, their courage in the face of adversity are revealed in excerpts from journals, letters, and oral histories. Illustrated with a fascinating collection of seldom-seen photographs, Pioneer Women reveals the faces as well as the voices of women who lived on the frontier.The authors portray a wide variety of women, from those who found liberty and confidence in undertaking "men’s work" to those who felt burdened by the wind, the weather, and the struggle of frontier life.

    A Massachusetts minister named Manasseh Cutler was instrumental in opening this vast territory to veterans of the Revolutionary War and their families for settlement. Included in the Northwest Ordinance were three remarkable conditions: freedom of religion, free universal education, and most importantly, the prohibition of slavery. In 1788 the first band of pioneers set out from New England for the Northwest Territory under the leadership of Revolutionary War veteran General Rufus Putnam. They settled in what is now Marietta on the banks of the Ohio River.McCullough tells the story through five major characters: Cutler and Putnam; Cutler’s son Ephraim; and two other men, one a carpenter turned architect, and the other a physician who became a prominent pioneer in American science. They and their families created a town in a primeval wilderness, while coping with such frontier realities as floods, fires, wolves and bears, no roads or bridges, no guarantees of any sort, all the while negotiating a contentious and sometimes hostile relationship with the native people. Like so many of McCullough’s subjects, they let no obstacle deter or defeat them.

    Thus began the reputation that made him a marked man to every gunslinger in the Wild West.James Butler Hickock was known across the frontier as a soldier, Union spy, scout, lawman, gunfighter, gambler, showman, and actor. He crossed paths with General Custer and Buffalo Bill Cody, as well as Ben Thompson and other young toughs gunning for the sheriff with the quickest draw west of the Mississippi.Wild Bill also fell in love--multiple times--before marrying the true love of his life, Agnes Lake, the impresario of a traveling circus. He would be buried however, next to fabled frontierswoman Calamity Jane.Even before his death, Wild Bill became a legend, with fiction sometimes supplanting fact in the stories that surfaced. Once, in a bar in Nebraska, he was confronted by four men, three of whom he killed in the ensuing gunfight. A famous Harper's Magazine article credited Hickok with slaying 10 men that day; by the 1870s, his career-long kill count was up to 100.The legend of Wild Bill has only grown since his death in 1876, when cowardly Jack McCall famously put a bullet through the back of his head during a card game. Bestselling author Tom Clavin has sifted through years of western lore to bring Hickock fully to life in this rip-roaring, spellbinding true story.

    The Tuskegee Study had nothing to do with treatment. Its purpose was to trace the spontaneous evolution of the disease in order to learn how syphilis affected black subjects.The men were not told they had syphilis; they were not warned about what the disease might do to them; and, with the exception of a smattering of medication during the first few months, they were not given health care. Instead of the powerful drugs they required, they were given aspirin for their aches and pains. Health officials systematically deceived the men into believing they were patients in a government study of “bad blood”, a catch-all phrase black sharecroppers used to describe a host of illnesses. At the end of this 40 year deathwatch, more than 100 men had died from syphilis or related complications.“Bad Blood” provides compelling answers to the question of how such a tragedy could have been allowed to occur. Tracing the evolution of medical ethics and the nature of decision making in bureaucracies, Jones attempted to show that the Tuskegee Study was not, in fact, an aberration, but a logical outgrowth of race relations and medical practice in the United States.Now, in this revised edition of “Bad Blood”, Jones traces the tragic consequences of the Tuskegee Study over the last decade. A new introduction explains why the Tuskegee Study has become a symbol of black oppression and a metaphor for medical neglect, inspiring a prize-winning play, a Nova special, and a motion picture. A new concluding chapter shows how the black community's wide-spread anger and distrust caused by the Tuskegee Study has hampered efforts by health officials to combat AIDS in the black community. “Bad Blood” was nominated for the Pulitzer Prize and was one of the “N.Y. Times” 12 best books of the year.

    In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. In England, cows attack their owners in the milking parlors, while in the American West, thousands of deer starve to death in fields full of grass.What these strange conditions–including fatal familial insomnia, kuru, scrapie, and mad cow disease–share is their cause: prions. Prions are ordinary proteins that sometimes go wrong, resulting in neurological illnesses that are always fatal. Even more mysterious and frightening, prions are almost impossible to destroy because they are not alive and have no DNA–and the diseases they bring are now spreading around the world.In The Family That Couldn’t Sleep, essayist and journalist D. T. Max tells the spellbinding story of the prion’s hidden past and deadly future

    With the authority of a scholar and the sparkle of an old-time storyteller, Dr. Volney Steele takes the reader from rotgut whiskey to modern anesthetics, from castor oil to antibiotics, and from barroom surgery to modern hospital operations. Dr. Steele wrote Bleed, Blister, and Purge "to shed light on and celebrate the dedication and humanitarianism of those many physicians, nurses, shamans, and people of sound practical sense who saw their patients--often friends and family--through the adversities that bedeviled them."

    Sybil became both a pop phenomenon and a revolutionary force in the psychotherapy industry. The book rocketed multiple personality disorder (MPD) into public consciousness and played a major role in having the diagnosis added to the psychiatric bible, Diagnostic and Statistical Manual of Mental Disorders. But what do we really know about how Sybil came to be? In her news-breaking book Sybil Exposed, journalist Debbie Nathan gives proof that the allegedly true story was largely fabricated. The actual identity of Sybil (Shirley Mason) has been available for some years, as has the idea that the book might have been exaggerated. But in Sybil Exposed, Nathan reveals what really powered the legend: a trio of women—the willing patient, her ambitious shrink, and the imaginative journalist who spun their story into bestseller gold. From horrendously irresponsible therapeutic practices—Sybil’s psychiatrist often brought an electroshock machine to Sybil’s apartment and climbed into bed with her while administering the treatment— to calculated business decisions (under an entity they named Sybil, Inc., the women signed a contract designating a three-way split of profits from the book and its spin-offs, including board games, tee shirts, and dolls), the story Nathan unfurls is full of over-the-top behavior. Sybil’s psychiatrist, driven by undisciplined idealism and galloping professional ambition, subjected the young woman to years of antipsychotics, psychedelics, uppers, and downers, including an untold number of injections with Pentothal, once known as “truth serum” but now widely recognized to provoke fantasies. It was during these “treatments” that Sybil produced rambling, garbled, and probably “false-memory”–based narratives of the hideous child abuse that her psychiatrist said caused her MPD. Sybil Exposed uses investigative journalism to tell a fascinating tale that reads like fiction but is fact. Nathan has followed an enormous trail of papers, records, photos, and tapes to unearth the lives and passions of these three women. The Sybil archive became available to the public only recently, and Nathan examined all of it and provides proof that the story was an elaborate fraud—albeit one that the perpetrators may have half-believed. Before Sybil was published, there had been fewer than 200 known cases of MPD; within just a few years after, more than 40,000 people would be diagnosed with it. Set across the twentieth century and rooted in a time when few professional roles were available to women, this is a story of corrosive sexism, unchecked ambition, and shaky theories of psychoanalysis exuberantly and drastically practiced. It is the story of how one modest young woman’s life turned psychiatry on its head and radically changed the course of therapy, and our culture, as well.

    An orphaned niece of President Theodore Roosevelt, she converted her Gilded Age childhood of denial and secrecy into an irreconcilable marriage with her ambitious fifth cousin Franklin. Despite their inability to make each other happy, Franklin Roosevelt transformed Eleanor from a settlement house volunteer on New York’s Lower East Side into a matching partner in New York’s most important power couple in a generation. When Eleanor discovered Franklin’s betrayal with her younger, prettier social secretary, Lucy Mercer, she offered a divorce and vowed to face herself honestly. Here is an Eleanor both more vulnerable and more aggressive, more psychologically aware and sexually adaptable than we knew. She came to accept FDR’s bond with his executive assistant, Missy LeHand; she allowed her children to live their own lives, as she never could; and she explored her sexual attraction to women, among them a star female reporter on FDR’s first presidential campaign, and younger men. Eleanor needed emotional connection. She pursued deeper relationships wherever she could find them. Throughout her life and travels, there was always another person or place she wanted to heal. As FDR struggled to recover from polio, Eleanor became a voice for the voiceless, her husband’s proxy in presidential ambition, and then the people’s proxy in the White House. Later, she would be the architect of international human rights and world citizen of the Atomic Age, urging Americans to cope with the anxiety of global annihilation by cultivating a “world mind.” She insisted that we cannot live for ourselves alone but must learn to live together or we will die together. Drawing on new research, Michaelis’s riveting portrait is not just a comprehensive biography of a major American figure, but the story of an American ideal: how our freedom is always a choice. Eleanor rediscovers a model of what is noble and evergreen in the American character, a model we need today more than ever.

    After barely surviving the agony of smallpox themselves, they flouted eighteenth-century medicine by borrowing folk knowledge from African slaves and Eastern women in frantic bids to protect their children. From their heroic struggles stems the modern science of immunology as well as the vaccinations that remain our only hope should the disease ever be unleashed again.Jennifer Lee Carrell transports readers back to the early eighteenth century to tell the tales of Lady Mary Wortley Montagu and Dr. Zabdiel Boylston, two iconoclastic figures who helped save London and Boston from the deadliest disease mankind has known.

    Peter Stark offers a harrowing saga in which a band of explorers battled nature, starvation, and madness to establish the first American settlement in the Pacific Northwest and opened up what would become the Oregon trail, permanently altering the nation's landscape and its global standing.Six years after Lewis and Clark began their journey to the Pacific Northwest, two of the Eastern establishment's leading figures, John Jacob Astor and Thomas Jefferson, turned their sights to founding a colony akin to Jamestown on the West Coast and transforming the nation into a Pacific trading power. Author and correspondent for Outside magazine Peter Stark recreates this pivotal moment in American history for the first time for modern readers, drawing on original source material to tell the amazing true story of the Astor Expedition.Unfolding over the course of three years, from 1810 to 1813, Astoria is a tale of high adventure and incredible hardship in the wilderness and at sea. Of the more than one hundred-forty members of the two advance parties that reached the West Coast—one crossing the Rockies, the other rounding Cape Horn—nearly half perished by violence. Others went mad. Within one year, the expedition successfully established Fort Astoria, a trading post on the Columbia River. Though the colony would be short-lived, it opened provincial American eyes to the potential of the Western coast and its founders helped blaze the Oregon Trail.

    Rich in detail, and woven with wit and insight, these fascinating portraits reveal the Shooters as they really lived, fought, and died.Shooters --Billy [the Kid]: the enduring legend --Sam Bass: a square shooter --Black Jack Ketchum: a true loser --Tom Smith: he brought them in alive --The James boys --The Daltons: brothers on the prowl --Elfego Baca: last of the old-time shooters --Print Olive: just plain mean a hell --Stoudenmire: El Paso marshal --King Fisher: frontier dandy --Butch Cassidy and the Sundance Kid --Dave Mather: a deadly shooter --Pat Garrett --Jim Miller: bushwhacker --Chisum: cattle baron --Luke Short and Jim Courtright --Johnson County War --Buffalo Bill: the remarkable showman --Wild Bill Hickok --Clay Allison: wild wolf of the Washita --Texas Rangers --Blood and salt --John Larn: Texas killer --Bass outlaw --James Garrett: Texas Ranger --Pearl Hart, John Ringo, and Jack Slade --John Wesley Hardin --Doc Holliday and Wyatt Earp

    Alongside this rapid expansion of the United States, a second, overlapping social shift was taking place: survival in a settler society busy building itself from scratch required two equally hardworking partners, compelling women to compromise eastern sensibilities and take on some of the same responsibilities as their husbands. At a time when women had very few legal or economic--much less political--rights, these women soon proved they were just as essential as men to westward expansion. Their efforts to attain equality by acting as men's equals paid off, and well before the Nineteenth Amendment, they became the first American women to vote.During the mid-nineteenth century, the fight for women's suffrage was radical indeed. But as the traditional domestic model of womanhood shifted to one that included public service, the women of the West were becoming not only coproviders for their families but also town mothers who established schools, churches, and philanthropies. At a time of few economic opportunities elsewhere, they claimed their own homesteads and graduated from new, free coeducational colleges that provided career alternatives to marriage. In 1869, the men of the Wyoming Territory gave women the right to vote--partly to persuade more of them to move west--but with this victory in hand, western suffragists fought relentlessly until the rest of the region followed suit. By 1914 most western women could vote--a right still denied to women in every eastern state.In New Women in the Old West, Winifred Gallagher brings to life the riveting history of the little-known women--the White, Black, and Asian settlers, and the Native Americans and Hispanics they displaced--who played monumental roles in one of America's most transformative periods. Like western history in general, the record of women's crucial place at the intersection of settlement and suffrage has long been overlooked. Drawing on an extraordinary collection of research, Gallagher weaves together the striking legacy of the persistent individuals who not only created homes on weather-wracked prairies and built communities in muddy mining camps, but also played a vital, unrecognized role in the women's rights movement and forever redefined the American woman.

    Powerfully conjuring up the world of the mining camps and the colorful communities of the central Rocky Mountains, Ellis interweaves an invaluable history of the nineteenth-century American West with a valiant personal tale.

    But the true saga of her life has never been fully told. Now, drawing on unpublished manuscripts, letters, diaries, and land and financial records, Caroline Fraser—the editor of the Library of America edition of the Little House series—masterfully fills in the gaps in Wilder’s biography. Revealing the grown-up story behind the most influential childhood epic of pioneer life, she also chronicles Wilder's tumultuous relationship with her journalist daughter, Rose Wilder Lane, setting the record straight regarding charges of ghostwriting that have swirled around the books.The Little House books, for all the hardships they describe, are paeans to the pioneer spirit, portraying it as triumphant against all odds. But Wilder’s real life was harder and grittier than that, a story of relentless struggle, rootlessness, and poverty. It was only in her sixties, after losing nearly everything in the Great Depression, that she turned to children’s books, recasting her hardscrabble childhood as a celebratory vision of homesteading—and achieving fame and fortune in the process, in one of the most astonishing rags-to-riches episodes in American letters.Spanning nearly a century of epochal change, from the Indian Wars to the Dust Bowl, Wilder’s dramatic life provides a unique perspective on American history and our national mythology of self-reliance. With fresh insights and new discoveries, Prairie Fires reveals the complex woman whose classic stories grip us to this day.WINNER OF THE PULITZER PRIZEWINNER OF THE NATIONAL BOOK CRITICS CIRCLE AWARDWINNER OF THE CHICAGO TRIBUNE HEARTLAND PRIZE FOR NON-FICTIONONE OF THE NEW YORK TIMES BOOK REVIEW'S 10 BEST BOOKS OF THE YEAROne of The New York Times Book Review's 10 Best Books of the YearThe first comprehensive historical biography of Laura Ingalls Wilder, the beloved author of the Little House on the Prairie books