Myers in his quest for unusual case studies as he unravels medical mysteries.

    Our language even has a word—Machiavellian—that encapsulates the images those responses conjure up: An indistinct figure quietly making his way through the darkest corridors of power, hatching plots to play one rival against another A cold-blooded political liar, ready to justify any duplicity undertaken in the name of a noble end that will ultimately justify the most malignant means A coolly practical leader—amoral at best—willing to do whatever is necessary in a world governed not by ideas of right or wrong, but by solutions dictated by realpolitik.But does the Machiavelli most of us think we know bear any resemblance to the Machiavelli who lived, pondered, and wrote?According to Professor William R. Cook, a reading of Machiavelli that considers only those qualities that we today call "Machiavellian" is incomplete, and Machiavelli himself "certainly would not recognize" such sinister interpretations or caricatures of his writings and beliefs. Indeed, The Prince—on the pages of which so much of this image was built—was not even published in his lifetime.In the 24 lectures that make up Machiavelli in Context, Professor Cook offers the opportunity to meet an extraordinarily thoughtful and sincere student of history and its lessons, and to learn that there is far more to him than can be gleaned from any reading of The Prince, no matter how thorough.Although The Prince is the work by which most of us think we know Machiavelli, and although some have indeed called it the first and most important book of political science ever written, it was not, according to Professor Cook, either Machiavelli's most important work or the one most representative of his beliefs. Those distinctions belong, instead, to his Discourses on the First Ten Books of Livy, a longer work started at about the same time and which would, like The Prince, not be published until well after his death."Everyone who has seriously studied the works of Machiavelli agrees that he ... believed in the superiority of a republican form of government, defined as a mixed constitution with elements of monarchy, aristocracy, and democracy."Once we recover the context of the writing of The Prince, and analyze it along with the Discourses on the First Ten Books of Livy, it will be clear how The Prince can be read as a book designed to guide leaders in the creation—for Machiavelli, restoration—of republican government in Italy."Ultimately, Machiavelli's goal wasn't much different from ours. It was to live in a free and equal participatory society, because he believed that was the greatest way in which human beings could live and flourish."In fact, says Professor Cook, "Machiavelli's republican thought influenced the development of institutions and values both in Europe and in America."To present a complete and well-rounded picture of Machiavelli's ideas on how human societies should be organized and governed, Professor Cook sets aside much of Machiavelli's written output—which included the political work The Art of War, a biography, many letters, and even some plays—to focus on The Prince, the Discourses, and, more briefly, his Florentine Histories.In doing so, Professor Cook draws on the same qualities so evident in his previous courses for The Teaching Company: Tocqueville and the American Experience, Dante's Divine Comedy, Francis of Assisi, and St. Augustine's Confessions.Teaching in the relaxed and informal style of those courses, Professor Cook moves easily among the different disciplines so pertinent to an understanding of Machiavelli's ideas, including history, philosophy, government, and the elements of leadership. He is unfailingly clear, always provides any definitions needed to understand the material at hand, and is always ready with a touch of wit whenever that is appropriate.Because so much of our contemporary misunderstanding of Machiavelli's ideas comes from a lack of context, Professor Cook carefully sets the stage for a complete perspective of Machiavelli's world.Long before he turns to the works themselves, you'll have learned about Florence and its political history, both before and during Machiavelli's lifetime; the developing Renaissance culture of Machiavelli's time, especially as it bears on the use of ancient political thought by writers and political leaders; and Machiavelli's own life story, including his education, service to the Florentine Republic, years spent in exile south of Florence, and the ways each period of his life affected his writings.The result is a thorough grounding in the information one needs to understand and appreciate this stunningly original thinker.You'll learn, for example, what Machiavelli means when he discusses the important ideas of virtù and Fortuna.Though these are today invariably translated as virtue and fortune, Machiavelli's meanings can involve much more. Though he sometimes uses virtù in the sense we would understand today, he often uses the word—which comes from the classical Latin word for Man—as a means of describing the way one practices successful statecraft: aggressively, with no reluctance to use lies, deceit, and cruelty that may be required to maintain power, and hence the stability the people deserve.In a similar way Machiavelli uses Fortuna in a different sense than might have been used by, say, Dante when he describes the vagaries of fate over which we have no control.Instead, Machiavelli uses the adage, "Fortune is like a river." Though we cannot control fortune, which may well choose to make the river flood, a good ruler, practicing virtù, can indeed prepare for it, and thus modify its effects.You'll see how Machiavelli first became exposed to history and one of its earliest great practitioners—the Roman historian, Livy—through his own experience of Fortuna.Though printed books such as Livy's Early History of Rome were too expensive for a family like the young Machiavelli's in the 15th century, his father did own a copy. He had written the index, and a copy of the book had been part of his payment. Thus Machiavelli grew up with the volumes about which he would one day write his own most important work, Discourses on the First Ten Books of Livy.You'll be introduced to Cesare Borgia, the son of Pope Alexander VI and the man regarded as Machiavelli's model for The Prince, especially in the way his actions embodied the virtù so important to Machiavelli.Professor Cook brings this out in a shocking story of Borgia's use of a tough and merciless Spaniard—Ramiro d'Orco—to impose order and stability on the area of north central Italy known as the Romagna that had come under Borgia's rule and was beset by crime and violence.D'Orco's brutal methods had the desired effect. And when the job was completed, the local people emerged from their homes one morning to find the two halves of Ramiro d'Orco's body on opposite sides of the town square of Cesana, because d'Orco had been too tough, and Cesare Borgia needed a way to advertise further his concern for the people whose loyalty he wanted.The story also embodies, for Machiavelli, the idea that cruelty can be "well-used," just as being merciful—withholding such cruelty when a leader deems it needed—may be less than merciful in its long-term impact.Finally, you will get to see, throughout these lectures, the development of Machiavelli's reliance on history for its lessons, his role as a Renaissance Humanist thinker, and the emergence of his republican views, which still have tremendous influence today as we ask how republics start, grow, succeed, or fail.As Professor Cook notes, we are not going to agree with all of Machiavelli's answers. But his commitment to asking the right questions—to thinking, reflecting, and learning everything history has to teach us about the best ways to govern and safeguard the future—was total.

    Through horrible physical deformities which were almost impossible to describe, he spent much of his life exhibited as a fairground freak until even nineteenth-century sensibilities could take no more. Hounded, persecuted and starving, he ended up at London's Liverpool Street Station where he was rescued, housed and fed by the distinguished surgeon Frederick Treves. To Treves' surprise, he discovered during the course of their friendship that lurking beneath the mass of Merrick's corrupting flesh lived a spirit that was as courageous as it had been tortured, and a nature as gentle and dignified as it had been deprived and tormented. The subject of several books, a Broadway hit, and a film, Joseph Merrick has become part of popular mythology. Here, in this fully revised edition containing new details, are the true and unromantic facts of his life. This is an extraordinary and moving story, set among the brutal realities of the Victorian world, telling of a tragic individual and his survival against overwhelming odds."

    Markel writes of the physical and emotional damage caused by the then-heralded wonder drug, and how each man ultimately changed the world in spite of it—or because of it. One became the father of psychoanalysis; the other, of modern surgery. Both men were practicing medicine at the same time in the 1880s: Freud at the Vienna General Hospital, Halsted at New York’s Bellevue Hospital. Markel writes that Freud began to experiment with cocaine as a way of studying its therapeutic uses—as an antidote for the overprescribed morphine, which had made addicts of so many, and as a treatment for depression.  Halsted, an acclaimed surgeon even then, was curious about cocaine’s effectiveness as an anesthetic and injected the drug into his arm to prove his theory. Neither Freud nor Halsted, nor their colleagues, had any idea of the drug’s potential to dominate and endanger their lives. Addiction as a bona fide medical diagnosis didn’t even exist in the elite medical circles they inhabited.  In An Anatomy of Addiction, Markel writes about the life and work of each man, showing how each came to know about cocaine; how Freud found that the drug cured his indigestion, dulled his aches, and relieved his depression. The author writes that Freud, after a few months of taking the magical drug, published a treatise on it, Über Coca, in which he described his “most gorgeous excitement.” The paper marked a major shift in Freud’s work: he turned from studying the anatomy of the brain to exploring the human psyche.  Halsted, one of the most revered of American surgeons, became the head of surgery at the newly built Johns Hopkins Hospital and then professor of surgery, the hospital’s most exalted position, committing himself repeatedly to Butler Hospital, an insane asylum, to withdraw from his out-of control cocaine use.  Halsted invented modern surgery as we know it today: devising new ways to safely invade the body in search of cures and pioneering modern surgical techniques that controlled bleeding and promoted healing. He insisted on thorough hand washing, on scrub-downs and whites for doctors and nurses, on sterility in the operating room—even inventing the surgical glove, which he designed and had the Goodyear Rubber Company make for him—accomplishing all of this as he struggled to conquer his unyielding desire for cocaine.  An Anatomy of Addiction tells the tragic and heroic story of each man, accidentally struck down in his prime by an insidious malady: tragic because of the time, relationships, and health cocaine forced each to squander; heroic in the intense battle each man waged to overcome his affliction as he conquered his own world with his visionary healing gifts. Here is the full story, long overlooked, told in its rich historical context.

    microbe.” —The Wall Street Journal   Did the Black Death destroy medieval Europe? Did cholera pave the way for modern Manhattan? Did yellow fever help end the slave trade? Remarkably, the answer to all of these questions is yes. Time and again, diseases have impacted the course of human history in surprisingly powerful ways. From influenza to smallpox, from tuberculosis to yellow fever, Bryn Barnard describes the symptoms and paths of the world’s worst diseases—and how the epidemics they spawned have changed history forever.   Filled with fascinating, often gory details about disease and history, Outbreak! is a wonderful combination of science and history.

    Sharon Moalem turns our current understanding of illness on its head and challenges us to fundamentally change the way we think about our bodies, our health, and our relationship to just about every other living thing on earth, from plants and animals to insects and bacteria.Through a fresh and engaging examination of our evolutionary history, Dr. Moalem reveals how many of the conditions that are diseases today actually gave our ancestors a leg up in the survival sweepstakes. When the option is a long life with a disease or a short one without it, evolution opts for disease almost every time.Everything from the climate our ancestors lived in to the crops they planted and ate to their beverage of choice can be seen in our genetic inheritance. But Survival of the Sickest doesn't stop there. It goes on to demonstrate just how little modern medicine really understands about human health, and offers a new way of thinking that can help all of us live longer, healthier lives..

    You’ll smile at some of Andy’s real patient encounters, while others will cause you to wipe a tear. Using official NHS documentation recorded at the time to give precise details of each incident, Andy has held firm to the real-life accounts, even in keeping the dialogue as close as his memory allows to what was really said at the time. It’s as if you’re there next to him, struggling with the effects of adrenaline and fighting to save life. This is a rare work of medical non-fiction delivered in a way that is factual, informative, but at the same time naturally entertaining and moving, written with candour and humour. And if you have ever thought what it takes to become a paramedic – or any other of the specialist vocations - and that you could never achieve it yourself, Andy’s inspiring story of how he went from postman to frontline healthcare professional, fulfilling his dream, will make you think again that anything is possible if you have the desire. Andy says there are no heroics in the book and that he simply did his job, but we are sure The Dark Side will leave you convinced there are true heroes on our streets right here, right now. Saving lives every day, every night and often against all the odds. It might even change your whole perspective on life.

    Whether it's something as minor as a brush with the common cold or as serious as Ebola, we all have grappled with infections and will continue to encounter them as we age.On a worldwide scale, infectious diseases account for 26 percent of all deaths, second only to cardiovascular diseases. And unlike chronic diseases, infectious diseases are unique in their potential for explosive global impacts.Now, in the 24 engaging lectures of Introduction to Infectious Diseases, you can get a comprehensive overview of diseases from the mundane to the fatal from renowned physician and award-winning professor Dr. Barry Fox.Begin with an overview of the microscopic particles responsible for disease: bacteria, fungi, hybrid germs, and viruses. You will see how they invade the body; look through the microscope at pathogens to identify their inner components; follow germs through to different body systems and see what effects they have; and learn why we may be losing the battle against some germs.

    The late-night passing of a beloved aunt summons a childhood bully who shows up minutes later, after twenty-five years, to be forgiven and to heal a broken doctor. This ER doctor finds God's opposite in: a battered child's bruises covered over by make-up, a dying patient whose son finally shows up at the end to reclaim the man's high-top sneakers, the rich or celebrity patients loaded with prescription drugs from doctor friends who end up addicted. But, his real outrage is directed at our cavalier treatment of the elderly, If you put a G-tube in your 80-year-old mother with Alzheimer's because she's no longer eating, you will probably have a fast track to hell.

    Judy Mikovits is a modern-day Rosalind Franklin, a brilliant researcher shaking up the old boys’ club of science with her groundbreaking discoveries. And like many women who have trespassed into the world of men, she uncovered decades-old secrets that many would prefer to stay buried. From her doctoral thesis, which changed the treatment of HIV-AIDS, saving the lives of millions, including basketball great Magic Johnson, to her spectacular discovery of a new family of human retroviruses, and her latest research which points to a new golden age of health, Dr. Mikovits has always been on the leading edge of science. With the brilliant wit one might expect if Erin Brockovich had a doctorate in molecular biology, Dr. Mikovits has seen the best and worst of science. When she was part of the research community that turned HIV-AIDS from a fatal disease into a manageable one, she saw science at its best. But when her investigations questioned whether the use of animal tissue in medical research were unleashing devastating plagues of chronic diseases, such as autism and chronic fatigue syndrome, she saw science at its worst. If her suspicions are correct, we are looking at a complete realignment of scientific practices, including how we study and treat human disease. Recounting her nearly four decades in science, including her collaboration of more than thirty-five years with Dr. Frank Ruscetti, one of the founders of the field of human retrovirology, this is a behind the scenes look at the issues and egos which will determine the future health of humanity.

    In 1750, the anatomist John Hunter described it as “a humiliating spectacle of the futility of science”; yet, over the next 150 years the feared, practical men of medicine benefited from a revolution in scientific progress and the increased availability of instructional textbooks. Anesthesia and antisepsis were introduced. Newly established medical schools improved surgeons’ understanding of the human body. For the first time, surgical techniques were refined, illustrated in color, and disseminated on the printed page.Crucial Interventions follows this evolution, drawing from magnificent examples of rare surgical textbooks from the mid-nineteenth century. Graphic and sometimes unnerving yet beautifully rendered, these fascinating illustrations, acquired from the Wellcome Collection’s extensive archives, include step-by-step surgical techniques paired with depictions of medical instruments and depictions of operations in progress.Arranged for the layman (from head to toe) Crucial Interventions is a captivating look at the early history of one of the world’s most mysterious and macabre professions.

    Michael Crichton created the series from his own experiences as a medical doctor in the emergency rooms, operating rooms and wards of Massachusetts General Hospital. Five Patients is Michael Crichton's true account of the real life dramas so vividly portrayed in ER. A construction worker is seriously injured in a scaffold collapse: a middle-aged dispatcher is brought in suffering from a fever that has reduced him to a delirious wreck; a young man nearly severs his hand in an accident; an airline traveller suffers chest pains; a mother of three is diagnosed with a life-threatening disease.

    In this gripping account, David Quammen takes the reader along on this astonishing quest to learn how, where from, and why these diseases emerge and asks the terrifying question: What might the next big one be?

    In this course brought to you in partnership with HISTORY, you will be visiting some of history’s deepest rabbit-holes, across centuries and continents, in search of secret societies in all their varieties. You will journey to some very dark places, and frankly some odd and sometimes silly ones as well. During 24 eye-opening lectures, Dr. Richard B. “Rick” Spence, Professor of History at the University of Idaho, guides you through the fascinating, often mystifying - sometimes disturbing - world of brotherhoods, sisterhoods, orders, cults, and cabals that have influenced human culture from ancient times to the present.You’ll understand how and why secret societies have attracted some of history’s most brilliant, and some of its most evil, minds. Often demonized by their enemies, many secret societies have become the stuff of myths and conspiracy theories. Why do they exist? And when they are invented or imagined, why would someone pretend they exist? What do secret societies believe? Who do they recruit? Most important, what influence do they have? Buckle up and get ready to find out.

    This edition retains the essence of the original, but has been updated with new features and integrated colour illustrations.