Elizabeth Blackburn discovered a biological indicator called telomerase, the enzyme that replenishes telomeres, which protect our genetic heritage. Dr. Blackburn and Dr. Elissa Epel's research shows that the length and health of one's telomeres are a biological underpinning of the long-hypothesized mind-body connection. They and other scientists have found that changes we can make to our daily habits can protect our telomeres and increase our health spans (the number of years we remain healthy, active, and disease-free).THE TELOMERE EFFECT reveals how Blackburn and Epel's findings, together with research from colleagues around the world, cumulatively show that sleep quality, exercise, aspects of diet, and even certain chemicals profoundly affect our telomeres, and that chronic stress, negative thoughts, strained relationships, and even the wrong neighborhoods can eat away at them. Drawing from this scientific body of knowledge, they share lists of foods and suggest amounts and types of exercise that are healthy for our telomeres, mind tricks you can use to protect yourself from stress, and information about how to protect your children against developing shorter telomeres, from pregnancy through adolescence. And they describe how we can improve our health spans at the community level, with neighborhoods characterized by trust, green spaces, and safe streets. THE TELOMERE EFFECT will make you reassess how you live your life on a day-to-day basis. It is the first book to explain how we age at a cellular level and how we can make simple changes to keep our chromosomes and cells healthy, allowing us to stay disease-free longer and live more vital and meaningful lives.

    The book is suitable for use as a text in similar overview courses about genes and social issues or genes and disease. It gives a good overview of the developments and status of this field for a wide range of biomedical researchers, physicians, and students, especially those interested in the prospects for the new, genetics-based personalized medicine.

    Plagued with fear that her friends and family will be taken from her if she's not watching--that her mother will die, or forget she has children and just move away--Stern treats every parting as her last. Shuttled between a barefoot bohemian life with her mother in Greenwich Village, and a sanitized, stricter world of affluence uptown with her father, Stern has little she can depend on. And when Etan Patz disappears down the block from their MacDougal Street home, she can't help but believe that all her worst fears are about to come true. Tenderly delivered and expertly structured, Stern's memoir is a document of the transformation of New York City and a deep, personal, and comedic account of the trials and errors of seeing life through a very unusual lens.

    Even worse, you may be tempted to research your diagnosis online, only to find doomsday scenarios and terrible prognoses everywhere you click. Take a deep breath. You can get through this—and this workbook will help guide you.Despite what you may have read or been told, BPD is not the worst thing that can happen to you. Like many mental health issues, it manifests on a spectrum, and while some people may encounter extreme symptoms and consequences on one end, others may be less affected on the other. What do you all have in common? You likely experience difficulty balancing your emotions, thoughts, and behaviors. And you may even have trouble seeing yourself clearly—continuously switching from the hero to the villain of the story you’ve written about your life. So, how can you make sense of it all and start on the road to healing?Rather than utilizing a one-size-fits-all treatment, this groundbreaking and comprehensive workbook meets you where you are on your therapeutic journey, and provides an integrative approach to treating BPD drawing on evidence-based dialectical behavior therapy (DBT), acceptance and commitment therapy (ACT), cognitive behavioral therapy (CBT), and interpersonal therapy. With this compassionate workbook, you’ll gain a greater understanding of your BPD, uncover your own emotional triggers, and discover your own personal motivators for positive change.Your BPD has determined how you see and live your life, but it doesn’t have to define you forever. With this workbook as your guide, you’ll be ready to face your diagnosis head-on, and take those important first steps toward lasting wellness.

    While on set, Mark met the women of Ward 81, the only locked hospital security ward for women in the state: the inmates were considered dangerous to themselves or to others. In February of 1976, just before the ward closed (it ceased to exist in November of 1977, when it became the female section of a coeducational treatment ward), Mark and Karen Folger Jacobs, a writer and social scientist, were given permission to make a more extended stay, living on the ward in order to photograph and interview the women. They spent 36 days on Ward 81, photographing and documenting. Jacobs recalls their slow, inevitable assimilation: "We felt the degeneration of our own bodies and the erosion of our self-confidence. We were horrified at the thought of what we might become after a year or two of confinement and therapy on Ward 81." This new hardcover edition adds 10 new pictures to the original. Ward 81 is a sobering investigation into the lives and treatment of the mentally ill.

    She explores the culture of genealogy buffs, the science of DNA, and the business of companies like Ancestry and 23andMe, all while tracing the story of one woman, her unusual results, and a relentless methodical drive for answers that becomes a thoroughly modern genetic detective story.

    In this book, he builds on that theme by showing why this is the luckiest time yet to be alive, giving you the keys to the new kingdom of wellness.Medicine is undergoing rapid change. In the old world, you followed general principles and doctors treated you based on broad, one-size-fits all solutions. In this new golden age, you’ll be able to take full advantage of the latest scientific findings and leverage the power of technology to customize your care. Only those who know how to access and adapt to these breakthroughs—without being distracted by hyped ideas and bad medicine—will benefit. Imagine being able to get fit and lose weight without dieting, train your immune system to fight cancer, edit your DNA to avoid a certain fate, erase the risk of a heart attack, reverse aging, and know exactly which drugs to take to optimize health with zero side effects.That’s the picture of the future that you can enter starting today. Welcome to The Lucky Years.

    Born and raised in a small town, they enjoy a close relationship, though each has her own tastes and personality. But the Hensels also share a body. Their two heads sit side-by-side on a single torso, with two arms and two legs. They have not only survived, but have developed into athletic, graceful young women. And that, writes Mark S. Blumberg, opens an extraordinary window onto human development and evolution.In Freaks of Nature, Blumberg turns a scientist's eye on the oddities of nature, showing how a subject once relegated to the sideshow can help explain some of the deepest complexities of biology. Why, for example, does a two-headed human so resemble a two-headed minnow? What we need to understand, Blumberg argues, is that anomalies are the natural products of development, and it is through developmental mechanisms that evolution works. Freaks of Nature induces a kind of intellectual vertigo as it upends our intuitive understanding of biology. What really is an anomaly? Why is a limbless human a freak, but a limbless reptile-a snake-a successful variation?What we see as deformities, Blumberg writes, are merely alternative paths for development, which challenge both the creature itself and our ability to fit it into our familiar categories. Rather than mere dead-ends, many anomalies prove surprisingly survivable-as in the case of the goat without forelimbs that learned to walk upright. Blumberg explains how such variations occur, and points to the success of the Hensel sisters and the goat as examples of the extraordinary flexibility inherent in individual development.In taking seriously a subject that has often been shunned as discomfiting and embarrassing, Mark Blumberg sheds new light on how individuals-and entire species-develop, survive, and evolve.

    Gwen Adshead provides fresh and surprising insights into violence and the mind. Through a collaboration with coauthor Eileen Horne, Dr. Adshead brings her extraordinary career to life in a series of unflinching portraits. Alongside doctor and patient, we discover what human cruelty, ranging from serial homicide to stalking, arson or sexual offending, means to perpetrators, experiencing first-hand how minds can change when the people some might label as “evil” are able to take responsibility for their life stories and get to know their own minds. With outcomes ranging from hope to despair, from denial to recovery, these men and women are revealed in all their complexity and shared humanity.

    Their IQ scores, added together, totaled just 81. Following prevailing eugenic beliefs of the times, Skeels and his colleague Marie Skodak assumed that the girls had inherited their parents’ low intelligence and were therefore unfit for adoption. The girls were sent to an institution for the “feebleminded” to be cared for by “moron” women. To Skeels and Skodak’s astonishment, under the women’s care, the children’s IQ scores became normal.Now considered one of the most important scientific findings of the twentieth century, the discovery that environment shapes children’s intelligence was also one of the most fiercely contested—and its origin story has never been told. In The Orphans of Davenport, psychologist and esteemed historian Marilyn Brookwood chronicles how a band of young psychologists in 1930s Iowa shattered the nature-versus-nurture debate and overthrew long-accepted racist and classist views of childhood development.Transporting readers to a rural Iowa devastated by dust storms and economic collapse, Brookwood reveals just how profoundly unlikely it was for this breakthrough to come from the Iowa Child Welfare Research Station. Funded by the University of Iowa and the Rockefeller Foundation, and modeled on America’s experimental agricultural stations, the Iowa Station was virtually unknown, a backwater compared to the renowned psychology faculties of Stanford, Harvard, and Princeton. Despite the challenges they faced, the Iowa psychologists replicated increased intelligence in thirteen more “retarded” children.When Skeels published their incredible work, America’s leading psychologists—eugenicists all—attacked and condemned his conclusions. The loudest critic was Lewis M. Terman, who advocated for forced sterilization of low-intelligence women and whose own widely accepted IQ test was threatened by the Iowa research. Terman and his opponents insisted that intelligence was hereditary, and their prestige ensured that the research would be ignored for decades. Remarkably, it was not until the 1960s that a new generation of psychologists accepted environment’s role in intelligence and helped launch the modern field of developmental neuroscience..Drawing on prodigious archival research, Brookwood reclaims the Iowa researchers as intrepid heroes and movingly recounts the stories of the orphans themselves, many of whom later credited the psychologists with giving them the opportunity to forge successful lives. A radiant story of the power and promise of science to better the lives of us all, The Orphans of Davenport unearths an essential history at a moment when race science is dangerously resurgent.

    But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought - just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportionof DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'?Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact ofits 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes ofNeanderthals as well as that of chimps about the development our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.

    Ecosystem: Structure and Function Biogeochemical Cycles, Aquatic Ecosystems: Freshwater Communities, Estuaries and Marine Communities Terrestrial Ecosystems Pollution Ecology and Human Welfare Wild Life Management Biogeography, Adaptations Indices

    The map leads David into the heart of the dangerous Basque mountains, where a genetic curse lies buried and a frightening secret about the Western world's past is hidden. Meanwhile, London journalist Simon Quinn may have found his big break. A wealthy, elderly woman has been murdered in the most horrific fashion, and another homicide soon follows. Both victims came from villages in the Basque region, both were interred at a top-secret Nazi camp, both have been silenced for what they know about the experiments conducted on the Basques, the Jews, and a dwindling mystical tribe of pre-Caucasian locals called Cagots. From the North Sea islands to the Arizona desert, from the graveyards of the Basque countryside to the heart of colonial Africa, Martinez's and Quinn's quests intersect to reveal the shocking roots of racial persecution, human violence, and war. The Genesis Secret-already in its fourth hardcover printing and appearing on several bestseller lists-immediately established Tom Knox as a searing, brilliant new voice in commercial fiction. The Marks of Cain dares to raise the bar even higher and promises to be an even greater success.

    In this extraordinarily moving exploration of his parents' lives, his mother's inexplicable suicide in her late fifties and his own bouts of depression, Tim Lott conjures up the pebble-dashed home of his childhood and the rapidly changing landscape of postwar suburban England. It is a story of grief, loss and dislocation, yet also of the power of memory and the bonds of family love.

    But before Evening Spiker’s head clears a strange boy named Solo is rushing her to her mother’s research facility. There, under the best care available, Eve is left alone to heal.Just when Eve thinks she will die—not from her injuries, but from boredom—her mother gives her a special project: Create the perfect boy.Using an amazingly detailed simulation, Eve starts building a boy from the ground up. Eve is creating Adam. And he will be just perfect... won’t he?