Updated to reflect all critical new developments in drug action and drug-disease interaction. This is the desert island book of all medical pharmacology - if you can own just one pharmacology book, this is it.

    Beginning with the study of DNA in Egyptian mummies in the early 1980s and culminating in the sequencing of the Neanderthal genome in 2010, Neanderthal Man describes the events, intrigues, failures, and triumphs of these scientifically rich years through the lens of the pioneer and inventor of the field of ancient DNA.We learn that Neanderthal genes offer a unique window into the lives of our hominin relatives and may hold the key to unlocking the mystery of why humans survived while Neanderthals went extinct. Drawing on genetic and fossil clues, Pääbo explores what is known about the origin of modern humans and their relationship to the Neanderthals and describes the fierce debate surrounding the nature of the two species’ interactions. His findings have not only redrawn our family tree, but recast the fundamentals of human history—the biological beginnings of fully modern Homo sapiens, the direct ancestors of all people alive today.A riveting story about a visionary researcher and the nature of scientific inquiry, Neanderthal Man offers rich insight into the fundamental question of who we are.

    For The Best of Gerald Durrell she has chosen evocative, quirky, engaging and humorous pieces to give a wonderful picture of how his extraordinary life unfolded. Starting with his early naturalist days and the rapid development of his passion for animals, this anthology includes writings of his collecting trips to such places as Cameroon, Argentina and Madagascar, his growing concern about the nature of zoos, the emergence of his conservation plans, and the realization of his lifelong dream, a zoo of his own, and how it became a model for the future.

    This special, large-format volume is geared as much to nonbirders as it is to the out-and-out obsessed, covering more than two hundred species and including more than 330 new illustrations by the author. While its focus is on familiar backyard birds--blue jays, nuthatches, chickadees--it also examines certain species that can be fairly easily observed, such as the seashore-dwelling Atlantic puffin. David Sibley's artwork and expertise bring observed behaviors vividly to life. (For most species, the primary illustration is reproduced life-sized.) And while the text is aimed at adults--including fascinating new scientific research on the myriad ways birds have adapted to environmental changes--it is nontechnical, making it the perfect occasion for parents and grandparents to share their love of birds with young children, who will delight in the big, full-color illustrations of birds in action.

    She explores the culture of genealogy buffs, the science of DNA, and the business of companies like Ancestry and 23andMe, all while tracing the story of one woman, her unusual results, and a relentless methodical drive for answers that becomes a thoroughly modern genetic detective story.

    But, despite appearances, these are not dogs—they are foxes. They are the result of the most astonishing experiment in breeding ever undertaken—imagine speeding up thousands of years of evolution into a few decades. In 1959, biologists Dmitri Belyaev and Lyudmila Trut set out to do just that, by starting with a few dozen silver foxes from fox farms in the USSR and attempting to recreate the evolution of wolves into dogs in real time in order to witness the process of domestication. This is the extraordinary, untold story of this remarkable undertaking. Most accounts of the natural evolution of wolves place it over a span of about 15,000 years, but within a decade, Belyaev and Trut’s fox breeding experiments had resulted in puppy-like foxes with floppy ears, piebald spots, and curly tails. Along with these physical changes came genetic and behavioral changes, as well. The foxes were bred using selection criteria for tameness, and with each generation, they became increasingly interested in human companionship. Trut has been there the whole time, and has been the lead scientist on this work since Belyaev’s death in 1985, and with Lee Dugatkin, biologist and science writer, she tells the story of the adventure, science, politics, and love behind it all.  In How to Tame a Fox, Dugatkin and Trut take us inside this path-breaking experiment in the midst of the brutal winters of Siberia to reveal how scientific history is made and continues to be made today. To date, fifty-six generations of foxes have been domesticated, and we continue to learn significant lessons from them about the genetic and behavioral evolution of domesticated animals. How to Tame a Fox offers an incredible tale of scientists at work, while also celebrating the deep attachments that have brought humans and animals together throughout time.

    An evolutionary perspective forms the foundation of the entire discussion. The book begins with the natural history of the planet, considers portions of the whole in the middle chapters, and ends with another perspective of the entire planet in the concluding chapter. Its unique organization of focusing only on several key concepts in each chapter sets it apart from the competition. .

    In 2013, the New York Times published an obituary for Yvonne Brill. It began: “She made a mean beef stroganoff, followed her husband from job to job, and took eight years off from work to raise three children.” It wasn’t until the second paragraph that readers discovered why the Times had devoted several hundred words to her life: Brill was a brilliant rocket scientist who invented a propulsion system to keep communications satellites in orbit, and had recently been awarded the National Medal of Technology and Innovation. Among the questions the obituary—and consequent outcry—prompted were, Who are the role models for today’s female scientists, and where can we find the stories that cast them in their true light?      Headstrong delivers a powerful, global, and engaging response. Covering Nobel Prize winners and major innovators, as well as lesser-known but hugely significant scientists who influence our every day, Rachel Swaby’s vibrant profiles span centuries of courageous thinkers and illustrate how each one’s ideas developed, from their first moment of scientific engagement through the research and discovery for which they’re best known. This fascinating tour reveals these 52 women at their best—while encouraging and inspiring a new generation of girls to put on their lab coats.

    Surprisingly, a great many players surveyed did not even know you need to hit down to get the ball up in the air. Hit Down @#!*% ! concisely explains the concept - and the technique - of hitting down at the golf ball for proper trajectory, increased backspin, much improved distance, proper divot taking, and best of all: consistent shotmaking.If you are inadvertently - or intentionally - hitting up at the ball, Hit Down @#!*% ! is for you. (Also available as DVD series, and MP3 download, all on Amazon.)If you are a seasoned amateur who has inexplicably “plateaud” - just cannot seem to get to the next level despite lessons and/or acquiring a library of books and videos - Hit Down @#!*% ! is for you.Symptoms of hitting up include (but are not limited to): - topping the ball- skulling the ball- pushing the ball- slicing the ball- poor distance- difficulty getting off back foot- poor backspin- no divot- fat divots- chunking the ball- thin/fat chip shots- roofing the ball with your driver- inability to hit long irons and/or fairway woods- good shots followed immediately by poor shotsHitting down at the golf ball is not a new concept, but it is a hitherto poorly explained (or completely avoided) concept. All pros agree on the need to hit down, so there is no debate there. Even Tiger Woods, in his 306 page “How I Play Golf”, states the need to hit down at the ball – but does not explain how. Hit Down @#!*% ! does. Learn to hit down, watch the ball go up, and your scores go down. BONUS: At the end of this book you will find a link to purchase the Hit Down @#!*% ! 4 DVD series and receive a full credit for the purchase of this Kindle ebook.

    It develops an understanding of function and evolution into the discussion of anatomy of the various systems.

    Here, historian Alexander Ivanov reveals their fears and betrayals, privilege and debauchery, conspiracies and rivalries, love and tragedy as they forged Russia into one of the world's greatest empires. No ruler in history has embodied the oppressive domination of these rulers more vividly than Alexander Ivanov's opening subject, Tsar Ivan IV, the first of all the Russian tsars, known to history as Ivan the Terrible. Although a gifted ruler who did much to unite and improve the conditions in his primitive country, Ivan was also a notorious sadist who delighted in torturing and murdering anyone who displeased him. Ivan's death in 1584 ushered in the Time of Troubles, thirty-five years of famine, plague, and war that crippled the nation. A series of rulers attempted to cope with the devastation, beginning with Ivan's successor Boris Godunov. Finally, grasping for stability, Russia's nobles begged young Michael Romanov, the great-nephew of Ivan's beloved wife Anastasia, to take the throne. Michael successfully united the war-torn and ravaged nation and founded a dynasty that would rule for 300 years. The Romanov line produced Russia's most brilliant yet most unconventional sovereign: Peter the Great, a towering figure of a man whose restless, creative mind led him on an inexorable quest to modernize and civilize the still backward nation. The reforms he enacted so enraged nobles and peasants alike that Peter had to quash a series of rebellions to keep his crown. Ruthlessly stifling dissent and massacring rebels, he ultimately cowed the Russian people into submission, achieving a legacy that nearly equaled his ambitions. It was left to a woman - and a foreigner, at that - to lead the nation further out of the darkness. German princess Sophie Friederike Auguste of Anhalt-Zerbst, known to the world as Catherine the Great, absorbed the principles of the eighteenth-century Enlightenment and applied them to a country built on the backs of millions of serfs. However ineffective some of her policies, in the end, she made Russia a major player on the European stage. Serfdom was finally abolished in the nineteenth century, but it would be decades before Russian peasants could own land of their own and learn to farm it productively. The boyars and tsars clung to power until the Bolshevik revolution of 1917. The sad fate of the last tsar, Nicholas II, and his family, marked the end of the absolute power that Ivan the Terrible had so exploited. The abuses would continue but under a new and drastically different form of government.

    The theory is sound, but something goes wrong, and a highly contagious combination of virus and prion is unleashed, a middle-stage organism too dangerous to test. With emergency services overwhelmed, a small community hospital tries to combat the unthinkable--an illness that causes aggression, spreads through violence, and won’t allow the dead to rest.

    

    While some books explore our genetic inheritance and popular television shows celebrate ancestry, this is the first book to explore how everything from DNA to emotions to names and the stories that form our lives are all part of our human legacy. This book shows how trust is inherited in Africa, silence is passed down in Tasmania, and how the history of nations is written in our DNA. From fateful, ancient encounters to modern mass migrations and medical diagnoses, Kenneally explains how the forces that shaped the history of the world ultimately shape each human who inhabits it. The Invisible History of the Human Race is a deeply researched, carefully crafted, and provocative perspective on how our stories, psychology, and genetics affect our past and our future.

    Each chapter focuses on one theory or group of theories, providing brief biographies that shed light on how the theories were formed.