The [Chithoni railway link] bridge was completed eleven weeks ahead of schedule and proved to be helpful to one and all.Two key railway projects changed the way India travels by train—the 760-km stretch of Konkan Railway and the Delhi Metro. Both the projects were up and running in seven years flat and the man in charge was Dr Elattuvalapil Sreedharan, popularly known as the Railway Man. He has been hailed as the messiah of new-age infrastructure projects and his success stories have become railway engineering benchmark.Respected, loved and equally hated, this book covers the amazing story of one man—his perseverance, beliefs, and public and private battles. India’s Railway Man: A Biography of E. Sreedharan is a tribute to this extraordinary man.

    It presents practical, clinically-oriented content across a range of topics: quick find features, portability, functionality, and more of the commonly-used clinical information.

    More than 1,000 questions cover everything from the fundamentals of gross and microscopic pathology to the latest findings in molecular biology and genetics. Based on two of the best-selling, most authoritative pathology textbooks-Robbins and Cotran Pathologic Basis of Disease, 7th Edition and Basic Pathology, 7th Edition-Robbins and Cotran Review of Pathology, 2nd Edition is an ideal aid for coursework, self-assessment, and examinations in pathology.Offers more than 1,000 questions that follow the clinical vignette style, emphasizing problem solving over rote memorization. Presented in both single-best-answer and extended-matching formats, they reflect levels of difficulty that prepare students for both examinations and the practice of medicine.Provides an answer and a detailed explanation for every question at the end of each chapter.Includes page references and a parallel organization to both Robbins and Cotran Pathologic Basis of Disease and Basic Pathology, making additional information easy to locate.Presents correlative laboratory, radiologic, and physical diagnostic data to enhance readers' understanding of pathophysiology and to integrate pathology with other medical disciplines.Uses numerous full-color illustrations to test readers' diagnostic skills.Delivers a 73-question chapter covering all subjects that mimics a comprehensive final examination.

    His brilliant mind, which saw him building power stations and literally bringing light into the lives of others, has succumbed to darkness.As Robyn settles back in the rhythms of life in the rain-soaked vast Welsh valleys, she keeps a diary charting her journey as the dad she knew disappears before her eyes. Lyrical, poignant and with flashes of brilliant humour, My Mad Dad explores how in helping others we can heal ourselves. 'At some point the cared for become the carers...this isn't a shame and it isn't a tragedy and it isn't a chore. It is an honour. To be able to return the gift of love that someone bestows upon you is a gift in itself. This is a story of caring...'

    What begins as a concussion with a diagnosed recovery time of seven-to-ten days becomes more than two years of debilitating pain with no apparent end and a string of unhelpful doctor and specialist visits. In the wreckage, jobs are canceled. Leases are broken. There is no second date. What’s left is Isabella, her body, and her pain. Because the source of her pain cannot be located within the body, she is told over and over that her pain is psychosomatic. And Isabella believes it, over and over. What follows is a surprisingly funny medical and spiritual journey, during which Isabella must learn to trust in all that she cannot see or quantify: her pain, God, and her inner voice. Everything fell apart and then something new emerged.

    Shubin describes how over the last half-century, scientists have been able to explore how genetic recipes build bodies during embryological development--how these inventions and adaptations occur in a nonprogressive manner in different contexts, at different speeds. Paleontology has been transformed over the last 50 years by tools and techniques of molecular biology--and it is that revolution in our understanding of the evolution of life that Shubin traces here. Each of us is a mosaic of precursors that came about at different times and places, with deep rooted connections across species that Darwin, for all he understood, could never even have imagined.

    The stewards of Earth, these organisms transformed the chemistry of our planet to make it habitable for plants, animals, and us. Life's Engines takes readers deep into the microscopic world to explore how these marvelous creatures made life on Earth possible--and how human life today would cease to exist without them.Paul Falkowski looks "under the hood" of microbes to find the engines of life, the actual working parts that do the biochemical heavy lifting for every living organism on Earth. With insight and humor, he explains how these miniature engines are built--and how they have been appropriated by and assembled like Lego sets within every creature that walks, swims, or flies. Falkowski shows how evolution works to maintain this core machinery of life, and how we and other animals are veritable conglomerations of microbes.A vibrantly entertaining book about the microbes that support our very existence, Life's Engines will inspire wonder about these elegantly complex nanomachines that have driven life since its origin. It also issues a timely warning about the dangers of tinkering with that machinery to make it more "efficient" at meeting the ever-growing demands of humans in the coming century.

    Possessed of great warmth, wit and, above all a humanity which informs every word in this extraordinary account of Jersey life during the German Occupation, he served the island community with unfailing resourcefulness and not a little courage for five long and stressful years. However, despite the awfulness of the time, Dr Lewis infuses his account of it with an irrepressible joie de vivre which is utterly delightful. It is an uplifting story of winning against the odds, by turns hysterically funny and then unbearably sad. Above all it has an immediacy which takes the reader right into the heart of the Occupation, you can smell the fear, feel the pain, suffer the loss, sense the victory as do the characters in this history and they are many and varied. You will meet the good Jersey folk like the brave and tragic Mrs Gould from St Ouens and the not so good Jersey folk in the shape of the collaborators and informers or the “Jerry bags” like the exotic Ginger Lou. Here too you will meet some of the most wretched victims of the war, the Russian Todt workers who were hidden and helped by the locals and of course the many sorts of Germans who made up the occupying force. It is a story of compelling interest.I had the good fortune to meet John Lewis and his wife in 1991 at his lovely Jersey home. He talked for hours that seemed like minutes of his life during the war years. He was just as I’d hoped he would be - endlessly kind, witty and understanding. I came away from that meeting feeling happy, elated and much wiser, as you will surely do after reading of the Doctor’s Occupation. John Nettles

    C. Walton Lillehei, who, along with colleagues at University Hospital in Minneapolis and a small band of pioneers elsewhere, accomplished what many experts considered to be an impossible feat: He opened the heart, repaired fatal defects, and made the miraculous routine.Acclaimed author G. Wayne Miller draws on archival research and exclusive interviews with Lillehei and legendary pioneers such as Michael DeBakey and Christiaan Barnard, taking readers into the lives of these doctors and their patients as they progress toward their landmark achievement. In the tradition of works by Richard Rhodes and Tracy Kidder, King of Hearts tells the story of an important and gripping piece of forgotten science history.From the Hardcover edition.

    Two scientists explore the potential of a revolutionary genetics technology capable of easily and affordably manipulating DNA in human embryos to prevent specific diseases, addressing key concerns about related ethical and societal repercussions.

    The 4th Edition of this bestseller has been completely revised and reorganized to present a more up-to-date approach to the field, with less emphasis on traditional hospital-based practice. It uses the APGO/CREOG curriculum objectives as a framework, with a special emphasis on women's health issues. A new, full-color design with many illustrations and photographs complements the text. Plus, a free downloadable PDA software program provides a complete guide to the most common disorders. The smart way to study Elsevier titles STUDENT CONSULT will help you master difficult concepts and study more efficiently in print and online Perform rapid searches. Integrate bonus content from other disciplines. Download text to your handheld device. And a lot more. Each STUDENT CONSULT title comes with full text online, a unique image library, case studies, USMLE style questions, and online note-taking to enhance your learning experience.

    Comparing gene sequences, examining atomic structures of proteins, and looking into the geochemistry of rocks have helped explain evolution in more detail than ever before. Nick Lane expertly reconstructs the history of life by describing the ten greatest inventions of evolution (including DNA, photosynthesis, sex, and sight), based on their historical impact, role in organisms today, and relevance to current controversies. Who would have guessed that eyes started off as light-sensitive spots used to calibrate photosynthesis in algae? Or that DNA’s building blocks form spontaneously in hydrothermal vents? Lane gives a gripping, lucid account of nature’s ingenuity, and the result is a work of essential reading for anyone who has ever pondered or questioned the science underlying evolution’s greatest gifts to man.

    Growing understanding of the immune system, and especially the creation of immune memory (long lasting protection), which can be harnessed in the design of vaccines, have been major breakthroughs in medicine.In this Very Short Introduction, Paul Klenerman describes the immune system, and how it works in health and disease. In particular he focuses on the human immune system, considering how it evolved, the basic rules that govern its behavior, and the major health threats where it is important. Theimmune system comprises a series of organs, cells and chemical messengers which work together as a team to provide defence against infection. Klenerman discusses these components, the critical signals that trigger them and how they exert their protective effects, including so-called innate immuneresponses, which react very fast to infection, and adaptive immune responses, which have huge diversity and a capacity to recognize and defend against a massive array of micro-organisms. Klenerman also considers what happens when our immune systems fail to be activated effectively, leading toserious infections, problems with inherited diseases, and also HIV/AIDS. At the opposite extreme, as Klenerman shows, an over-exaggerated immune response leads to inflammatory diseases such as Multiple Sclerosis and Rheumatoid Arthritis, as well as allergy and asthma. Finally he looks at the Immunesystem v2.o - how immune therapies and vaccines can be advanced to protect us against the major diseases of the 21st century.ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, andenthusiasm to make interesting and challenging topics highly readable.

    That one bite changed her life forever, pulling her into the abyss of a devastating illness that took ten doctors to diagnose and years to recover: Newby had become one of the 300,000 Americans who are afflicted with Lyme disease each year.As a science writer, she was driven to understand why this disease is so misunderstood, and its patients so mistreated. This quest led her to Willy Burgdorfer, the Lyme microbe's discoverer, who revealed that he had developed bug-borne bioweapons during the Cold War, and believed that the Lyme epidemic was started by a military experiment gone wrong.In a superb, meticulous work of narrative journalism, Bitten takes readers on a journey to investigate these claims, from biological weapons facilities to interviews with biosecurity experts and microbiologists doing cutting-edge research, all the while uncovering darker truths about Willy. It also leads her to uncomfortable questions about why Lyme can be so difficult to both diagnose and treat, and why the government is so reluctant to classify chronic Lyme as a disease.A gripping, infectious page-turner, Bitten will shed a terrifying new light on an epidemic that is exacting an incalculable toll on us, upending much of what we believe we know about it.

    The shocking story of blinded eyes, and the medical school that allowed it.