She was a poor Southern tobacco farmer who worked the same land as her enslaved ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia — a land of wooden quarters for enslaved people, faith healings, and voodoo — to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family — past and present — is inextricably connected to the history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance?Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

    But in her mother, a would-be artist burdened by the endless arrival of new babies, young Kate saw the consequences of a dream deferred. Determined to pursue her own no matter the cost, at 18 she left her small Midwestern town for New York, where, studying with the legendary Stella Adler, she learned the lesson that would define her as an actress: "Use it," Adler told her. Whatever disappointment, pain, or anger life throws in your path, channel it into the work.It was a lesson she would need. At twenty-two, just as her career was taking off, she became pregnant and gave birth to a daughter. Having already signed the adoption papers, she was allowed only a fleeting glimpse of her child. As her star continued to rise, her life became increasingly demanding and fulfilling, a whirlwind of passionate love affairs, life-saving friendships, and bone-crunching work. Through it all, Mulgrew remained haunted by the loss of her daughter, until, two decades later, she found the courage to face the past and step into the most challenging role of her life, both on and off screen.We know Kate Mulgrew for the strong women she's played--Captain Janeway on Star Trek; the tough-as-nails "Red" on Orange is the New Black. Now, we meet the most inspiring and memorable character of all: herself. By turns irreverent and soulful, laugh-out-loud funny and heart-piercingly sad, BORN WITH TEETH is the breathtaking memoir of a woman who dares to live life to the fullest, on her own terms.

    You will be born in New Mexico. You will get your big break at an acting camp. You will get into a bizarre confrontation outside a nightclub with actor Scott Caan. Even better, at each critical juncture of your life, you will choose how to proceed. You will decide whether to try out for Doogie Howser, M.D. You will decide whether to spend years struggling with your sexuality. You will decide what kind of caviar you want to eat on board Elton John’s yacht. Choose correctly and you’ll find fame, fortune, and true love. Choose incorrectly and you’ll find misery, heartbreak, and a hideous death by piranhas. All this, plus magic tricks, cocktail recipes, embarrassing pictures from your time as a child actor, and even a closing song. Yes, if you buy one book this year, congratulations on being above the American average, but make that book Neil Patrick Harris: Choose Your Own Autobiography!

    The disintegration of this group, a process that has been slowly occurring now for more than forty years, has been reported with growing frequency and alarm, but has never before been written about as searingly from the inside. J. D. Vance tells the true story of what a social, regional, and class decline feels like when you were born with it hung around your neck.The Vance family story begins hopefully in postwar America. J. D.’s grandparents were “dirt poor and in love,” and moved north from Kentucky’s Appalachia region to Ohio in the hopes of escaping the dreadful poverty around them. They raised a middle-class family, and eventually one of their grandchildren would graduate from Yale Law School, a conventional marker of success in achieving generational upward mobility. But as the family saga of Hillbilly Elegy plays out, we learn that J.D.'s grandparents, aunt, uncle, sister, and, most of all, his mother struggled profoundly with the demands of their new middle-class life, never fully escaping the legacy of abuse, alcoholism, poverty, and trauma so characteristic of their part of America. With piercing honesty, Vance shows how he himself still carries around the demons of his chaotic family history.A deeply moving memoir, with its share of humor and vividly colorful figures, Hillbilly Elegy is the story of how upward mobility really feels. And it is an urgent and troubling meditation on the loss of the American dream for a large segment of this country.

    From Senator Al Franken - #1 bestselling author and beloved SNL alum - comes the story of an award-winning comedian who decided to run for office and then discovered why award-winning comedians tend not to do that.This is a book about an unlikely campaign that had an even more improbable ending: the closest outcome in history and an unprecedented eight-month recount saga, which is pretty funny in retrospect.It's a book about what happens when the nation's foremost progressive satirist gets a chance to serve in the United States Senate and, defying the low expectations of the pundit class, actually turns out to be good at it.It's a book about our deeply polarized, frequently depressing, occasionally inspiring political culture, written from inside the belly of the beast.In this candid personal memoir, the honorable gentleman from Minnesota takes his army of loyal fans along with him from Saturday Night Live to the campaign trail, inside the halls of Congress, and behind the scenes of some of the most dramatic and/or hilarious moments of his new career in politics.Has Al Franken become a true Giant of the Senate? Franken asks readers to decide for themselves.

    Last year, he made the stunning announcement that he had been diagnosed with stage four pancreatic cancer. What followed was an incredible outpouring of love and kindness. Social media was flooded with messages of support, and the Jeopardy! studio received boxes of cards and letters offering guidance, encouragement, and prayers.For over three decades, Trebek had resisted countless appeals to write a book about his life. Yet he was moved so much by all the goodwill, he felt compelled to finally share his story. “I want people to know a little more about the person they have been cheering on for the past year,” he writes in The Answer Is…: Reflections on My Life.The book combines illuminating personal anecdotes with Trebek’s thoughts on a range of topics, including marriage, parenthood, education, success, spirituality, and philanthropy. Trebek also addresses the questions he gets asked most often by Jeopardy! fans, such as what prompted him to shave his signature mustache, his insights on legendary players like Ken Jennings and James Holzhauer, and his opinion of Will Ferrell’s Saturday Night Live impersonation. The book uses a novel structure inspired by Jeopardy!, with each chapter title in the form of a question, and features dozens of never-before-seen photos that candidly capture Trebek over the years.This wise, charming, and inspiring book is further evidence why Trebek has long been considered one of the most beloved and respected figures in entertainment.

    Everyone is doing it now.Disarmed of falsehood, he was left only with the awful truth: John Hodgman is an older white male monster with bad facial hair, wandering like a privileged Sasquatch through three wildernesses: the hills of Western Massachusetts where he spent much of his youth; the painful beaches of Maine that want to kill him (and some day will); and the metaphoric haunted forest of middle age that connects them.Vacationland collects these real life wanderings, and through them you learn of the horror of freshwater clams, the evolutionary purpose of the mustache, and which animals to keep as pets and which to kill with traps and poison. There is also some advice on how to react when the people of coastal Maine try to sacrifice you to their strange god.Though wildly, Hodgmaniacally funny as usual, it is also a poignant and sincere account of one human facing his forties, those years when men in particular must stop pretending to be the children of bright potential they were and settle into the failing bodies of the wiser, weird dads that they are.

    After college, armed with a backpack, her personal mission statement, and a wad of traveler’s checks, she took off for Australia to see things and do things and Become Interesting.  But it didn’t turn out the way she pictured it. In a matter of months, her savings shot, she had a choice: get a job or go home. That’s how Kelly met John Tanner, a newly widowed father of two looking for a live-in nanny. They chatted for an hour, discussed timing and pay, and a week later, Kelly moved in. And there, in that house in a suburb north of Sydney, 10,000 miles from the house where she was raised, her mother’s voice was suddenly everywhere, nudging and advising, cautioning and directing, escorting her through a terrain as foreign as any she had ever trekked. Every day she spent with the Tanner kids was a day spent reconsidering her relationship with her mother, turning it over in her hands like a shell, straining to hear whatever messages might be trapped in its spiral.   This is a book about the difference between travel and life experience, stepping out and stepping up, fathers and mothers. But mostly it’s about who you admire and why, and how that changes over time.

    In Talking as Fast as I Can, Lauren Graham hits pause for a moment and looks back on her life, sharing laugh-out-loud stories about growing up, starting out as an actress, and, years later, sitting in her trailer on the Parenthood set and asking herself, “Did you, um, make it?” She opens up about the challenges of being single in Hollywood (“Strangers were worried about me; that’s how long I was single!”), the time she was asked to audition her butt for a role, and her experience being a judge on Project Runway (“It’s like I had a fashion-induced blackout”). In “What It Was Like, Part One,” Graham sits down for an epic Gilmore Girls marathon and reflects on being cast as the fast-talking Lorelai Gilmore. The essay “What It Was Like, Part Two” reveals how it felt to pick up the role again nine years later, and what doing so has meant to her. Some more things you will learn about Lauren: She once tried to go vegan just to bond with Ellen DeGeneres, she’s aware that meeting guys at awards shows has its pitfalls (“If you’re meeting someone for the first time after three hours of hair, makeup, and styling, you’ve already set the bar too high”), and she’s a card-carrying REI shopper (“My bungee cords now earn points!”). Including photos and excerpts from the diary Graham kept during the filming of the recent Gilmore Girls: A Year in the Life, this book is like a cozy night in, catching up with your best friend, laughing and swapping stories, and—of course—talking as fast as you can.

    Days earlier, she had been on the threshold of a new, adult life: at the beginning of her first serious relationship and a promising career at a major New York newspaper. Now she was labeled violent, psychotic, a flight risk. What happened?In a swift and breathtaking narrative, Cahalan tells the astonishing true story of her descent into madness, her family’s inspiring faith in her, and the lifesaving diagnosis that nearly didn’t happen.

    If so, you've come to the right book, mostly!In Is Everyone Hanging Out Without Me?, Mindy invites readers on a tour of her life and her unscientific observations on romance, friendship, and Hollywood, with several conveniently placed stopping points for you to run errands and make phone calls. Mindy Kaling really is just a Girl Next Door - not so much literally anywhere in the continental United States, but definitely if you live in India or Sri Lanka.

    Krakauer's book, Into the Wild, became an international bestseller, translated into thirty-one languages, and Sean Penn's inspirational film by the same name further skyrocketed Chris McCandless to global fame. But the real story of Chris's life and his journey has not yet been told—until now. The missing pieces are finally revealed in The Wild Truth, written by Carine McCandless, Chris's beloved and trusted sister. Featured in both the book and film, Carine has wrestled for more than twenty years with the legacy of her brother's journey to self-discovery, and now tells her own story while filling in the blanks of his. Carine was Chris's best friend, the person with whom he had the closest bond, and who witnessed firsthand the dysfunctional and violent family dynamic that made Chris willing to embrace the harsh wilderness of Alaska. Growing up in the same troubled household, Carine speaks candidly about the deeper reality of life in the McCandless family. In the many years since the tragedy of Chris's death, Carine has searched for some kind of redemption. In this touching and deeply personal memoir, she reveals how she has learned that real redemption can only come from speaking the truth.

    A failed salesman turned local reporter, he wanted to test himself, see how he might respond to pressure and danger. He signed up for emergency medical training and became, at age twenty-six, a newly minted EMT running calls in the worst sections of Atlanta. His life entered a different realm—one of blood, violence, and amazing grace.Thoroughly intimidated at first and frequently terrified, he experienced on a nightly basis the adrenaline rush of walking into chaos. But in his downtime, Kevin reflected on how people’s facades drop away when catastrophe strikes. As his hours on the job piled up, he realized he was beginning to see into the truth of things. There is no pretense five beats into a chest compression, or in an alley next to a crack den, or on a dimly lit highway where cars have collided. Eventually, what had at first seemed impossible happened: Kevin acquired mastery. And in the process he was able to discern the professional differences between his freewheeling peers, what marked each—as he termed them—as “a tourist,” “true believer,” or “killer.”Combining indelible scenes that remind us of life’s fragile beauty with laugh-out-loud moments that keep us smiling through the worst, A Thousand Naked Strangers is an absorbing read about one man’s journey of self-discovery—a trip that also teaches us about ourselves.

    Mary Anne Schwalbe is waiting for her chemotherapy treatments when Will casually asks her what she's reading. The conversation they have grows into tradition: soon they are reading the same books so they can have something to talk about in the hospital waiting room. The ones they choose range from classic to popular, from fantastic to spiritual, and we hear their passion for reading and their love for each other in their intimate and searching discussions. A profoundly moving testament to the power of love between a child and parent, and the power of reading in our lives.

    An experienced falconer—Helen had been captivated by hawks since childhood—she'd never before been tempted to train one of the most vicious predators, the goshawk. But in her grief, she saw that the goshawk's fierce and feral temperament mirrored her own. Resolving to purchase and raise the deadly creature as a means to cope with her loss, she adopted Mabel, and turned to the guidance of The Once and Future King author T.H. White's chronicle The Goshawk to begin her challenging endeavor. Projecting herself "in the hawk's wild mind to tame her" tested the limits of Macdonald's humanity and changed her life. Heart-wrenching and humorous, this book is an unflinching account of bereavement and a unique look at the magnetism of an extraordinary beast, with a parallel examination of a legendary writer's eccentric falconry. Obsession, madness, memory, myth, and history combine to achieve a distinctive blend of nature writing and memoir from an outstanding literary innovator.