But if we are supposedly evolution’s greatest creation, why do we have such bad knees? Why do we catch head colds so often—two hundred times more often than a dog does? How come our wrists have so many useless bones? Why is the vast majority of our genetic code pointless? And are we really supposed to swallow and breathe through the same narrow tube? Surely there’s been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last. The human body is one big pile of compromises. But that is also a testament to our greatness: as Lents shows, humans have so many design flaws precisely because we are very, very good at getting around them.   A rollicking, deeply informative tour of humans’ four billion year long evolutionary saga, Human Errors both celebrates our imperfections and offers an unconventional accounting of the cost of our success.

    Chapters cover cancer, infection, immune disorders, genetics, and disorders of each body system, highlighting pathophysiologic processes, resulting signs and symptoms, diagnostic test findings, and current treatments. Reader-friendly features include illustrations, checklists, and full-color miniguides illustrating the pathophysiology of specific disorders.This edition has new full-color miniguides on cancer pathophysiology and neuropathology. A new Focus on Genetics feature identifies gene-related discoveries and their implications for treatment or diagnosis. Review questions and answers follow current NCLEX-RN® requirements and alternate-format questions are included.

    We see it, touch it, and live in it every day. It is a habitat for a mesmerizingly complex world of micro-organisms and physical functions that are vital to our health and our survival. It is also a waste removal plant, a warning system for underlying disease and a dynamic immune barrier to infection. One of the first things people see about us, skin is crucial to our sense of identity, providing us with social significance and psychological meaning. And yet our skin and the fascinating way it functions is largely unknown to us. In prose as lucid as his research underlying it is rigorous, blending in memorable stories from the past and from his own medical experience, Monty Lyman has written a revelatory book exploring our outer surface that will surprise and enlighten in equal measure. Through the lenses of science, sociology, and history--on topics as diverse as the mechanics and magic of touch (how much goes on in the simple act of taking keys out of a pocket and unlocking a door is astounding), the close connection between the skin and the gut, what happens instantly when one gets a paper cut, and how a midnight snack can lead to sunburn--Lyman leads us on a journey across our most underrated and unexplored organ and reveals how our skin is far stranger, more wondrous, and more complex than we have ever imagined.

    But its roots stretch back as far as ancient Greece, when medicine first departed from the divine and the mystical and moved toward observation and logic. Its early development was slow, constrained by the taboo around dissection (only external symptoms could be used for diagnosis), as well as superstition and mysticism (illness was the work of demons and pixies and curable only by penitence). Paul Strathern steers us skillfully through the maze of discoveries, diseases, and wrong turns that have made medicine what it is today—super efficient, high tech, and increasingly costly. A Brief History of Medicine offers an accessible history of the arguments, missteps, and dumb luck that led to the world's most important medical breakthroughs—from anatomy, grave robbing, the plague, and germ theory to vaccination, quackery, microorganisms, and penicillin.

    Barbara Ravage has fashioned an enlightening, invaluable book.” —Stewart O’Nan, author of The Circus Fire: A True Story of an American TragedyThough each of us is just a spark away from being a burn victim, the public knows little and understands less about the world that patients inhabit. Pulling the curtains back on this private and sterile environment, Burn Unit is a riveting account of the frontline efforts—both modern-day and historical—to save lives devastated by fire. With unflinching urgency, Barbara Ravage follows an extraordinary team of healers at Massachusetts General Hospital, the cradle of modern burn treatment and the site of one of the best burn units in the world. From Boston’s Cocoanut Grove fire of 1942 to the treatment of the victims of the Rhode Island nightclub fire in early 2003, we watch everyday heroes do their incredible but punishing work against the backdrop of history. Both a moving human drama and an engrossing scientific exploration of this little-known field of medicine, Burn Unit is an unforgettably powerful read.

    The threat of the disease kept ships close to home and doomed those vessels that ventured too far from port. The willful ignorance of the royal medical elite, who endorsed ludicrous medical theories based on speculative research while ignoring the life-saving properties of citrus fruit, cost tens of thousands of lives and altered the course of many battles at sea. The cure for scurvy ranks among the greatest of human accomplishments, yet its impact on history has, until now, been largely ignored.From the earliest recorded appearance of the disease in the sixteenth century, to the eighteenth century, where a man had only half a chance of surviving the scourge, to the early nineteenth century, when the British conquered scurvy and successfully blockaded the French and defeated Napoleon, Scurvy is a medical detective story for the ages, the fascinating true story of how James Lind (the surgeon), James Cook (the mariner), and Gilbert Blane (the gentleman) worked separately to eliminate the dreaded affliction.Scurvy is an evocative journey back to the era of wooden ships and sails, when the disease infiltrated every aspect of seafaring life: press gangs "recruit" mariners on the way home from a late night at the pub; a terrible voyage in search of riches ends with a hobbled fleet and half the crew heaved overboard; Cook majestically travels the South Seas but suffers an unimaginable fate. Brimming with tales of ships, sailors, and baffling bureaucracy, Scurvy is a rare mix of compelling history and classic adventure story.

    At the heart of their chilling scenario is their contention that the plague was spread by direct human contact (not from rat fleas) and was, in fact, a virus perhaps similar to AIDS and Ebola. Noting the periodic occurrence of plagues throughout history, the authors predict its inevitable re--emergence sometime in the future, transformed by mass mobility and bioterrorism into an even more devastating killer.

    Bell ruling made government sterilization of "undesirable" citizens the law of the land. New York Times bestselling author Adam Cohen tells the story in Imbeciles of one of the darkest moments in the American legal tradition: the Supreme Court's decision to champion eugenic sterilization for the greater good of the country. In 1927, when the nation was caught up in eugenic fervor, the justices allowed Virginia to sterilize Carrie Buck, a perfectly normal young woman, for being an "imbecile." It is a story with many villains, from the superintendent of the Dickensian Virginia Colony for Epileptics and Feebleminded who chose Carrie for sterilization to the former Missouri agriculture professor and Nazi sympathizer who was the nation's leading advocate for eugenic sterilization. But the most troubling actors of all were the eight Supreme Court justices who were in the majority--including William Howard Taft, the former president; Louis Brandeis, the legendary progressive; and Oliver Wendell Holmes, Jr., America's most esteemed justice, who wrote the decision urging the nation to embark on a program of mass eugenic sterilization

    After centuries of ineffective treatments, the microorganism that causes TB was identified, and the cure was thought to be within reach—but drug-resistant varieties continue to plague and panic the human race.The “biography” of this deadly germ, an account of the diagnosis, treatment, and “cure” of the disease over time,and the social history of an illness that could strike anywhere but was most prevalent among the poor are woven together in an engrossing, carefully researched narrative. Bibliography, source notes, index.

    Torn from their homes and families, these men, women, and children were loaded into shipboard cattle stalls and abandoned in a lawless place where brutality held sway. Many did not have leprosy, and many who did were not contagious, yet all were ensnared in a shared nightmare. Here, for the first time, John Tayman reveals the complete history of the Molokai settlement and its unforgettable inhabitants. It's an epic of ruthless manhunts, thrilling escapes, bizarre medical experiments, and tragic, irreversible error. Carefully researched and masterfully told, The Colony is a searing tale of individual bravery and extraordinary survival, and stands as a testament to the power of faith, compassion, and the human spirit.

    Distinguished science journalist Edward Hooper presents the meticulously researched -- and highly readable -- history of HIV and its possible origins. Pursuing leads across the U.S., the Caribbean, Europe, and Africa, Hooper pieces together the tantalizing clues offered by long-archived blood samples, early AIDS-like cases (such as the "Manchester sailor" case of 1959), immunodeficiency viruses (SIVs), and the medical interventions in Africa and elsewhere that may have played a role in SIVs' crossover into humans.Hooper examines over two dozen theories of origin, and eventually discards most of them. What remains is a remarkable and well-supported theory for the sudden appearance of AIDS, and the definitive story of its lethal spread. Drawing on more than 4,000 sources and 600 interviews, The River is a thorough and provocative investigation into the most terrible epidemic of the twentieth century.

    Often they seem aloof, uncaring, and hurried. Of course, they’re not all like that, and most didn’t start out that way. Here are voices of third-year students just as they begin to take on clinical responsibilities. Their words focus on the odd transition students face when they must deal with real people in real time and in real crises and when they must learn to put aside their emotions to make quick, accurate, and sensitive decisions. Their decisions aren’t always right, and the consequences can be life-altering—for all involved. Moving, disturbing, and candid, their true stories show us a side of the profession that few ever see, or could even imagine. They show, often painfully, how medical students grow up, right at the bedside.

    Doctors stymied by mysterious symptoms of the killer: soaring temperature, painful backache, swelling of the throat and neck, discolored skin! Latest victim airlifted to special isolation ward at New York's Columbia Presbyterian Hospital, blood samples rushed to Yale's Arborvirus Laboratory, all-out search launches to discover an antidote. U. S. Public Health officials alarmed, virus has the potential to decimate the whole population, aviation officials consider cancellation of all jet travel to critical world areas.

    Bonnie Henry has been called one of the most effective public health figures in the world by The New York Times. She has been called a calming voice in a sea of coronavirus madness, and our hero in national newspapers. But in the waning days of 2019, when the first rumours of a strange respiratory ailment in Wuhan, China began to trickle into her office in British Colombia, these accolades lay in a barely imaginable future.Only weeks later, the whole world would look back on the previous year with the kind of nostalgia usually reserved for the distant past. With a staggering suddenness, our livelihoods, our closest relationships, our habits and our homes had all been transformed.In a moment when half-truths threatened to drown out the truth, when recklessness all too often exposed those around us to very real danger, and when it was difficult to tell paranoia from healthy respect for an invisible threat, Dr. Henry's transparency, humility, and humanity became a beacon for millions of Canadians.And her trademark enjoinder to be kind, be calm, and be safe became words for us all to live by.Coincidentally, Dr. Henry's sister, Lynn, arrived in BC for a long-planned visit on March 12, just as the virus revealed itself as a pandemic. For the four ensuing weeks, Lynn had rare insight into the whirlwind of Bonnie's daily life, with its moments of agony and gravity as well as its occasional episodes of levity and grace. Both a global story and a family story, Be Kind, Be Calm, Be Safe combines Lynn's observations and knowledge of Bonnie's personal and professional background with Bonnie's recollections of how and why decisions were made, to tell in a vivid way the dramatic tale of the four weeks that changed all our lives.Be Kind, Be Calm, Be Safe is about communication, leadership, and public trust; about the balance between politics and policy; and, at heart, about what and who we value, as individuals and a society.The authors' advance from the publisher will be donated to charities with a focus on alleviating communities hit particularly hard by the pandemic: True North Aid with its Covid-19 response in Northern Indigenous communities, and First Book Canada, with its focus on reading and literacy for underserved, marginalized youth.

    Its defeat was a reflection not only of progress in medical knowledge but of enduring changes in American social thought. Rosenberg has focused his study on New York City, the most highly developed center of this new society. Carefully documented, full of descriptive detail, yet written with an urgent sense of the drama of the epidemic years, this narrative is as absorbing for general audiences as it is for the medical historian. In a new Afterword, Rosenberg discusses changes in historical method and concerns since the original publication of The Cholera Years."A major work of interpretation of medical and social thought . . . this volume is also to be commended for its skillful, absorbing presentation of the background and the effects of this dread disease."—I.B. Cohen, New York Times"The Cholera Years is a masterful analysis of the moral and social interest attached to epidemic disease, providing generally applicable insights into how the connections between social change, changes in knowledge and changes in technical practice may be conceived."—Steven Shapin, Times Literary Supplement"In a way that is all too rarely done, Rosenberg has skillfully interwoven medical, social, and intellectual history to show how medicine and society interacted and changed during the 19th century. The history of medicine here takes its rightful place in the tapestry of human history."—John B. Blake, Science