Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with - and perished from - for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. From the Persian Queen Atossa, whose Greek slave cut off her malignant breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee’s own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive—and to increase our understanding of this iconic disease. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

    It was like roaring surf, one of them said later. Like a runaway two-horse team smashing through a fence, said another. A third firefighter jumped up from his chair to look out a window-"Oh my God!" he shouted to the other men, "Run!"A 50-foot-tall steel tank filled with 2.3 million gallons of molasses had just collapsed on Boston's waterfront, disgorging its contents as a 15-foot-high wave of molasses that at its outset traveled at 35 miles an hour. It demolished wooden homes, even the brick fire station. The number of dead wasn't known for days. It would be years before a landmark court battle determined who was responsible for the disaster.

    On March 25, 1911, the Triangle Shirtwaist Factory in New York City burst into flames.  The factory was crowded.  The doors were locked to ensure workers stay inside.  One hundred forty-six people—mostly women—perished; it was one of the most lethal workplace fires in American history until September 11, 2001.But the story of the fire is not the story of one accidental moment in time.  It is a story of immigration and hard work to make it in a new country, as Italians and Jews and others traveled to America to find a better life.  It is the story of poor working conditions and greedy bosses, as garment workers discovered the endless sacrifices required to make ends meet.  It is the story of unimaginable, but avoidable, disaster.  And it the story of the unquenchable pride and activism of fearless immigrants and women who stood up to business, got America on their side, and finally changed working conditions for our entire nation, initiating radical new laws we take for granted today.With Flesh and Blood So Cheap, Albert Marrin has crafted a gripping, nuanced, and poignant account of one of America's defining tragedies.

    organized crime for a bloody half century, there was the one-fingered criminal genius Giuseppe Morello–known as “The Clutch Hand”–and his lethal coterie of associates. In The First Family, historian, journalist, and New York Times bestselling author Mike Dash brings to life this little-known story, following the rise of the Mafia in America from the 1890s to the 1920s, from the lawless villages of Sicily to the streets of Little Italy. Using an impressive array of primary sources–hitherto untapped Secret Service archives, prison records, trial transcripts, and interviews with surviving family members–this is the first Mafia history that applies scholarly rigor to the story of the Morello syndicate and the birth of organized crime on these shores.Progressing from small-time scams to counterfeiting rings to even bigger criminal enterprises, Giuseppe Morello exerted ruthless control of Italian neighborhoods in New York, and through adroit coordination with other Sicilian crime families, his Clutch Hand soon reached far beyond the Hudson River.The men who battled Morello’s crews were themselves colorful and legendary figures, including William Flynn, a fearless Secret Service agent, and Lieutenant Detective Giuseppe “Joe” Petrosino of the New York Police Department’s elite Italian Squad, whose pursuit of the brutal gangs ultimately cost him his life. Combining first-rate scholarship and pulse-quickening action, and set amid rustic Sicilian landscapes and the streets of old New York, The First Family is a groundbreaking account of the crucial period when the American criminal underworld exploded with violent fury across the nation.

    Here, a young graduate student from Rome, Francesca Cappelletti, makes a discovery that inspires a search for a work of art of incalculable value, a painting lost for almost two centuries.The artist was Caravaggio, a master of the Italian Baroque. He was a genius, a revolutionary painter, and a man beset by personal demons. Four hundred years ago, he drank and brawled in the taverns and streets of Rome, moving from one rooming house to another, constantly in and out of jail, all the while painting works of transcendent emotional and visual power. He rose from obscurity to fame and wealth, but success didn't alter his violent temperament. His rage finally led him to commit murder, forcing him to flee Rome a hunted man. He died young, alone, and under strange circumstances.Caravaggio scholars estimate that between sixty and eighty of his works are in existence today. Many others -- no one knows the precise number -- have been lost to time. Somewhere, surely, a masterpiece lies forgotten in a storeroom, or in a small parish church, or hanging above a fireplace, mistaken for a mere copy.Jonathan Harr embarks on a journey to discover the long-lost painting known as The Taking of Christ -- its mysterious fate and the circumstances of its disappearance have captivated Caravaggio devotees for years. After Francesca Cappelletti stumbles across a clue in that dusty archive, she tracks the painting across a continent and hundreds of years of history. But it is not until she meets Sergio Benedetti, an art restorer working in Ireland, that she finally manages to assemble all the pieces of the puzzle.

    It would not stop there. Before long, the business had turned into a sprawling multinational conglomerate engaged in almost every conceivable aspect of criminal mayhem. Yachts carrying $100 million in cocaine. Safe houses in Hong Kong filled with gold bars. Shipments of methamphetamine from North Korea. Weapons deals with Iran. Mercenary armies in Somalia. Teams of hitmen in the Philippines. Encryption programs so advanced that the government could not break them.The man behind it all, pulling the strings from a laptop in Manila, was Paul Calder Le Roux—a reclusive programmer turned criminal genius who could only exist in the networked world of the twenty-first century, and the kind of self-made crime boss that American law enforcement had never imagined.For half a decade, DEA agents played a global game of cat-and-mouse with Le Roux as he left terror and chaos in his wake. Each time they came close, he would slip away. It would take relentless investigative work, and a shocking betrayal from within his organization, to catch him. And when he was finally caught, the story turned again, as Le Roux struck a deal to bring down his own organization and the people he had once employed.Award-winning investigative journalist Evan Ratliff spent four years piecing together this intricate puzzle, chasing LeRoux's empire and his shadowy henchmen around the world, conducting hundreds of interviews and uncovering thousands of documents. The result is a riveting, unprecedented account of a crime boss built by and for the digital age.Advance praise for The Mastermind“As directors, we spend countless hours imagining heightened plots and memorable characters that will leave a lasting impression on audiences. The true tale of obsession, genius, intrigue, and vengeance detailed in The Mastermind is as gripping and cinematic as anything we could endeavor to conjure up.”—Joe and Anthony Russo, directors of Captain America: The Winter Soldier, Captain America: Civil War, and Avengers: Infinity War“With his relentless and fearless reporting, Evan Ratliff has pried open a hidden world filled with high-tech gangsters and drug kingpins and double-crossers and stone-cold hitmen. The story is as fascinating as it is terrifying, and it is one that will hold you in its grip.”—David Grann, author of Killers of the Flower Moon“If truth is stranger than fiction, then The Mastermind is the truest book you’ll read this year. The only thing predictable about it is how quickly you’ll turn the pages.”—Noah Hawley, author of Before the Fall and creator of the TV series Fargo “This is a mesmerizing, absolutely bonkers story about a man as brilliant as he is villainous. You’ll find yourself sucked in, freaked out, and ultimately blown away by Ratliff's storytelling and tireless reporting. The Mastermind is a masterpiece.”—Nick Thompson, editor-in-chief, Wired

    Peter Stark offers a harrowing saga in which a band of explorers battled nature, starvation, and madness to establish the first American settlement in the Pacific Northwest and opened up what would become the Oregon trail, permanently altering the nation's landscape and its global standing.Six years after Lewis and Clark began their journey to the Pacific Northwest, two of the Eastern establishment's leading figures, John Jacob Astor and Thomas Jefferson, turned their sights to founding a colony akin to Jamestown on the West Coast and transforming the nation into a Pacific trading power. Author and correspondent for Outside magazine Peter Stark recreates this pivotal moment in American history for the first time for modern readers, drawing on original source material to tell the amazing true story of the Astor Expedition.Unfolding over the course of three years, from 1810 to 1813, Astoria is a tale of high adventure and incredible hardship in the wilderness and at sea. Of the more than one hundred-forty members of the two advance parties that reached the West Coast—one crossing the Rockies, the other rounding Cape Horn—nearly half perished by violence. Others went mad. Within one year, the expedition successfully established Fort Astoria, a trading post on the Columbia River. Though the colony would be short-lived, it opened provincial American eyes to the potential of the Western coast and its founders helped blaze the Oregon Trail.

    The man strikes the piano player as forgettable.He looks bland and inconspicuous. Not at all what you think a serial killer looks like. But that’s what he is, and tonight, he has his sights set on a gray haired man. He will not be his first victim.Nor will he be his last.The Last Call Killer preyed upon gay men in New York in the ‘80s and ‘90s and had all the hallmarks of the most notorious serial killers. Yet because of the sexuality of his victims, the skyhigh murder rates, and the AIDS epidemic, his murders have been almost entirely forgotten.This gripping true-crime narrative tells the story of the Last Call Killer and the decades-long chase to find him. And at the same time, it paints a portrait of his victims and a vibrant community navigating threat and resilience.

    Once Anthony entered Baghdad he discovered that full-scale combat and uncontrolled looting had killed nearly all the animals of the zoo.But not all of them. U.S. soldiers had taken the time to help care for the remaining animals, and the zoo's staff had returned to work in spite of the constant firefights. Together the Americans and Iraqis had managed to keep alive the animals that had survived the invasion.Babylon's Ark chronicles the zoo's transformation from bombed-out rubble to peaceful park. Along the way, Anthony recounts hair-raising efforts to save a pride of the dictator's lions, close a deplorable black-market zoo, and rescue Saddam's Arabian horses. His unique ground-level experience makes Babylon's Ark an uplifting story of both sides working together for the sake of innocent animals caught in the war's crossfire.

    Haunting, moving, and beautifully written, Dray and Kamoie used thousands of letters and original sources to tell Eliza’s story as it’s never been told before—not just as the wronged wife at the center of a political sex scandal—but also as a founding mother who shaped an American legacy in her own right.A general’s daughter…Coming of age on the perilous frontier of revolutionary New York, Elizabeth Schuyler champions the fight for independence. And when she meets Alexander Hamilton, Washington’s penniless but passionate aide-de-camp, she’s captivated by the young officer’s charisma and brilliance. They fall in love, despite Hamilton’s bastard birth and the uncertainties of war.A founding father’s wife...But the union they create—in their marriage and the new nation—is far from perfect. From glittering inaugural balls to bloody street riots, the Hamiltons are at the center of it all—including the political treachery of America’s first sex scandal, which forces Eliza to struggle through heartbreak and betrayal to find forgiveness.The last surviving light of the Revolution…When a duel destroys Eliza’s hard-won peace, the grieving widow fights her husband’s enemies to preserve Alexander’s legacy. But long-buried secrets threaten everything Eliza believes about her marriage and her own legacy. Questioning her tireless devotion to the man and country that have broken her heart, she’s left with one last battle—to understand the flawed man she married and the imperfect union he could never have created without her…

      We think of the FBI as America’s police force. But secret intelligence is the Bureau’s first and foremost mission. Enemies is the story of how presidents have used the FBI as the most formidable intelligence force in American history.   Here is the hidden history of America’s hundred-year war on terror. The FBI has fought against terrorists, spies, anyone it deemed subversive—and sometimes American presidents. The FBI’s secret intelligence and surveillance techniques have created a tug-of-war between protecting national security and infringing upon civil liberties. It is a tension that strains the very fabric of a free republic.

    These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    Then he disappeared, eluding capture by multiple police forces and some of the best detectives in the area.Three decades later, Michelle McNamara, a true crime journalist who created the popular website TrueCrimeDiary.com, was determined to find the violent psychopath she called "the Golden State Killer." Michelle pored over police reports, interviewed victims, and embedded herself in the online communities that were as obsessed with the case as she was.At the time of the crimes, the Golden State Killer was between the ages of eighteen and thirty, Caucasian, and athletic—capable of vaulting tall fences. He always wore a mask. After choosing a victim—he favored suburban couples—he often entered their home when no one was there, studying family pictures, mastering the layout. He attacked while they slept, using a flashlight to awaken and blind them. Though they could not recognize him, his victims recalled his voice: a guttural whisper through clenched teeth, abrupt and threatening.I’ll Be Gone in the Dark—the masterpiece McNamara was writing at the time of her sudden death—offers an atmospheric snapshot of a moment in American history and a chilling account of a criminal mastermind and the wreckage he left behind. It is also a portrait of a woman’s obsession and her unflagging pursuit of the truth. Framed by an introduction by Gillian Flynn and an afterword by her husband, Patton Oswalt, the book was completed by Michelle’s lead researcher and a close colleague. Utterly original and compelling, it is destined to become a true crime classic—and may at last unmask the Golden State Killer.

    But none has been quite so dramatic or compelling as the Jonestown massacre of 1978, in which the Reverend Jim Jones and 913 of his disciples perished. Deborah Layton had been a member of the Peoples Temple for seven years when she departed for Jonestown, Guyana, the promised land nestled deep in the South American jungle. When she arrived, however, Layton saw that something was seriously wrong. Jones constantly spoke of a revolutionary mass suicide, and Layton knew only too well that he had enough control over the minds of the Jonestown residents to carry it out. But her pleas for help--and her sworn affidavit to the U.S. government--fell on skeptical ears. In this very personal account, Layton opens up the shadowy world of cults and shows how anyone can fall under their spell. Seductive Poison is both an unflinching historical document and a riveting story of intrigue, power, and murder.

    In the spring of 1865, the bloody saga of America's Civil War finally comes to an end after a series of increasingly harrowing battles. President Abraham Lincoln's generous terms for Robert E. Lee's surrender are devised to fulfill Lincoln's dream of healing a divided nation, with the former Confederates allowed to reintegrate into American society. But one man and his band of murderous accomplices, perhaps reaching into the highest ranks of the U.S. government, are not appeased.In the midst of the patriotic celebrations in Washington D.C., John Wilkes Booth—charismatic ladies' man and impenitent racist—murders Abraham Lincoln at Ford's Theatre. A furious manhunt ensues and Booth immediately becomes the country's most wanted fugitive. Lafayette C. Baker, a smart but shifty New York detective and former Union spy, unravels the string of clues leading to Booth, while federal forces track his accomplices. The thrilling chase ends in a fiery shootout and a series of court-ordered executions—including that of the first woman ever executed by the U.S. government, Mary Surratt. Featuring some of history's most remarkable figures, vivid detail, and page-turning action, Killing Lincoln is history that reads like a thriller. http://catalog.loc.gov/cgi-bin/Pwebre...~