With more than one in every five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide. If we are not victims ourselves, we all know someone struggling with the merciless compulsion to alter their experience by changing how their brain functions.Drawing on years of research--as well as personal experience as a recovered addict--researcher and professor Judy Grisel has reached a fundamental conclusion: for the addict, there will never be enough drugs. The brain's capacity to learn and adapt is seemingly infinite, allowing it to counteract any regular disruption, including that caused by drugs. What begins as a normal state punctuated by periods of being high transforms over time into a state of desperate craving that is only temporarily subdued by a fix, explaining why addicts are unable to live either with or without their drug. One by one, Grisel shows how different drugs act on the brain, the kind of experiential effects they generate, and the specific reasons why each is so hard to kick.Grisel's insights lead to a better understanding of the brain's critical contributions to addictive behavior, and will help inform a more rational, coherent, and compassionate response to the epidemic in our homes and communities.

    Chanda Prescod-Weinstein shares her love for physics, from the Standard Model of Particle Physics and what lies beyond it, to the physics of melanin in skin, to the latest theories of dark matter — all with a new spin informed by history, politics, and the wisdom of Star Trek.One of the leading physicists of her generation, Dr. Chanda Prescod-Weinstein is also one of fewer than one hundred Black American women to earn a PhD from a department of physics. Her vision of the cosmos is vibrant, buoyantly non-traditional, and grounded in Black feminist traditions.Prescod-Weinstein urges us to recognize how science, like most fields, is rife with racism, sexism, and other dehumanizing systems. She lays out a bold new approach to science and society that begins with the belief that we all have a fundamental right to know and love the night sky. The Disordered Cosmos dreams into existence a world that allows everyone to tap into humanity’s wealth of knowledge about the wonders of the universe.

    In this gripping account, David Quammen takes the reader along on this astonishing quest to learn how, where from, and why these diseases emerge and asks the terrifying question: What might the next big one be?

    Men grow up being told that boys don’t cry and dolls are for girls. They learn they must hide their feelings and anxieties, that their masculinity must constantly be proven. They must be the breadwinners. They must be the romantic pursuers. This hasn’t been good for the culture at large: 99% of school shooters are male; men in fraternities are 300% more likely to rape; a woman serving in uniform has a higher likelihood of being assaulted by a fellow soldier than to be killed by enemy fire.In For the Love of Men, author Liz Plank offers a smart, insightful, and deeply researched guide for what we're all going to do about toxic masculinity. For both women looking to guide the men in their lives and men who want to do better and just don’t know how, For the Love of Men will lead the conversation on men's issues in a society where so much is changing but gender roles have remained strangely stagnant.What are we going to do about men? Plank has the answer--and it has the possibility to change the world for men and women alike.

    But in the inevitable condition of aging and death, the goals of medicine seem too frequently to run counter to the interest of the human spirit. Nursing homes, preoccupied with safety, pin patients into railed beds and wheelchairs. Hospitals isolate the dying, checking for vital signs long after the goals of cure have become moot. Doctors, committed to extending life, continue to carry out devastating procedures that in the end extend suffering.Gawande, a practicing surgeon, addresses his profession's ultimate limitation, arguing that quality of life is the desired goal for patients and families. Gawande offers examples of freer, more socially fulfilling models for assisting the infirm and dependent elderly, and he explores the varieties of hospice care to demonstrate that a person's last weeks or months may be rich and dignified.

    Your head hurts. You're mildly annoyed as you get the kids ready for school and dress for work yourself. Meanwhile, an epic war is being fought, just below your skin. Millions are fighting and dying for you to be able to complain as you head out the door.So what, exactly, is your immune system?Second only to the human brain in its complexity, it is one of the oldest and most critical facets of life on Earth. Without it, you would die within days. In Immune, Philipp Dettmer, the brains behind the most popular science channel on YouTube, takes readers on a journey through the fortress of the human body and its defenses. There is a constant battle of staggering scale raging within us, full of stories of invasion, strategy, defeat, and noble self-sacrifice. In fact, in the time you've been reading this, your immune system has probably identified and eradicated a cancer cell that started to grow in your body.Each chapter delves into an element of the immune system, including defenses like antibodies and inflammation as well as threats like bacteria, allergies, and cancer, as Dettmer reveals why boosting your immune system is actually nonsense, how parasites sneak their way past your body's defenses, how viruses work, and what goes on in your wounds when you cut yourself.Enlivened by engaging graphics and immersive descriptions, Immune turns one of the most intricate, interconnected, and confusing subjects—immunology—into a gripping adventure through an astonishing alien landscape. Immune is a vital and remarkably fun crash course in what is arguably, and increasingly, the most important system in the body.

    They are told that in the name of sexual consent and feminist empowerment, they must proclaim their desires clearly and confidently. Sex researchers tell us that women don't know what they want. And men are on hand to persuade women that what they want is, in fact, exactly what men want. In this environment, how can women possibly know what they want—and how can they be expected to?In this elegantly written, searching book Katherine Angel surveys medical and psychoanalytic understandings of female desire, from Freud to Kinsey to present-day science; MeToo-era debates over consent, assault, and feminism; and popular culture, TV, and film to challenge our assumptions about female desire. Why, she asks, do we expect desire to be easily understood? Why is there not space for the unsure, the tentative, the maybe, the let's just see? In contrast to the endless exhortation to know what we want, Angel proposes that sex can be a conversation, requiring insight, interaction, and mutual vulnerability—a shared collaboration into the unknown.In this crucial moment of renewed attention to violence and power, Angel urges that we remake our thinking about sex, pleasure, and autonomy without any illusions of perfect self-knowledge. Only then will we bring about Michel Foucault's sardonic promise, in 1976, that "tomorrow sex will be good again."

    She then looks at the historical practices of Chinese foot binding and Medieval European witch burning from a radical feminist perspective. The book's final section discusses the concept of androgyny within various cultures' creation myths and argues for "the development of a new kind of human being and a new kind of human community" free from gender and gendered roles.

    On the eve of this centenary, journalist Johann Hari set off on an epic three-year, thirty-thousand-mile journey into the war on drugs. What he found is that more and more people all over the world have begun to recognize three startling truths: Drugs are not what we think they are. Addiction is not what we think it is. And the drug war has very different motives to the ones we have seen on our TV screens for so long.In Chasing the Scream, Hari reveals his discoveries entirely through the stories of people across the world whose lives have been transformed by this war. They range from a transsexual crack dealer in Brooklyn searching for her mother, to a teenage hit-man in Mexico searching for a way out. It begins with Hari's discovery that at the birth of the drug war, Billie Holiday was stalked and killed by the man who launched this crusade--and it ends with the story of a brave doctor who has led his country to decriminalize every drug, from cannabis to crack, with remarkable results.Chasing the Scream lays bare what we really have been chasing in our century of drug war--in our hunger for drugs, and in our attempt to destroy them. This book will challenge and change how you think about one of the most controversial--and consequential--questions of our time.

    The Ivy League institution dedicated to graduating “one thousand male leaders” each year had finally decided to open its doors to the nation’s top female students. The landmark decision was a huge step forward for women’s equality in education.Or was it?The experience the first undergraduate women found when they stepped onto Yale’s imposing campus was not the same one their male peers enjoyed. Isolated from one another, singled out as oddities and sexual objects, and barred from many of the privileges an elite education was supposed to offer, many of the first female students found themselves immersed in an overwhelmingly male culture they were unprepared to face. Yale Needs Women is the story of how these young women fought against the backward-leaning traditions of a centuries-old institution and created the opportunities that would carry them into the future. Anne Gardiner Perkins’s unflinching account of a group of young women striving for change is an inspiring story of strength, resilience, and courage that continues to resonate today.

    Guy Leschziner's patients, there is no rest for the weary in mind and body. Insomnia, narcolepsy, night terrors, sleep apnea, and sleepwalking are just a sampling of conditions afflicting sufferers who cannot sleep--and their experiences in trying are the stuff of nightmares. Demoniac hallucinations frighten people into paralysis. Restless legs rock both the sleepless and their sleeping partners with unpredictable and uncontrollable kicking. Out-of-sync circadian rhythms confuse the natural body clock's days and nights.Then there are the extreme cases. A woman in a state of deep sleep who gets dressed, unlocks her car, and drives for several miles before returning to bed. The man who has spent decades cleaning out kitchens while "sleep-eating." The teenager prone to the serious, yet unfortunately nicknamed "Sleeping Beauty Syndrome" stuck in a cycle of excessive unconsciousness, binge eating, and uncharacteristic displays of aggression and hyper-sexuality while awake.With compassionate stories of his patients and their conditions, Dr. Leschziner illustrates the neuroscience behind our sleeping minds, revealing the many biological and psychological factors necessary in getting the rest that will not only maintain our physical and mental health, but improve our cognitive abilities and overall happiness.

    Full of extraordinary facts and astonishing stories, The Body: A Guide for Occupants is a brilliant, often very funny attempt to understand the miracle of our physical and neurological make up.A wonderful successor to A Short History of Nearly Everything, this book will have you marvelling at the form you occupy, and celebrating the genius of your existence, time and time again.

    Introduced at a workshop in Boston University led by the acclaimed and famous poet Robert Lowell, Sylvia Plath and Anne Sexton formed a friendship that would soon evolve into a fierce rivalry, colored by jealousy and respect in equal terms. In the years that followed, these two women would not only become iconic figures in literature, but also lead curiously parallel lives haunted by mental illness, suicide attempts, self-doubt, and difficult personal relationships. With weekly martini meetings at the Ritz to discuss everything from sex to suicide, theirs was a relationship as complex and subversive as their poetry. Based on in-depth research and unprecedented archival access, Three-Martini Afternoons at the Ritz is a remarkable and unforgettable look at two legendary poets and how their work has turned them into lasting and beloved cultural figures.

    The popular image of the Regency continues to be mythologized by the hundreds of romance novels set in the period, which focus almost exclusively on wealthy, white, Christian members of the upper classes.But there are hundreds of fascinating women who don't fit history books limited perception of what was historically accurate for early 19th century England. Women like Dido Elizabeth Belle, whose mother was a slave but was raised by her white father's family in England, Caroline Herschel, who acted as her brother's assistant as he hunted the heavens for comets, and ended up discovering eight on her own, Anne Lister, who lived on her own terms with her common-law wife at Shibden Hall, and Judith Montefiore, a Jewish woman who wrote the first English language Kosher cookbook.As one of the owners of the successful romance-only bookstore The Ripped Bodice, Bea Koch has had a front row seat to controversies surrounding what is accepted as "historically accurate" for the wildly popular Regency period. Following in the popular footsteps of books like Ann Shen's Bad Girls Throughout History, Koch takes the Regency, one of the most loved and idealized historical time periods and a huge inspiration for American pop culture, and reveals the independent-minded, standard-breaking real historical women who lived life on their terms. She also examines broader questions of culture in chapters that focus on the LGBTQ and Jewish communities, the lives of women of color in the Regency, and women who broke barriers in fields like astronomy and paleontology. In Mad and Bad, we look beyond popular perception of the Regency into the even more vibrant, diverse, and fascinating historical truth.

    They wound, they inflate, they define, they demean. They have nuance and power. "Effortless," "Sassy," "Ambitious," "Aggressive": What subtle digs and sneaky implications are conveyed when women are described with words like these? Words are made into weapons, warnings, praise, and blame, bearing an outsized influence on women's lives -- to say nothing of our moods.No one knows this better than Lizzie Skurnick, writer of the New York Times' column "That Should be A Word" and a veritable queen of cultural coinage. And in Pretty Bitches, Skurnick has rounded up a group of powerhouse women writers to take on the hidden meanings of these words, and how they can limit our worlds -- or liberate them. From Laura Lipmann and Meg Wolizer to Jennifer Weiner and Rebecca Traister, each writer uses her word as a vehicle for memoir, cultural commentary, critique, or all three. Spanning the street, the bedroom, the voting booth, and the workplace, these simple words have huge stories behind them -- stories it's time to examine, re-imagine, and change.