But things changed dramatically when he began suffering from inexplicable fatigue. In a matter of weeks, his organs were failing and he was read his last rites. Doctors were baffled by his condition, which they had yet to even diagnose. Floating in and out of consciousness, Fajgenbaum prayed for a second chance, the equivalent of a dramatic play to second the game into overtime.Miraculously, Fajgenbaum survived--only to endure repeated near-death relapses from what would eventually be identified as a form of Castleman disease, an extremely deadly and rare condition that acts like a cross between cancer and an autoimmune disorder. When he relapsed while on the only drug in development and realized that the medical community was unlikely to make progress in time to save his life, Fajgenbaum turned his desperate hope for a cure into concrete action: Between hospitalizations he studied his own charts and tested his own blood samples, looking for clues that could unlock a new treatment. With the help of family, friends, and mentors, he also reached out to other Castleman disease patients and physicians, and eventually came up with an ambitious plan to crowdsource the most promising research questions and recruit world-class researchers to tackle them. Instead of waiting for the scientific stars to align, he would attempt to align them himself.More than five years later and now married to his college sweetheart, Fajgenbaum has seen his hard work pay off: A treatment he identified has induced a tentative remission and his novel approach to collaborative scientific inquiry has become a blueprint for advancing rare disease research. His incredible story demonstrates the potency of hope, and what can happen when the forces of determination, love, family, faith, and serendipity collide.

    Can our world support that? What kind of world will it be? Those answering these questions generally fall into two deeply divided groups--Wizards and Prophets, as Charles Mann calls them in this balanced, authoritative, nonpolemical new book. The Prophets, he explains, follow William Vogt, a founding environmentalist who believed that in using more than our planet has to give, our prosperity will lead us to ruin. Cut back! was his mantra. Otherwise everyone will lose! The Wizards are the heirs of Norman Borlaug, whose research, in effect, wrangled the world in service to our species to produce modern high-yield crops that then saved millions from starvation. Innovate! was Borlaug's cry. Only in that way can everyone win! Mann delves into these diverging viewpoints to assess the four great challenges humanity faces--food, water, energy, climate change--grounding each in historical context and weighing the options for the future. With our civilization on the line, the author's insightful analysis is an essential addition to the urgent conversation about how our children will fare on an increasingly crowded Earth.

    National bestseller "Medicine Men" follows the beloved #1 bestselling "Heart in the Right Place". This is a collection of the most memorable moments from more than a dozen rural physicians who each practiced medicine for more than 50 years in the Southern Appalachian Mountains from 1930-2012. Hilarious, heroic, true stories of miracle cures, ghost dogs, and much madcap medical mayhem. Unimaginably funny and touching situations where men with nerves of steel and hearts of gold get stuck between a rock and a hard place in the Smoky Mountains. These men are saints who walk among us and Jourdan's father is one of them. Jourdan's work is often compared to James Herriot and Bill Bryson. This story collection is like "All Creatures Great and Small" but with people instead of animals or vingnettes from country doctors who took "A Walk in the Woods".Jourdan's first book is on hundreds of lists of best books of the year, best book club books, and funniest books. "Heart in the Right Place" was chosen as Family Circle magazine's first ever Book of the Month, won the Elle magazine Reader's Prize, named a Wall Street Journal Nonfiction Bestseller and ranked #1 on Amazon in Biography, Memoir, Science, and Medicine.

    Though the process obeyed all the rules of chemistry and physics, the details of that original event pose as deep a mystery as any facing science. How did non-living chemicals become alive? While the question is (deceivingly) simple, the answers are unquestionably complex. Science inevitably plays a key role in any discussion of life's origins, dealing less with the question of why life appeared on Earth than with where, when, and how it emerged on the blasted, barren face of our primitive planet. Astrobiologist Robert Hazen has spent many years dealing with the fundamental questions of life's genesis. As an active research scientist, he is down deep in all the messy details that science has to offer on the subject, tracing the inexorable sequence of events that led to the complicated interactions of carbonbased molecules. As he takes us through the astounding process of emergence, we are witness to the first tentative steps toward life?from the unfathomable abundance of carbon biomolecules synthesized in the black vacuum of space to the surface of the Earth to deep within our planet's restless crust. We are privy to the breathtaking drama that rapidly unfolds as life prevails. The theory of emergence is poised to answer a multitude of questions?even as it raises the possibility that natural processes exist beyond what we now know, perhaps beyond what we even comprehend. Genesis tells the tale of transforming scientific advances in our quest for life's origins. Written with grace, beauty, and authority, it goes directly to the heart of who we are and why we are here.

    This autobiography traces Janet Frame's childhood in a poor but intellectually intense family, life as a student, years of incarceration in mental hospitals and eventual entry into the saving world of writers.

    The book opens with his father's fond, vivid portrait of his son - a young man of extraordinary intellectual promise, who excelled at physics, math, and chess, but was also an active, good-hearted, and fun-loving kid. But the heart of the book is a description of the agonized months during which Gunther and his former wife Frances try everything in their power to halt the spread of Johnny's cancer and to make him as happy and comfortable as possible. In the last months of his life, Johnny strove hard to complete his high school studies. The scene of his graduation ceremony from Deerfield Academy is one of the most powerful - and heartbreaking - in the entire book. Johnny maintained his courage, wit and quiet friendliness up to the end of his life. He died on June 30, 1947, less than a month after graduating from Deerfield.

    The Beatles learn to be brilliant in an hour and a half. An Englishman arrives back from Calcutta but refuses to adjust his watch. Beethoven has his symphonic wishes ignored. A US Senator begins a speech that will last for 25 hours. The horrors of war are frozen at the click of a camera. A woman designs a ten-hour clock and reinvents the calendar. Roger Bannister lives out the same four minutes over a lifetime. And a prince attempts to stop time in its tracks.Timekeepers is a book about our obsession with time and our desire to measure it, control it, sell it, film it, perform it, immortalise it and make it meaningful. It has two simple intentions: to tell some illuminating stories, and to ask whether we have all gone completely nuts.

    He also found the notes Darwin kept throughout Annie's illness, the eulogy he delivered at her funeral—and provocative new insights into Darwin’s views on nature, evolution, and the human condition. In Darwin, His Daughter & Human Evolution, Keynes shows that Darwin was not "a cold intellect with no place for love in his famous 'struggle for existence,' [but]...a man of uncommon warmth" (Scientific American).Creation: The True Story of Charles Darwin is now a major motion picture and the movie tie-in paperback is also available from Riverhead Books.

    She was a poor Southern tobacco farmer who worked the same land as her enslaved ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia — a land of wooden quarters for enslaved people, faith healings, and voodoo — to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family — past and present — is inextricably connected to the history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance?Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

    While there, she reached out to the trapped Jewish families, going from door to door and asking the parents to trust her with their young children. She started smuggling them out of the walled district, convincing her friends and neighbors to hide them. Driven to extreme measures and with the help of a network of local tradesmen, ghetto residents, and her star-crossed lover in the Jewish resistance, Irena ultimately smuggled thousands of children past the Nazis. She made dangerous trips through the city’s sewers, hid children in coffins, snuck them under overcoats at checkpoints, and slipped them through secret passages in abandoned buildings.But Irena did something even more astonishing at immense personal risk: she kept secret lists buried in bottles under an old apple tree in a friend’s back garden. On them were the names and true identities of those Jewish children, recorded with the hope that their relatives could find them after the war. She could not have known that more than ninety percent of their families would perish.

    And yet for many years it was equally baffling for scientists themselves. Manjit Kumar gives a dramatic and superbly-written history of this fundamental scientific revolution, and the divisive debate at its heart.For 60 years most physicists believed that quantum theory denied the very existence of reality itself. Yet Kumar shows how the golden age of physics ignited the greatest intellectual debate of the twentieth century.Quantum sets the science in the context of the great upheavals of the modern age. In 1925 the quantum pioneers nearly all hailed from upper-middle-class academic families; most were German; and their average age was 24. But it was their irrational, romantic spirit, formed in reaction to the mechanised slaughter of the First World War that inspired their will to test science to its limits.The essential read for anyone fascinated by this complex and thrilling story and by the band of young men at its heart.

    As Professor of Anatomy and Forensic Anthropology, she focuses on mortal remains in her lab, at burial sites, at scenes of violence, murder and criminal dismemberment, and when investigating mass fatalities due to war, accident or natural disaster. In All that Remains she reveals the many faces of death she has come to know, using key cases to explore how forensic science has developed, and what her work has taught her. Do we expect a book about death to be sad? Macabre? Sue’s book is neither. There is tragedy, but there is also humour in stories as gripping as the best crime novel. Our own death will remain a great unknown. But as an expert witness from the final frontier, Sue Black is the wisest, most reassuring, most compelling of guides.

    The girl with the pigtails, the symbol of innocence in The Wizard of Oz. The brightest star of the Hollywood musical and an entertainer of almost magical power. The woman of a half-dozen comebacks, a hundred heartbreaks, and thousands of headlines. Yet much of what has been written about her is either inaccurate or incomplete, and the Garland the world thought it knew was merely a sketch for the astonishing woman Gerald Clarke portrays in Get Happy. Here, more than thirty years after her death, is the real Judy.

    In 2013, the New York Times published an obituary for Yvonne Brill. It began: “She made a mean beef stroganoff, followed her husband from job to job, and took eight years off from work to raise three children.” It wasn’t until the second paragraph that readers discovered why the Times had devoted several hundred words to her life: Brill was a brilliant rocket scientist who invented a propulsion system to keep communications satellites in orbit, and had recently been awarded the National Medal of Technology and Innovation. Among the questions the obituary—and consequent outcry—prompted were, Who are the role models for today’s female scientists, and where can we find the stories that cast them in their true light?      Headstrong delivers a powerful, global, and engaging response. Covering Nobel Prize winners and major innovators, as well as lesser-known but hugely significant scientists who influence our every day, Rachel Swaby’s vibrant profiles span centuries of courageous thinkers and illustrate how each one’s ideas developed, from their first moment of scientific engagement through the research and discovery for which they’re best known. This fascinating tour reveals these 52 women at their best—while encouraging and inspiring a new generation of girls to put on their lab coats.

    It has been inspired by the scientific ferment that swept through Britain at the end of the 18th century, and which Holmes now radically redefines as 'the revolution of Romantic Science'.